Cited by 462Mesenchymal stem cell researchHematopoietic Stem Cell TransplantationPeriodontal Regeneration and Treatments

Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative Medicine

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Abstract

Mesenchymal stem cells (MSCs) are self-renewing precursor cells that can differentiate into bone, fat, cartilage, and stromal cells of the bone marrow. Recent studies suggest that MSCs themselves are critical for forming a niche that maintains hematopoietic stem cells (HSCs). The ease by which human MSC-like and stromal progenitor cells can be isolated from the bone marrow and other tissues has led to the rapid development of clinical investigations exploring their anti-inflammatory properties, tissue preservation capabilities, and regenerative potential. However, the identity of genuine MSCs and their specific contributions to these various beneficial effects have remained enigmatic. In this article, we examine the definition of MSCs and discuss the importance of rigorously characterizing their stem cell activity. We review their role and that of other putative niche constituents in the regulation of bone marrow HSCs. Additionally, how MSCs and their stromal progeny alter immune function is discussed, as well as potential therapeutic implications.

Integrity signals

Registry

Crossref · 10.1146/annurev-immunol-032712-095919

Cites

236 of 236 references verified0 citation errors · 0 not checkable

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  • Microorganisms can interact with the microbiome to control metabolic processes, chronic inflammatory processes, and mucosal immunity.

    “For instance, reprogrammed immune cells can use the immune system to treat cancer and administer vaccinations, while microorganisms can interact with the microbiome to control metabolic processes, chronic inflammatory processes, and mucosal immunity.320–322”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [322]

  • Reprogrammed immune cells can use the immune system to treat cancer and administer vaccinations.

    “For instance, reprogrammed immune cells can use the immune system to treat cancer and administer vaccinations, while microorganisms can interact with the microbiome to control metabolic processes, chronic inflammatory processes, and mucosal immunity.320–322”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [322]

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Authors
Frenette, P. S., Pinho, S., Lucas, D., & Scheiermann, C.
Affiliations
Albert Einstein College of Medicine (US)
Venue
Annual Review of Immunology
Published
2013-03-21
Volume
31
Issue
1
Pages
285-316
ISSN
  • 0732-0582 (ISSN-L)
  • 1545-3278
OpenAlex
W2138953281
Cited by
462
References
235
Citations by year
2026: 8 · 2025: 14 · 2024: 27 · 2023: 27 · 2022: 23 · 2021: 39 · 2020: 35 · 2019: 34 · 2018: 41 · 2017: 42 · 2016: 38 · 2015: 51 · 2014: 54 · 2013: 27 · 2012: 2
FWCI
7.76
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Annual Review of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders
  • National Heart, Lung, and Blood Institute (R01HL116340, R01HL097700, R01HL069438, R01HL097819)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056638)
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
Keywords
mesenchymal stem cells, hematopoietic stem cells, bone marrow microenvironment, stromal progenitor cells, immune function, anti-inflammatory activity, regenerative medicine, stem cell therapy
MeSH terms
Animals, Bone Marrow Cells, Humans, Inflammation, Stem Cells, Stromal Cells, Hematopoietic Stem Cell Transplantation, Regenerative Medicine, Mesenchymal Stem Cell Transplantation

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