Autophagy and apoptosis dysfunction in neurodegenerative disorders
Open accessAbstract
Autophagy and apoptosis are basic physiologic processes contributing to the maintenance of cellular homeostasis. Autophagy encompasses pathways that target long-lived cytosolic proteins and damaged organelles. It involves a sequential set of events including double membrane formation, elongation, vesicle maturation and finally delivery of the targeted materials to the lysosome. Apoptotic cell death is best described through its morphology. It is characterized by cell rounding, membrane blebbing, cytoskeletal collapse, cytoplasmic condensation, and fragmentation, nuclear pyknosis, chromatin condensation/fragmentation, and formation of membrane-enveloped apoptotic bodies, that are rapidly phagocytosed by macrophages or neighboring cells. Neurodegenerative disorders are becoming increasingly prevalent, especially in the Western societies, with larger percentage of members living to an older age. They have to be seen not only as a health problem, but since they are care-intensive, they also carry a significant economic burden. Deregulation of autophagy plays a pivotal role in the etiology and/or progress of many of these diseases. Herein, we briefly review the latest findings that indicate the involvement of autophagy in neurodegenerative diseases. We provide a brief introduction to autophagy and apoptosis pathways focusing on the role of mitochondria and lysosomes. We then briefly highlight pathophysiology of common neurodegenerative disorders like Alzheimer's diseases, Parkinson's disease, Huntington's disease and Amyotrophic lateral sclerosis. Then, we describe functions of autophagy and apoptosis in brain homeostasis, especially in the context of the aforementioned disorders. Finally, we discuss different ways that autophagy and apoptosis modulation may be employed for therapeutic intervention during the maintenance of neurodegenerative disorders.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some neurodevelopmental disorders can present later in the teens to early adulthood, while early-onset neurodegenerative disorders can be seen in the 4th or 5th decade of life.
“For example, some “neurodevelopmental” disorders can present later in the teens to early adulthood, while early-onset “neurodegenerative” disorders can be seen in the 4th or 5th decade of life.”
From The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases (2025) · cites this paper as [63]
Section 12 (Amyotrophic lateral sclerosis; page not provided) reports a typical ALS onset between ages 35 and 50, supporting the example of a neurodegenerative disorder appearing in the fourth or fifth decade. The passages found do not address neurodevelopmental disorders presenting in the teens or early adulthood (searched: neurodevelopmental disorders, neurodevelopmental). (LLM, conf=0.86)
Experimental — accuracy not yet measuredKufor-Rakeb syndrome can present in adulthood, quite late for a neurodevelopmental disorder.
“It can present in adulthood, quite late for a neurodevelopmental disorder.62,63”
From The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases (2025) · cites this paper as [63]
The Parkinson’s disease section discusses variable onset ages in inherited Parkinson’s disease, but does not address Kufor-Rakeb syndrome specifically. Searches for Kufor-Rakeb, ATP13A2/PARK9, and adult presentation of a neurodevelopmental disorder found no passage establishing the claim in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measuredKufor-Rakeb syndrome is an autosomal recessive early-onset form of Parkinson's disease caused by mutations in the lysosomal ATPase protein, ATP13A2.
“A striking example of this overlap is Kufor-Rakeb syndrome, an autosomal recessive early-onset form of Parkinson’s disease caused by mutations in the lysosomal ATPase protein, ATP13A2.”
From The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases (2025) · cites this paper as [63]
Section 10 (Parkinson’s disease; page unavailable) discusses genetic forms of Parkinson’s disease, particularly LRRK2, but does not address Kufor-Rakeb syndrome. Searches for Kufor-Rakeb, ATP13A2, and PARK9 found no passage stating its inheritance, onset, or proposed cause. (LLM, conf=0.75)
Experimental — accuracy not yet measuredDisruption of normal autophagy/mitophagy may contribute to mitochondrial malfunction and thereby promote PCD.
“The data suggest that a disruption of normal autophagy/mitophagy may contribute to mitochondrial malfunction and thereby promote PCD (Ghavami et al., 2014; Hroudova et al., 2014; Nixon and Yang, 2012).”
From Programmed cell death in aging (2015) · cites this paper as Ghavami et al., 2014
PCD is increasingly implicated in several aging-associated neurodegenerative diseases.
“However, PCD is increasingly implicated in several aging-associated neurodegenerative diseases(Ghavami et al., 2014).”
From Programmed cell death in aging (2015) · cites this paper as Ghavami et al., 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Atkin, J. D., Farg, M. A., Turner, B. J., Tomas, D., Lysaght, J. A., Nunan, J., Rembach, A., Nagley, P., Beart, P. M., Cheema, S. S., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603393200 · Cited by 279 · see citing works
RetractedMutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240 · see citing works
Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
Neumann, M., Sampathu, D. M., Kwong, L. K., Truax, A. C., Micsenyi, M. C., Chou, T. T., Bruce, J., Schuck, T., Grossman, M., Clark, C. M., et al. (2006) · Science · doi:10.1126/science.1134108 · Cited by 6,576 · see citing works
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452 · see citing works
Parkinson's disease: clinical features and diagnosis
Jankovic, J. (2008) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2007.131045 · Cited by 5,720 · cited 1× · see citing works
“Nonmotoric symptoms include cognitive impairment, depression and sleep disorders (Jankovic, 2008).”
