Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer
Witt, A E, Lee, C-W, Lee, T I, Azzam, D J, Wang, B, Caslini, C, Petrocca, F, Grosso, J, Jones, M, Cohick, E B, Gropper, A B, Wahlestedt, C, Richardson, A L, Shiekhattar, R, Young, R A, Ince, T A·2017·Oncogene
Cited by (182)
Items 101–182 of 182
- Natural Products Extracted from Fungal Species as New Potential Anti-Cancer Drugs: A Structure-Based Drug Repurposing Approach Targeting HDAC7Annalisa Maruca, Roberta Rocca, Raffaella Catalano, Francesco Mesiti, Giosuè Costa, Delia Lanzillotta, Alessandro Salatino, Francesco Ortuso, Francesco Trapasso, Stefano Alcaro et al. · 2020 · Molecules
- Manganese Superoxide Dismutase Acetylation and Regulation of Protein Structure in Breast Cancer Biology and TherapyMeredith M. Ogle, Rolando Trevino, Joseph R. Schell, Mahboubeh Varmazyad, Nobuo Horikoshi, David R. Gius · 2022 · Antioxidants
- Dissimilar tumor cell populations in ascitic fluid of ovarian cancer patientsЕ. В. Кайгородова, N. V. Fedulova, М. О. Очиров, D. A. Dyakov, Sergey V. Molchanov, N. Yu. Chasovskikh · 2020 · Bulletin of Siberian Medicine
- The epigenetic regulation of cancer cell recovery from therapy exposure and its implications as a novel therapeutic strategy for preventing disease recurrenceChristiana O. Appiah, Manjulata Singh, Lauren May, Ishita Bakshi, Ashish Vaidyanathan, Paul Dent, Gordon D. Ginder, Steven Grant, Harry D. Bear, Joseph W. Landry · 2023 · Advances in cancer research
- Complexation of histone deacetylase inhibitor belinostat to Cu(II) prevents premature metabolic inactivation in vitro and demonstrates potent anti-cancer activity in vitro and ex vivo in colon cancerE. Finnegan, Wei Ding, Ziga Ude, Sara Terer, T. McGivern, Anna M. Blümel, G. Kirwan, Xinxin Shao, F. Genua, Xiao-Fei Yin et al. · 2023 · Cellular Oncology
- Suberoylanilide hydroxamic acid-induced specific epigenetic regulation controls Leptin-induced proliferation of breast cancer cell linesXiuyan Feng, Han Han, Dan Zou, Jiaming Zhou, Weiqiang Zhou · 2016 · Oncotarget
- Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer TumorsMafalda Laranjo, Maria João Carvalho, Beatriz Serambeque, André Alves, Carlos Miguel Marto, Isabel Silva, Artur Augusto Paiva, Maria Filomena Botelho · 2020 · Journal of Visualized Experiments
- Targeting Epigenetic Dependencies in Solid Tumors: Evolutionary Landscape Beyond Germ Layers OriginFrancesca Citron, Linda Fabris · 2020 · Cancers
- Predictive bioinformatics identifies novel regulators of proliferation in a cancer stem cell modelEvan Fields, Jonathan D. Wren, Constantin Georgescu, John R. Daum, Gary J. Gorbsky · 2017 · Stem Cell Research
- Characteristics of in vitro model systems for ovarian cancer studiesPatrycja Tudrej, Katarzyna Aleksandra Kujawa, Alexander Jorge Cortez, Katarzyna Marta Lisowska · 2019 · Oncology in Clinical Practice
- Targeting Stem Cells in Radiation OncologyRobert Paul Coppes, Anna Dubrovska · 2017 · Clinical Oncology
- ARID1A deficiency promotes malignant proliferation of hepatocellular carcinoma by activating HDAC7/ENO1 signaling pathwayShanshan Zhang, Gang Wu, Lan Shi, Pengsheng Ding, Gan Liu, Wenjiao Chang, Yuanyuan Dai, Xinghua Han, Xiaoling Ma · 2025 · Hepatology Communications
