Cited by 451Cell death mechanisms and regulationPhagocytosis and Immune RegulationCancer-related Molecular Pathways

A fate worse than death: apoptosis as an oncogenic process

Ichim, Gabriel, Tait, Stephen W. G.·2016·Nature Reviews Cancer

Abstract

Apoptotic cell death is widely considered a positive process that both prevents and treats cancer. Although undoubtedly having a beneficial role, paradoxically, apoptosis can also cause unwanted effects that may even promote cancer. In this Opinion article we highlight some of the ways by which apoptosis can exert oncogenic functions. We argue that fully understanding this dark side will be required to optimally engage apoptosis, thereby maximizing tumour cell kill while minimizing unwanted pro-tumorigenic effects.

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Crossref · 10.1038/nrc.2016.58

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Authors
Ichim, G., & Tait, S. W. G.
Affiliations
Cancer Research UK Scotland Institute (GB)
Corresponding author
Tait, Stephen W. G.
Venue
Nature Reviews Cancer
Published
2016-07-01
Volume
16
Issue
8
Pages
539-548
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W2474601761
Cited by
451
References
158
Citations by year
2026: 21 · 2025: 33 · 2024: 35 · 2023: 37 · 2022: 43 · 2021: 49 · 2020: 68 · 2019: 59 · 2018: 56 · 2017: 40 · 2016: 7 · 2015: 1
FWCI
4.89
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
Funders
  • Cancer Research UK (20145)
  • Biotechnology and Biological Sciences Research Council (BB/K008374/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords
apoptosis, cancer, tumor suppression, tumor promotion, cancer therapy
MeSH terms
Animals, Humans, Neoplasms, Oncogenes, Prognosis, Apoptosis, Carcinogenesis

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