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227 · see citing works
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569 · see citing works
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396 · see citing works
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026 · see citing works
Autophagy: process and functionPreprint
Mizushima, N. (2007) · Genes & Development · doi:10.1101/gad.1599207 · Cited by 3,967 · see citing works
Autophagy: cellular and molecular mechanisms
Glick, D. R., Barth, S., & Macleod, K. F. (2010) · The Journal of Pathology · doi:10.1002/path.2697 · Cited by 3,815 · see citing works
Mitochondrial Fission, Fusion, and Stress
Youle, R. J., & van der Bliek, A. M. (2012) · Science · doi:10.1126/science.1219855 · Cited by 3,674 · see citing works
Mechanisms underlying inflammation in neurodegeneration
Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580 · see citing works
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500 · see citing works
TFEB Links Autophagy to Lysosomal Biogenesis
Settembre, C., Di Malta, C., Polito, V. A., Arencibia, M. G., Vetrini, F., Erdin, S., Erdin, S. U., Huynh, T., Medina, D., Colella, P., et al. (2011) · Science · doi:10.1126/science.1204592 · Cited by 3,365 · see citing works
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
Nakagawa, T., Zhu, H., Morishima, N., Li, E., Xu, J., Yankner, B. A., & Yuan, J. (2000) · Nature · doi:10.1038/47513 · Cited by 3,262 · see citing works
Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology
Zimprich, A. A., Biskup, S., Leitner, P., Lichtner, P., Farrer, M. J., Lincoln, S., Kachergus, J. M., Hulihan, M., Uitti, R. J., Calne, D. B., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.005 · Cited by 3,024 · see citing works
McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990 · see citing works
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F. C., Rothfuss, O. C., Kahle, P. J., & Springer, W. (2010) · Nature Cell Biology · doi:10.1038/ncb2012 · Cited by 2,835 · see citing works
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C. J., Squitieri, F., Ibáñez, P., Joosse, M., et al. (2003) · Science · doi:10.1126/science.1077209 · Cited by 2,800 · see citing works
Programmed Cell Death in Animal Development
Jacobson, M. D., Weil, M., & RAFF, M. C. (1997) · Cell · doi:10.1016/s0092-8674(00)81873-5 · Cited by 2,685 · see citing works
TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
Sreedharan, J., Blair, I. P., Tripathi, V. B., Hu, X., Vance, C., Rogelj, B., Ackerley, S., Durnall, J. C., Williams, K. L., Buratti, E., et al. (2008) · Science · doi:10.1126/science.1154584 · Cited by 2,630 · see citing works
Walker, F. O. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60111-1 · Cited by 2,623 · see citing works
Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
Vance, C. A., Rogelj, B., Hortobágyi, T., Vos, K. J. D., Nishimura, A. L., Sreedharan, J., Hu, X., Smith, B. N., Ruddy, D., Wright, P. D., et al. (2009) · Science · doi:10.1126/science.1165942 · Cited by 2,531 · see citing works
Cho, Y., Challa, S., Moquin, D., Genga, R., Ray, T. D., Guildford, M., & Chan, F. K.-M. (2009) · Cell · doi:10.1016/j.cell.2009.05.037 · Cited by 2,435 · see citing works
Molecular mechanisms of necroptosis: an ordered cellular explosion
Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2970 · Cited by 2,382 · see citing works
Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347 · see citing works
Gutierrez, M. G., Master, S. S., Singh, S. B., Taylor, G. A., Colombo, M. I., & Deretic, V. (2004) · Cell · doi:10.1016/j.cell.2004.11.038 · Cited by 2,252 · see citing works
Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144 · see citing works
Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107 · see citing works
Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy
Cuervo, A. M., Stefanis, L., Fredenburg, R., Lansbury, P. T., & Sulzer, D. (2004) · Science · doi:10.1126/science.1101738 · Cited by 2,024 · cited 15× · see citing works
“…mutated a-syn (Vogiatzi et al., 2008) CMA degrades wild-type a-syn (Cuervo et al., 2004; Vogiatzi et al., 2008) CMA is inhibited by mutated a-syn (Cuervo et al., 2004) CMA activity is reduced in the brain of PD patient (Alvarez-Erviti et al., 2010) Rapamycin (Dehay et al., 2010; Mendelsohn and…”
InfluentialInclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
Arrasate, M., Mitra, S., Schweitzer, E. S., Segal, M. R., & Finkbeiner, S. (2004) · Nature · doi:10.1038/nature02998 · Cited by 1,979 · see citing works
Holler, N., Zaru, R., Micheau, O., Thome, M., Attinger, A., Valitutti, S., Bodmer, J.-L., Schneider, P., Seed, B., & Tschopp, J. (2000) · Nature Immunology · doi:10.1038/82732 · Cited by 1,932 · see citing works
Programmed Cell Death in Animal Development and Disease
Fuchs, Y., & Steller, H. (2011) · Cell · doi:10.1016/j.cell.2011.10.033 · Cited by 1,915 · see citing works
Axe, E. L., Walker, S. A., Manifava, M., Chandra, P., Roderick, H. L., Habermann, A., Griffiths, G., & Ktistakis, N. T. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200803137 · Cited by 1,885 · see citing works
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
Kuida, K., Zheng, T. S., Na, S., Kuan, C.-Y., Yang, D., Karasuyama, H., RAKIC, P. T., & Flavell, R. A. (1996) · Nature · doi:10.1038/384368a0 · Cited by 1,881 · see citing works
Rowland, L. P., & Shneider, N. A. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105313442207 · Cited by 1,851 · see citing works
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
Burré, J., Sharma, M., Tsetsenis, T., Buchman, V. L., Etherton, M. R., & Südhof, T. C. (2010) · Science · doi:10.1126/science.1195227 · Cited by 1,817 · see citing works
Alzheimer Mechanisms and Therapeutic Strategies
Huang, Y., & Mucke, L. (2012) · Cell · doi:10.1016/j.cell.2012.02.040 · Cited by 1,758 · see citing works
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
Ravikumar, B., Sarkar, S., Davies, J. E., Futter, M., Garcı́a-Arencibia, M., Green-Thompson, Z. W., Jiménez-Sánchez, M., Korolchuk, V. I., Lichtenberg, M., Luo, S., et al. (2010) · Physiological Reviews · doi:10.1152/physrev.00030.2009 · Cited by 1,726 · see citing works
The roles of intracellular protein-degradation pathways in neurodegeneration
Rubinsztein, D. C. (2006) · Nature · doi:10.1038/nature05291 · Cited by 1,625 · see citing works
Control of microglial neurotoxicity by the fractalkine receptor