- Super-enhancer landscape rewiring in cancer: The epigenetic control at distal sitesEros Di Giorgio, Roberta Benetti, Emanuela Kerschbamer, Luigi Emilio Xodo, Claudio Brancolini · 2023 · International review of cytology
- Histone Deacetylase 7 Gene Overexpression Is Associated with Poor Prognosis of Triple-Negative Breast Cancer PatientsBojana Uzelac, Ana Krivokuća, Snežana V. Šušnjar, Zorka Milovanović, Gordana Šupić · 2021 · Genetic Testing and Molecular Biomarkers
- The role and application of transcriptional repressors in cancer treatmentMiso Park, Keon Wook Kang, Ji Won Kim · 2023 · Archives of Pharmacal Research
- Analysis of Chromatin Opening in Heterochromatic Non-Small Cell Lung Cancer Tumor-Initiating Cells in Relation to DNA-Damaging Antitumor TreatmentMina Eriksson, Petra Hååg, B. Brzozowska, Magdalena Lipka, Halina Lisowska, Rolf Lewensohn, Andrzej Wójcik, Kristina Viktorsson, Lovisa Lundholm · 2017 · International Journal of Radiation Oncology*Biology*Physics
- Pan-HDAC inhibitor LAQ824 inhibits the progression of pancreatic ductal adenocarcinoma and suppresses immune escape by promoting antigen presentationYuchen Jia, Jie Li, Wentong Mei, Haoyu Zhang, Zheng Wang, Xiaozhou Xie, Gao Chongchong, Xiaoqing Xu, Fei Li · 2025 · International Immunopharmacology
- Role of Histone Deacetylases in the Pathogenesis of Salivary Gland Tumors and Therapeutic Targeting OptionsMaria Manou, Dimitrios S. Kanakoglou, Theodoros Loupis, Dimitrios Miltiadis Vrachnos, Stamatios E Theocharis, Athanasios G. Papavassiliou, Christina Piperi · 2023 · International Journal of Molecular Sciences
- Design and evaluation of nanoscale materials with programmed responsivity towards epigenetic enzymesPriyanka Ray, Abbas Sedigh, Matthew I. Confeld, Lina Alhalhooly, Kweeni Iduoku, Gerardo M. Casañola‐Martín, Hai Pham‐The, Bakhtiyor Rasulev, Yongki Choi, Zhongyu Yang et al. · 2024 · Journal of Materials Chemistry B
- Inhibiting HDAC1 Enhances the Anti-Cancer Effects of Statins through Downregulation of GGTase-Iβ ExpressionRan Li, Yehua Gan · 2017 · International Journal of Molecular Sciences
- Nuclear to Cytoplasmic Transport Is a Druggable Dependency in HDAC7‐driven Small Cell Lung CancerTingting Qin, Jingya Wang, Jian Wang, Qingwu Du, Liuchun Wang, Hai‐Lin Liu, Wenting Liu, Xueyang Li, Yantao Jiang, Qi Xu et al. · 2025 · Advanced Science
- Mechanistic Underpinnings of Epigenetic Enzyme-Responsive NanoparticlesRaj Shankar Hazra, Debasmita Dutta, Md Rakib Hasan Khan, Sakurako Tani, Chowdhury S. Abdullah, Naznin Sultana Remex, Richa Aishwarya, Tamjid Islam, Zhongyu Yang, Sanku Mallik et al. · 2025 · ACS Applied Bio Materials
- Kinase library screening identifies IGF-1R as an oncogenic vulnerability in intrahepatic cholangiocarcinoma stem-like cellsChotirat Rattanasinchai, Panida Navasumrit, Chidchanok Chornkrathok, Mathuros Ruchirawat · 2024 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Inhibition of HDAC7 reprograms the histone H3.3 landscape to induce heterochromatin spreading and DNA replication defects in cancer cellsOla Hassan, Mattia D. Pizzagalli, Owen P. Leary, John P. Zepecki, Adrianne Corseri, Laura Jinxuan Wu, Shiven Sasipalli, Daniel Lee, Lindsey Hayward, Lily H. Tran et al. · 2025 · Journal of Biological Chemistry
