The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells
Open accessAbstract
Malignant breast tissue contains a rare population of multi-potent cells with the capacity to self-renew; these cells are known as cancer stem-like cells (CSCs) or tumor-initiating cells. Primitive mammary CSCs/progenitor cells can be propagated in culture as floating spherical colonies termed 'mammospheres'. We show here that the expression of the autophagy protein Beclin 1 is higher in mammospheres established from human breast cancers or breast cancer cell lines (MCF-7 and BT474) than in the parental adherent cells. As a result, autophagic flux is more robust in mammospheres. We observed that basal and starvation-induced autophagy flux is also higher in aldehyde dehydrogenase 1-positive (ALDH1(+)) population derived from mammospheres than in the bulk population. Beclin 1 is critical for CSC maintenance and tumor development in nude mice, whereas its expression limits the development of tumors not enriched with breast CSCs/progenitor cells. We found that decreased survival in autophagy-deficient cells (MCF-7 Atg7 knockdown cells) during detachment does not contribute to an ultimate deficiency in mammosphere formation. This study demonstrates that a prosurvival autophagic pathway is critical for CSC maintenance, and that Beclin 1 plays a dual role in tumor development.
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Self-citationInduction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival
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Regulation of mammary stem/progenitor cells by PTEN/Akt/β-catenin signaling
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Self-citationAutophagy and apoptosis dysfunction in neurodegenerative disorders
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Self-citationSenescence and aging: the critical roles of p53
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Metadata
- Authors
- Gong, C., Bauvy, C., Tonelli, G., Yue, W., Deloménie, C., Nicolas, V, Zhu, Y., Domergue, V, Marin-Esteban, V, Tharinger, H., Delbos, L., Gary-Gouy, H., Morel, A.-P., Ghavami, S., Song, E., Codogno, P., & Mehrpour, M.
- Venue
- Oncogene
- Published
- 2012-06-25
- Volume
- 32
- Issue
- 18
- Pages
- 2261-2272
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2093500494
- Cited by
- 369
- References
- 10
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells. https://app.cochat.ai/papers/10.1038/onc.2012.252
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- Gong, C., Bauvy, C., Tonelli, G., Yue, W., Deloménie, C., Nicolas, V, Zhu, Y., Domergue, V, Marin-Esteban, V, Tharinger, H., Delbos, L., Gary-Gouy, H., Morel, A.-P., Ghavami, S., Song, E., Codogno, P., & Mehrpour, M. (2013). Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells. Oncogene. https://doi.org/10.1038/onc.2012.252
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