Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative Medicine
Open accessAbstract
Mesenchymal stem cells (MSCs) are self-renewing precursor cells that can differentiate into bone, fat, cartilage, and stromal cells of the bone marrow. Recent studies suggest that MSCs themselves are critical for forming a niche that maintains hematopoietic stem cells (HSCs). The ease by which human MSC-like and stromal progenitor cells can be isolated from the bone marrow and other tissues has led to the rapid development of clinical investigations exploring their anti-inflammatory properties, tissue preservation capabilities, and regenerative potential. However, the identity of genuine MSCs and their specific contributions to these various beneficial effects have remained enigmatic. In this article, we examine the definition of MSCs and discuss the importance of rigorously characterizing their stem cell activity. We review their role and that of other putative niche constituents in the regulation of bone marrow HSCs. Additionally, how MSCs and their stromal progeny alter immune function is discussed, as well as potential therapeutic implications.
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Reprogrammed immune cells can use the immune system to treat cancer and administer vaccinations.
“For instance, reprogrammed immune cells can use the immune system to treat cancer and administer vaccinations, while microorganisms can interact with the microbiome to control metabolic processes, chronic inflammatory processes, and mucosal immunity.320–322”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [322]
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Immunogenic Cell Death in Cancer Therapy
Kroemer, G., Galluzzi, L., Kepp, O., & Zitvogel, L. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100008 · Cited by 3,303 · see citing works
The evolution of commercial drug delivery technologies
Vargason, A. M., Anselmo, A. C., & Mitragotri, S. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00698-w · Cited by 1,361 · see citing works
Arteriolar niches maintain haematopoietic stem cell quiescence
Kunisaki, Y., Bruns, I., Scheiermann, C., Ahmed, J. U., Pinho, S., Zhang, D., Mizoguchi, T., Wei, Q., Lucas, D., Ito, K., et al. (2013) · Nature · doi:10.1038/nature12612 · Cited by 1,236 · see citing works
“The association and quiescence of both haematopoietic and mesenchymal stem cells at this site may thus endow arterioles with the potential for orchestrating haematopoietic and stromal regeneration 40 .”
Self-citationSmart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
“322 Additionally, living cells are modi fi able.”
BackgroundHaematopoietic stem cell activity and interactions with the niche
Pinho, S., & Frenette, P. S. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0103-9 · Cited by 990 · see citing works
Self-citationGuidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
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Hematopoietic stem cell niche maintenance during homeostasis and regeneration
Mendelson, A., & Frenette, P. S. (2014) · Nature Medicine · doi:10.1038/nm.3647 · Cited by 819 · see citing works
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Denervation suppresses gastric tumorigenesis
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“Previous studies suggested that nerves contribute to the normal stem cell niche (1, 2, 38), and a recent report has linked sympathetic nerves to prostate cancer progression (7).”
Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion
Bruns, I., Lucas, D., Pinho, S., Ahmed, J. U., Lambert, M. P., Kunisaki, Y., Scheiermann, C., Schiff, L., Poncz, M., Bergman, A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3707 · Cited by 624 · see citing works
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“…reside in the bone marrow (BM) cavity, where they interact with different types of stromal cells expressing important regulatory molecules including stem cell factor (SCF), C-X-C motif chemokine 12 (CXCL12, also called SDF1a), and transforming growth factor b (TGF-b) (Frenette et al., 2013).”
BackgroundResultInfluentialMesenchymal Stromal Cell Homing: Mechanisms and Strategies for Improvement
Ullah, M., Liu, D. D., & Thakor, A. S. (2019) · iScience · doi:10.1016/j.isci.2019.05.004 · Cited by 553 · see citing works
“Accordingly, MSCs have been investigated for a wide breadth of clinical applications, such as immune modulation in inflammatory and autoimmune diseases, tissue protection following injury, and regenerative medicine (Frenette et al., 2013).”