Cardona, A. E., Pioro, E. P., Sasse, M. E., Kostenko, V., Cardona, S. M., Dijkstra, I. M., Huang, D., Kidd, G., Dombrowski, S., Dutta, R., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1715 · Cited by 1,531 · see citing works
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
Lee, I. H., Cao, L., Mostoslavsky, R., Lombard, D. B., Liu, J., Bruns, N. E., Tsokos, M., Alt, F. W., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712145105 · Cited by 1,473 · see citing works
ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim
Puthalakath, H., O’Reilly, L. A., Gunn, P. A., Lee, L., Kelly, P. N., Huntington, N. D., Hughes, P., Michalak, E. M., McKimm‐Breschkin, J. L., Motoyama, N., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.027 · Cited by 1,428 · see citing works
Lysosomal membrane permeabilization in cell death
Boya, P., & Kroemer, G. (2008) · Oncogene · doi:10.1038/onc.2008.310 · Cited by 1,425 · see citing works
Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation
Hailey, D. W., Rambold, A. S., Satpute‐Krishnan, P., Mitra, K., Sougrat, R., Kim, P. K., & Lippincott‐Schwartz, J. (2010) · Cell · doi:10.1016/j.cell.2010.04.009 · Cited by 1,419 · see citing works
Mitochondrial abnormalities in Alzheimer's disease
Hirai, K., Aliev, G., Nunomura, A., Fujioka, H., Russell, R. L., Atwood, C. S., Johnson, A. B., Kress, Y., Vinters, H. V., Tabaton, M., et al. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03017.2001 · Cited by 1,367 · see citing works
Samii, A., Nutt, J. G., & Ransom, B. R. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16305-8 · Cited by 1,305 · see citing works
ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease
Lustbader, J. W., Cirilli, M., Lin, C., Xu, H. W., Takuma, K., Wang, N., Caspersen, C., Chen, X., Pollak, S., Chaney, M., et al. (2004) · Science · doi:10.1126/science.1091230 · Cited by 1,303 · see citing works
Lysosomes and autophagy in cell death control
Kroemer, G., & Jäättelä, M. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1738 · Cited by 1,291 · see citing works
Wyss-Coray (2006) · doi:10.1038/nm1484 · Cited by 1,284 · see citing works
Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo
Hakem, R., Hakem, A., Duncan, G. S., Henderson, J. T., Woo, M., Soengas, M. S., Elia, A., de la Pompa, J. L., Kägi, D., Khoo, W., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81477-4 · Cited by 1,284 · see citing works
Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein
Giasson, B. I., Duda, J. E., Quinn, S. M., Zhang, B., Trojanowski, J. Q., & Lee, V. M.-Y. (2002) · Neuron · doi:10.1016/s0896-6273(02)00682-7 · Cited by 1,266 · see citing works
Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS
Johnson, J. O., Mandrioli, J., Benatar, M., Abramzon, Y., Van Deerlin, V. M., Trojanowski, J. Q., Gibbs, J. R., Brunetti, M., Gronka, S., Wuu, J., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.036 · Cited by 1,235 · see citing works
Matsunaga, K., Saitoh, T., Tabata, K., Omori, H., Satoh, T., Kurotori, N., Maejima, I., Shirahama-Noda, K., Ichimura, T., Isobe, T., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1846 · Cited by 1,235 · see citing works
Pickford, F., Masliah, E., Britschgi, M., Lucin, K. M., Narasimhan, R., Jaeger, P. A., Small, S., Spencer, B., Rockenstein, E., Levine, B., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33585 · Cited by 1,186 · see citing works
Life and death partners: apoptosis, autophagy and the cross-talk between them
Eisenberg‐Lerner, A., Bialik, S., Simon, H.-U., & Kimchi, A. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.33 · Cited by 1,183 · see citing works
Wu, D. C., Jackson-Lewis, V., Vila, M., Tieu, K., Teismann, P., Vadseth, C., Choi, D.-K., Ischiropoulos, H., & Przedborski, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01763.2002 · Cited by 1,183 · see citing works
Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis
Lakhani, S. A., Masud, A. J., Kuida, K., Porter, G. A., Jr., Booth, C. J., Mehal, W. Z., Inayat, I., & Flavell, R. A. (2006) · Science · doi:10.1126/science.1115035 · Cited by 1,175 · see citing works
Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice
Motoyama, N., Wang, F., Roth, K. A., Sawa, H., Nakayama, K., Nakayama, K., Negishi, I., Senju, S., Zhang, Q., Fujii, S., et al. (1995) · Science · doi:10.1126/science.7878471 · Cited by 1,164 · see citing works
Sarkar, S., Davies, J. E., Huang, Z., Tunnacliffe, A., & Rubinsztein, D. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609532200 · Cited by 1,142 · see citing works
Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development
Yoshida, H., Kong, Y., Yoshida, R., Elia, A., Hakem, A., Hakem, R., Penninger, J. M., & Mak, T. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81733-x · Cited by 1,138 · see citing works
Activated microglia mediate neuronal cell injury via a nitric oxide mechanism
Chao, C. C., Hu, S., Molitor, T. W., Shaskan, E. G., & Peterson, P. K. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.8.2736 · Cited by 1,137 · see citing works
Proteolysis: from the lysosome to ubiquitin and the proteasome
Ciechanover, A. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1552 · Cited by 1,133 · see citing works
Wu, Y.-T., Tan, H.-L., Shui, G., Bauvy, C., Huang, Q., Wenk, M. R., Ong, C.-N., Codogno, P., & Shen, H.-M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.080796 · Cited by 1,127 · see citing works
Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)
Miller, R. G., Mitchell, J. D., & Moore, D. H. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001447.pub3 · Cited by 1,123 · see citing works
Molecular biology of amyotrophic lateral sclerosis: insights from genetics
Pasinelli, P., & Brown, R. H. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1971 · Cited by 1,107 · see citing works
Manczak, M., Anekonda, T. S., Henson, E., Park, B. S., Quinn, J., & Reddy, P. H. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl066 · Cited by 1,104 · see citing works
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
Ravikumar, B. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.9.1107 · Cited by 1,099 · see citing works
Kim, D., Nguyen, M. D., Dobbin, M. M., Fischer, A., Sananbenesi, F., Rodgers, J. T., Delalle, I., Baur, J. A., Sui, G., Armour, S. M., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601758 · Cited by 1,074 · see citing works
The role of the Atg1/ULK1 complex in autophagy regulation
Mizushima, N. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.004 · Cited by 1,062 · see citing works
Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.
