TRIMming p53’s anticancer activity

Transcriptional control of human p53-regulated genes

Riley, T., Sontag, E., Chen, P., & Levine, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2395 · Cited by 1,921 · see citing works

SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

Schultz, D. C., Ayyanathan, K., Negorev, D., Maul, G. G., & Rauscher, F. J. (2002) · Genes & Development · doi:10.1101/gad.973302 · Cited by 1,313 · see citing works

TRIM family proteins and their emerging roles in innate immunity

Ozato, K., Shin, D.-M., Chang, T.-H., & Morse, H. (2008) · Nature reviews. Immunology · doi:10.1038/nri2413 · Cited by 1,120 · see citing works

TRIM/RBCC, a novel class of ‘single protein RING finger’ E3 ubiquitin ligases

Meroni, G., & Diez‐Roux, G. (2005) · BioEssays · doi:10.1002/bies.20304 · Cited by 731 · see citing works

KAP-1, a novel corepressor for the highly conserved KRAB repression domain.Preprint

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Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

Hofmann, T. G., Möller, A., Sirma, H., Zentgraf, H., Taya, Y., Dröge, W., Will, H., & Schmitz, M. L. (2001) · Nature Cell Biology · doi:10.1038/ncb715 · Cited by 591 · see citing works

Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2α subunit of NuRDPreprint

Schultz, D., Friedman, J. R., & Rauscher, F. J. (2001) · Genes & Development · doi:10.1101/gad.869501 · Cited by 530 · see citing works

The function of PML in p53-dependent apoptosis

Guo, A., Salomoni, P., Luo, J., Shih, A. H., Zhong, S., Gu, W., & Pandolfi, P. P. (2000) · Nature Cell Biology · doi:10.1038/35036365 · Cited by 466 · see citing works

TRIM24 links a non-canonical histone signature to breast cancer

Tsai, W.-W., Wang, Z., Yiu, T. T., Akdemir, K. C., Xia, W., Winter, S., Tsai, C., Shi, X., Schwarzer, D., Plunkett, W. K., et al. (2010) · Nature · doi:10.1038/nature09542 · Cited by 435 · see citing works

Efp targets 14-3-3σ for proteolysis and promotes breast tumour growth

Urano, T., Saito, T., Tsukui, T., Fujita, M., Hosoi, T., Muramatsu, M., Ouchi, Y., & Inoue, S. (2002) · Nature · doi:10.1038/nature00826 · Cited by 357 · see citing works

PML regulates p53 stability by sequestering Mdm2 to the nucleolus

Bernardi, R., Scaglioni, P. P., Bergmann, S., Horn, H. F., Vousden, K. H., & Pandolfi, P. P. (2004) · Nature Cell Biology · doi:10.1038/ncb1147 · Cited by 348 · see citing works

Loss of the Tumor Suppressor PML in Human Cancers of Multiple Histologic Origins

Gurrieri, C., Capodieci, P., Bernardi, R., Scaglioni, P. P., Nafa, K., Rush, L. J., Verbel, D., Cordon‐Cardo, C., & Pandolfi, P. P. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh043 · Cited by 331 · see citing works

Subclassification of the RBCC/TRIM Superfamily Reveals a Novel Motif Necessary for Microtubule Binding

Short, K. M., & Cox, T. C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512755200 · Cited by 323 · see citing works

A Novel Nuclear Receptor Corepressor Complex, N-CoR, Contains Components of the Mammalian SWI/SNF Complex and the Corepressor KAP-1*

Underhill, C., Qutob, M. S., Yee, S.-P., & Torchia, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007864200 · Cited by 323 · see citing works

PML Is a Direct p53 Target that Modulates p53 Effector Functions

de Stanchina, E., Querido, E., Narita, M., Davuluri, R. V., Pandolfi, P. P., Ferbeyre, G., & Lowe, S. W. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00062-0 · Cited by 312 · see citing works

The Interferon-inducible Ubiquitin-protein Isopeptide Ligase (E3) EFP Also Functions as an ISG15 E3 Ligase

Zou, W., & Zhang, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510787200 · Cited by 305 · see citing works

Trim24 targets endogenous p53 for degradation

Allton, K., Jain, A. K., Herz, H.-M., Tsai, W.-W., Jung, S. Y., Qin, J., Bergmann, A., Johnson, R. L., & Barton, M. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813177106 · Cited by 292 · see citing works