BackgroundInfluentialGuidelines for the use of flow cytometry and cell sorting in immunological studies *
Cossarizza, A., Chang, H., Radbruch, A., Akdiş, M., Andrä, I., Annunziato, F., Bächer, P., Barnaba, V., Battistini, L., Bauer, W. M., et al. (2017) · European Journal of Immunology · doi:10.1002/eji.201646632 · Cited by 594 · see citing works
Self-citationSkin tissue engineering: wound healing based on stem-cell-based therapeutic strategies
Dehkordi, A. N., Mirahmadi, F., Chehelgerdi, M., & Dehkordi, S. R. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1212-2 · Cited by 547 · see citing works
Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation
Huebsch, N., Lippens, E., Lee, K., Mehta, M., Koshy, S. T., Darnell, M., Desai, R. M., Madl, C. M., Xu, M. M., Zhao, X., et al. (2015) · Nature Materials · doi:10.1038/nmat4407 · Cited by 530 · see citing works
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531 · see citing works
Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application
Wang, M., Yuan, Q., & Xie, L. (2018) · Stem Cells International · doi:10.1155/2018/3057624 · Cited by 506 · see citing works
“In fact, a variety of immune disorder diseases, including multiple sclerosis, Crohn’s disease, GVHD, SLEs, and type 1 diabetes, have entered clinical trials for treatment with MSCs [80].”
BackgroundPinho, S., Lacombe, J., Hanoun, M., Mizoguchi, T., Bruns, I., Kunisaki, Y., & Frenette, P. S. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20122252 · Cited by 504 · see citing works
“Nevertheless, these markers are not homogeneously expressed across cultures, varying with isolation protocols and passage and therefore not necessarily representative of MSCs in vivo (Bianco et al., 2013; Frenette et al., 2013).”
BackgroundSelf-citationMizoguchi, T., Pinho, S., Ahmed, J. U., Kunisaki, Y., Hanoun, M., Mendelson, A., Ono, N., Kronenberg, H. M., & Frenette, P. S. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.03.013 · Cited by 441 · see citing works
“The bone marrow (BM) environment is composed of multiple cell types, most of which are thought to be derived from mesenchymal stem and progenitor cells (MSPCs) (Bianco et al., 2013; Caplan, 1991; Frenette et al., 2013).”
BackgroundSelf-citationMesenchymal stem cells in fibrotic disease
El Agha, E., Kramann, R., Schneider, R. K., Li, X., Seeger, W., Humphreys, B. D., & Bellusci, S. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.07.011 · Cited by 430 · see citing works
“Although there is significant functional overlap between MSC populations in terms of multipotency and self-renewal capacities, their distribution in the BM cavity and their association with the endosteum or blood vessels are distinct (Frenette et al., 2013; Morrison and Scadden, 2014).”
BackgroundDifferential cytokine contributions of perivascular haematopoietic stem cell niches
Asada, N., Kunisaki, Y., Pierce, H., Wang, Z., Fernandez, N., Birbrair, A., Ma’ayan, A., & Frenette, P. S. (2017) · Nature Cell Biology · doi:10.1038/ncb3475 · Cited by 431 · see citing works
Self-citationNormal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities
Schepers, K., Campbell, T., & Passegué, E. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.02.014 · Cited by 416 · see citing works
“However, additional studies have since refuted this observation and showed that mature OBs do not directly affect HSC maintenance in the BM (Frenette et al., 2013).”
InfluentialRecognition of Bacteria by Inflammasomes
von Moltke, J., Ayres, J. S., Kofoed, E. M., Chavarría‐Smith, J., & Vance, R. E. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095944 · Cited by 414 · see citing works
A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones
Ono, N., Ono, W., Nagasawa, T., & Kronenberg, H. M. (2014) · Nature Cell Biology · doi:10.1038/ncb3067 · Cited by 418 · see citing works
Niches for Hematopoietic Stem Cells and Their Progeny
Wei, Q., & Frenette, P. S. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.024 · Cited by 398 · see citing works
“…remains elusive in part due to different processing protocols, such as bone crushing or BM flushing, and difficulty in visualization comparisons (Hu et al., 2016, Pinho et al., 2013, Churchman et al., 2012, Morikawa et al., 2009, Sacchetti et al., 2007, Isern et al., 2013, Frenette et al., 2013).”
Self-citationHanoun, M., Zhang, D., Mizoguchi, T., Pinho, S., Pierce, H., Kunisaki, Y., Lacombe, J., Armstrong, S. A., Dührsen, U., & Frenette, P. S. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.06.020 · Cited by 381 · see citing works
“Recent studies have demonstrated that healthy HSCs reside in specific perivascular bone marrow niches, which tightly regulate their function (reviewed in Frenette et al., 2013).”
BackgroundSelf-citationStemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment
Aponte, P. M., & Caicedo, A. (2017) · Stem Cells International · doi:10.1155/2017/5619472 · Cited by 375 · see citing works
“Even thoughmore research is required to understand the stemness properties of MSCs, their role in providing support not only to SCs in normal niches but also to pathologic CSCs is well-documented [122, 136].”