Anglade, P., Vyas, S., Javoy-Agid, F., Herrero, M. T., Michel, P. P., Marquez, J., Prigent, A., Ruberg, M., Hirsch, É. C., & Agid, Y. (1997) · PubMed · Cited by 1,045 · see citing works
Spilman, P., Podlutskaya, N., Hart, M. J., Debnath, J., Gorostiza, O., Bredesen, D., Richardson, A., Strong, R., & Galvan, V. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009979 · Cited by 1,033 · see citing works
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
Liang, C., Feng, P., Ku, B., Dotan, I., Canaani, D., Oh, B., & Jung, J. U. (2006) · Nature Cell Biology · doi:10.1038/ncb1426 · Cited by 1,025 · see citing works
α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration
Chandra, S. S., Gallardo, G., Fernández‐Chacón, R., Schlüter, O. M., & Südhof, T. C. (2005) · Cell · doi:10.1016/j.cell.2005.09.028 · Cited by 967 · see citing works
Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
Yu, W. H., Cuervo, A. M., Kumar, A., Peterhoff, C. M., Schmidt, S. D., Lee, J.-H., Mohan, P. S., Mercken, M., Farmery, M. R., Tjernberg, L. O., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505082 · Cited by 967 · see citing works
Du, H., Guo, L., Fang, F., Chen, D., Sosunov, A. A., McKhann, G. M., Yan, Y., Wang, C., Zhang, H., Molkentin, J. D., et al. (2008) · Nature Medicine · doi:10.1038/nm.1868 · Cited by 935 · see citing works
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
Takahashi, Y., Coppola, D., Matsushita, N., Cualing, H. D., Sun, M., Sato, Y., Liang, C., Jung, J. U., Cheng, J. Q., Mul, J. J., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1634 · Cited by 928 · see citing works
Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)
Miller, R. G., Jd, M., Lyon, M., & Moore, D. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001447 · Cited by 910 · see citing works
Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration
Sheng, Z., & Cai, Q. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3156 · Cited by 906 · see citing works
A Double-Blind, Delayed-Start Trial of Rasagiline in Parkinson's Disease
Olanow, C. W., Rascol, O., Hauser, R. A., Feigin, P. D., Jankovic, J. J., Lang, A. E., Langston, J. W., Melamed, E., Poewe, W. H., Stocchi, F., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0809335 · Cited by 902 · see citing works
Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development
Cecconi, F., Álvarez-Bolado, G., Meyer, B. I., Roth, K. A., & Gruß, P. (1998) · Cell · doi:10.1016/s0092-8674(00)81732-8 · Cited by 894 · see citing works
Cargo recognition failure is responsible for inefficient autophagy in Huntington’s disease
Martinez-Vicente, M., Talloczy, Z., Wong, E., Tang, G., Koga, H., Kaushik, S., de Vries, R., Arias, E., Harris, S., Sulzer, D., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2528 · Cited by 885 · see citing works
Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease
Zuccato, C., Valenza, M., & Cattaneo, E. (2010) · Physiological Reviews · doi:10.1152/physrev.00041.2009 · Cited by 848 · see citing works
Pathogenic Lysosomal Depletion in Parkinson's Disease
Dehay, B., Bové, J., Rodríguez-Muela, N., Perier, C., Recasens, A., Boya, P., & Vila, M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1920-10.2010 · Cited by 825 · see citing works
The Interplay Between Mitochondrial Dynamics and Mitophagy
Twig, G., & Shirihai, O. S. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3779 · Cited by 778 · see citing works
Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis
Daugas, É., Susín, S. A., Zamzami, N., Ferri, K. F., Irinopoulou, T., Larochette, N., Prévost, M., Leber, B. F., Andrews, D. W., Penninger, J. M., et al. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.5.729 · Cited by 776 · see citing works
The Pathogenesis of Senile Plaques
DICKSON, D. W. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199704000-00001 · Cited by 753 · see citing works
BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development
Deckwerth, T. L., Elliott, J. L., Knudson, C. M., Johnson, E. M., Snider, W. D., & Korsmeyer, S. J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80173-7 · Cited by 749 · see citing works
Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-β Peptides
Marambaud, P., Zhao, H., & Davies, P. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508246200 · Cited by 749 · see citing works
Hartmann, A., Hunot, S., Michel, P. P., Muriel, M., Vyas, S., Faucheux, B. A., Prigent, A., Turmel, H., Srinivasan, A. N., Ruberg, M., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040556597 · Cited by 717 · see citing works
Apoptosis and cancer: mutations within caspase genes
Ghavami, S., Hashemi, M. M., Ande, S. R., Yeganeh, B., Xiao, W., Eshraghi, M., Bus, C., Kadkhoda, K., Wiecheć, E., Halayko, A. J., et al. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2009.066944 · Cited by 712 · see citing works
Self-citationNeuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease
Agostinho, P., A. Cunha, R., & Oliveira, C. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210793176572 · Cited by 685 · cited 2× · see citing works
“facilitate Ab generation and NFTs formation (Agostinho et al., 2010; Cai et al., 2013) and finally throw in to the progressive”
Vogiatzi, T., Xilouri, M., Vekrellis, K., & Stefanis, L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801992200 · Cited by 683 · see citing works
Gandhi, S., Wood-Kaczmar, A., Yao, Z., Plun-Favreau, H., Deas, E., Klupsch, K., Downward, J., Latchman, D. S., Tabrizi, S. J., Wood, N. W., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.02.013 · Cited by 682 · see citing works
Lipinski, M. M., Zheng, B., Lu, T., Yan, Z., Py, B. F., Ng, A., Xavier, R. J., Li, C., Yankner, B. A., Scherzer, C. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009485107 · Cited by 680 · see citing works
Rab7 is required for the normal progression of the autophagic pathway in mammalian cells
Gutierrez, M. G., Munafó, D. B., Berón, W., & Colombo, M. I. (2004) · Journal of Cell Science · doi:10.1242/jcs.01114 · Cited by 680 · see citing works
Lazarou, M., Jin, S. M., Kane, L. A., & Youle, R. J. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.12.014 · Cited by 670 · see citing works
Autophagic programmed cell death by selective catalase degradation
Yu, L., Wan, F., Dutta, S., Welsh, S., Liu, Z., Freundt, E. C., Baehrecke, E. H., & Lenardo, M. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511288103 · Cited by 668 · see citing works
Normal huntingtin function: an alternative approach to Huntington's disease
Cattaneo, E. F., Zuccato, C., & Tartari, M. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1806 · Cited by 655 · see citing works