- A risk score model based on TGF-β pathway-related genes predicts survival, tumor microenvironment and immunotherapy for liver hepatocellular carcinomaJingsheng Liao, Qi Liu, Jingtang Chen, Zhibin Lu, Huiting Mo, Jun Hua Jia · 2022 · Proteome Science
- Effect of histone deacetylase 8 gene deletion on breast cancer cellular mechanism in vitro and in vivo studyGolebagh Rahmani, Mohammad Raman Moloudi, Razieh Amini, Karim Rahimi, Fardin Fathi, Mohammad Abdi, Rezvan Najafi · 2022 · Life Sciences
- Gene network profiling in muscle-invasive bladder cancer: A systematic review and meta-analysisIlaha Isali, Phillip E. McClellan, Adam Christopher Calaway, Megan C. Prunty, Philip H. Abbosh, Kirtishri Mishra, Lee Evan Ponsky, Sarah Coseo Markt, Sarah P. Psutka, Laura Bukavina · 2022 · Urologic Oncology Seminars and Original Investigations
- HDAC7 promotes ovarian cancer malignancy via AKT / mTOR signalling pathwayQi Feng, Hao Sheng, Xiongxiu Liu, Zhong Yan, Kai Sheng, Yanping Li, Peng Zhang, Xiugui Sheng · 2024 · Journal of Cellular and Molecular Medicine
- FBXW7 induces apoptosis in glioblastoma cells by regulating HDAC7Xiaohu Nie, Weiqiang Jia, Xiaobin Li, Xuyan Pan, Rui Ming Yin, Ning Liu, Zhongzhou Su · 2021 · Cell Biology International
- Advances in Biomarkers and Endogenous Regulation of Breast Cancer Stem CellsWen‐Ming Chen, Lu Zhang, Suling Liu, Ceshi Chen · 2022 · Cells
- Modulatory effects of cancer stem cell-derived extracellular vesicles on the tumor immune microenvironmentXinyu Li, Cuilian Zhang, Wei Yue, Yuening Jiang · 2024 · Frontiers in Immunology
- A Regulative Epigenetic Circuit Supervised by HDAC7 Represses IGFBP6 and IGFBP7 Expression to Sustain Mammary StemnessEros Di Giorgio, Valentina Cutano, Martina Minisini, Vanessa Tolotto, Emiliano Dalla, Claudio Brancolini · 2021 · Epigenomics
- Strong Involvement of Classical Histone Deacetylases and Mechanistically Distinct Sirtuins in Bellicose CancersShabir Ahmad Ganai · 2020 · Springer eBooks
- Histone acetylation risk model predicts prognosis and guides therapy selection in glioblastoma: implications for chemotherapy and anti-CTLA-4 immunotherapyXingyi Jin, Zhigang Qin, Hang Zhao · 2024 · BMC Immunology
- DFT Study, Linear and Nonlinear Multiple Regression in the Prediction of HDAC7 Inhibitory Activities on a Series of Hydroxamic AcidsSoro Doh, Lynda Ekou, Bafétigué Ouattara, Mamadou Guy-Richard Koné, Tchirioua Ekou, Nahossé Ziao · 2019 · Computational Molecular Bioscience
- Harmine inhibits ovarian cancer migration and invasion and epithelial-mesenchymal transition (EMT) by inhibiting HDAC7 to restore RECK expressionYin Bao, Jun Zhu, Xiaoling Mao, Mingyue Zhang, Qiang Ao, Hong Zhu, Jun Gao · 2025 · Biochemical Pharmacology
- Molecular mechanisms for sustaining cancer stem cells characteristics and targeted therapeutic strategiesChen-xi Zhao, Shuyun Wang, Ke Li · 2026 · Acta Pharmacologica Sinica
- Role of Transcription Factor BEND3 and Its Potential Effect on Cancer ProgressionSarah Naiyer, Lalita Dwivedi, Nishant Singh, Swastik Phulera, Vijay Mohan, Mohammad Zahid Kamran · 2023 · Cancers
