MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Redox Control of Cell Senescence
Open accessAbstract
Cell senescence is critical in diverse aspects of organism life. It is involved in tissue development and homeostasis, as well as in tumor suppression. Consequently, it is tightly integrated with basic physiological processes during life. On the other hand, senescence is gradually being considered as a major contributor of organismal aging and age-related diseases. Increased oxidative stress is one of the main risk factors for cellular damages, and thus a driver of senescence. In fact, there is an intimate link between cell senescence and response to different types of cellular stress. Oxidative stress occurs when the production of reactive oxygen species/reactive nitrogen species (ROS/RNS) is not adequately detoxified by the antioxidant defense systems. Non-coding RNAs are endogenous transcripts that govern gene regulatory networks, thus impacting both physiological and pathological events. Among these molecules, microRNAs, long non-coding RNAs, and more recently circular RNAs are considered crucial mediators of almost all cellular processes, including those implicated in oxidative stress responses. Here, we will describe recent data on the link between ROS/RNS-induced senescence and the current knowledge on the role of non-coding RNAs in the senescence program.
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Oxidative stress is an important senescence-triggering stimulus.
“Because OS is an important senescence-triggering stimulus [13], the thorough investigation of existing antioxidants and the search for new ones are of major interest.”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [13]
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3 retracted
Xiao, Y., Yan, W., Lu, L., Wang, Y., Lu, W., Cao, Y. L., & Cai, W. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1026491 · Cited by 74 · see citing works
RetractedGuo, J., Xiao, F., Ren, W., Zhu, Y., Du, Q., Li, Q., & Li, X. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.685466 · Cited by 23 · see citing works
RetractedDu, S., Shao, J., Qi, Y., Liu, X., Liu, J., & Zhang, F. (2020) · Aging · doi:10.18632/aging.102800 · Cited by 15 · see citing works
RetractedMicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · see citing works
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691 · see citing works
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508 · see citing works
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
Sies, H., & Jones, D. P. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0230-3 · Cited by 5,335 · see citing works
Landscape of transcription in human cells
Djebali, S., Davis, C. A., Merkel, A., Dobin, A., Lassmann, T., Mortazavi, A., Tanzer, A., Lagarde, J., Lin, W., Schlesinger, F., et al. (2012) · Nature · doi:10.1038/nature11233 · Cited by 5,187 · see citing works
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,178 · cited 2× · see citing works
“Finally, most types of senescent cells possess peculiar areas of heterochromatin called senescence-associated heterochromatin foci (SAHF), responsible for E2F target genes silencing [49], in parallel with pRb/p16 INK4a activation [166].”
BackgroundThe biogenesis, biology and characterization of circular RNAs
Kristensen, L. S., Andersen, M. S., Stagsted, L. V. W., Ebbesen, K. K., Hansen, T. B., & Kjems, J. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0158-7 · Cited by 4,823 · see citing works
Mitochondria, Oxidants, and Aging
Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388 · see citing works
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
Ray, P. D., Huang, B.-W., & Tsuji, Y. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.008 · Cited by 4,373 · see citing works
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317 · see citing works
The multilayered complexity of ceRNA crosstalk and competition
Tay, Y., Rinn, J., & Pandolfi, P. P. (2014) · Nature · doi:10.1038/nature12986 · Cited by 3,910 · see citing works
Schreck, R., RIEBER, P., & Baeuerle, P. A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07761.x · Cited by 3,816 · see citing works
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 1× · see citing works
“In particular, the double-strand DNA breaks initiate a DNA damage response (DDR), which if it becomes persistent converges on two DDR effectors: p53/p21 [7,48–50,62] and/or pRb/p16 [18,49,50] (Figure 3A).”
BackgroundSies, H., Berndt, C., & Jones, D. P. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061516-045037 · Cited by 3,520 · see citing works
Cellular Senescence: Defining a Path Forward
Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.005 · Cited by 3,225 · cited 7× · see citing works
“Despite their inability to replicate, senescent cells acquire specific features, such as morphological changes, metabolic and transcriptional reprogramming, as well as chromatin reorganization [27,60,61].”
BackgroundInfluentialOxidative stress: a concept in redox biology and medicine
Sies, H. (2015) · Redox Biology · doi:10.1016/j.redox.2015.01.002 · Cited by 3,015 · see citing works
Causes and consequences of microRNA dysregulation in cancer
Croce, C. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2634 · Cited by 3,003 · see citing works
A DNA damage checkpoint response in telomere-initiated senescence
Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,855 · cited 1× · see citing works
“Cells sense short telomeres as unresolved DNA damage and develop a double-strand DNA break response that irreversibly arrests proliferation [41,42].”
BackgroundTet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
He, Y., Li, B.-Z., Li, Z., Liu, P., Wang, Y., Tang, Q., Ding, J., Jia, Y., Chen, Z., Li, L., et al. (2011) · Science · doi:10.1126/science.1210944 · Cited by 2,776 · see citing works
A microRNA component of the p53 tumour suppressor network
He, L., He, X., Lim, L. P., de Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., et al. (2007) · Nature · doi:10.1038/nature05939 · Cited by 2,692 · see citing works
Detecting and characterizing circular RNAs
Jeck, W. R., & Sharpless, N. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2890 · Cited by 2,685 · see citing works
The role of senescent cells in ageing
van Deursen, J. M. (2014) · Nature · doi:10.1038/nature13193 · Cited by 2,623 · see citing works
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473 · see citing works
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278 · cited 1× · see citing works
“In fact, cell senescence is rapidly elicited in response to different types of stressors, such as increased oxidative stress [25,26,43,44], mitochondrial dysfunctions [45,46], aberrant oncogene activation [47–49], ionizing/ultraviolet radiations [50,51], epigenetic and chromatin perturbations [52], chemotherapeutic dr…”
BackgroundA complex secretory program orchestrated by the inflammasome controls paracrine senescence
Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T.-W., Lasitschka, F., Andrulis, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2784 · Cited by 2,278 · see citing works
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
Di Micco, R., Krizhanovsky, V., Baker, D., & d’Adda di Fagagna, F. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00314-w · Cited by 2,277 · cited 3× · see citing works
“Histone acetylation/deacetylation processes could be shaped by ROS/RNS at various levels, directly or indirectly [42,155,160].”
BackgroundPersistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232 · see citing works
Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling
Wang, Y., Branicky, R. S., Noë, A., & Hekimi, S. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201708007 · Cited by 2,199 · see citing works
BRAFE600-associated senescence-like cell cycle arrest of human naevi
Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature · doi:10.1038/nature03890 · Cited by 2,160 · see citing works
Cellular mechanisms and physiological consequences of redox-dependent signalling
Holmström, K. M., & Finkel, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3801 · Cited by 2,093 · see citing works
The Biogenesis, Functions, and Challenges of Circular RNAs
Li, X., Yang, L. C., & Chen, L. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.06.034 · Cited by 2,043 · see citing works
The essence of senescence: Figure 1.
Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development · doi:10.1101/gad.1971610 · Cited by 2,038 · see citing works
Senescence of activated stellate cells limits liver fibrosis
Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.06.049 · Cited by 2,029 · see citing works
Senescence of Activated Stellate Cells Limits Liver Fibrosis
Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.09.015 · Cited by 2,027
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
Chen, Z., Trotman, L. C., Shaffer, D., Lin, H.-K., Dotan, Z. A., Niki, M., Koutcher, J. A., Scher, H. I., Ludwig, T., Gerald, W., et al. (2005) · Nature · doi:10.1038/nature03918 · Cited by 1,993 · see citing works
Role of ROS and RNS Sources in Physiological and Pathological Conditions
Meo, S. D., Reed, T. T., Venditti, P., & Víctor, V. M. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/1245049 · Cited by 1,638 · see citing works
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
Kumari, R., & Jat, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645593 · Cited by 1,622 · see citing works
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
Jones, R. G., Plas, D. R., Kubek, S., Buzzai, M., Mu, J., Xu, Y., Birnbaum, M. J., & Thompson, C. B. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.027 · Cited by 1,619 · see citing works
NAD+ metabolism and its roles in cellular processes during ageing
Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00313-x · Cited by 1,617 · see citing works
MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship
Pasquinelli, A. E. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3162 · Cited by 1,587 · see citing works
Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.037 · Cited by 1,482 · see citing works
Senescence in premalignant tumours
Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguría, A., Zaballos, A., Flores, J. M., Barbacid, M., et al. (2005) · Nature · doi:10.1038/436642a · Cited by 1,482 · see citing works
The mitochondrial basis of aging
Sun, N., Youle, R. J., & Finkel, T. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.028 · Cited by 1,441 · see citing works
Programmed cell senescence during mammalian embryonic development
Muñoz-Espín, D., Cañamero, M., Maraver, A., Gómez-López, G., Contreras, J., Murillo-Cuesta, S., Rodríguez-Baeza, A., Varela-Nieto, I., Ruberte, J., Collado, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.019 · Cited by 1,428 · see citing works
Mitochondrial electron transport chain, ROS generation and uncoupling (Review)
Zhao, R., Jiang, S., Zhang, L., & Yu, Z. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4188 · Cited by 1,415 · see citing works
Yap, K. L., Li, S., Muñoz-Cabello, A. M., Raguz, S., Zeng, L., Mujtaba, S., Gil, J., Walsh, M. J., & Zhou, M.-M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.021 · Cited by 1,391 · see citing works
From discoveries in ageing research to therapeutics for healthy ageing
Campisi, J., Kapahi, P., Lithgow, G. J., Melov, S., Newman, J. C., & Verdin, E. (2019) · Nature · doi:10.1038/s41586-019-1365-2 · Cited by 1,389 · see citing works
Cellular functions of long noncoding RNAs
Yao, R.-W., Wang, Y., & Chen, L. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0311-8 · Cited by 1,381 · see citing works
Small non-coding RNAs in animal development
Stefani, G., & Slack, F. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2347 · Cited by 1,361 · see citing works
Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery
Paulsen, C. E., & Carroll, K. S. (2013) · Chemical Reviews · doi:10.1021/cr300163e · Cited by 1,283 · see citing works
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype
Wiley, C. D., Velarde, M. C., Lecot, P., Liu, S., Sarnoski, E. A., Freund, A., Shirakawa, K., Lim, H. W., Davis, S. S., Ramanathan, A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.11.011 · Cited by 1,275 · cited 1× · see citing works
“In fact, cell senescence is rapidly elicited in response to different types of stressors, such as increased oxidative stress [25,26,43,44], mitochondrial dysfunctions [45,46], aberrant oncogene activation [47–49], ionizing/ultraviolet radiations [50,51], epigenetic and chromatin perturbations [52], chemotherapeutic dr…”
BackgroundThe miR-34 family in cancer and apoptosis
Hermeking, H. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.56 · Cited by 1,236 · see citing works
Oncogene-induced senescence as an initial barrier in lymphoma development
Braig, M., Lee, S., Loddenkemper, C., Rudolph, C., Peters, A. H. F. M., Schlegelberger, B., Stein, H., Dörken, B., Jenuwein, T., & Schmitt, C. A. (2005) · Nature · doi:10.1038/nature03841 · Cited by 1,220 · see citing works
Mouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.016 · Cited by 1,210 · see citing works
Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR
Lytle, J., Yario, T. A., & STEITZ, J. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703820104 · Cited by 1,196 · see citing works
Senescence is a developmental mechanism that contributes to embryonic growth and patterning
Storer, M., Mas, A., Robert-Moreno, A., Pecoraro, M., Ortells, M. C., Di Giacomo, V., Yosef, R., Pilpel, N., Krizhanovsky, V., Sharpe, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.041 · Cited by 1,186 · see citing works
Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases
Nandi, A., Yan, L.-J., Jana, C. K., & Das, N. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9613090 · Cited by 1,185 · see citing works
Senescence and the SASP: many therapeutic avenues
Birch, J., & Gil, J. (2020) · Genes & Development · doi:10.1101/gad.343129.120 · Cited by 1,177 · cited 2× · see citing works
“Other transcription factors, such as CCAAT/enhancer-binding protein-β (C/EBPβ) and GATA4, as well as p38 MAP kinase and mammalian target of rapamycin (mTOR) signaling can intervene to produce selective secretome/s [20].”
BackgroundSenescence in tumours: evidence from mice and humans
Collado, M., & Serrano, M. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2772 · Cited by 1,124 · cited 2× · see citing works
“mor suppressor mechanism [48], a crucial contributor to embryonic morphogenesis [2,3]”
BackgroundMicroRNAs in Development and Disease
Sayed, D. H., & Abdellatif, M. (2011) · Physiological Reviews · doi:10.1152/physrev.00006.2010 · Cited by 1,074 · see citing works
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases
Davalli, P., Mitic, T., Caporali, A., Lauriola, A., & D’Arca, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3565127 · Cited by 1,059 · see citing works
Chien, Y., Scuoppo, C., Wang, X., Fang, X., Balgley, B., Bolden, J. E., Premsrirut, P., Luo, W., Chicas, A., Lee, C. S., et al. (2011) · Genes & Development · doi:10.1101/gad.17276711 · Cited by 1,046 · see citing works
Freund, A., Patil, C. K., & Campisi, J. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.69 · Cited by 1,039 · see citing works
Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
Yosef, R., Pilpel, N., Tokarsky-Amiel, R., Biran, A., Ovadya, Y., Cohen, S., Vadai, E., Dassa, L., Shahar, E., Condiotti, R., et al. (2016) · Nature Communications · doi:10.1038/ncomms11190 · Cited by 1,032 · see citing works
Feedback between p21 and reactive oxygen production is necessary for cell senescence
Passos, J. F., Nelson, G., Wang, C., Richter, T., Simillion, C., Proctor, C. J., Miwa, S., Olijslagers, S., Hallinan, J., Wipat, A., et al. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.5 · Cited by 1,019 · cited 6× · see citing works
“Excessive ROS/RNS derived from mitochondria were initially considered as a principal cause of cell senescence [28,92].”