Rhein, V., Song, X., Wiesner, A., Ittner, L. M., Baysang, G., Meier, F., Ozmen, L., Bluethmann, H., Dröse, S., Brandt, U., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905529106 · Cited by 655 · see citing works
Vingtdeux, V., Giliberto, L., Zhao, H., Chandakkar, P., Wu, Q., Simon, J. E., Janle, E. M., Lobo, J., Ferruzzi, M. G., Davies, P. J., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.060061 · Cited by 646 · see citing works
Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis
Łoś, M., de Craen, M. V., Penning, L. C., Schenk, H., Westendorp, M. O., Baeuerle, P. A., Dröge, W., Krammer, P. H., Fiers, W., & Schulze‐Osthoff, K. (1995) · Nature · doi:10.1038/375081a0 · Cited by 607 · see citing works
Growth Arrest and Autophagy Are Required for Salivary Gland Cell Degradation in Drosophila
Berry, D. L., & Baehrecke, E. H. (2007) · Cell · doi:10.1016/j.cell.2007.10.048 · Cited by 602 · see citing works
A role for motoneuron subtype–selective ER stress in disease manifestations of FALS mice
Saxena, S., Cabuy, E., & Caroni, P. (2009) · Nature Neuroscience · doi:10.1038/nn.2297 · Cited by 600 · see citing works
Spencer, B., Potkar, R., Trejo, M., Rockenstein, E., Patrick, C., Gindi, R., Adame, A., Wyss-Coray, T., & Masliah, E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4390-09.2009 · Cited by 595 · see citing works
Abramov, A. Y., Canevari, L., & Duchen, M. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4042-03.2004 · Cited by 587 · see citing works
A Controlled Trial of Rasagiline in Early Parkinson Disease
Parkinson Study Group (2002) · Archives of Neurology · doi:10.1001/archneur.59.12.1937 · Cited by 579 · see citing works
Anandatheerthavarada, H. K., Biswas, G., Robin, M.-A., & Avadhani, N. G. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200207030 · Cited by 571 · see citing works
Mechanisms of cross‐talk between the ubiquitin‐proteasome and autophagy‐lysosome systems
Korolchuk, V. I., Menzies, F. M., & Rubinsztein, D. C. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.12.047 · Cited by 565 · see citing works
Sawa, A., Wiegand, G. W., Cooper, J. K., Margolis, R. L., Sharp, A. H., Lawler, J. F., Greenamyre, J. T., Snyder, S. H., & Ross, C. A. (1999) · Nature Medicine · doi:10.1038/13518 · Cited by 552 · see citing works
Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains
Alvarez‐Erviti, L., Rodríguez-Oroz, M. C., Cooper, J. A. D., Caballero, C., Ferrer, I., Obeso, J. A., & Schapira, A. H. V. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.198 · Cited by 550 · see citing works
Lithium delays progression of amyotrophic lateral sclerosis
Fornai, F., Longone, P., Cafaro, L., Kastsiuchenka, O., Ferrucci, M., Manca, M. L., Lazzeri, G., Spalloni, A., Bellio, N., Lenzi, P., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708022105 · Cited by 550 · see citing works
Targeting programmed cell death in neurodegenerative diseases
Vila, M., & Przedborski, S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1100 · Cited by 545 · see citing works
Aging as an event of proteostasis collapse
Taylor, R. C., & Dillin, A. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004440 · Cited by 538 · see citing works
Huntingtin Expression Stimulates Endosomal–Lysosomal Activity, Endosome Tubulation, and Autophagy
Kegel, K. B., Kim, M., Sapp, E., McIntyre, C., Castaño, J. G., Aronin, N., & DiFiglia, M. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07268.2000 · Cited by 533 · see citing works
Hetz, C., Thielen, P., Matus, S., Nassif, M., Court, F., Kiffin, R., Martinez, G., Cuervo, A. M., Brown, R. H., & Glimcher, L. H. (2009) · Genes & Development · doi:10.1101/gad.1830709 · Cited by 530 · see citing works
Milnerwood, A. J., Gladding, C. M., Pouladi, M. A., Kaufman, A. M., Hines, R. M., Boyd, J. D., Ko, R. W. Y., Vasuta, O. C., Graham, R. K., Hayden, M. R., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.008 · Cited by 516 · see citing works
Łoś, M., Mozoluk, M., Ferrari, D., Stępczyńska, A., Stroh, C., Renz, A., Herceg, Z., Wang, Z., & Schulze‐Osthoff, K. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-05-0272 · Cited by 505 · see citing works
Schapira, A. H. V. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61305-6 · Cited by 499 · see citing works
Hashimoto, M., Rockenstein, E. M., Crews, L. A., & Masliah, E. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:4:1-2:21 · Cited by 498 · see citing works
Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease
Wu, Y., Li, X., Zhu, J. X., Xie, W., Le, W., Fan, Z., Jankovic, J. J., & Pan, T. (2011) · Neurosignals · doi:10.1159/000328516 · Cited by 495 · see citing works
Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?
Candé, C., Cecconi, F., Dessen, P., & Kroemer, G. (2002) · Journal of Cell Science · doi:10.1242/jcs.00210 · Cited by 491 · see citing works
ESCRT-III Dysfunction Causes Autophagosome Accumulation and Neurodegeneration
Lee, J., Beigneux, A. P., Ahmad, S. T., Young, S. G., & Gao, F. (2007) · Current Biology · doi:10.1016/j.cub.2007.07.029 · Cited by 490 · see citing works
Terman, A., Kurz, T., Navratil, M., Arriaga, E. A., & Brunk, U. T. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2598 · Cited by 490 · see citing works
Mechanisms of Autophagosome Biogenesis
Rubinsztein, D. C., Shpilka, T., & Elazar, Z. (2012) · Current Biology · doi:10.1016/j.cub.2011.11.034 · Cited by 489 · see citing works
Lee, S., Satō, Y., & Nixon, R. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6412-10.2011 · Cited by 471 · see citing works
Inflammatory processes in amyotrophic lateral sclerosis
McGeer, P. L., & McGeer, E. G. (2002) · Muscle & Nerve · doi:10.1002/mus.10191 · Cited by 470 · see citing works
Regulation of apoptosis-associated lysosomal membrane permeabilization
Johansson, A., Appelqvist, H., Nilsson, C., Kågedal, K., Roberg, K. B., & Öllinger, K. M. (2010) · APOPTOSIS · doi:10.1007/s10495-009-0452-5 · Cited by 463 · see citing works
Minocycline and Neurodegenerative Diseases
Kim, H.-S., & Suh, Y.-H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.040 · Cited by 447 · see citing works
Distinct Role for Microglia in Rotenone-Induced Degeneration of Dopaminergic Neurons
Gao, H., Hong, J., Zhang, W., & Liu, B. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00782.2002 · Cited by 439 · see citing works
Widespread Elimination of Naturally Occurring Neuronal Death inBax-Deficient Mice
White, F. A., Keller-Peck, C. R., Knudson, C. M., Korsmeyer, S. J., & Snider, W. D. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-04-01428.1998 · Cited by 436 · see citing works
Glial pathology but absence of apoptotic nigral neurons in long‐standing Parkinson's disease
Banati, R. B., Daniel, S. E., & Blunt, S. B. (1998) · Movement Disorders · doi:10.1002/mds.870130205 · Cited by 430 · see citing works