- Stem Cell Theory of Cancer: Clinical Implications of Epigenomic versus Genomic Biomarkers in Cancer CareShi‐Ming Tu, Jim Zhongning Chen, Sunny R. K. Singh, Ahmet Murat Aydın, Neriman Gökden, Neville N.C. Tam, Yuet‐Kin Leung, Timothy Langford, Shuk‐Mei Ho · 2023 · Cancers
- Cancer stem cell plasticity: mechanisms, immune microenvironment crosstalk, and therapeutic implicationsJingyu Tan, Tao Wen, J S Liu, Xiaoli Ru · 2026 · Journal of Hematology & Oncology
- Epigenetics of Breast CancerManuraj Pandey, Archana Lalwani, Rajendra G. Mehta · 2022 · BENTHAM SCIENCE PUBLISHERS eBooks
- Epigenetic factors of green tea consumption in cancer preventionLászló Gy. Szabó, Ferenc Budán, Dávid Szép, Zoltán Gyöngyi, Bence László Raposa, István Kiss · 2024 · Tea in Health and Disease Prevention
- Modeling anticancer pharmacophore based on inhibition of HDAC7Laboratoire de Thermodynamique et de Physico-Chimie du Milieu, Unité de Formation et de Recherche Sciences Fondamentales et Appliquées, Université Nangui Abrogoua, Abidjan, Côte d’Ivoire, Sopi Thomas Affi, Soro Doh, Souleymane Coulibaly, Bibata Konaté, Nahossé Ziao · 2021 · SDRP Journal of Computational Chemistry & Molecular Modelling
- The presence of stem cells in ovarian cancer: a reviewTricia Dewi Anggraeni, Jenivia Thiono, Intan Winta Pratiwi, Ariananda Hariadi, Tera Dria Kispa, Aria Kekalih, Brahmana Askandar Tjokroprawiro, Lisnawati, Ani Retno Prijanti, Mohamad Farid Aziz et al. · 2023 · Bali Medical Journal
- Research Progresses in Cancer Stem Cells of Three Common Fertility-Related Female MalignanciesXiping Zhang, Qi-hui Cheng, Hongjian Yang, Enqi Qiao · 2018 · Pathology & Oncology Research
- Breast cancer stem cells, epigenetics, and radiationPranela Rameshwar, Garima Sinha, Alejandra I. Ferrer, Yahaira Naaldijk, Caitlyn A. Moore, Qunfeng Wu, Henning Ulrich · 2018 · Journal of Radiation and Cancer Research
- HISTONE DEACETYLASES (HDACs) CLASS II GENES AS POTENTIAL DRUG TARGETS IN CANCERM Sabeena, Kaiser Jamil, A. V. N. Swamy · 2018 · Journal of Emerging Technologies and Innovative Research
- Updates of Role of Stem Cells in Cancer TherapyMaged Naser, Mohamed Mn, Lamia H. Shehata · 2022 · International Journal of Progressive Sciences and Technologies
- Engineering Approaches in Ovarian Cancer Cell CultureMarcin Iwanicki, Tonja Pavlovič, Panteha Behboodi · 2023 · Current cancer research
- Signaling mechanisms of chemoresistance in breast cancer stem cells for therapeuticsSurbhi Shivhare, Amitava Das · 2023 · Elsevier eBooks
- Silencing HDAC1 Expression Regulates Extracellular Regulated Protein Kinases/Mitogen-Activated Protein Kinase Signaling Activation and Enhances Chemosensitivity of Ovarian CarcinomaJia Ming Stella Xu, Yan Li, Haixu Wang, Chunlei Qi, Qian Guo, Guoqing Cai, Guyuan Qiao · 2024 · Journal of Biomedical Nanotechnology
- Construction of a Cancer Stem Cell related Histone Acetylation Regulatory Genes Prognostic Model for Hepatocellular Carcinoma via Bioinformatics Analysis: Implications for Tumor Chemotherapy and ImmunityQian Dai, Jie Zhu, Jing Yang, Chunyan Zhang, Wenjing Yang, Baishen Pan, Xin‐Rong Yang, Wei Guo, Beili Wang · 2024 · Current Stem Cell Research & Therapy