BackgroundInfluentialJun, J.-I., & Lau, L. F. (2010) · Nature Cell Biology · doi:10.1038/ncb2070 · Cited by 998 · see citing works
Glutathione: new roles in redox signaling for an old antioxidant
Aquilano, K., Baldelli, S., & Ciriolo, M. R. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00196 · Cited by 869 · see citing works
Self-citationHuman SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence
Langley, E., Pearson, M., Faretta, M., Bauer, U., Frye, R. A., Minucci, S., Pelicci, P. G., & Kouzarides, T. (2002) · The EMBO Journal · doi:10.1093/emboj/21.10.2383 · Cited by 859 · see citing works
Cellular senescence and its effector programs
Salama, R., Sadaie, M., Hoare, M., & Narita, M. (2014) · Genes & Development · doi:10.1101/gad.235184.113 · Cited by 855 · see citing works
Bracken, A. P., Kleine-Kohlbrecher, D., Dietrich, N., Pasini, D., Gargiulo, G., Beekman, C., Theilgaard-Mönch, K., Minucci, S., Porse, B. T., Marine, J.-C., et al. (2007) · Genes & Development · doi:10.1101/gad.415507 · Cited by 850 · see citing works
Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T., & Hayes, J. D. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.021 · Cited by 837 · see citing works
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression
Neumann, C. A., Krause, D. S., Carman, C. V., Das, S., Dubey, D. P., Abraham, J. L., Bronson, R. T., Fujiwara, Y., Orkin, S. H., & Van Etten, R. A. (2003) · Nature · doi:10.1038/nature01819 · Cited by 801 · see citing works
Stem cell aging: mechanisms, regulators and therapeutic opportunities
Oh, J., Lee, Y. D., & Wagers, A. J. (2014) · Nature Medicine · doi:10.1038/nm.3651 · Cited by 796 · see citing works
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
Passos, J. F., Saretzki, G., Ahmed, S., Nelson, G., Richter, T., Peters, H., Wappler, I., Birket, M. J., Harold, G., Schaeuble, K., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050110 · Cited by 796 · cited 1× · see citing works
“In fact, cell senescence is rapidly elicited in response to different types of stressors, such as increased oxidative stress [25,26,43,44], mitochondrial dysfunctions [45,46], aberrant oncogene activation [47–49], ionizing/ultraviolet radiations [50,51], epigenetic and chromatin perturbations [52], chemotherapeutic dr…”
BackgroundMitochondria are required for pro-ageing features of the senescent phenotype
Correia‐Melo, C., Marques, F. D., Anderson, R., Hewitt, G., Hewitt, R., Cole, J., Carroll, B. M., Miwa, S., Birch, J., Merz, A., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201592862 · Cited by 796 · see citing works
Nogueira, V., Park, Y., Chen, C.-C., Xu, P.-Z., Chen, M.-L., Tonic, I., Unterman, T., & Hay, N. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.11.003 · Cited by 780 · see citing works
A senescent cell bystander effect: senescence‐induced senescence
Nelson, G., Wordsworth, J., Wang, C., Jurk, D., Lawless, C., Martin‐Ruiz, C., & von Zglinicki, T. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00795.x · Cited by 755 · see citing works
Du, W. W., Yang, W., Chen, Y., Wu, Z., Foster, F. S., Yang, Z., Li, X., & Yang, B. B. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw001 · Cited by 731 · see citing works
Kong, X., Wang, R., Xue, Y., Liu, X., Zhang, H., Chen, Y., Fang, F., & Chang, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011707 · Cited by 718 · see citing works
Non-Coding RNAs and their Integrated Networks
Zhang, P., Wu, W., Chen, Q., & Chen, M. (2019) · Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics · doi:10.1515/jib-2019-0027 · Cited by 691 · see citing works
MicroRNA-125b is a novel negative regulator of p53Preprint
Le, M. T. N., Teh, C., Shyh‐Chang, N., Xie, H., Zhou, B., Korzh, V. P., Lodish, H. F., & Lim, B. (2009) · Genes & Development · doi:10.1101/gad.1767609 · Cited by 655 · see citing works
Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.
Chen, Q., & Ames, B. N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4130 · Cited by 641 · see citing works
Senescent cells as a source of inflammatory factors for tumor progression
Davalos, A. R., Coppe, J.-P., Campisi, J., & Desprez, P.-Y. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9220-9 · Cited by 636 · see citing works
Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach
Cuadrado, A., Manda, G., Hassan, A., Alcaraz, M. J., Barbas, C., Daiber, A., Ghezzi, P., León, R., López, M. G., Oliva, B., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014753 · Cited by 632 · see citing works
The senescence-associated secretory phenotype and its regulation
Lopes-Paciencia, S., Saint-Germain, E., Rowell, M.-C., Ruiz, A. F., Kalegari, P., & Ferbeyre, G. (2019) · Cytokine · doi:10.1016/j.cyto.2019.01.013 · Cited by 601 · see citing works
Tissue damage and senescence provide critical signals for cellular reprogramming in vivo
Mosteiro, L., Pantoja, C., Alcazar, N., Marión, R. M., Chondronasiou, D., Rovira, M., Fernandez-Marcos, P. J., Muñoz-Martin, M., Blanco-Aparicio, C., Pastor, J., et al. (2016) · Science · doi:10.1126/science.aaf4445 · Cited by 589 · see citing works
Accumulation of senescent cells in Mitotic tissue of aging primates
Jeyapalan, J. C., Ferreira, M., Sedivy, J. M., & Herbig, U. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.008 · Cited by 571 · see citing works
Shah, P. P., Donahue, G., Otte, G. L., Capell, B. C., Nelson, D. M., Cao, K., Aggarwala, V., Cruickshanks, H. A., Rai, T. S., McBryan, T., et al. (2013) · Genes & Development · doi:10.1101/gad.223834.113 · Cited by 550 · see citing works
Sun, Y., Zheng, Y., Wang, C., & Liu, Y. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0794-4 · Cited by 550 · see citing works
Bhaumik, D., Scott, G. K., Schokrpur, S., Patil, C. K., Orjalo, A. V., Rodier, F., Lithgow, G. J., & Campisi, J. (2009) · Aging · doi:10.18632/aging.100042 · Cited by 500 · see citing works
Bmi1, stem cells, and senescence regulation
Park, I.-K., Morrison, S. J., & Clarke, M. F. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420800 · Cited by 495 · see citing works
MicroRNA 217 Modulates Endothelial Cell Senescence via Silent Information Regulator 1
Menghini, R., Casagrande, V., Cardellini, M., Martelli, E., Terrinoni, A., Amati, F., Vasa‐Nicotera, M., Ippoliti, A., Novelli, G., Melino, G., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.864629 · Cited by 479 · see citing works
Bmi1 regulates mitochondrial function and the DNA damage response pathway
Liu, J., Cao, L., Chen, J., Song, S., Lee, I. H., Quijano, C., Liu, H., Keyvanfar, K., Chen, H., Cao, L.-Y., et al. (2009) · Nature · doi:10.1038/nature08040 · Cited by 474 · see citing works