Pesticide exposure and risk for Parkinson's disease
Ascherio, A., Chen, H.-L., Weisskopf, M., O'Reilly, É., McCullough, M. L., Calle, E. E., Schwarzschild, M., & Thun, M. (2006) · Annals of Neurology · doi:10.1002/ana.20904 · Cited by 429 · see citing works
Galvin, J. E., Uryu, K., Lee, V. M. ‐., & Trojanowski, J. Q. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13450 · Cited by 422 · see citing works
The epidemiology of the dementias: an update
Qiu, C., Ronchi, D. D., & Fratiglioni, L. (2007) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32816ebc7b · Cited by 418 · see citing works
Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB
Ohmi, K., Greenberg, D., Rajavel, K. S., Ryazantsev, S., Li, H. H., & Neufeld, E. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252784899 · Cited by 413 · see citing works
Lysosomes and lysosomal cathepsins in cell death
Repnik, U., Stoka, V., Türk, V., & Turk, B. (2011) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2011.08.016 · Cited by 403 · see citing works
Majumder, S., Richardson, A. G., Strong, R., & Oddo, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025416 · Cited by 401 · see citing works
Rapamycin pre-treatment protects against apoptosis
Ravikumar, B., Berger, Z., Vacher, C., O’Kane, C. J., & Rubinsztein, D. C. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl036 · Cited by 400 · see citing works
Kim, Y. J., Yi, Y., Sapp, E., Wang, Y., Cuiffo, B., Kegel, K. B., Qin, Z., D, N. A. M., & DiFiglia, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221451398 · Cited by 393 · see citing works
The Role of Caspases in Development, Immunity, and Apoptotic Signal Transduction
Łoś, M., Wesselborg, S., & Schulze‐Osthoff, K. (1999) · Immunity · doi:10.1016/s1074-7613(00)80062-x · Cited by 392 · see citing works
Krebiehl, G., Ruckerbauer, S., Burbulla, L. F., Kieper, N., Maurer, B., Waak, J., Wolburg, H., Gizatullina, Z. Z., Gellerich, F. N., Woitalla, D., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009367 · Cited by 370 · see citing works
Gong, C., Bauvy, C., Tonelli, G., Yue, W., Deloménie, C., Nicolas, V., Zhu, Y., Domergue, V., Marin‐Esteban, V., Tharinger, H., et al. (2012) · Oncogene · doi:10.1038/onc.2012.252 · Cited by 369 · see citing works
Self-citationGene expression during ER stress–induced apoptosis in neurons
Reimertz, C., Kögel, D., Rami, A., Chittenden, T., & Prehn, J. H. M. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200305149 · Cited by 367 · see citing works
Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham Study
Seshadri, S. S., & Wolf, P. A. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70291-0 · Cited by 367 · see citing works
Zhang, X., Li, L., Chen, S., Yang, D., Wang, Y., Zhang, X., Wang, Z., & Le, W. (2011) · Autophagy · doi:10.4161/auto.7.4.14541 · Cited by 364 · see citing works
Pathological roles of α-synuclein in neurological disorders
Vekrellis, K., Xilouri, M., Emmanouilidou, E., Rideout, H. J., & Stefanis, L. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70213-7 · Cited by 359 · see citing works
Wellington, C. L., Singaraja, R. R., Ellerby, L., Savill, J. M., Roy, S., Leavitt, B. R., Cattaneo, E. F., Hackam, A. S., Sharp, A. H., Thornberry, N. A., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001475200 · Cited by 358 · see citing works
A possible role for humoral immunity in the pathogenesis of Parkinson's disease
Orr, C., Rowe, D. B., Mizuno, Y., Mori, H., & Halliday, G. M. (2005) · Brain · doi:10.1093/brain/awh625 · Cited by 352 · see citing works
Cataldo, A., Hamilton, D. J., Barnett, J. L., Paskevich, P. A., & Nixon, R. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-01-00186.1996 · Cited by 350 · see citing works
The Oxidation State of DJ-1 Regulates its Chaperone Activity Toward α-Synuclein
Zhou, W., Zhu, M., Wilson, M. A., Petsko, G. A., & Fink, A. L. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.12.030 · Cited by 350 · see citing works
Jeyakumar, M. (2003) · Brain · doi:10.1093/brain/awg089 · Cited by 348 · see citing works
Carra, S., Seguin, S. J., Lambert, H., & Landry, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706304200 · Cited by 347 · see citing works
Atg17 Functions in Cooperation with Atg1 and Atg13 in Yeast Autophagy
Kabeya, Y., Kamada, Y., Baba, M., Takikawa, H., Sasaki, M., & Ohsumi, Y. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0669 · Cited by 345 · see citing works
Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity
Subramaniam, S., Sixt, K. M., Barrow, R. K., & Snyder, S. H. (2009) · Science · doi:10.1126/science.1172871 · Cited by 340 · see citing works
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
Liu, G.-H., Qu, J., Suzuki, K., Nivet, E., Li, M., Montserrat, N., Yi, F., Xu, X., Ruiz, S., Zhang, W., et al. (2012) · Nature · doi:10.1038/nature11557 · Cited by 339 · see citing works
Various modes of cell death induced by DNA damage
Surova, O., & Zhivotovsky, B. (2013) · Oncogene · doi:10.1038/onc.2012.556 · Cited by 334 · see citing works
Crippa, V., Sau, D., Rusmini, P., Boncoraglio, A., Onesto, E., Bolzoni, E., Galbiati, M., Fontana, E., Marino, M., Carra, S., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq257 · Cited by 330 · see citing works
Pandi-Perumal, S. R., BaHammam, A. S., Brown, G. M., Spence, D. W., Bharti, V. K., Kaur, C., Hardeland, R., & Cardinali, D. P. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9337-4 · Cited by 320 · see citing works
Gervais, F. G., Singaraja, R. R., Xanthoudakis, S., Gutekunst, C., Leavitt, B. R., Metzler, M., Hackam, A. S., Tam, J., Vaillancourt, J. P., Houtzager, V. M., et al. (2002) · Nature Cell Biology · doi:10.1038/ncb735 · Cited by 313 · see citing works
Molecular and cellular pathways of neurodegeneration in motor neurone disease
Shaw, P. J. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.048652 · Cited by 311 · see citing works
Siklós, L., Engelhardt, J. I., Harati, Y., Smith, R. G., Joó, F., & Appel, S. H. (1996) · Annals of Neurology · doi:10.1002/ana.410390210 · Cited by 308 · see citing works
Apoptosomes: engines for caspase activation
Adams, J. M., & Cory, S. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00381-2 · Cited by 305 · see citing works
Microglia are the major cell type expressing MHC class II in human white matter
Hayes, G. M., Woodroofe, M. N., & Cuzner, M. L. (1987) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(87)90218-8 · Cited by 302 · see citing works
Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease
The Parkinson Study Group PRECEPT Investigators (2007) · Neurology · doi:10.1212/01.wnl.0000277648.63931.c0 · Cited by 296 · see citing works
The end of autophagic cell death?