- Additional file 4 of HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathwayKai Xia Guo, Zhiqiang Ma, Yujiao Zhang, Lu Han, Changjian Shao, Yingtong Feng, Gao, Fei, Shouyin Di, Zhipei Zhang, Jiao Zhang et al. · 2022 · Figshare
- Involvement of epigenetic modifications in cancer stem cells and chemoresistancePrajakta Oak, Chitra Thakur · 2024 · Elsevier eBooks
- A study conducted in breast cancer cells found that (valproic acid) inhibits CIP2A/c-MYC/PI3K/Akt/mTOR signaling molecules and PD-L1Elahe Zeinali, Vahid Bagheri, Esmaeil Rostami, Atena Mansouri, Gholamreza Anani Sarab · 2025 · Human Gene
- Additional file 3 of A risk score model based on TGF-β pathway-related genes predicts survival, tumor microenvironment and immunotherapy for liver hepatocellular carcinomaLiao, Jingsheng, Liu, Qi, Chen, Jingtang, Lu, Zhibin, Huiting Mo, Jia, Jun · 2022 · Figshare
- Additional file 1 of Histone acetylation risk model predicts prognosis and guides therapy selection in glioblastoma: implications for chemotherapy and anti-CTLA-4 immunotherapyXingyi Jin, Qin, Zhigang, Hang Zhao · 2024 · Figshare
- Additional file 5 of The impact of selective HDAC inhibitors on the transcriptome of early mouse embryosRUIQI SHAO, Suzuki, Takayoshi, Mikita Suyama, Yu-ichi Tsukada · 2024 · Figshare
- Additional file 2 of A risk score model based on TGF-β pathway-related genes predicts survival, tumor microenvironment and immunotherapy for liver hepatocellular carcinomaLiao, Jingsheng, Liu, Qi, Chen, Jingtang, Lu, Zhibin, Huiting Mo, Jia, Jun · 2022 · Figshare
- Additional file 2 of The impact of selective HDAC inhibitors on the transcriptome of early mouse embryosRUIQI SHAO, Suzuki, Takayoshi, Mikita Suyama, Yu-ichi Tsukada · 2024 · Figshare
- Additional file 7 of The impact of selective HDAC inhibitors on the transcriptome of early mouse embryosRUIQI SHAO, Suzuki, Takayoshi, Mikita Suyama, Yu-ichi Tsukada · 2024 · Figshare
- Additional file 2 of HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathwayGuo, Kai, Zhiqiang Ma, Zhang, Yujiao, Han, Lu, Shao, Changjian, Feng, Yingtong, Gao, Fei, Di, Shouyin, Zhang, Zhipei, Zhang, Jiao et al. · 2022 · Figshare
- Additional file 1 of SOX4 maintains the stemness of cancer cells via transcriptionally enhancing HDAC1 revealed by comparative proteomics studyLiu, Jingshu, Qiu, Jiangfeng, Zhang, Zhiqi, Zhou, Lei, Li, Yunzhe, Ding, Dongyan, Zhang, Yang, Zou, Dongling, Dong Wang, Zhou, Qi et al. · 2021 · Figshare
- Additional file 8 of The impact of selective HDAC inhibitors on the transcriptome of early mouse embryosRUIQI SHAO, Suzuki, Takayoshi, Mikita Suyama, Yu-ichi Tsukada · 2024 · Figshare
- Additional file 1 of Morphologic and molecular correlates of EZH2 as a predictor of platinum resistance in high-grade ovarian serous carcinomaReid, Brett M., Vyas, Shraddha, Chen, Zhihua, Chen, Ann, Kanetsky, Peter A., Jennifer B. Permuth, Sellers, Thomas A., Ozlen Saglam · 2021 · Figshare
- Additional file 3 of Histone acetylation risk model predicts prognosis and guides therapy selection in glioblastoma: implications for chemotherapy and anti-CTLA-4 immunotherapyXingyi Jin, Qin, Zhigang, Zhao, Hang · 2024 · Figshare