BackgroundPathogenesis of immune thrombocytopenia
Audia, S., Mahévas, M., Samson, M., Godeau, B., & Bonnotte, B. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.04.012 · Cited by 395 · see citing works
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Stem Cell Extracellular Vesicles: Extended Messages of Regeneration
Riazifar, M., Pone, E. J., Lötvall, J. O., & Zhao, W. (2016) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-061616-030146 · Cited by 326 · see citing works
“In current practice, MSCs (usually obtained from adult bone marrow, adipose tissue, or neonatal umbilical cord) are among the most widely used types of adult stem cells in animal studies and human clinical trials (121, 122) for reasons that include easy isolation and expansion in culture, their comparatively infrequen…”
BackgroundChemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration
Lucas, D., Scheiermann, C., Chow, A. T., Kunisaki, Y., Bruns, I., Barrick, C. A., Tessarollo, L., & Frenette, P. S. (2013) · Nature Medicine · doi:10.1038/nm.3155 · Cited by 300 · see citing works
Self-citationInteractions between mesenchymal stem cells and the immune system
Li, N., & Hua, J. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2473-5 · Cited by 338 · see citing works
“[18, 19], with effective outcomes in several cases [41, 181–184].”
BackgroundEnhancing the Migration Ability of Mesenchymal Stromal Cells by Targeting the SDF-1/CXCR4 Axis
Marquez‐Curtis, L. A., & Janowska‐Wieczorek, A. (2013) · BioMed Research International · doi:10.1155/2013/561098 · Cited by 288 · see citing works
“Endogenous MSCs are mobilized and contribute to tissue repair by acting as a reservoir of cells for regeneration [30, 31] and guarding against inflammation [32].”
BackgroundCharacterization of bone marrow-derived mesenchymal stem cells in aging
Baker, N., Boyette, L. B., & Tuan, R. S. (2014) · Bone · doi:10.1016/j.bone.2014.10.014 · Cited by 287 · see citing works
“Furthermore, an age-related decline in BMSCs expressing CD146 has been reported [22] (For further information on novel MSC markers, see reviews by [10,17,18]).”
BackgroundInfluentialNeural Regulation of Hematopoiesis, Inflammation, and Cancer
Hanoun, M., Maryanovich, M., Arnal-Estapé, A., & Frenette, P. S. (2015) · Neuron · doi:10.1016/j.neuron.2015.01.026 · Cited by 265 · see citing works
Self-citationEndothelial Jagged-1 Is Necessary for Homeostatic and Regenerative Hematopoiesis
Poulos, M. G., Guo, P., Kofler, N. M., Pinho, S., Gutkin, M. C., Tikhonova, A. N., Aifantis, I., Frenette, P. S., Kitajewski, J., Rafii, S., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.07.048 · Cited by 249 · see citing works
“, 2005), and PDGFRα+ CD51+ MSCs (Frenette et al., 2013; Pinho et al., 2013) or Leptin Receptor+ (Ding et al.”
BackgroundSelf-citationStem cell-based bone and dental regeneration: a view of microenvironmental modulation
Zheng, C., Chen, J., Liu, S., & Jin, Y. J. (2019) · International Journal of Oral Science · doi:10.1038/s41368-019-0060-3 · Cited by 242 · see citing works
Identification, discrimination and heterogeneity of fibroblasts
Lendahl, U., Muhl, L., & Betsholtz, C. (2022) · Nature Communications · doi:10.1038/s41467-022-30633-9 · Cited by 242 · see citing works
Regenerative Stem Cell Therapy for Neurodegenerative Diseases: An Overview
Sivandzade, F., & Cucullo, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042153 · Cited by 224 · see citing works
“Scientists are continually trying to find sturdy, safe, and readily available stem cell sources while refining and/or developing new delivery methods to improve the treatment’s efficiency and effectiveness and reduce the side effects [11].”
BackgroundTriana, S., Vonficht, D., Jopp-Saile, L., Raffel, S., Lutz, R., Leonce, D., Antes, M., Hernández-Malmierca, P., Ordoñez-Rueda, D., Ramasz, B., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-01059-0 · Cited by 195 · see citing works
“MSCs constitute a rare and heterogeneous group of cells in the bone marrow (Al-Sabah et al., 2020; Frenette et al., 2013).”