Shen, S., Kepp, O., & Kroemer, G. (2012) · Autophagy · doi:10.4161/auto.8.1.16618 · Cited by 289 · see citing works
Calcium dysregulation in amyotrophic lateral sclerosis
Großkreutz, J., Bosch, L. V. D., & Keller, B. U. (2010) · Cell Calcium · doi:10.1016/j.ceca.2009.12.002 · Cited by 284 · see citing works
Reduced oxidative damage in ALS by high‐dose enteral melatonin treatment
Weishaupt, J. H., Bartels, C., Pölking, E., Dietrich, J., Rohde, G., Pöeggeler, B., Mertens, N., Sperling, S., Bohn, M., Huether, G., et al. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00377.x · Cited by 284 · see citing works
Chaabane, W., User, S. D., El-Gazzah, M., Jaksik, R., Sajjadi, E., Rzeszowska‐Wolny, J., & Łoś, M. (2012) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-012-0205-y · Cited by 281 · see citing works
Self-citationHarnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein
Bauer, P. O., Goswami, A., Wong, H. K., Okuno, M., Kurosawa, M., Yamada, M., Miyazaki, H., Matsumoto, G., Kino, Y., Nagai, Y., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1608 · Cited by 280 · see citing works
Khan, M. M., Ahmad, A., Ishrat, T., Khan, M. B., Hoda, M. N., Khuwaja, G., Raza, S. S., Khan, A., Javed, H., Vaibhav, K., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.02.031 · Cited by 279 · see citing works
Reviews: Current Concepts in Alzheimer's Disease: A Multidisciplinary Review
Minati, L., Edginton, T. L., Bruzzone, M. G., & Giaccone, G. (2008) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317508328602 · Cited by 266 · see citing works
Yakovlev, A. G., Ota, K., Wang, G., Movsesyan, V. A., Bao, W., Yoshihara, K., & Faden, A. I. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07439.2001 · Cited by 265 · see citing works
Cassarino, D. S., Fall, C. P., Swerdlow, R. H., Smith, T. S., Halvorsen, E. M., Miller, S. W., Parks, J. K., Parker, W. D., & Bennett, J. P. (1997) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(97)00070-7 · Cited by 265 · see citing works
The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family
Heath-Engel, H. M., Chang, N. C., & Shore, G. C. (2008) · Oncogene · doi:10.1038/onc.2008.309 · Cited by 263 · see citing works
Filomeni, G., Graziani, I., Zio, D. D., Dini, L., Centonze, D., Rotilio, G., & Ciriolo, M. R. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.021 · Cited by 262 · see citing works
Betin, V. M. S., & Lane, J. D. (2009) · Journal of Cell Science · doi:10.1242/jcs.046250 · Cited by 261 · see citing works
Cytoprotective roles for autophagy
Moreau, K., Luo, S., & Rubinsztein, D. C. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.002 · Cited by 260 · see citing works
Olcese, J., Cao, C., Mori, T., Mamcarz, M. B., Maxwell, A. K., Runfeldt, M. J., Wang, L., Zhang, C., Lin, X., Zhang, G., et al. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00692.x · Cited by 260 · see citing works
Etiology of Parkinson’s disease
Schapira, A. H. V. (2006) · Neurology · doi:10.1212/wnl.66.10_suppl_4.s10 · Cited by 251 · see citing works
Autophagy regulates the processing of amino terminal huntingtin fragments
Qin, Z. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg346 · Cited by 250 · see citing works
Autophagy in Spinal Cord Motor Neurons in Sporadic Amyotrophic Lateral Sclerosis
Sasaki, S. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182160690 · Cited by 249 · see citing works
Martínez‐Vicente, M., Sovak, G., & Cuervo, A. M. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.07.005 · Cited by 245 · see citing works
Autophagic Cell Death and Its Execution by Lysosomal Cathepsins.
UCHIYAMA, Y. (2001) · Archives of Histology and Cytology · doi:10.1679/aohc.64.233 · Cited by 243 · see citing works
Jain, M. V., Paczulla, A., Klonisch, T. C., Dimgba, F. N., Rao, S. B., Roberg, K. B., Schweizer, F., Lengerke, C., Davoodpour, P., Palicharla, V. R., et al. (2013) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12001 · Cited by 241 · see citing works
Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin
Klamt, F., Zdanov, S., Levine, R. L., Pariser, A. C., Zhang, Y., Zhang, B., Yu, L., Veenstra, T. D., & Shacter, E. B. (2009) · Nature Cell Biology · doi:10.1038/ncb1968 · Cited by 241 · see citing works
Liu, D., Pitta, M., Jiang, H., Lee, J.-H., Zhang, G., Chen, X., Kawamoto, E. M., & Mattson, M. P. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.020 · Cited by 238 · see citing works
β-Amyloid1–42Induces Neuronal Death through the p75 Neurotrophin Receptor
Sotthibundhu, A., Sykes, A. M., Fox, B., Underwood, C. K., Thangnipon, W., & Coulson, E. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0350-08.2008 · Cited by 238 · see citing works
Cha, M.-Y., Han, S.-H., Son, S. M., Hong, H., Choi, Y.-J., Byun, J., & Mook‐Jung, I. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034929 · Cited by 236 · see citing works
Resende, R., Ferreiro, E., Pereira, C., & Resende de Oliveira, C. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.036 · Cited by 235 · see citing works
Liang, C.-C., Wang, C., Xu, P., Gan, B., & Guan, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.072389 · Cited by 234 · see citing works
The Antiapoptotic Activity of Melatonin in Neurodegenerative Diseases
Wang, X. (2009) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2009.00105.x · Cited by 232 · see citing works
Vingtdeux, V., Chandakkar, P., Zhao, H., d’Abramo, C., Davies, P., & Marambaud, P. (2010) · The FASEB Journal · doi:10.1096/fj.10-167361 · Cited by 229 · see citing works
A Short Mitochondrial Form of p19ARF Induces Autophagy and Caspase-Independent Cell Death
Reef, S., Zalckvar, E., Shifman, O., Bialik, S., Sabanay, H., Oren, M., & Kimchi, A. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.04.014 · Cited by 226 · see citing works
Ghosh, A. P., Klocke, B. J., Ballestas, M. E., & Roth, K. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039586 · Cited by 225 · see citing works
Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma
Lamy, L., Ngo, V. N., Emre, N. C. T., Shaffer, A. L., Yang, Y., Tian, E., Nair, V., Kruhlak, M. J., Zingone, A., Landgren, O., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.02.017 · Cited by 222 · see citing works
Tumor Necrosis Factor α Is Toxic to Embryonic Mesencephalic Dopamine Neurons