NF-κB inhibition delays DNA damage–induced senescence and aging in mice
Tilstra, J. S., Robinson, A. R., Wang, J., Gregg, S. Q., Clauson, C. L., Reay, D. P., Nasto, L. A., St Croix, C. M., Usas, A., Vo, N., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci45785 · Cited by 462 · see citing works
Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination
Yoon, J., Abdelmohsen, K., Kim, J., Yang, X., Martindale, J. L., Tominaga, K., White, E. J., Orjalo, A. V., Rinn, J. L., Kreft, S. G., et al. (2013) · Nature Communications · doi:10.1038/ncomms3939 · Cited by 460 · see citing works
Magenta, A., Cencioni, C., Fasanaro, P., Zaccagnini, G., Greco, S., Sarra-Ferraris, G., Antonini, A., Martelli, F., & Capogrossi, M. C. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.42 · Cited by 456 · see citing works
Masaldan, S., Clatworthy, S. A. S., Gamell, C., Meggyesy, P. M., Rigopoulos, A.-T., Haupt, S., Haupt, Y., Denoyer, D., Adlard, P. A., Bush, A. I., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2017.08.015 · Cited by 452 · see citing works
Dimitrova, N., Zamudio, J. R., Jong, R. M., Soukup, D., Resnick, R., Sarma, K., Ward, A. J., Raj, A., Lee, J. T., Sharp, P. A., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.04.025 · Cited by 445 · see citing works
Chen, Q. M., Bartholomew, J. C., Campisi, J., Acosta, M., REAGAN, J. D., & Ames, B. N. (1998) · Biochemical Journal · doi:10.1042/bj3320043 · Cited by 442 · see citing works
Sirtuin signaling in cellular senescence and aging
Lee, S.-H., Lee, J.-H., Lee, H., & Min, K. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.1.290 · Cited by 438 · see citing works
Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks
Hirotsu, Y., Katsuoka, F., Funayama, R., Nagashima, T., Nishida, Y., Nakayama, K., Engel, J. D., & Yamamoto, M. P. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks827 · Cited by 431 · see citing works
Leung, A., Calabrese, J. M., & Sharp, P. (2006) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0608845103 · Cited by 428 · see citing works
Chen, Z., Li, Y., Zhang, H., Huang, P., & Luthra, R. (2010) · Oncogene · doi:10.1038/onc.2010.193 · Cited by 426 · see citing works
Puisségur, M.-P., Mazure, N. M., Bertero, T., Pradelli, L. A., Grosso, S., Robbe-Sermesant, K., Maurin, T., Lebrigand, K., Cardinaud, B., Hofman, V., et al. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.119 · Cited by 422 · see citing works
MicroRNA‐146 represses endothelial activation by inhibiting pro‐inflammatory pathways
Cheng, H. S., Sivachandran, N., Lau, A. C., Boudreau, É., Zhao, J. L., Baltimore, D., Delgado-Olguı́n, P., Cybulsky, M. I., & Fish, J. E. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202318 · Cited by 418 · see citing works
Takasugi, M., Okada, R., Takahashi, A., Virya Chen, D., Watanabe, S., & Hara, E. (2017) · Nature Communications · doi:10.1038/ncomms15728 · Cited by 410 · see citing works
Zhu, X., Chen, Z., Shen, W., Huang, G., Sedivy, J. M., Wang, H., & Ju, Z. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00646-9 · Cited by 410 · see citing works
Disruption of methylarginine metabolism impairs vascular homeostasis
LEIPER, J. M., Nandi, M., Torondel, B., Murray‐Rust, J., Malaki, M., O'Hara, B. P., Rossiter, S., Anthony, S., Madhani, M., Selwood, D. L., et al. (2007) · Nature Medicine · doi:10.1038/nm1543 · Cited by 403 · see citing works
Recurrent turnover of senescent cells during regeneration of a complex structure
Yun, M. H., Davaapil, H., & Brockes, J. P. (2015) · eLife · doi:10.7554/elife.05505 · Cited by 385 · see citing works
The role of DNA methylation in epigenetics of aging
Unnikrishnan, A., Freeman, W. M., Jackson, J. A., Wren, J. D., Porter, H. L., & Richardson, A. G. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.11.001 · Cited by 381 · see citing works
Höhn, A., Weber, D., Jung, T., Ott, C., Hugo, M., Kochlik, B., Kehm, R., König, J., Grune, T., & Castro, J. P. (2016) · Redox Biology · doi:10.1016/j.redox.2016.12.001 · Cited by 368 · see citing works
The roles of senescence and telomere shortening in cardiovascular disease
Fyhrquist, F., Saijonmaa, O. J., & Strandberg, T. E. (2013) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2013.30 · Cited by 368 · see citing works
Redox control of senescence and age-related disease.
Chandrasekaran, A., Idelchik, M. D. P. S., & Melendez, J. A. (2017) · Redox Biology · doi:10.1016/j.redox.2016.11.005 · Cited by 360 · see citing works
Vizioli, M. G., Liu, T., Miller, K. N., Robertson, N. A., Gilroy, K., Lagnado, A. B., Perez-Garcia, A., Kiourtis, C., Dasgupta, N., Lei, X., et al. (2020) · Genes & Development · doi:10.1101/gad.331272.119 · Cited by 359 · see citing works
Sangokoya, C., Telen, M. J., & Chi, J. (2010) · Blood · doi:10.1182/blood-2009-04-214817 · Cited by 357 · see citing works
miR‐17, miR‐19b, miR‐20a, and miR‐106a are down‐regulated in human aging
Hackl, M., Brunner, S. M., Fortschegger, K., Schreiner, C., Mičutková, L., Mück, C., Laschober, G. T., Lepperdinger, G., Sampson, N., Berger, P., et al. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00549.x · Cited by 356 · see citing works
Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging
Ziegler, D. V., Wiley, C. D., & Velarde, M. C. (2014) · Aging Cell · doi:10.1111/acel.12287 · Cited by 353 · see citing works
p53 Suppresses the Nrf2-dependent Transcription of Antioxidant Response Genes
Faraonio, R., Vergara, P., Marzo, D. D., Pierantoni, G. M., Napolitano, M., Russo, T., & Cimino, F. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605707200 · Cited by 350 · see citing works
Self-citationMicroRNA-34a regulation of endothelial senescence
Ito, T., Yagi, S., & Yamakuchi, M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.07.012 · Cited by 336 · see citing works
Oxidative eustress: On constant alert for redox homeostasis
Sies, H. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101867 · Cited by 333 · see citing works
Miyauchi, H., Minamino, T., Tateno, K., Kunieda, T., Toko, H., & Komuro, I. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600045 · Cited by 332 · see citing works
Forkhead Homeobox Type O Transcription Factors in the Responses to Oxidative Stress
Störz, P. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3405 · Cited by 331 · see citing works
Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation
Ogrunc, M., Di Micco, R., Liontos, M., Bombardelli, L., Mione, M., Fumagalli, M., Gorgoulis, V. G., & d'Adda di Fagagna, F. (2014) · Cell Death & Differentiation · doi:10.1038/cdd.2014.16 · Cited by 328 · see citing works
