Cited by 62Pregnancy and preeclampsia studiesBirth, Development, and HealthElasticity and Material Modeling

Increased arterial stiffness and extracellular matrix reorganization in intrauterine growth–restricted fetal sheep

Open access
Dodson, Reuben Blair, Rozance, Paul J., Fleenor, Bradley S., Petrash, Carson C., Shoemaker, Lauren G., Hunter, Kendall S., Ferguson, Virginia L.·2013·Pediatric Research

Abstract

Background Fetal intrauterine growth restriction (IUGR) results in increased placental resistance to blood flow, fetal hypertension, and increased pulsatility stresses shown to lead to vascular remodeling. We tested our hypothesis that IUGR causes decreased compliance in the carotid and umbilical arteries due to altered extracellular matrix (ECM) composition and structure.Methods A sheep model of placental insufficiency-induced IUGR (PI-IUGR) was created by exposure of the pregnant ewe to elevated ambient temperatures. Umbilical and carotid arteries from near-term fetuses were tested with pressure-diameter measurements to compare passive compliance in control and PI-IUGR tissues. ECM composition was measured via biochemical assay, and the organization was determined by using histology and second-harmonic generation imaging.Results We found that PI-IUGR increased arterial stiffness with increased collagen engagement, or transition stretch. PI-IUGR carotid arteries exhibited increased collagen and elastin quantity, and PI-IUGR umbilical arteries exhibited increased sulfated glycosaminoglycans. Histomorphology showed altered collagen-to-elastin ratios with altered cellular proliferation. Increased stiffness indicates altered collagen-to-elastin ratios with less elastin contribution leading to increased collagen engagement.Conclusion Because vessel stiffness is a significant predictor in the development of hypertension, disrupted ECM deposition in IUGR provides a potential link between IUGR and adult hypertension.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/pr.2012.156

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A growth-restricted fetus has smaller coronary arteries, fewer but more immature cardiomyocytes, less elastin in the arteries, and fewer nephrons in the kidney.

    “For example, a growth-restricted fetus has smaller coronary arteries (288), fewer but more immature cardiomyocytes (55,348,394), less elastin in the arteries (152, 362, 526), and fewer nephrons in the kidney (22,352).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [152]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. [13]Boer RD Trends in Continuum Mechanics of Porous Media 2005 Norwell, MA Springer

Cited by

Sorted by citations

Authors
Dodson, R. B., Rozance, P. J., Fleenor, B. S., Petrash, C. C., Shoemaker, L. G., Hunter, K. S., & Ferguson, V. L.
Affiliations
  • University of Colorado Boulder (US)
  • University of Colorado Anschutz (US)
Corresponding author
Ferguson, Virginia L.
Venue
Pediatric Research
Published
2012-11-15
Volume
73
Issue
2
Pages
147-154
ISSN
  • 0031-3998 (ISSN-L)
  • 1530-0447
OpenAlex
W2071376278
Cited by
62
References
38
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 9 · 2017: 4 · 2016: 3 · 2015: 10 · 2014: 3 · 2013: 5
FWCI
6.95
Type
journal article
Language
en
Open access
Locations
  • Pediatric Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • American Heart Association (1K08HD060688-1)
  • National Institutes of Health (4r01hl114887-05)
  • National Heart, Lung, and Blood Institute (K25HL094749, R01 HL-114887)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK088139)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (K08HD060688)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
Keywords
fetal growth restriction, arterial stiffness, extracellular matrix, vascular remodeling, placental insufficiency, carotid artery, umbilical artery, elastin, glycosaminoglycans, fetal hypertension, fetal sheep model, vascular compliance
MeSH terms
Animals, Carotid Arteries, Collagen, Compliance, Disease Models, Animal, Elastin, Extracellular Matrix, Female, Fetal Growth Retardation, Gestational Age, Glycosaminoglycans, Hypertension, Male, Pregnancy, Sheep, Umbilical Arteries, Cell Proliferation, Vascular Stiffness

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review