McGuire, S. O., Ling, Z. D., Lipton, J. W., Sortwell, C. E., Collier, T. J., & Carvey, P. M. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7688 · Cited by 222 · see citing works
Biomarkers of Oxidative Damage and Inflammation in Alzheimer's Disease
Galasko, D. R., & Montine, T. J. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.09.89 · Cited by 221 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins
Singh, R., Letai, A., & Sarosiek, K. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0089-8 · Cited by 2,111 · see citing works
Heras-Sandoval, D., Pérez-Rojas, J. M., Hernández-Damián, J., & Pedraza-Chaverri, J. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.08.019 · Cited by 1,091 · see citing works
Elusive roles for reactive astrocytes in neurodegenerative diseases
Ben Haim, L., Carrillo-de Sauvage, M.-A., Ceyzériat, K., & Escartin, C. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00278 · Cited by 453 · see citing works
Programmed cell death in aging
Tower, J. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.04.002 · Cited by 426 · see citing works
Lee, J.-H., McBrayer, M. K., Wolfe, D. M., Haslett, L. J., Kumar, A., Sato, Y., Lie, P. P. Y., Mohan, P., Coffey, E. E., Kompella, U., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.050 · Cited by 358 · see citing works
Guo, X., Sun, X., Hu, D., Wang, Y.-J., Fujioka, H., Vyas, R., Chakrapani, S., Joshi, A. U., Luo, Y., Mochly-Rosen, D., et al. (2016) · Nature Communications · doi:10.1038/ncomms12646 · Cited by 200 · see citing works
Reglodi, D., Renaud, J., Tamas, A., Tizabi, Y., Socías, S. B., Del-Bel, E., & Raisman-Vozari, R. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.10.004 · Cited by 162 · see citing works
Di Domenico, F., Barone, E., Perluigi, M., & Butterfield, D. A. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6759 · Cited by 114 · see citing works
Lotfi, P., Tse, D. Y., Di Ronza, A., Seymour, M. L., Martano, G., Cooper, J. D., Pereira, F. A., Passafaro, M., Wu, S. M., & Sardiello, M. (2018) · Autophagy · doi:10.1080/15548627.2018.1474313 · Cited by 106 · see citing works
Bernardo, T. C., Marques‐Aleixo, I., Beleza, J., Oliveira, P. J., Ascensão, A., & Magalhães, J. (2016) · Brain Pathology · doi:10.1111/bpa.12403 · Cited by 108 · see citing works
Balmus, I. M., Ciobica, A., Antioch, I., Dobrin, R., & Timofte, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3975101 · Cited by 103 · see citing works
Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy
Chornenkyy, Y., Fardo, D. W., & Nelson, P. T. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0196-y · Cited by 93 · see citing works
Su, C., Yang, X., & Lou, J. (2016) · Brain Research · doi:10.1016/j.brainres.2016.05.011 · Cited by 73 · see citing works
Tribbles Pseudokinase 3 Induces Both Apoptosis and Autophagy in Amyloid-β-induced Neuronal Death
Saleem, S., & Biswas, S. C. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.744730 · Cited by 70 · see citing works
Shah, S. Z. A., Zhao, D., Hussain, T., & Yang, L. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.004 · Cited by 55 · see citing works
The contribution of altered neuronal autophagy to neurodegeneration
Filippone, A., Esposito, E., Mannino, D., Lyssenko, N., & Praticò, D. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108178 · Cited by 55 · see citing works
Accumulation of APP-CTF induces mitophagy dysfunction in the iNSCs model of Alzheimer’s disease
Lee, S.-E., Kwon, D., Shin, N., Kong, D., Kim, N. G., Kim, H.-Y., Kim, M.-J., Choi, S. W., & Kang, K.-S. (2022) · Cell Death Discovery · doi:10.1038/s41420-021-00796-3 · Cited by 53 · see citing works
Di Domenico, F., Head, E., Butterfield, D. A., & Perluigi, M. (2014) · Advances in Geriatrics · doi:10.1155/2014/527518 · Cited by 50 · see citing works
Gut microbiota as a potential player in mn-induced neurotoxicity
Tinkov, A. A., Martins, A. C., Avila, D. S., Gritsenko, V. A., Skalny, A. V., Santamaria, A., Lee, E., Bowman, A. B., & Aschner, M. (2021) · Biomolecules · doi:10.3390/biom11091292 · Cited by 45 · see citing works
Unified theory of Alzheimer’s disease (UTAD): implications for prevention and curative therapy
Nehls, M. (2016) · Journal of Molecular Psychiatry · doi:10.1186/s40303-016-0018-8 · Cited by 41 · see citing works
Li, L., Zhang, L.-Y., Jin, Q.-Q., & Hölscher, C. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.303045 · Cited by 38 · see citing works
Lane-Donovan, C., Paredes, M., & Kao, A. W. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102854 · Cited by 3 · see citing works
Boda, F., Banfai, K., Garai, K., Kovacs, B., Almasi, A., Scheffer, D., Sinkler, R. L., Csonka, R., Czompoly, T., & Kvell, K. (2020) · Journal of Venomous Animals and Toxins including Tropical Diseases · doi:10.1590/1678-9199-jvatitd-2020-0057 · Cited by 2 · see citing works
- Authors
- Ghavami, S., Shojaei, S., Yeganeh, B., Ande, S. R., Jangamreddy, J. R., Mehrpour, M., Christoffersson, J., Chaabane, W., Moghadam, A. R., Kashani, H. H., Hashemi, M., Owji, A. A., & Łos, M. J.
- Affiliations
- Children's Hospital Research Institute of Manitoba (CA)
- Shiraz University of Medical Sciences (IR)
- University of Toronto (CA)
- University of Manitoba (CA)
- Linköping University (SE)
- Inserm (FR)
- Islamic Azad University Ardabil (IR)
- Zahedan University of Medical Sciences (IR)
- Corresponding author
- Owji, Ali A.
- ORCID
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 112
- Pages
- 24-49
- ISSN
- 0301-0082 (ISSN-L)
- OpenAlex
- W2125461230
- Cited by
- 1,039
- References
- 387
- Citations by year
- 2026: 31 · 2025: 56 · 2024: 90 · 2023: 78 · 2022: 87 · 2021: 112 · 2020: 110 · 2019: 102 · 2018: 86 · 2017: 72 · 2016: 93 · 2015: 81 · 2014: 39 · 2013: 1 · 2012: 1
- FWCI
- 8.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Progress in Neurobiology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
- Funders
- Manitoba Health Research Council
- Cancerfonden
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- autophagy, apoptosis, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, mitochondria, lysosomes, brain homeostasis, autophagy modulation, therapeutic interventions
- MeSH terms
- Animals, Autophagy, Brain, Brain Diseases, Humans, Neurons, Peripheral Nervous System Diseases, Apoptosis, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