Mitochondrial dysfunction and cell senescence: deciphering a complex relationship
Chapman, J., Fielder, E., & Passos, J. F. (2019) · FEBS Letters · doi:10.1002/1873-3468.13498 · Cited by 325 · see citing works
Biochemical basis and metabolic interplay of redox regulation
Zhang, L., Wang, X., Cueto, R., Effi, C., Zhang, Y., Tan, H., Qin, X., Ji, Y., Yang, X., & Wang, H. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101284 · Cited by 308 · see citing works
A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing
Florian, M. C., Nattamai, K. J., Dörr, K., Marka, G., Überle, B., Vas, V., Eckl, C., Andrä, I., Schiemann, M., Oostendorp, R. A. J., et al. (2013) · Nature · doi:10.1038/nature12631 · Cited by 303 · see citing works
Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · see citing works
MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment
Quiat, D., & Olson, E. N. (2013) · Journal of Clinical Investigation · doi:10.1172/jci62876 · Cited by 302 · see citing works
Molecular Mechanisms behind Free Radical Scavengers Function against Oxidative Stress
Ahmadinejad, F., Møller, S. G., Chaleshtori, M. H., Bidkhori, G., & Jami, M. (2017) · Antioxidants · doi:10.3390/antiox6030051 · Cited by 299 · see citing works
An Update on Mitochondrial Reactive Oxygen Species Production
Mailloux, R. J. (2020) · Antioxidants · doi:10.3390/antiox9060472 · Cited by 286 · see citing works
Cellular Senescence in Neurodegenerative Diseases
Martínez‐Cué, C., & Rueda, N. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00016 · Cited by 285 · see citing works
Kosar, M., Bartkova, J., Hubackova, S., Hodny, Z., Lukas, J., & Bartek, J. (2011) · Cell Cycle · doi:10.4161/cc.10.3.14707 · Cited by 283 · see citing works
Fumarate induces redox-dependent senescence by modifying glutathione metabolism
Zheng, L., Cardaci, S., Jerby, L., MacKenzie, E. D., Sciacovelli, M., Johnson, T. I., Gaude, E., King, A., Leach, J. D. G., Edrada-Ebel, R., et al. (2015) · Nature Communications · doi:10.1038/ncomms7001 · Cited by 281 · see citing works
Liu, J., Ding, Y., Liu, Z., & Liang, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00258 · Cited by 272 · see citing works
Debacq‐Chainiaux, F., Borlon, C., Pascal, T. G., Royer, V., Eliaers, F., Ninane, N., Carrard, G., Friguet, B., de Longueville, F., Boffe, S., et al. (2005) · Journal of Cell Science · doi:10.1242/jcs.01651 · Cited by 267 · see citing works
Özeş, A., Miller, D. F., Özeş, O. N., Fang, F., Liu, Y., Matei, D. E., Huang, T. H. ‐., & Nephew, K. P. (2016) · Oncogene · doi:10.1038/onc.2016.75 · Cited by 266 · see citing works
Amodio, N., Stamato, M. A., Juli, G., Morelli, E., Fulciniti, M., Manzoni, M., Taìana, E., Agnelli, L., Cantafio, M. E. G., Romeo, E., et al. (2018) · Leukemia · doi:10.1038/s41375-018-0067-3 · Cited by 263 · see citing works
RNA silencing and genome regulation
Almeida, R., & Allshire, R. C. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.03.006 · Cited by 260 · see citing works
Long Noncoding RNA, Polycomb, and the Ghosts Haunting INK4b-ARF-INK4a Expression
Aguiló, F., Zhou, M., & Walsh, M. J. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4379 · Cited by 255 · see citing works
Panda, A. C., Grammatikakis, I., Kim, K. M., De, S., Martindale, J. L., Munk, R. B., Yang, X., Abdelmohsen, K., & Gorospe, M. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1201 · Cited by 254 · see citing works
Physiological and pathological consequences of cellular senescence
Burton, D. G. A., & Krizhanovsky, V. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1691-3 · Cited by 253 · see citing works
The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system
Kietzmann, T., Petry, A., Shvetsova, A., Gerhold, J. M., & Görlach, A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13792 · Cited by 253 · see citing works
Aging and chronic DNA damage response activate a regulatory pathway involving miR‐29 and p53
Ugalde, A. P., Ramsay, A. J., Rosa, J. D. L., Varela, I., Mariño, G., Cadiñanos, J., Lü, J., Freije, J. M. P., & López-Otı́n, C. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.124 · Cited by 252 · see citing works
Choi, S., Fu, T., Seok, S., Kim, D., Yu, E., Lee, K. W., KANG, Y. Y., Li, X., KEMPER, B. W., & Kemper, J. K. (2013) · Aging Cell · doi:10.1111/acel.12135 · Cited by 245 · see citing works
Small molecule compounds that induce cellular senescence.
Petrova, N. V., Velichko, A. K., Razin, S. V., & Kantidze, O. L. (2016) · Aging Cell · doi:10.1111/acel.12518 · Cited by 240 · see citing works
Adaptive homeostasis and the free radical theory of ageing
Pomatto, L. C. D., & Davies, K. J. A. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.06.016 · Cited by 224 · see citing works
Alterations in microRNA expression in stress-induced cellular senescence
Li, G., Luna, C., Qiu, J., Epstein, D. L., & González, P. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.09.002 · Cited by 220 · see citing works
Origin and evolution of the free radical theory of aging: a brief personal history, 1954–2009
Harman, D. (2009) · Biogerontology · doi:10.1007/s10522-009-9234-2 · Cited by 219 · see citing works
miR-335 and miR-34a Promote Renal Senescence by Suppressing Mitochondrial Antioxidative Enzymes
Bai, X., Ma, Y., Ding, R., Fu, B., Shi, S., & Chen, X. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010040367 · Cited by 213 · see citing works
Li, N., Muthusamy, S., Liang, R., Sarojini, H., & Wang, E. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.12.004 · Cited by 211 · see citing works
Senescence-associated lncRNAs: senescence-associated long noncoding RNAs
Abdelmohsen, K., Panda, A. C., Kang, M. J., Xu, J. Z., Selimyan, R., Yoon, J., Martindale, J. L., De, S., Wood, W. H., Becker, K. G., et al. (2013) · Aging Cell · doi:10.1111/acel.12115 · Cited by 208 · see citing works
Rizza, S., Cardaci, S., Montagna, C., Giacomo, G. D., Zio, D. D., Bordi, M., Maiani, E., Campello, S., Borreca, A., Puca, A. A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1722452115 · Cited by 202 · see citing works
Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit
Pavan Kumar, P., Desetty, R. D., Pineau, P., Marchio, A., Moon, A., Dejean, A., & Bischof, O. (2014) · Nature Communications · doi:10.1038/ncomms6323 · Cited by 200 · see citing works
Reactive oxygen species and hematopoietic stem cell senescence
Shao, L., Li, H., Pazhanisamy, S. K., Meng, A., Wang, Y., & Zhou, D. (2011) · International Journal of Hematology · doi:10.1007/s12185-011-0872-1 · Cited by 198 · see citing works
microRNAs: A Safeguard against Turmoil?