PML, a Growth Suppressor Disrupted in Acute Promyelocytic Leukemia

Mu, Z. M., Chin, K., Liu, H., Lozano, G., & Chang, K. S. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.10.6858 · Cited by 288 · see citing works

MAGE-A, mMage-b, and MAGE-C Proteins Form Complexes with KAP1 and Suppress p53-Dependent Apoptosis in MAGE-Positive Cell Lines

Yang, B., O’Herrin, S. M., Wu, J., Reagan‐Shaw, S., Ma, Y., Bhat, K. M. R., Gravekamp, C., Setaluri, V., Peters, N. R., Hoffmann, F. M., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1478 · Cited by 272 · see citing works

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation

Wang, C., Ivanov, A. V., Chen, L., Fredericks, W. J., Seto, E., Rauscher, F. J., & Chen, J. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600791 · Cited by 263 · see citing works

Mechanism of USP7/HAUSP Activation by Its C-Terminal Ubiquitin-like Domain and Allosteric Regulation by GMP-Synthetase

Faesen, A. C., Dirac, A. M. G., Shanmugham, A., Ovaa, H., Anastassis Perrakis, A., & Sixma, T. K. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.034 · Cited by 251 · see citing works

PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

Yang, S., Kuo, C. S., Bisi, J., & Kim, M. K. (2002) · Nature Cell Biology · doi:10.1038/ncb869 · Cited by 238 · see citing works

Deconstructing PML‐induced premature senescence

Bischof, O., Kirsh, O., Pearson, M. A., Itahana, K., Pelicci, P. G., & Dejean, A. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf341 · Cited by 229 · see citing works

Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma

Herquel, B., Ouararhni, K., Khetchoumian, K., Ignat, M., Teletin, M., Mark, M., Béchade, G., van Dorsselaer, A., Sanglier-Cianférani, S., Hamiche, A., et al. (2011) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1101544108 · Cited by 225 · see citing works

Oncogenic Function of ATDC in Pancreatic Cancer through Wnt Pathway Activation and β-Catenin Stabilization

Wang, L., Heidt, D. G., Lee, C. J., Yang, H., Logsdon, C. D., Zhang, L., Fearon, E. R., Ljungman, M. E., & Simeone, D. M. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.018 · Cited by 216 · see citing works

SUMO E3 ligase activity of TRIM proteins

Chu, Y., & Yang, X. (2010) · Oncogene · doi:10.1038/onc.2010.462 · Cited by 215 · see citing works

TRIM59 Is Up-regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of p53

Zhou, Z., Ji, Z., Wang, Y., Li, J., Cao, H., Zhu, H. H., & Gao, W. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.07.021 · Cited by 170 · see citing works

Differential Roles of PML Isoforms

Nisole, S., Maroui, M. A., Mascle, X. H., Aubry, M., & Chelbi‐Alix, M. K. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00125 · Cited by 168 · see citing works

Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein.

Inoue, S., Orimo, A., Hosoi, T., Kondo, S., Toyoshima, H., Kondo, T., Ikegami, A., Ouchi, Y., Orimo, H., & Muramatsu, M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11117 · Cited by 162 · see citing works

MOZ increases p53 acetylation and premature senescence through its complex formation with PML

Rokudai, S., Laptenko, O., Arnal, S. M., Taya, Y., Kitabayashi, I., & Prives, C. L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300490110 · Cited by 155 · see citing works

TRIM Proteins in Cancer

Cambiaghi, V., Giuliani, V., Lombardi, S., Marinelli, C., Toffalorio, F., & Pelicci, P. G. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5398-7_6 · Cited by 146 · see citing works

E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

Liu, J., Zhang, C., Wang, X. L., Ly, P., Белый, В. А., Xu-Monette, Z. Y., Young, K. H., Hu, W., & Feng, Z. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.121 · Cited by 137 · see citing works

The Promyelocytic Leukemia Protein Protects p53 from Mdm2-mediated Inhibition and Degradation

Louria‐Hayon, I., Grossman, T., Sionov, R. V., Alsheich-Bartok, O., Pandolfi, P. P., & Haupt, Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301264200 · Cited by 135 · see citing works

Nucleotide Biosynthetic Enzyme GMP Synthase Is a TRIM21-Controlled Relay of p53 Stabilization

