The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics
Open accessAbstract
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and agonistic antibodies against TRAIL death receptors (DR) kill tumor cells while causing virtually no damage to normal cells. Several novel drugs targeting TRAIL receptors are currently in clinical trials. However, TRAIL resistance is a common obstacle in TRAIL-based therapy and limits the efficiency of these drugs. In this review article we discuss different mechanisms of TRAIL resistance, and how they can be predicted and therapeutically circumvented. In addition, we provide a brief overview of all TRAIL-based clinical trials conducted so far. It is apparent that although the effects of TRAIL therapy are disappointingly modest overall, a small subset of patients responds very well to TRAIL. We argue that the true potential of targeting TRAIL DRs in cancer can only be reached when we find efficient ways to select for those patients that are most likely to benefit from the treatment. To achieve this, it is crucial to identify biomarkers that can help us predict TRAIL sensitivity.
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Cites
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Cited by
A fate worse than death: apoptosis as an oncogenic process
Ichim, G., & Tait, S. W. G. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.58 · Cited by 451
Jiang, G.-M., Tan, Y., Wang, H., Peng, L., Chen, H.-T., Meng, X.-J., Li, L.-L., Liu, Y., Li, W.-F., & Shan, H. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0944-z · Cited by 365
Genetics and biomarkers in personalisation of lung cancer treatment
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Onto better TRAILs for cancer treatment
de Miguel, D., Lemke, J., Anel, A., Walczak, H., & Martinez-Lostao, L. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.174 · Cited by 304
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Self-citation
Metadata
- Authors
- Dimberg, L. Y., Anderson, C. K., Camidge, R., Behbakht, K., Thorburn, A., & Ford, H. L.
- Venue
- Oncogene
- Published
- 2012-05-14
- Volume
- 32
- Issue
- 11
- Pages
- 1341-1350
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2007718868
- Cited by
- 276
- References
- 100
- FWCI
- 11.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Dimberg, L. Y., Anderson, C. K., Camidge, R., Behbakht, K., Thorburn, A., & Ford, H. L. (2013). On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics. Oncogene. https://doi.org/10.1038/onc.2012.164
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