Leung, A. K. L., & Sharp, P. A. (2007) · Cell · doi:10.1016/j.cell.2007.08.010 · Cited by 192 · see citing works
Glutaredoxin: Discovery, redox defense and much more
Ogata, F. T., Branco, V., Vale, F. F., & Coppo, L. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101975 · Cited by 189 · see citing works
miR-CLIP capture of a miRNA targetome uncovers a lincRNA H19–miR-106a interaction
Imig, J., Brunschweiger, A., Brümmer, A., Guennewig, B., Mittal, N., Kishore, S., Tsikrika, P., Gerber, A. P., Zavolan, M., & Hall, J. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1713 · Cited by 188 · see citing works
Harman, D. (2009) · Biogerontology · doi:10.1007/s10522-009-9253-z · Cited by 187 · see citing works
Mensa’, E., Guescini, M., Giuliani, A., Bacalini, M. G., Ramini, D., Corleone, G., Ferracin, M., Fulgenzi, G., Graciotti, L., Prattichizzo, F., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1725285 · Cited by 186 · see citing works
Zhang, Y., Unnikrishnan, A., Deepa, S. S., Liu, Y., Li, Y., Ikeno, Y., Sosnowska, D., Van Remmen, H., & Richardson, A. (2017) · Redox Biology · doi:10.1016/j.redox.2016.10.014 · Cited by 185 · see citing works
MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart
Jazbutyte, V., Fiedler, J., Kneitz, S., Galuppo, P., Just, A., Holzmann, A., Bauersachs, J. K., & Thum, T. (2012) · AGE · doi:10.1007/s11357-012-9407-9 · Cited by 182 · see citing works
The role of mitochondrial sirtuins in health and disease
Osborne, B., Bentley, N. L., Montgomery, M. K., & Turner, N. A. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.197 · Cited by 179 · see citing works
Spatial and Temporal Control of Senescence
Ito, Y., Hoare, M., & Narita, M. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.07.004 · Cited by 178 · cited 1× · see citing works
“Of note, the SASP is cell type specific and can drive both physiological and pathological effects on local and/or distal tissues during life (reviewed in [20,27,59,65,66]).”
BackgroundVenkataraman, S., Alimova, I. N., Fan, R., Harris, P. S., Foreman, N. K., & Vibhakar, R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010748 · Cited by 178 · see citing works
Baker, J. R., Vuppusetty, C., Colley, T., Papaioannou, A. Ι., Fenwick, P. S., Donnelly, L., Ito, K., & Barnes, P. J. (2016) · Scientific Reports · doi:10.1038/srep35871 · Cited by 175 · see citing works
Tabuchi, T., Satoh, M., Itoh, T., & Nakamura, M. (2012) · Clinical Science · doi:10.1042/cs20110563 · Cited by 174 · see citing works
Senescence in Post-Mitotic Cells: A Driver of Aging?
von Zglinicki, T., Wan, T., & Miwa, S. (2021) · Antioxidants & Redox Signaling · doi:10.1089/ars.2020.8048 · Cited by 170 · see citing works
Bailey‐Downs, L. C., Mitschelen, M. C., Sosnowska, D., Tóth, P., Pinto, J. T., Ballabh, P., Valcarcel‐Ares, M. N., Farley, J. A., Koller, Á., Henthorn, J., et al. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr164 · Cited by 169 · see citing works
Weeraratne, S. D., Amani, V. M., Teider, N., Francois, J. P., Winter, D., Kye, M. J., Sengupta, S., Archer, T. C., Remke, M., Bai, A. H. C., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0969-5 · Cited by 158 · see citing works
Cell senescence and hypermitogenic arrest
Blagosklonny, M. V. (2003) · The EMBO Reports · doi:10.1038/sj.embor.embor806 · Cited by 156 · see citing works
Impact of oxidative stress on telomere biology
Ahmed, W., & Lingner, J. (2018) · Differentiation · doi:10.1016/j.diff.2017.12.002 · Cited by 153 · see citing works
A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts
Faraonio, R., Salerno, P., Passaro, F., Sedia, C., Iaccio, A., Bellelli, R., Nappi, T. C., Comegna, M., Romano, S., Salvatore, G., et al. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.143 · Cited by 150 · see citing works
Self-citationThe Nrf2 induction prevents ferroptosis in Friedreich's Ataxia
Rosa, P. L., Petrillo, S., Turchi, R., Berardinelli, F., Schirinzi, T., Vasco, G., Lettieri‐Barbato, D., Fiorenza, M. T., Bertini, E., Aquilano, K., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101791 · Cited by 149 · see citing works
Self-citationLong non-coding RNA H19 regulates endothelial cell aging via inhibition of STAT3 signalling
Hofmann, P., Sommer, J., Theodorou, K., Kirchhof, L., Fischer, A., Li, Y., Matic, L. P., Hedin, U., Mäegdefessel, L., Dimmeler, S., et al. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy206 · Cited by 147 · see citing works
Epigenetic Regulation of Cellular Senescence and Aging
Sidler, C. L., Kovalchuk, O., & Kovalchuk, I. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00138 · Cited by 147 · see citing works
Xie, L., Huang, W., Fang, Z., Ding, F., Zou, F., Ma, X., Tao, J., Guo, J., Xia, X., Wang, H., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1978-2 · Cited by 142 · see citing works
MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways
Hu, Z., Klein, J. D., Mitch, W. E., Zhang, L., Martínez, I., & Wang, X. H. (2014) · Aging · doi:10.18632/aging.100643 · Cited by 138 · see citing works
Lang, A., Grether‐Beck, S., Singh, M., Kuck, F., Jakob, S., Kefalas, A., Altinoluk-Hambüchen, S., Graffmann, N., Schneider, M., Lindecke, A., et al. (2016) · Aging · doi:10.18632/aging.100905 · Cited by 138 · see citing works
AntimiR-21 Prevents Myocardial Dysfunction in a Pig Model of Ischemia/Reperfusion Injury
Hinkel, R., Ramanujam, D. P., Kaczmarek, V., Howe, A., Klett, K., Beck, C. M., Dueck, A., Thum, T., Laugwitz, K., Mäegdefessel, L., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.02.041 · Cited by 138 · see citing works
Oxidative Stress-Induced miR-200c Disrupts the Regulatory Loop Among SIRT1, FOXO1, and eNOS
Carlomosti, F., D'Agostino, M., Beji, S., Torcinaro, A., Rizzi, R., Zaccagnini, G., Maimone, B., Stefano, V. D., Santa, F. D., Cordisco, S., et al. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6643 · Cited by 132 · see citing works
MicroRNA-182-5p targets a network of genes involved in DNA repair
Krishnan, K., Steptoe, A. L., Martin, H. C., Wani, S., Nones, K., Waddell, N., Mariasegaram, M., Simpson, P. T., Lakhani, S. R., Gabrielli, B. G., et al. (2012) · RNA · doi:10.1261/rna.034926.112 · Cited by 130 · see citing works
Li, M., Chiu, J., Mossman, B. T., & Fukagawa, N. K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606596200 · Cited by 128 · see citing works