Reddy, B. A., van der Knaap, J. A., Bot, A. G. M., Mohd-Sarip, A., Dekkers, D. H. W., Timmermans, M. A. M., Martens, J. W. M., Demmers, J., & Verrijzer, C. P. (2014) · Molecular Cell · doi:10.1016/j.molcel.2013.12.017 · Cited by 131 · see citing works

Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins

Fridell, R. A., Harding, L. S., Bogerd, H. P., & Cullen, B. R. (1995) · Virology · doi:10.1006/viro.1995.1266 · Cited by 129 · see citing works

Tripartite Motif Protein 32 Facilitates Cell Growth and Migration via Degradation of Abl-Interactor 2

Kano, S., Miyajima, N., Fukuda, S., & Hatakeyama, S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6231 · Cited by 127 · see citing works

RING protein Trim32 associated with skin carcinogenesis has anti-apoptotic and E3-ubiquitin ligase properties

Horn, E. J. (2003) · Carcinogenesis · doi:10.1093/carcin/bgh003 · Cited by 126 · see citing works

KAP1 Promotes Proliferation and Metastatic Progression of Breast Cancer Cells

Addison, J., Koontz, C., Fugett, J. H., Creighton, C. J., Chen, D., Farrugia, M. K., Padon, R. R., Voronkova, M. A., McLaughlin, S. L., Livengood, R. H., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1561 · Cited by 120 · see citing works

Novel Breast Cancer Metastasis-Associated Proteins

Ho, J., Kong, J.-W.-F., Choong, L., Loh, M., Toy, W., Chong, P., Wong, C., Wong, C., Shah, N., & Lim, Y.-P. (2008) · Journal of Proteome Research · doi:10.1021/pr8007368 · Cited by 119 · see citing works

Impairment of p53 acetylation, stability and function by an oncogenic transcription factor

Insinga, A., Monestiroli, S., Ronzoni, S., Carbone, R., Pearson, M. A., Pruneri, G., Viale, G., Appella, E., Pelicci, P. G., & Minucci, S. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600109 · Cited by 117 · see citing works

The ATDC (TRIM29) Protein Binds p53 and Antagonizes p53-Mediated Functions

Yuan, Z., Villagra, A., Peng, L., Coppola, D., Glozak, M. A., Sotomayor, E. M., Chen, J., Lane, W. S., & Seto, E. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01023-09 · Cited by 115 · see citing works

The RBCC GeneRFP2(Leu5) Encodes a Novel Transmembrane E3 Ubiquitin Ligase Involved in ERAD

Lerner, M., Corcoran, M., Cepeda, D., Nielsen, M. L., Zubarev, R. A., Pontén, F., Uhlén, M., Hober, S., Grandér, D., & Sangfelt, O. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-03-0248 · Cited by 109 · see citing works

Regulation of p53 - insights into a complex process

Boehme, K. A., & Blattner, C. (2009) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409230903401507 · Cited by 106 · see citing works

Cloning of a candidate gene for ataxia-telangiectasia group D.

Kapp, L. N., Painter, R. B., Yu, L. C., van Loon, N., Richard, C. W., James, M. R., Cox, D. R., & Murnane, J. P. (1992) · PubMed · Cited by 99 · see citing works

TRIM24 Is a p53-Induced E3-Ubiquitin Ligase That Undergoes ATM-Mediated Phosphorylation and Autodegradation during DNA Damage

Jain, A. K., Allton, K. L., Duncan, A. D., & Barton, M. C. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01705-12 · Cited by 99 · see citing works

Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis

Le, X., Vallian, S., Mu, Z.-M., Hung, M., & Chang, K.-S. (1998) · Oncogene · doi:10.1038/sj.onc.1201705 · Cited by 98 · see citing works

Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2

加納, 里. (2009) · Medical Entomology and Zoology · Cited by 96 · see citing works

Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells

Obad, S., Brunnström, H., Vallon-Christersson, J., Borg, Å., Drott, K., & Gullberg, U. (2004) · Oncogene · doi:10.1038/sj.onc.1207524 · Cited by 90 · see citing works

TRIM29 negatively regulates p53 via inhibition of Tip60

Sho, T., Tsukiyama, T., Sato, T. Z., Kondo, T., Cheng, J., Saku, T., Asaka, M., & Hatakeyama, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.03.018 · Cited by 89 · see citing works

The transcription-independent mitochondrial p53 program is a major contributor to Nutlin-induced apoptosis in tumor cells