BackgroundLuo, Y., Chen, G., Hannemann, N., Ipseiz, N., Krönke, G., Bäuerle, T., Munos, L., Wirtz, S. J., Schett, G. A., & Bözec, A. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.020 · Cited by 198 · see citing works
“Communication between the mesenchymal tissue and the hematopoietic system primarily occurs in the bone marrow (BM), where bone forms a niche based on mesenchymal cells for the developing blood and immune cells (Frenette et al., 2013).”
BackgroundVignais, M., Caicedo, A., Brondello, J., & Jørgensen, C. (2017) · Stem Cells International · doi:10.1155/2017/6917941 · Cited by 190 · see citing works
Hematopoiesis and Cardiovascular Disease
Poller, W. C., Nahrendorf, M., & Świrski, F. K. (2020) · Circulation Research · doi:10.1161/circresaha.120.315895 · Cited by 183 · see citing works
Kartogenin-Incorporated Thermogel Supports Stem Cells for Significant Cartilage Regeneration
Li, X., Ding, J., Zhang, Z., Yang, M., Yu, J., Wang, J., Chang, F., & Chen, X. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b12212 · Cited by 183 · see citing works
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Roles of nonmyogenic mesenchymal progenitors in pathogenesis and regeneration of skeletal muscle
Uezumi, A., Ikemoto‐Uezumi, M., & Tsuchida, K. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00068 · Cited by 163 · see citing works
“Their differentiation might be undesired in most cases because adipogenic differentiation has a negative impact on hematopoiesis in bone marrow (Naveiras et al., 2009).”
BackgroundBone metastasis and the metastatic niche
Ren, G., Esposito, M., & Kang, Y. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1329-4 · Cited by 161 · see citing works
“Accumulating evidence has shown that there is an intricately-organized microenvironment inside the bone that regulates the dynamic balance among various stem cells, progenitor cells, mature immune cells, and supporting stromal cells; this has been named the bone niche [12, 16].”
Functional inhibition of mesenchymal stromal cells in acute myeloid leukemia
Geyh, S., Rodríguez‐Paredes, M., Jäger, P. S., Khandanpour, C., Cadeddu, R.-P., Gutekunst, J., Wilk, C. M., Fenk, R. R., Zilkens, C., Hermsen, D. F., et al. (2015) · Leukemia · doi:10.1038/leu.2015.325 · Cited by 152 · see citing works
Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems
Ohno, S., Drummen, G. P. C., & Kuroda, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020172 · Cited by 150 · see citing works
“Mesenchymal stem cells (MSCs) are self-renewing precursor cells (multipotent stem cells) that are able to differentiate into a variety of cell types, including bone, cartilage, muscle, marrow, ligament, adipose and connective tissues [26,27].”
BackgroundSkrahin, A., Ahmed, R. K. S., Ferrara, G., Rane, L., Poiret, T., Isaikina, Y., Skrahina, A. M., Zumla, A. I., & Maeurer, M. J. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70234-0 · Cited by 143 · see citing works
Liu, J., Zhang, H., Zhang, Y., Li, N., Wen, Y., Cao, F., Ai, H., & Xue, X. (2014) · Molecules and Cells · doi:10.14348/molcells.2014.0145 · Cited by 139 · see citing works
“Cells 871 Frenette et al., 2013).”
Haider, K. H., & Aramini, B. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1548-7 · Cited by 139 · see citing works
“tors and cytokines to regulate their activity [13, 14].”
BackgroundMetabolism and the Control of Cell Fate Decisions and Stem Cell Renewal
Ito, K., & Ito, K. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125134 · Cited by 137 · see citing works
“…2009, Suda et al. 2011), and cell-intrinsic networks integrate and cooperate with cumulative signals from the microenvironment to fine-tune their self-renewal capacity and maintain whole-tissue balance (Frenette et al. 2013, Morrison & Scadden 2014, Scadden 2006, Watt & Hogan 2000, Zon 2008).”
Conforti, A., Scarsella, M., Starc, N., Giorda, E., Biagini, S., Proia, A., Carsetti, R., Locatelli, F., & Bernardo, M. E. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0091 · Cited by 134 · see citing works
“…in vitro data, MSCs have been tested in phase I/II clinical trials aimed at treating steroid-resistant acute graft-versus-host disease (aGvHD) and favoring hematopoietic engraftment/recovery after hematopoietic stem cell transplantation [12–14], and in strategies of Regenerative Medicine [15,16].”
