A Hypothesis About A Mechanism For The Programming Of Blood Pressure And Vascular Disease In Early Life
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SUMMARY: 1. There is now a great deal of evidence that people whose weight at birth was low tend to have higher blood pressure and increased risk of death from cardiovascular disease as adults. 2. We argue that, in fetuses whose growth is impaired, synthesis of elastin in the walls of the aorta and large arteries is deficient and that this deficiency leads to permanent changes in the mechanical properties of these vessels. 3. Over a lifetime, such changes could predispose an individual to higher blood pressure and cardiovascular disease.
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A growth-restricted fetus has smaller coronary arteries, fewer but more immature cardiomyocytes, less elastin in the arteries, and fewer nephrons in the kidney.
“For example, a growth-restricted fetus has smaller coronary arteries (288), fewer but more immature cardiomyocytes (55,348,394), less elastin in the arteries (152, 362, 526), and fewer nephrons in the kidney (22,352).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [362]
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Placental Origins of Chronic Disease
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- Authors
- Martyn, C., & Greenwald, S.
- Affiliations
- Royal London Hospital (GB)
- Corresponding author
- Martyn, Cn
- Venue
- Clinical and Experimental Pharmacology and Physiology
- Publisher
- Wiley
- Published
- 2001-11-30
- Volume
- 28
- Issue
- 11
- Pages
- 948-951
- ISSN
- 0305-1870 (ISSN-L)
- 1440-1681
- OpenAlex
- W2071703012
- Cited by
- 88
- References
- 31
- Citations by year
- 2022: 5 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 8 · 2012: 2
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical and Experimental Pharmacology and Physiology (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- fetal growth restriction, low birth weight, blood pressure, vascular disease, elastin synthesis, aortic wall, arterial stiffness, vascular mechanical properties, cardiovascular risk, developmental origins of health and disease
- MeSH terms
- Adult, Aging, Aorta, Arteries, Blood Pressure, Compliance, Elastin, Humans, Infant, Low Birth Weight, Infant, Newborn, Vascular Diseases
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