Vaseva, A. V., Marchenko, N. D., & Moll, U. M. (2009) · Cell Cycle · doi:10.4161/cc.8.11.8596 · Cited by 88 · see citing works

TRIM25 has a dual function in the p53/Mdm2 circuit

Zhang, P., Elabd, S., Hammer, S., Solozobova, V., Yan, H., Bartel, F., Inoue, S., Henrich, T., Wittbrodt, J., Loosli, F., et al. (2015) · Oncogene · doi:10.1038/onc.2015.21 · Cited by 79 · see citing works

Estrogen-Responsive Finger Protein as a New Potential Biomarker for Breast Cancer

Suzuki, T., Urano, T., Tsukui, T., Horie‐Inoue, K., Moriya, T., Ishida, T., Muramatsu, M., Ouchi, Y., Sasano, H., & Inoue, S. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0040 · Cited by 76 · see citing works

Nonhomologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53

Dahm‐Daphi, J., Hubbe, P., Horvath, F., El‐Awady, R., Bouffard, K. E., Powell, S. N., & Willers, H. (2005) · Oncogene · doi:10.1038/sj.onc.1208396 · Cited by 74 · see citing works

Physical and Functional Interactions between PML and MDM2

Wei, X., Yu, Z. K., Ramalingam, A., Grossman, S. R., Jiang, Y., Bloch, D. B., & Maki, C. G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212215200 · Cited by 74 · see citing works

Whole-genome cartography of p53 response elements ranked on transactivation potential

Tebaldi, T., Zaccara, S., Alessandrini, F., Bisio, A., Ciribilli, Y., & Inga, A. (2015) · BMC Genomics · doi:10.1186/s12864-015-1643-9 · Cited by 72 · see citing works

Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2

Joo, H. M., Kim, J.-Y., Jeong, J. B., Seong, K. M., Nam, S. Y., Yang, K. H., Kim, C. S., Kim, H. S., Jeong, M., An, S., et al. (2011) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2010.12.001 · Cited by 70 · see citing works

TRIM24 Overexpression Is Common in Locally Advanced Head and Neck Squamous Cell Carcinoma and Correlates with Aggressive Malignant Phenotypes

Cui, Z., Cao, W., Li, J., Song, X., Mao, L., & Chen, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063887 · Cited by 70 · see citing works

PML enhances the regulation of p53 by CK1 in response to DNA damage

Alsheich-Bartok, O., Haupt, S., Snir-Alkalay, I., Saito, S., Appella, E., & Haupt, Y. (2008) · Oncogene · doi:10.1038/sj.onc.1211036 · Cited by 69 · see citing works

TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin

Masuda, Y., Takahashi, H., Sato, S., Tomomori‐Sato, C., Saraf, A., Washburn, M. P., Florens, L. A., Conaway, R., Conaway, J. W., & Hatakeyama, S. (2015) · Nature Communications · doi:10.1038/ncomms8299 · Cited by 68 · see citing works

TRIM66 overexpresssion contributes to osteosarcoma carcinogenesis and indicates poor survival outcome

Chen, Y., Guo, Y., Yang, H., Shi, G., Xu, G., Shi, J., Yin, N., & Chen, D. (2015) · Oncotarget · doi:10.18632/oncotarget.4291 · Cited by 68 · see citing works

A cosmid and cDNA fine physical map of a human chromosome 13q14 region frequently lost in B‐cell chronic lymphocytic leukemia and identification of a new putative tumor suppressor gene, Leu5

Kapanadze, B., Kashuba, V. I., Baranova, A. V., Rasool, O., Everdink, W. J. V., Liu, Y., Syomov, A. B., Corcoran, M., Poltaraus, A. B., Brodyansky, V. M., et al. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00357-3 · Cited by 65 · see citing works

TRIM28, a new molecular marker predicting metastasis and survival in early-stage non-small cell lung cancer

Liu, L., Zhao, E., Li, C., Huang, L., Xiao, L., Cheng, L., Huang, X., Song, Y., & Xu, D. (2012) · Cancer Epidemiology · doi:10.1016/j.canep.2012.08.005 · Cited by 59 · see citing works

Promyelocytic Leukemia Protein is Required for Gain of Function by Mutant p53

Haupt, S., Agostino, S. D., Mizrahi, I., Alsheich-Bartok, O., Voorhoeve, M., Damalas, A., Blandino, G., & Haupt, Y. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4010 · Cited by 59 · see citing works