Jiang, B., Yan, L., Wang, X., Li, E., Murphy, K. A., Vaccaro, K., Li, Y., & Xu, R. (2018) · Stem Cells · doi:10.1002/stem.2964 · Cited by 125 · see citing works
Neural regulation of bone and bone marrow
Maryanovich, M., Takeishi, S., & Frenette, P. S. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031344 · Cited by 114 · see citing works
“Bones not only play a variety of mechanical roles, but also have synthetic aspects, one of which is production of blood cells from hematopoietic stem cells (HSCs) in the bone marrow (BM) (Frenette et al. 2013; Mendelson and Frenette 2014).”
BackgroundSelf-citationAzadniv, M., Myers, J. R., McMurray, H. R., Guo, N., Rock, P., Coppage, M. L., Ashton, J. M., Becker, M. W., Calvi, L. M., & Liesveld, J. L. (2019) · Leukemia · doi:10.1038/s41375-019-0568-8 · Cited by 112 · see citing works
Neuronal Activity in Ontogeny and Oncology
Venkatesh, H. S., & Monje, M. (2017) · Trends in cancer · doi:10.1016/j.trecan.2016.12.008 · Cited by 105 · see citing works
“Perivascular mesenchymal stem and progenitor cells (MSPCs) are also a key component of the BM niche and maintain the HSC population through expression of growth and retention factors including CXCL12, SCF, and ANGPT1 [135,136].”
BackgroundThe impact of tumor stroma on drug response in breast cancer
Dittmer, J., & Leyh, B. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2014.05.006 · Cited by 107 · see citing works
Hox genes in the adult skeleton: Novel functions beyond embryonic development
Rux, D. R., & Wellik, D. M. (2016) · Developmental Dynamics · doi:10.1002/dvdy.24482 · Cited by 105 · see citing works
“In addition, they have important roles in maintenance of the hematopoietic stem cell niche (Calvi et al., 2003; Zhang et al., 2003; Adams et al., 2007; Mendez-Ferrer et al., 2010; Frenette et al., 2013; Kunisaki et al., 2013).”
BackgroundModulation of TNF-Induced Macrophage Polarization by Synovial Fibroblasts
Donlin, L. T., Jayatilleke, A., Γιαννοπούλου, Ε., Kalliolias, G. D., & Ivashkiv, L. B. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400486 · Cited by 106 · see citing works
“Mesenchymal stromal cell–derived immunomodulatory factors are commonly secreted in response to inflammatory stimuli (1, 2).”
BackgroundMesenchymal Stromal Cells and Toll-Like Receptor Priming: A Critical Review
Najar, M., Krayem, M., Meuleman, N., Bron, D., & Lagneaux, L. (2017) · Immune Network · doi:10.4110/in.2017.17.2.89 · Cited by 101 · see citing works
“MSCs actively participate in the regulation of HSC survival, quiescence and, upon specific triggers, differentiation into mature cells (11) suggesting their role in the enhancement of hematopoietic engraftment during use in HSC transplantation (12).”
BackgroundRoles of microRNA-34a targeting SIRT1 in mesenchymal stem cells
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“Since MSCs are easily obtained and exhibit impressive paracrine ability as well as multilineage differentiation potential [33], autologous MSCs offer a great advantage when transplanted into ischemic or infarcted heart to regenerate and repopulate the injured myocardium and restore heart function.”
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- Authors
- Frenette, P. S., Pinho, S., Lucas, D., & Scheiermann, C.
- Affiliations
- Albert Einstein College of Medicine (US)
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2013-03-21
- Volume
- 31
- Issue
- 1
- Pages
- 285-316
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2138953281
- Cited by
- 462
- References
- 235
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 27 · 2023: 27 · 2022: 23 · 2021: 39 · 2020: 35 · 2019: 34 · 2018: 41 · 2017: 42 · 2016: 38 · 2015: 51 · 2014: 54 · 2013: 27 · 2012: 2
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- National Heart, Lung, and Blood Institute (R01HL116340, R01HL097700, R01HL069438, R01HL097819)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056638)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Keywords
- mesenchymal stem cells, hematopoietic stem cells, bone marrow microenvironment, stromal progenitor cells, immune function, anti-inflammatory activity, regenerative medicine, stem cell therapy
- MeSH terms
- Animals, Bone Marrow Cells, Humans, Inflammation, Stem Cells, Stromal Cells, Hematopoietic Stem Cell Transplantation, Regenerative Medicine, Mesenchymal Stem Cell Transplantation
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