The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990
Open accessAbstract
BACKGROUND: Intrapartum hypoxic events ("birth asphyxia") may result in stillbirth, neonatal or postneonatal mortality, and impairment. Systematic morbidity estimates for the burden of impairment outcomes are currently limited. Neonatal encephalopathy (NE) following an intrapartum hypoxic event is a strong predictor of long-term impairment. METHODS: Linear regression modeling was conducted on data identified through systematic reviews to estimate NE incidence and time trends for 184 countries. Meta-analyses were undertaken to estimate the risk of NE by sex of the newborn, neonatal case fatality rate, and impairment risk. A compartmental model estimated postneonatal survivors of NE, depending on access to care, and then the proportion of survivors with impairment. Separate modeling for the Global Burden of Disease 2010 (GBD2010) study estimated disability adjusted life years (DALYs), years of life with disability (YLDs), and years of life lost (YLLs) attributed to intrapartum-related events. RESULTS: In 2010, 1.15 million babies (uncertainty range: 0.89-1.60 million; 8.5 cases per 1,000 live births) were estimated to have developed NE associated with intrapartum events, with 96% born in low- and middle-income countries, as compared with 1.60 million in 1990 (11.7 cases per 1,000 live births). An estimated 287,000 (181,000-440,000) neonates with NE died in 2010; 233,000 (163,000-342,000) survived with moderate or severe neurodevelopmental impairment; and 181,000 (82,000-319,000) had mild impairment. In GBD2010, intrapartum-related conditions comprised 50.2 million DALYs (2.4% of total) and 6.1 million YLDs. CONCLUSION: Intrapartum-related conditions are a large global burden, mostly due to high mortality in low-income countries. Universal coverage of obstetric care and neonatal resuscitation would prevent most of these deaths and disabilities. Rates of impairment are highest in middle-income countries where neonatal intensive care was more recently introduced, but quality may be poor. In settings without neonatal intensive care, the impairment rate is low due to high mortality, which is relevant for the scale-up of basic neonatal resuscitation.
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Cites
Lozano, R., Naghavi, M., Foreman, K., Lim, S., Shibuya, K., Aboyans, V., Abraham, J., Adair, T., Aggarwal, R., Ahn, S. Y., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61728-0 · Cited by 14,070
Self-citationMurray, C. J. L., Vos, T., Lozano, R., Naghavi, M., Flaxman, A. D., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61689-4 · Cited by 8,888
Self-citationVos, T., Flaxman, A. D., Naghavi, M., Lozano, R., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., Aboyans, V., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61729-2 · Cited by 8,291
Self-citationGlobal mortality, disability, and the contribution of risk factors: Global Burden of Disease Study
Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07495-8 · Cited by 4,492 · cited 1×
“In previous Global Burden of Disease (GBD) estimates, “birth asphyxia” accounted for one of the highest numbers of disability adjusted life years (DALYs) for any single condition (3).”
BackgroundGluckman, P. D., Wyatt, J. S., Azzopardi, D., Ballard, R., Edwards, A. D., Ferriero, D. M., Polin, R. A., Robertson, C. M., Thoresen, M., Whitelaw, A., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17946-x · Cited by 2,270
GBD 2010: design, definitions, and metrics
Murray, C. J., Ezzati, M., Flaxman, A. D., Lim, S., Lozano, R., Michaud, C., Naghavi, M., Salomon, J. A., Shibuya, K., Vos, T., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61899-6 · Cited by 1,103 · cited 3×
“DALYs at all ages were then calculated as the sum of YLLs and YLDs due to intrapartum complications (11,40).”
BackgroundMethodSelf-citationMacLennan, A. (1999) · BMJ · doi:10.1136/bmj.319.7216.1054 · Cited by 731
Two million intrapartum-related stillbirths and neonatal deaths: Where, why, and what can be done?
Lawn, J. E., Lee, A. C., Kinney, M., Sibley, L., Carlo, W. A., Paul, V. K., Pattinson, R., & Darmstadt, G. L. (2009) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2009.07.016 · Cited by 561
Self-citationDarmstadt, G. L., Lee, A. C., Cousens, S., Sibley, L., Bhutta, Z. A., Donnay, F., Osrin, D., Bang, A., Kumar, V., Wall, S. N., et al. (2009) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2009.07.010 · Cited by 264
Self-citationPattinson, R., Kerber, K., Waiswa, P., Day, L. T., Mussell, F., Asiruddin, S., Blencowe, H., & Lawn, J. E. (2009) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2009.07.011 · Cited by 161
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Every Newborn: progress, priorities, and potential beyond survival
Lawn, J. E., Blencowe, H., Oza, S., You, D., Lee, A. C., Waiswa, P., Lalli, M., Bhutta, Z., Barros, A. J., Christian, P., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60496-7 · Cited by 1,929
Self-citationStillbirths: rates, risk factors, and acceleration towards 2030
Lawn, J. E., Blencowe, H., Waiswa, P., Amouzou, A., Mathers, C., Hogan, D., Flenady, V., Frøen, J. F., Qureshi, Z. U., Calderwood, C., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00837-5 · Cited by 1,778
Self-citationSeale, A. C., Bianchi-Jassir, F., Russell, N. J., Kohli-Lynch, M., Tann, C. J., Hall, J., Madrid, L., Blencowe, H., Cousens, S., Baker, C. J., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix664 · Cited by 511
Self-citationNeonatal encephalopathy and hypoxic-ischemic encephalopathy: the state of the art
Chakkarapani, E., de Vries, L. S., Ferriero, D. M., & Gunn, A. J. (2025) · Pediatric Research · doi:10.1038/s41390-025-03986-2 · Cited by 90
Ma, Q., Dasgupta, C., Li, Y., Huang, L., & Zhang, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071356 · Cited by 76
Metadata
- Authors
- Lee, A. C., Kozuki, N., Blencowe, H., Vos, T., Bahalim, A., Darmstadt, G. L., Niermeyer, S., Ellis, M., Robertson, N. J., Cousens, S., & Lawn, J. E.
- Venue
- Pediatric Research
- Published
- 2013-12
- Volume
- 74
- Issue
- S1
- Pages
- 50-72
- ISSN
- 0031-3998 (ISSN-L)
- 1530-0447
- OpenAlex
- W2083733099
- Cited by
- 665
- References
- 11
- FWCI
- 15.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lee, A. C., Kozuki, N., Blencowe, H., Vos, T., Bahalim, A., Darmstadt, G. L., Niermeyer, S., Ellis, M., Robertson, N. J., Cousens, S., & Lawn, J. E. (2013). Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990. Pediatric Research. https://doi.org/10.1038/pr.2013.206
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