New prognostic markers revealed by evaluation of genes correlated with clinical parameters in Wilms tumors

Wittmann, S., Wunder, C., Zirn, B., Furtwängler, R., Wegert, J., Graf, N., & Gessler, M. (2008) · Genes, Chromosomes and Cancer · doi:10.1002/gcc.20544 · Cited by 59 · see citing works

Overexpression of TRIM25 in Lung Cancer Regulates Tumor Cell Progression

Qin, Y., Cui, H., & Zhang, H. (2015) · Technology in Cancer Research & Treatment · doi:10.1177/1533034615595903 · Cited by 58 · see citing works

Identification of TRIML2, a Novel p53 Target, that Enhances p53 SUMOylation and Regulates the Transactivation of Proapoptotic Genes

Kung, C.-P., Khaku, S., Jennis, M., Zhou, Y., & Murphy, M. E. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0385 · Cited by 57 · see citing works

Ubiquitylation of p53 by the APC/C inhibitor Trim39

Zhang, L., Huang, N.-J., Chen, C., Tang, W., & Kornbluth, S. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212047110 · Cited by 51 · see citing works

TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma

Caratozzolo, M. F., Valletti, A., Gigante, M., Aiello, I., Mastropasqua, F., Marzano, F., Ditonno, P., Carrieri, G., Simonnet, H., D’Erchia, A. M., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2081 · Cited by 45 · see citing works

Presence of serum tripartite motif‐containing 21 antibodies in patients with esophageal squamous cell carcinoma

Kuboshima, M., Shimada, H., Liu, T., Nomura, F., Takiguchi, M., Hiwasa, T., & Ochiai, T. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00192.x · Cited by 40 · see citing works

Modulation of TRIM5α Activity in Human Cells by Alternatively Spliced TRIM5 Isoforms

Battivelli, E., Migraine, J., Lecossier, D., Matsuoka, S., Perez-Bercoff, D., Saragosti, S., Clavel, F., & Hance, A. J. (2011) · Journal of Virology · doi:10.1128/jvi.00648-11 · Cited by 40 · see citing works

Expression of estrogen-responsive finger protein (Efp) is associated with advanced disease in human epithelial ovarian cancer

Sakuma, M., Akahira, J., Suzuki, T., Inoue, S., Ito, K., Moriya, T., Sasano, H., Okamura, K., & Yaegashi, N. (2005) · Gynecologic Oncology · doi:10.1016/j.ygyno.2005.07.103 · Cited by 38 · see citing works

A Novel RING Finger-B Box-Coiled-Coil Protein, GERP

Vincent, S. R., Kwasnicka, D. A., & Fretier, P. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3984 · Cited by 34 · see citing works

MDM2 and Promyelocytic Leukemia Antagonize Each Other through Their Direct Interaction with p53

Zhu, H., Wu, L., & Maki, C. G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308302200 · Cited by 30 · see citing works

Ataxia-Telangiectasia Group D Complementing Gene (ATDC) Promotes Lung Cancer Cell Proliferation by Activating NF-κB Pathway

Tang, Z., Dong, Q., Cui, Q., Papavassiliou, P., Wang, E.-D., & Wang, E.-H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063676 · Cited by 25 · see citing works

Down-regulation of Tripartite-motif containing 22 expression in breast cancer is associated with a lack of p53-mediated induction

Sun, Y., Ho, G. H., Koong, H. N., Sivaramakrishnan, G., Ang, W. T., Koh, Q. M., & Lin, V. C. L. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.10.110 · Cited by 24 · see citing works

Dynamic movements of Ro52 cytoplasmic bodies along microtubules

Tanaka, M., Tanji, K., Niida, M., & Kamitani, T. (2009) · Histochemistry and Cell Biology · doi:10.1007/s00418-009-0669-y · Cited by 22 · see citing works

ATDC (Ataxia Telangiectasia Group D Complementing) Promotes Radioresistance through an Interaction with the RNF8 Ubiquitin Ligase

Yang, H., Palmbos, P. L., Wang, L., Kim, E. H., Ney, G. M., Liu, C., Prasad, J., Misek, D. E., Yu, X., Ljungman, M. E., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.665489 · Cited by 21 · see citing works

AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation

Li, Q., He, Y., Wei, L., Wu, X., Wu, D., Lin, S., Wang, Z., Ye, Z., & Lin, S.-C. (2010) · Oncogene · doi:10.1038/onc.2010.499 · Cited by 17 · see citing works

