The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
NF-κB-HOTAIR axis links DNA damage response, chemoresistance and cellular senescence in ovarian cancer
Open accessAbstract
The transcription factor nuclear factor kappa B (NF-κB) and the long non-coding RNA (lncRNA) HOTAIR (HOX transcript antisense RNA) have diverse functional roles in cancer. In this study, we show that upregulation of HOTAIR induced platinum resistance in ovarian cancer, and increased HOTAIR levels were observed in recurrent platinum-resistant ovarian tumors vs primary ovarian tumors. To investigate the role of HOTAIR during DNA damage induced by platinum, we monitored double-strand breaks and show that HOTAIR expression results in sustained activation of DNA damage response (DDR) after platinum treatment. We demonstrate that ectopic expression of HOTAIR induces NF-κB activation during DDR and interleukin-6 and interleukin-6 expression, both key NF-κB target genes. We show that HOTAIR regulates activation of NF-κB by decreasing Iκ-Bα (NF-κB inhibitor) and establish that by inducing prolonged NF-κB activation and expression of NF-κB target genes during DNA damage, HOTAIR has a critical role in cellular senescence and platinum sensitivity. Our findings suggest that an NF-κB-HOTAIR axis drives a positive-feedback loop cascade during DDR and contributes to cellular senescence and chemotherapy resistance in ovarian and other cancers.
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Cites
Integrated genomic analyses of ovarian carcinoma
Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/hvp3-wg08 · Cited by 7,925
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
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The DNA Damage Response: Making It Safe to Play with Knives
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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
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Paradoxical roles of the immune system during cancer development
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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232
Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086 · cited 1×
“In addition, IL-6 secretion, an established marker for cell senescence [25, 27], was increased (P<0.”
BackgroundA Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response
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NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase
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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
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Cited by
MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Redox Control of Cell Senescence
Lettieri-Barbato, D., Aquilano, K., Punziano, C., Minopoli, G., & Faraonio, R. (2022) · Antioxidants · doi:10.3390/antiox11030480 · Cited by 51
Chang, C. Y.-Y., Tseng, C.-C., Lai, M.-T., Chiang, A.-J., Lo, L.-C., Chen, C.-M., Yen, M.-J., Sun, L., Yang, L., Hwang, T., et al. (2021) · PLOS ONE · doi:10.1371/journal.pone.0248168 · Cited by 20
“In ovarian cancer, emerging evidence confirms the involvement of HOTAIR in cancer progression and drug-resistance, possibly though promoting mesenchymal stem cell formation [21,22].”
Background
Metadata
- Authors
- Özeş, A. R., Miller, D. F., Özeş, O. N., Fang, F., Liu, Y., Matei, D., Huang, T., & Nephew, K. P.
- Venue
- Oncogene
- Published
- 2016-04-04
- Volume
- 35
- Issue
- 41
- Pages
- 5350-5361
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2339067031
- Cited by
- 265
- References
- 57
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Özeş, A. R., Miller, D. F., Özeş, O. N., Fang, F., Liu, Y., Matei, D., Huang, T., & Nephew, K. P. (2016). NF-κB-HOTAIR axis links DNA damage response, chemoresistance and cellular senescence in ovarian cancer. Oncogene. https://doi.org/10.1038/onc.2016.75
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