Cited by 51Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsMicroRNA in disease regulation

MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Redox Control of Cell Senescence

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Lettieri-Barbato, Daniele, Aquilano, Katia, Punziano, Carolina, Minopoli, Giuseppina, Faraonio, Raffaella·2022·Antioxidants

Abstract

Cell senescence is critical in diverse aspects of organism life. It is involved in tissue development and homeostasis, as well as in tumor suppression. Consequently, it is tightly integrated with basic physiological processes during life. On the other hand, senescence is gradually being considered as a major contributor of organismal aging and age-related diseases. Increased oxidative stress is one of the main risk factors for cellular damages, and thus a driver of senescence. In fact, there is an intimate link between cell senescence and response to different types of cellular stress. Oxidative stress occurs when the production of reactive oxygen species/reactive nitrogen species (ROS/RNS) is not adequately detoxified by the antioxidant defense systems. Non-coding RNAs are endogenous transcripts that govern gene regulatory networks, thus impacting both physiological and pathological events. Among these molecules, microRNAs, long non-coding RNAs, and more recently circular RNAs are considered crucial mediators of almost all cellular processes, including those implicated in oxidative stress responses. Here, we will describe recent data on the link between ROS/RNS-induced senescence and the current knowledge on the role of non-coding RNAs in the senescence program.

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Authors
Lettieri-Barbato, D., Aquilano, K., Punziano, C., Minopoli, G., & Faraonio, R.
Affiliations
  • Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
  • University of Rome Tor Vergata (IT)
  • University of Naples Federico II (IT)
Corresponding author
Faraonio, Raffaella
Venue
Antioxidants
Publisher
MDPI AG
Published
2022-02-28
Volume
11
Issue
3
Pages
480
ISSN
2076-3921 (ISSN-L)
OpenAlex
W4214683892
Cited by
51
References
292
Citations by year
2026: 7 · 2025: 12 · 2024: 9 · 2023: 18 · 2022: 5
FWCI
1.51
Type
journal article
Language
en
Open access
Locations
  • Antioxidants (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Ministry of Education, Universities and Research (DM 738, 08.08.2019)
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Keywords
cellular senescence, microRNA, long non-coding RNA, circular RNA, oxidative stress, reactive oxygen species, reactive nitrogen species, non-coding RNA regulation, aging, age-related diseases, antioxidant defense

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