Census and evaluation of p53 target genes

Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971 · see citing works

TRIM Proteins and Their Roles in Antiviral Host Defenses

van Gent, M., Sparrer, K. M. J., & Gack, M. U. (2018) · Annual Review of Virology · doi:10.1146/annurev-virology-092917-043323 · Cited by 325 · see citing works

MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer

Tisato, V., Voltan, R., Gonelli, A., Secchiero, P., & Zauli, G. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0500-5 · Cited by 255 · see citing works

TRIM family contribute to tumorigenesis, cancer development, and drug resistance

Huang, N., Sun, X., Li, P., Liu, X., Zhang, X., Chen, Q., & Xin, H. (2022) · Experimental Hematology and Oncology · doi:10.1186/s40164-022-00322-w · Cited by 169 · see citing works

TRIM67 Activates p53 to Suppress Colorectal Cancer Initiation and Progression

Wang, S., Zhang, Y., Huang, J., Wong, C. C., Zhai, J., Li, C., Wei, G., Zhao, L., Wang, G., Wei, H., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3614 · Cited by 104 · see citing works

TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10

Tan, P., Ye, Y., He, L., Xie, J., Ji, J., Ma, G., Pan, H., Han, L., Han, W., & Zhou, Y. (2018) · PLoS Biology · doi:10.1371/journal.pbio.3000051 · Cited by 95 · see citing works

The implication of SUMO in intrinsic and innate immunity

Hannoun, Z., Maarifi, G., & Chelbi‐Alix, M. K. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.04.003 · Cited by 75 · see citing works

TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A

Fan, W., Wu, M., Qian, S., Zhou, Y., Chen, H., Li, X., & Qian, P. (2016) · Scientific Reports · doi:10.1038/srep33698 · Cited by 74 · see citing works

TRIM11, a direct target of miR-24-3p, promotes cell proliferation and inhibits apoptosis in colon cancer

Yin, Y., Zhong, J., Li, S., Li, J., Zhou, M., Chen, Y., Sang, Y., & Liu, L. (2016) · Oncotarget · doi:10.18632/oncotarget.13550 · Cited by 74 · see citing works

Elevated TRIM44 promotes intrahepatic cholangiocarcinoma progression by inducing cell EMT via MAPK signaling

Peng, R., Zhang, P., Zhang, C., Huang, X., Ding, Y., Deng, B., Bai, D., & Xu, Y. (2018) · Cancer Medicine · doi:10.1002/cam4.1313 · Cited by 61 · see citing works

TRIM proteins in lung cancer: Mechanisms, biomarkers and therapeutic targets

Zhan, W., & Zhang, S. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.118985 · Cited by 59 · see citing works

β2‐AR activation induces chemoresistance by modulating p53 acetylation through upregulating Sirt1 in cervical cancer cells

Chen, H., Zhang, W., Cheng, X., Guo, L., Xie, S., Yuan-fang Ma, A., Guo, N., & Shi, M. (2017) · Cancer Science · doi:10.1111/cas.13275 · Cited by 56 · see citing works

Tumor suppressor p53 cross-talks with TRIM family proteins

Liu, J., Zhang, C., Wang, X., Hu, W., & Feng, Z. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.07.003 · Cited by 55 · see citing works

Targeting Chemoresistant Tumors: Could TRIM Proteins-p53 Axis Be a Possible Answer?

Valletti, A., Marzano, F., Pesole, G., Sbisà, E., & Tullo, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071776 · Cited by 55 · see citing works

TRIM67 Suppresses TNFalpha-Triggered NF-kB Activation by Competitively Binding Beta-TrCP to IkBa

Fan, W., Liu, X., Zhang, J., Qin, L., Du, J., Li, X., Qian, S., Chen, H., & Qian, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.793147 · Cited by 50 · see citing works

MiR-204 enhances mitochondrial apoptosis in doxorubicin-treated prostate cancer cells by targeting SIRT1/p53 pathway

Yan, S., Ren, L., Xie, B., Liang, Z. C., & Chen, J. (2017) · Oncotarget · doi:10.18632/oncotarget.21960 · Cited by 41 · see citing works

Downregulation of TRIM58 expression is associated with a poor patient outcome and enhances colorectal cancer cell invasion