Mercken, E. M., Majounie, E., Ding, J., Guo, R., Kim, J., Bernier, M., Mattison, J. A., Cookson, M., Gorospe, M., de Cabo, R., et al. (2013) · Aging · doi:10.18632/aging.100598 · Cited by 125 · see citing works
Maes, O. C., Sarojini, H., & Wang, E. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21834 · Cited by 124 · see citing works
MicroRNA Regulation of Oxidative Stress‐Induced Cellular Senescence
Bu, H., Wedel, S., Cavinato, M. S., & Jansen‐Dürr, P. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2398696 · Cited by 123 · see citing works
Yamamoto, H., Morino, K., Nishio, Y., Ugi, S., Yoshizaki, T., Kashiwagi, A., & Maegawa, H. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00097.2012 · Cited by 123 · see citing works
Okada, M., Kim, H. W., Matsu-ura, K., Wang, Y.-G., Xu, M., & Ashraf, M. (2015) · Stem Cells · doi:10.1002/stem.2211 · Cited by 121 · see citing works
Regulation of cellular senescence via the FOXO 4‐p53 axis
Bourgeois, B. M. R., & Madl, T. (2018) · FEBS Letters · doi:10.1002/1873-3468.13057 · Cited by 120 · see citing works
Olivieri, F., Capri, M., Bonafè, M., Morsiani, C., Jung, H. J., Spazzafumo, L., Viña, J., & Suh, Y. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.12.004 · Cited by 120 · see citing works
Kim, Y. J., Hwang, S. H., Lee, S. Y., Shin, K. K., Cho, H. H., Bae, Y. C., & Jung, J. S. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0429 · Cited by 116 · see citing works
Catalysis of Peroxide Reduction by Fast Reacting Protein Thiols
Zeida, A., Trujillo, M., Ferrer‐Sueta, G., Denicola, A., Estrin, D. A., & Radí, R. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00371 · Cited by 114 · see citing works
Genome-wide profiling of the microRNA-mRNA regulatory network in skeletal muscle with aging
Kim, J. Y., Park, Y. K., Lee, K., Lee, S.-M., Kang, T.-W., Kim, H.-J., Dho, S. H., Kim, S., & Kwon, K. (2014) · Aging · doi:10.18632/aging.100677 · Cited by 113 · see citing works
Novel modulators of senescence, aging, and longevity: Small non-coding RNAs enter the stage.
Grillari, J., & Grillari-Voglauer, R. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.01.007 · Cited by 112 · see citing works
Metabolic features and regulation in cell senescence
Kwon, S. M., Hong, S. M., Lee, Y.-K., Min, S., & Yoon, G. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.1.291 · Cited by 111 · cited 1× · see citing works
“Despite their inability to replicate, senescent cells acquire specific features, such as morphological changes, metabolic and transcriptional reprogramming, as well as chromatin reorganization [27,60,61].”
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Fundamentals of redox regulation in biology
Sies, H., Mailloux, R. J., & Jakob, U. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00730-2 · Cited by 546 · see citing works
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
Research progress of therapeutic drugs for doxorubicin-induced cardiomyopathy
Chen, Y., Shi, S., & Dai, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113903 · Cited by 123 · see citing works
Nrf2-mediated therapeutic effects of dietary flavones in different diseases
Huang, W., Zhong, Y., Gao, B., Zheng, B., & Liu, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1240433 · Cited by 77 · see citing works
Antioxidant Systems as Modulators of Ferroptosis: Focus on Transcription Factors
Punziano, C., Trombetti, S., Cesaro, E., Grosso, M., & Faraonio, R. (2024) · Antioxidants · doi:10.3390/antiox13030298 · Cited by 67 · see citing works
Self-citationOxidative Stress and Cell Senescence Process
Faraonio, R. (2022) · Antioxidants · doi:10.3390/antiox11091718 · Cited by 61 · see citing works
Self-citationDogaru, B. G., & Munteanu, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612555 · Cited by 51 · see citing works
Michelacci, Y. M., Baccarin, R., & Rodrigues, N. N. P. (2023) · Life · doi:10.3390/life13071460 · Cited by 45 · see citing works
Immunometabolism and oxidative stress: roles and therapeutic strategies in cancer and aging
Zhou, N.-J., Bao, W.-Q., Zhang, C., Jiang, M., Liang, T.-L., Ma, G.-Y., Liu, L., Pan, H., & Li, R.-Z. (2025) · npj Aging · doi:10.1038/s41514-025-00250-z · Cited by 44 · see citing works
Advancements of metallic nanoparticles: A promising frontier in cancer treatment
Al-Samydai, A. M., Hajleh, M. N. A., Al-Sahlawi, F., Nsairat, H., Khatib, A. O. A., Alqaraleh, M., & Ibrahim, A. K. (2024) · Science Progress · doi:10.1177/00368504241274967 · Cited by 38 · see citing works
Silva-Llanes, I., Shin, C. H., Jiménez-Villegas, J., Gorospe, M., & Lastres‐Becker, I. (2023) · Antioxidants · doi:10.3390/antiox12030641 · Cited by 33 · see citing works
Mesenchymal stem cell-derived exosomes: A paradigm shift in clinical therapeutics
Chattopadhyay, S., Rajendran, R. L., Chatterjee, G., Reyaz, D., Prakash, K., Hong, C. M., Ahn, B., ArulJothi, K. N., & Gangadaran, P. (2025) · Experimental Cell Research · doi:10.1016/j.yexcr.2025.114616 · Cited by 29 · see citing works
Song, B., Qian, J., & Fu, J. (2023) · International Journal of Legal Medicine · doi:10.1007/s00414-023-03091-1 · Cited by 25 · see citing works
Ramini, D., Latini, S., Giuliani, A., Matacchione, G., Sabbatinelli, J., Mensa’, E., Bacalini, M. G., Garagnani, P., Rippo, M. R., Bronte, G., et al. (2022) · Cells · doi:10.3390/cells11233799 · Cited by 25 · see citing works
Rehman, A., Satyam, S. M., El‐Tanani, M., Prabhakar, S., KUMARI, R. R., Shetty, P., Mohammed, S. S. N., Nafees, Z., & Alomar, B. (2025) · Cancers · doi:10.3390/cancers17152466 · Cited by 17 · see citing works
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Wang, Y., Wu, J., Xia, S.-W., Zhao, F., Ding, Q., Ye, X., Zhong, J., Chen, K., & Wang, H. (2023) · Cell Stress and Chaperones · doi:10.1007/s12192-023-01334-z · Cited by 12 · see citing works
Ahmed, I. A., Zamakshshari, N. H., Mikail, M. A., Bello, I., & Hossain, M. S. (2024) · Fitoterapia · doi:10.1016/j.fitote.2024.106282 · Cited by 9 · see citing works
Sha, D., Zhang, J., Xu, F., Wang, X., He, X., & Shu, X. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1595847 · Cited by 9 · see citing works