- Additional file 12 of The impact of selective HDAC inhibitors on the transcriptome of early mouse embryosRUIQI SHAO, Suzuki, Takayoshi, Mikita Suyama, Yu-ichi Tsukada · 2024 · Figshare
- Additional file 6 of The impact of selective HDAC inhibitors on the transcriptome of early mouse embryosRUIQI SHAO, Suzuki, Takayoshi, Mikita Suyama, Yu-ichi Tsukada · 2024 · Figshare
- Additional file 1 of A risk score model based on TGF-β pathway-related genes predicts survival, tumor microenvironment and immunotherapy for liver hepatocellular carcinomaLiao, Jingsheng, Liu, Qi, Chen, Jingtang, Lu, Zhibin, Huiting Mo, Jia, Jun · 2022 · Figshare
- Additional file 2 of Histone acetylation risk model predicts prognosis and guides therapy selection in glioblastoma: implications for chemotherapy and anti-CTLA-4 immunotherapyXingyi Jin, Qin, Zhigang, Hang Zhao · 2024 · Figshare
- Additional file 9 of The impact of selective HDAC inhibitors on the transcriptome of early mouse embryosRUIQI SHAO, Suzuki, Takayoshi, Mikita Suyama, Yu-ichi Tsukada · 2024 · Figshare
- Additional file 10 of The impact of selective HDAC inhibitors on the transcriptome of early mouse embryosRUIQI SHAO, Suzuki, Takayoshi, Mikita Suyama, Yu-ichi Tsukada · 2024 · Figshare
- Additional file 1 of HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathwayGuo, Kai, Zhiqiang Ma, Zhang, Yujiao, Han, Lu, Shao, Changjian, Feng, Yingtong, Gao, Fei, Di, Shouyin, Zhang, Zhipei, Zhang, Jiao et al. · 2022 · Figshare
- Additional file 1 of The impact of selective HDAC inhibitors on the transcriptome of early mouse embryosRUIQI SHAO, Suzuki, Takayoshi, Mikita Suyama, Yu-ichi Tsukada · 2024 · Figshare
- Additional file 13 of The impact of selective HDAC inhibitors on the transcriptome of early mouse embryosRUIQI SHAO, Suzuki, Takayoshi, Mikita Suyama, Yu-ichi Tsukada · 2024 · Figshare
- Additional file 3 of HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathwayGuo, Kai, Ma, Zhiqiang, Zhang, Yujiao, Han, Lu, Shao, Changjian, Feng, Yingtong, Gao, Fei, Di, Shouyin, Zhang, Zhipei, Zhang, Jiao et al. · 2022 · Figshare
- Additional file 4 of The impact of selective HDAC inhibitors on the transcriptome of early mouse embryosRUIQI SHAO, Suzuki, Takayoshi, Mikita Suyama, Yu-ichi Tsukada · 2024 · Figshare
- Additional file 11 of The impact of selective HDAC inhibitors on the transcriptome of early mouse embryosRUIQI SHAO, Suzuki, Takayoshi, Mikita Suyama, Yu-ichi Tsukada · 2024 · Figshare
- Additional file 3 of The impact of selective HDAC inhibitors on the transcriptome of early mouse embryosRUIQI SHAO, Suzuki, Takayoshi, Mikita Suyama, Yu-ichi Tsukada · 2024 · Figshare
- Acetylation in ovarian cancer: mechanistic insights into drug resistance and emerging therapeutic opportunitiesShujie Chen, Qinhong He, Yunxiao He, Jingji Jin, Aiping Wen · 2026 · Journal of Ovarian Research
- HDAC1 promotes lung adenocarcinoma progression via the nuclear accumulation of β‑cateninShijie Xu, Xiaolu Chang, Xiayu Wu, Fabao WANG, Jing Xiang, Chaoxiang Lin, He Zhao, Junzhe Li, Xianhua Xu · 2026 · Oncology Reports
- BindingDB Entry 50013161: HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates.BindingDB · 2022 · UC San Diego