Liu, M., Zhang, X., Cai, J. Q., Li, Y., Luo, Q., Wu, H., Yang, Z., Wang, L., & Chen, D. (2018) · Oncology Reports · doi:10.3892/or.2018.6525 · Cited by 41 · see citing works

TRIM47 promotes malignant progression of renal cell carcinoma by degrading P53 through ubiquitination

Chen, J., Xu, D., Cao, J., Zuo, L., Han, Z., Tian, Y., Chu, C., Wang, Z., Pan, X., & Cui, X. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01831-0 · Cited by 41 · see citing works

Multifaceted Roles of TRIM Proteins in Colorectal Carcinoma

Eberhardt, W., Haeussler, K., Nasrullah, U., & Pfeilschifter, J. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207532 · Cited by 38 · see citing works

LncRNA MST1P2/miR‐133b axis affects the chemoresistance of bladder cancer to cisplatin‐based therapy via Sirt1/p53 signaling

Chen, J., Li, Y., Li, Z., & Cao, L. (2020) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22452 · Cited by 37 · see citing works

TRIM8: Making the Right Decision between the Oncogene and Tumour Suppressor Role

Caratozzolo, M. F., Marzano, F., Mastropasqua, F., Sbisà, E., & Tullo, A. (2017) · Genes · doi:10.3390/genes8120354 · Cited by 34 · see citing works

Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors

Wang, C., Zhang, L.-Y., Ke, L., Ding, W.-Y., Jiang, S.-Z., Li, D., Narita, Y., Hou, I., Liang, J., Li, S.-J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-20136-w · Cited by 31 · see citing works

TRIM E3 Ubiquitin Ligases in Rare Genetic Disorders

Meroni, G. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-38266-7_14 · Cited by 33 · see citing works

The role of TRIM25 in the occurrence and development of cancers and inflammatory diseases

Tesiye, M. R., Zaersabet, M., Salehiyeh, S., & Jafari, S. Z. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188954 · Cited by 30 · see citing works

TRIM Proteins in Colorectal Cancer: TRIM8 as a Promising Therapeutic Target in Chemo Resistance

Marzano, F., Caratozzolo, M. F., Pesole, G., Sbisà, E., & Tullo, A. (2021) · Biomedicines · doi:10.3390/biomedicines9030241 · Cited by 24 · see citing works

TRIM59 induces epithelial‑to‑mesenchymal transition and promotes migration and invasion by PI3K/AKT signaling pathway in medulloblastoma

Gao, R., Lv, G., Zhang, C., Wang, X., & Chen, L. (2018) · Oncology Letters · doi:10.3892/ol.2018.8432 · Cited by 22 · see citing works

TRIM50 Suppresses Pancreatic Cancer Progression and Reverses the Epithelial-Mesenchymal Transition via Facilitating the Ubiquitous Degradation of Snail1

Li, R., Zhu, L., Peng, Y., Zhang, X., Dai, C., & Liu, D. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.695740 · Cited by 21 · see citing works

Knockdown of tripartite motif-59 inhibits the malignant processes in human colorectal cancer cells

Wu, W., Chen, J., Wu, J., Lin, J., Yang, S., & Yu, H. (2017) · Oncology Reports · doi:10.3892/or.2017.5896 · Cited by 18 · see citing works

Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment

Fitzgerald, S. T., Espina, V. A., Liotta, L. A., Sheehan, K. M., O’Grady, A., Cummins, R., O’Kennedy, R. J., Kay, E. W., & Kijanka, G. S. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1465-z · Cited by 17 · see citing works

The Janus Face of p53-Targeting Ubiquitin Ligases

Hao, Q., Chen, Y., & Zhou, X. Y. (2020) · Cells · doi:10.3390/cells9071656 · Cited by 15 · see citing works

TRIM8: a double-edged sword in glioblastoma with the power to heal or hurt

Hosseinalizadeh, H., Mohamadzadeh, O., Kahrizi, M. S., Bahabadi, Z. R., Klionsky, D. J., & Mirzei, H. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00418-z · Cited by 11 · see citing works

TRIM59-mediated ferroptosis enhances neuroblastoma development and chemosensitivity through p53 ubiquitination and degradation

Liu, Y., Jiang, N., Chen, W.-C., Zhang, W., Shen, X., Jia, B., & Chen, G. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e26014 · Cited by 11 · see citing works

Tripartite motif-containing protein 26 promotes colorectal cancer growth by inactivating p53

