The DOI matches its Crossref record; 156 of the 156 references it cites were found in a registry or an index.
Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches
Open accessAbstract
Prostate cancer is the second-leading cause of cancer-related mortality in men in Western societies. Androgen receptor (AR) signaling is a critical survival pathway for prostate cancer cells, and androgen-deprivation therapy (ADT) remains the principal treatment for patients with locally advanced and metastatic disease. Although a majority of patients initially respond to ADT, most will eventually develop castrate resistance, defined as disease progression despite serum testosterone levels of <20 ng/dl. The recent discovery that AR signaling persists during systemic castration via intratumoral production of androgens led to the development of novel anti-androgen therapies including abiraterone acetate and enzalutamide. Although these agents effectively palliate symptoms and prolong life, metastatic castration-resistant prostate cancer remains incurable. An increased understanding of the mechanisms that underlie the pathogenesis of castrate resistance is therefore needed to develop novel therapeutic approaches for this disease. The aim of this review is to summarize the current literature on the biology and treatment of castrate-resistant prostate cancer.
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Cites
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Cited by
PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
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“This finding suggests that DNA copy gain affecting this locus, commonly by tandem duplication, may be a frequent mechanism by which prostate tumor cells initially develop ADT resistance (Karantanos et al., 2013).”
Il-23 secreted by myeloid cells drives castration-resistant prostate cancer
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WNT signalling in prostate cancer
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Hepcidin regulation in prostate and its disruption in prostate cancer
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Metadata
- Authors
- Karantanos, T., Corn, P. G., & Thompson, T. C.
- Venue
- Oncogene
- Published
- 2013-06-10
- Volume
- 32
- Issue
- 49
- Pages
- 5501-5511
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2159810380
- Cited by
- 866
- References
- 156
- FWCI
- 47.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
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