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Yang, M., Zhang, M., Li, Z., Liu, J., Li, Y., Yang, Z., Wang, X., Huang, X., Yu, B., Hou, J., et al. (2023) · Genomics · doi:10.1016/j.ygeno.2023.110573 · Cited by 9 · see citing works
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Yue, T., & Li, D. (2023) · Stem Cells and Development · doi:10.1089/scd.2023.0065 · Cited by 7 · see citing works
Lazzarato, L., Bianchi, L., Andolfo, A., Granata, A., Lombardi, M., Sinelli, M., Rolando, B., Carini, M., Corsini, A., Fruttero, R., et al. (2023) · Molecules · doi:10.3390/molecules28155724 · Cited by 7 · see citing works
Zhao, X., Li, X., Zhang, W., Gao, M., Zhong, C., Zhang, B., Sun, C., Zhang, Y., Han, S., & Yin, H. (2025) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-025-01257-y · Cited by 6 · see citing works
Wu, J., Jiang, Y., Sun, J., & Sun, X. (2023) · Gerontology · doi:10.1159/000531287 · Cited by 6 · see citing works
Mokhtari, M., Khoshbakht, S., Akbari, M. E., & Sajjad, M. S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22874 · Cited by 6 · see citing works
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Li, Y., Fan, A., Zhang, Y., Guo, Z., Meng, W., Pan, W. X., Ma, Z., & Chen, W. (2023) · MedComm – Oncology · doi:10.1002/mog2.61 · Cited by 5 · see citing works
Advances in Genetic Polymorphisms
Abdelmoula, N. B., & Abdelmoula, B. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.1001553 · Cited by 5 · see citing works
miR-124 in Neuroblastoma: Mechanistic Insights, Biomarker Potential, and Therapeutic Prospects
Monisha, K. M., Shivakumar, D. A., Mutthuraj, D., Nandini, G., Muthusami, S., & Basalingappa, K. M. (2024) · Current Proteomics · doi:10.2174/0115701646331003240821061517 · Cited by 4 · see citing works
New insights into the role of cellular senescence and rheumatic diseases
Wen, J., Li, J., Wan, L., & Wang, F. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1557402 · Cited by 4 · see citing works
Giurgiu, M., Kaltenbach, R. F. I., Ahrend, F., Weeks, S., Clifton, H., Bouldo, M. G., Voloshin, V., Zhong, J., Harden, S., & Kofman, A. V. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.1002250 · Cited by 4 · see citing works
MiRNA-3Age: a microRNA-based biological age model and its modulation by lifestyle and nutrition
Schneider, J., Preyer, C., Steil, M., Biazid, M., Pointner, A., Haslberger, A. G., & Hippe, B. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1659730 · Cited by 3 · see citing works
Hatami, M., & Malik, S. (2026) · Phytoresearch and Technology · doi:10.67443/pt-2026-01010003 · Cited by 3 · see citing works
Yin, Y., Zhou, B., Bai, L., Feng, D., Qin, T., & Li, C. (2022) · Applied Sciences · doi:10.3390/app122211343 · Cited by 3 · see citing works
Huynh, T. D., Isacco, C. G., Ngo, Q. N., Nguyen, B. T., Nguyen, T. H. N., Bui, T. M. D., Minh, V. N., Truong, K. D., Chau, T. V., Truong, H. C., et al. (2025) · Bioengineering · doi:10.3390/bioengineering12101129 · Cited by 2 · see citing works
miR-656-3p inhibits melanomas in vitro and in vivo by inducing senescence via inhibiting LMNB2
Sun, J., KaHo, L. U. I., Pang, Q., Xu, M., Zhao, H., Shao, J., Yu, Y., Chu, X., Liang, Y., Xu, J., et al. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-04953-2 · Cited by 2 · see citing works
Guo, Y., Qiu, S., Zhang, Z. G., Guo, J., Liang, H., You, H., Lu, F., Xu, Y., & Hu, Y. (2026) · Aging Cell · doi:10.1111/acel.70572 · Cited by 1 · see citing works
Cell Proteomic Footprinting: Advances in the Quality of Cellular and Cell-Derived Cancer Vaccines
Lokhov, P. G., Balashova, E. E., Trifonova, O. P., Maslov, D. L., & Archakov, A. I. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020661 · Cited by 1 · see citing works
Communication in miRNAs Between Inflammation and Cancer
Fujii, Y. R. (2023) · Springer eBooks · doi:10.1007/978-981-99-3165-1_7
Soliman, N. A., Dahmy, S. I. E., Shalaby, A. A., & Mohammed, K. A. (2024) · Research Square · doi:10.21203/rs.3.rs-3826623/v1
Molecular Morbidity Score–Can MicroRNAs Assess the Burden of Disease?
Butler, T., Davey, M. G., & Kerin, M. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158042
Soliman, N. A., Dahmy, S. I. E., Shalaby, A. A., & Mohammed, K. A. (2024) · Research Square · doi:10.21203/rs.3.rs-4993212/v1
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Kryvozub, D., Riabenko, T. V., & Ponyrko, A. (2025) · Eastern Ukrainian Medical Journal · doi:10.21272/eumj.2025;13(2):352-363
Unraveling inflammation's role in tumorigenesis: Toward rational anticancer therapeutic design
Chakraborty, S., Boyina, H. K., Sanka, K., Komakula, S. S. B., Pramoda, N. S., & Aligeti, S. K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-36500-3.00010-6
Cellular senescence: the “hidden driver” in chronic inflammatory skin disorders
Liang, H., Li, J., & Zhang, K. (2026) · Immunity & Ageing · doi:10.1186/s12979-026-00580-w
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Arjmand, B., Shahrahmani, F., Moradi, S., Alavi-Moghadam, S., Rezaei–Tavirani, M., Janbabaei, G., & Rad, S. (2026) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-026-00621-2
Agu, P. C., Aja, P. M., Ofor, C. O., Ross, K., & Lu, J. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1907571
Sulaiman, S. H., Omer, R. A., Omar, Z. A., Qadir, A. M., & Barzani, H. A. H. (2026) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-026-02075-3
- Authors
- Lettieri-Barbato, D., Aquilano, K., Punziano, C., Minopoli, G., & Faraonio, R.
- Affiliations
- Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
- University of Rome Tor Vergata (IT)
- University of Naples Federico II (IT)
- Corresponding author
- Faraonio, Raffaella
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2022-02-28
- Volume
- 11
- Issue
- 3
- Pages
- 480
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC8944605
- OpenAlex
- W4214683892
- Cited by
- 51
- References
- 292
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 9 · 2023: 18 · 2022: 5
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Education, Universities and Research (DM 738, 08.08.2019)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Keywords
- cellular senescence, microRNA, long non-coding RNA, circular RNA, oxidative stress, reactive oxygen species, reactive nitrogen species, non-coding RNA regulation, aging, age-related diseases, antioxidant defense
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