Tan, Z., Ko, H. M., Naji, P., Zhu, R., Wang, J., Huang, S., Zhang, Y., Zeng, S. X., & Lu, H. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01463-1 · Cited by 11 · see citing works

Pan-cancer illumination of TRIM gene family reveals immunology regulation and potential therapeutic implications

Gao, Y., Pan, T., Xu, G., Li, S., Guo, J., Zhang, Y., Xu, Q., Pan, J., Ma, Y., Xu, J., et al. (2022) · Human Genomics · doi:10.1186/s40246-022-00441-9 · Cited by 8 · see citing works

Exploring the Mechanisms, Biomarkers, and Therapeutic Targets of TRIM Family in Gastrointestinal Cancer

Weng, C., Jin, R., Jin, X., Yang, Z., He, C., Zhang, Q., Xu, J., & Lv, B. (2024) · Drug Design Development and Therapy · doi:10.2147/dddt.s482340 · Cited by 7 · see citing works

TRIM47 Facilitates Osteosarcoma Progression via Destabilising FBP1 and Thus Activation of Wnt/β‐Catenin Pathway

Wang, H., Chen, X., Nie, F., Zhong, M., Fang, Z., Qiu, Z., Zhou, L., Le, Y., Wei, X., Liao, Y., et al. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70753 · Cited by 4 · see citing works

TRIM25 targets p300 for degradation

Elabd, S., Pauletto, E., Solozobova, V., Eickhoff, N., Padrão, N., Zwart, W. T., & Blattner, C. (2023) · Life Science Alliance · doi:10.26508/lsa.202301980 · Cited by 4 · see citing works

Comprehensive Analysis of the Prognostic Significance of the TRIM Family in the Context of TP53 Mutations in Cancers

Vu, T., Fowler, A., & McCarty, N. (2023) · Cancers · doi:10.3390/cancers15153792 · Cited by 4 · see citing works

Latest News from the “Guardian”: p53 Directly Activates Asymmetric Stem Cell Division Regulators

Carmena, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073171 · Cited by 1 · see citing works

Role of TP53 Gene Mutations in the Pathogenesis of Colorectal Carcinoma

Muazzam, A., Hamal, C., Reddy, L. S. D., Tabowei, G., Gaddipati, G. N., Mughal, M., Alzubaidee, M. J., Dwarampudi, R. S., Mathew, S., Bichenapally, S., et al. (2022) · Journal For International Medical Graduates · doi:10.56570/jimgs.v1i2.29

TRIM31 inhibits ferroptosis in LUAD through facilitating ubiquitination and degradation of P53

Dou, T., Liu, Y., Fang, X., Yang, L., Shu, L., Chen, T., Yang, T., Yin, Y., Wang, H., Feng, M., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-45280-z

TRIM37 (nanisme Mulibrey) : implication dans le cycle cellulaire et régulation post-transcriptionnelle par le miR-223 dans les chondrocytes

Brigant, B. (2019) · doi:10.70675/b6ab0eb3z8948z4bfbzb02ezda040728909e

Aberrant TRIM10β expression perturbs mitochondrial function and centrosome organization

Kim, H., Lee, S., & Park, B. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112939

Tumor suppressor p53 and TRIM family proteins

(2015) · Cancer Cell & Microenvironment · doi:10.14800/ccm.470 · Cited by 2 · see citing works

TRIM25 has a dual function in the p53/Mdm2 circuit

Zhang, P., Elabd, S., Hammer, S., Solozobova, V., Yan, H., Bartel, F., Inoue, S., Henrich, T., Wittbrodt, J., Loosli, F., et al. (2015) · Oncogene · doi:10.1038/onc.2015.21 · Cited by 79 · see citing works

Tumor suppressor p53 cross-talks with TRIM family proteins

Liu, J., Zhang, C., Wang, X., Hu, W., & Feng, Z. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.07.003 · Cited by 55 · see citing works

TRIM8 modulates p53 activity to dictate cell cycle arrest

Caratozzolo, M. F., Micale, L., Turturo, M. G., Cornacchia, S., Fusco, C., Marzano, F., Augello, B., D’Erchia, A. M., Guerrini, L., Pesole, G., et al. (2012) · Cell Cycle · doi:10.4161/cc.11.3.19008 · Cited by 73 · see citing works

Trim family and tumor

Yang, Q., & Xu, Z. (2015) · Guoji zhongliuxue zazhi · doi:10.3760/cma.j.issn.1673-422x.2015.06.011