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Cited by 5,583Wnt/β-catenin signaling in development and cancerSignaling Pathways in DiseaseHedgehog Signaling Pathway Studies

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

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MacDonald, Bryan T., Tamai, Keiko, He, Xi·2009·Developmental Cell
DOI 10.1016/j.devcel.2009.06.016PMC PMC2861485
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Abstract

Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator beta-catenin controls embryonic development and adult homeostasis. Here we review recent progress in this so-called canonical Wnt signaling pathway. We discuss Wnt ligands, agonists, and antagonists, and their interactions with Wnt receptors. We also dissect critical events that regulate beta-catenin stability, from Wnt receptors to the cytoplasmic beta-catenin destruction complex, and nuclear machinery that mediates beta-catenin-dependent transcription. Finally, we highlight some key aspects of Wnt/beta-catenin signaling in human diseases including congenital malformations, cancer, and osteoporosis, and discuss potential therapeutic implications.

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Crossref · 10.1016/j.devcel.2009.06.016

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  • Network analysis of the DMRs showed involvement of β-catenin-related WNT/frizzled signalling, a pathway involved in neuroplasticity.

    “Network analysis of the DMRs showed involvement of β-catenin-related WNT/frizzled signalling, a pathway involved in neuroplasticity.”

    From Epigenetics and depression (2019) · cites this paper as [52]

    The Introduction (page unavailable) describes Wnt binding to Frizzled and activating β-catenin signaling, supporting the pathway identification. The Perspectives section mentions potential links to neurological disorders but does not establish a role in neuroplasticity. The DMR network-analysis result is the citing authors’ own finding, not a finding attributed to this review. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • Wnt signaling is one of the fundamental mechanisms regulating embryonic development and is closely associated with hair follicle morphogenesis and differentiation.

    “Wnt signaling is one of the fundamental mechanisms regulating embryonic development and is closely associated with hair follicle morphogenesis and differentiation (32–34).”

    From Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction (2022) · cites this paper as [32]

    The Introduction describes Wnt signaling as fundamental to embryonic development, and Perspectives identifies hair follicle development and homeostasis as examples of Wnt-regulated biology. The section on Wnt target genes says Wnt regulates differentiation generally, but our copy does not specifically connect it to hair follicle differentiation. No page numbers are available in our copy. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • Expression levels of Apc, Axin1, Lef, Lrp5, and Wnt10b were significantly increased in hair follicloids.

    “Specifically, the expression levels of genes involved in hair follicle development—Apc, Axin1, Lef, Lrp5, and Wnt10b (32, 35)—were significantly increased in hair follicloids (Fig. 5, A and B).”

    From Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction (2022) · cites this paper as [32]

    The Perspectives section (page unavailable) says Wnt signaling regulates hair follicle development, and the pathway sections identify APC, Axin, TCF/LEF, and LRP5 as signaling components. The review does not establish that every named gene, particularly Wnt10b, is involved in hair follicle development. The reported increase in hair follicloids is the citing authors’ Figure 5 result, not a finding attributed to this review. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • The canonical Wnt or Wnt/β-catenin signaling pathway is the most intensively studied Wnt signaling pathway, in vitro and in silico.

    “Among the different Wnt signaling pathways, the canonical Wnt or Wnt/β-catenin signaling pathway is the most intensively studied one, in vitro [22] as well as in silico [23].”

    From Relating simulation studies by provenance—Developing a family of Wnt signaling models (2021) · cites this paper as [22]

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Cited by

Sorted by citations

Authors
MacDonald, B. T., Tamai, K., & He, X.
Affiliations
  • Boston Children's Hospital (US)
  • Case Western Reserve University (US)
Corresponding author
He, Xi
ORCID
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2009-07
Volume
17
Issue
1
Pages
9-26
ISSN
1534-5807 (ISSN-L)
DOI
10.1016/j.devcel.2009.06.016
PMC
PMC2861485
OpenAlex
W2158021558
Cited by
5,583
References
18
Citations by year
2026: 167 · 2025: 259 · 2024: 314 · 2023: 337 · 2022: 387 · 2021: 452 · 2020: 441 · 2019: 374 · 2018: 404 · 2017: 420 · 2016: 339 · 2015: 361 · 2014: 318 · 2013: 306 · 2012: 285
FWCI
17.89
Type
journal article
Language
en
Open access
Licence
Locations
  • Developmental Cell (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
  • National Institute of General Medical Sciences (R01GM057603, R01GM074212, GM 57603, R01GM074241, GM74212)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
Keywords
Wnt/β-catenin signaling, canonical Wnt pathway, Wnt ligands, Wnt receptors, β-catenin stability, β-catenin destruction complex, embryonic development, congenital malformations, cancer, osteoporosis, therapeutic target
MeSH terms
Animals, Disease, Humans, Ligands, Receptors, LDL, Repressor Proteins, Signal Transduction, Active Transport, Cell Nucleus, Wnt Proteins, Frizzled Receptors, beta Catenin, TCF Transcription Factors, Axin Protein, Low Density Lipoprotein Receptor-Related Protein-6

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