Downregulation of CXCL12 in mesenchymal stromal cells by TGFβ promotes breast cancer metastasis
Open accessAbstract
Mesenchymal stromal cells (MSCs) are one of major components of the tumour microenvironment. Recent studies have shown that MSC tumour residence and their close interactions with inflammatory factors are important factors that affect tumour progression. Among tumour-associated inflammatory factors, transforming growth factor β (TGFβ) is regarded as a key determinant of malignancy. By employing a lung metastasis model of a murine breast cancer, we show here that the prometastatic effect of MSCs was dependent on their response to TGFβ. Interestingly, we found that MSC-produced CXCL12, an important chemokine in tumour metastasis, was markedly inhibited by TGFβ. Furthermore, silencing of CXCL12 in TGFβ-unresponsive MSCs restored their ability to promote tumour metastasis. We found that 4T1 breast cancer cells expressed high levels of CXCR7, but not of CXCR4, both of which are CXCL12 receptors. In presence of CXCL12, CXCR7 expression on tumour cells was decreased. Indeed, when CXCR7 was silenced in breast cancer cells, their metastatic ability was inhibited. Therefore, our data demonstrated that sustained expression of CXCL12 by MSCs in the primary tumour site inhibits metastasis through reduction of CXCR7, while, in the presence of TGFβ, this CXCL12 effect of MSCs on tumour cells is relieved. Importantly, elevated CXCR7 and depressed CXCL12 expression levels were prominent features of clinical breast cancer lesions and were related significantly with poor survival. Our findings reveal a novel mechanism of MSC effects on malignant cells through which crosstalk between MSCs and TGFβ regulates tumour metastasis.
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The ability of tumor cells to induce new blood vessel formation is essential for tumor growth and metastatic cancer dissemination.
“The ability of tumor cells to induce new blood vessel formation is essential for tumor growth and metastatic cancer dissemination44,263.”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [263]
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- Authors
- Yu, P. F., Huang, Y., Xu, C. L., Lin, L. Y., Han, Y. Y., Sun, W. H., Hu, G. H., Rabson, A. B., Wang, Y., & Shi, Y. F.
- Affiliations
- Chinese Academy of Sciences (CN)
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Wang, Y
- Shi, Y F
- Venue
- Oncogene
- Published
- 2016-09-26
- Volume
- 36
- Issue
- 6
- Pages
- 840-849
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- PMC
- PMC5311419
- OpenAlex
- W2525107653
- Cited by
- 88
- References
- 39
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 14 · 2020: 12 · 2019: 7 · 2018: 12 · 2017: 6
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Oncogene (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Chinese Academy of Sciences (XDA01040100, GJHZ201307)
- Youth Innovation Promotion Association of the Chinese Academy of Sciences
- Shanghai Rising-Star Program (14QA1404200)
- Youth Innovation Promotion Association
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- CXCL12, mesenchymal stem cells, TGF-beta, breast cancer metastasis, CXCR7, CXCR4, tumor microenvironment, chemokines, 4T1 cells, lung metastasis, prognostic factors
- MeSH terms
- Animals, Breast Neoplasms, Female, Humans, Mice, Inbred BALB C, Neoplasm Metastasis, Transfection, Signal Transduction, Down-Regulation, Mice, SCID, Mice, Inbred NOD, Cell Line, Tumor, Mice, Chemokine CXCL12, Receptors, CXCR, Mesenchymal Stem Cells
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