Maternal creatine supplementation during pregnancy prevents acute and long-term deficits in skeletal muscle after birth asphyxia: a study of structure and function of hind limb muscle in the spiny mouse
Open accessAbstract
Background Maternal antenatal creatine supplementation protects the brain, kidney, and diaphragm against the effects of birth asphyxia in the spiny mouse. In this study, we examined creatine's potential to prevent damage to axial skeletal muscles.Methods Pregnant spiny mice were fed a control or creatine-supplemented diet from mid-pregnancy, and 1 d before term (39 d), fetuses were delivered by c-section with or without 7.5 min of birth asphyxia. At 24 h or 33 ± 2 d after birth, gastrocnemius muscles were obtained for ex-vivo study of twitch-tension, muscle fatigue, and structural and histochemical analysis.Results Birth asphyxia significantly reduced cross-sectional area of all muscle fiber types (P < 0.05), and increased fatigue caused by repeated tetanic contractions at 24 h of age (P < 0.05). There were fewer (P < 0.05) Type I and IIa fibers and more (P < 0.05) Type IIb fibers in male gastrocnemius at 33 d of age. Muscle oxidative capacity was reduced (P < 0.05) in males at 24 h and 33 d and in females at 24 h only. Maternal creatine treatment prevented all asphyxia-induced changes in the gastrocnemius, improved motor performance.Conclusion This study demonstrates that creatine loading before birth protects the muscle from asphyxia-induced damage at birth.
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Maternal creatine supplementation has been reported to improve neonatal survival and organ function following birth asphyxia in animals.
“Maternal creatine supplementation has been reported to improve neonatal survival and organ function following birth asphyxia in animals [228, 229, 231, 233–235, 237].”
From International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine (2017) · cites this paper as [229]
The Articles discussion (page unavailable) reports protection against asphyxia-induced damage to the neonatal brain, kidney and diaphragm, and this study reports protective effects on gastrocnemius muscle function. It says creatine supplementation could prevent asphyxia-induced mortality, but does not report an improvement in neonatal survival. (LLM, conf=0.84)
Experimental — accuracy not yet measuredCreatine supplementation has been shown to improve brain and heart bioenergetics during ischemic conditions and possess neuroprotective properties.
“Since creatine supplementation has been shown to improve brain and heart bioenergetics during ischemic conditions and possess neuroprotective properties, there has been recent interest in use of creatine during pregnancy to promote neural development and reduce complications resulting from birth asphyxia [228–237].”
From International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine (2017) · cites this paper as [229]
The Abstract and Articles passages report that maternal creatine supplementation protects the neonatal spiny-mouse brain against birth-asphyxia damage and describe a plausible ATP-preserving mechanism. They do not report improved heart bioenergetics during ischemia; the heart is mentioned only in a description of fetal blood-flow redistribution. Page numbers were not supplied in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredCreatine supplementation has been shown to improve cellular bioenergetics during ischemic conditions and possess neuroprotective properties.
“Since creatine supplementation has been shown to improve cellular bioenergetics during ischemic conditions and possess neuroprotective properties, there has been interest in creatine use during pregnancy to promote neural development and reduce complications resulting from birth asphyxia [7,277,278,279,280,281,282,283,284,285].”
From Creatine in health and disease (2021) · cites this paper as [278]
Maternal creatine supplementation has been reported to improve neonatal survival and organ function following birth asphyxia in animals.
“Maternal creatine supplementation has been reported to improve neonatal survival and organ function following birth asphyxia in animals [277,278,279,281,282,283,285].”
From Creatine in health and disease (2021) · cites this paper as [278]
Available literature suggests that creatine metabolism may play an essential role in the bioenergetics of successful reproduction and that creatine supplementation may improve reproductive and/or perinatal outcomes.
“Available literature suggests that creatine metabolism may play an essential role in the bioenergetics of successful reproduction and that creatine supplementation may improve reproductive and/or perinatal outcomes [7,277,278,279,280,283,284,286,288].”
From Creatine in health and disease (2021) · cites this paper as [278]
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NEONATAL MULTIPLE ORGAN FAILURE AFTER PERINATAL ASPHYXIA
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- Authors
- LaRosa, D. A., Ellery, S. J., Snow, R. J., Walker, D. W., & Dickinson, H.
- Affiliations
- Hudson Institute of Medical Research (AU)
- Deakin University (AU)
- Corresponding author
- LaRosa, Domenic A.
- Venue
- Pediatric Research
- Published
- 2016-07-28
- Volume
- 80
- Issue
- 6
- Pages
- 852-860
- ISSN
- 0031-3998 (ISSN-L)
- 1530-0447
- OpenAlex
- W2487059830
- Cited by
- 29
- References
- 40
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 2
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pediatric Research (publishedVersion)
- PubMed (publishedVersion)
- RMIT Research Repository (RMIT University Library) (submittedVersion)
- Own your potential (DEAKIN) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Figshare (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- neonatal asphyxia, skeletal muscle, gastrocnemius, hindlimb muscles, muscle fiber composition, muscle fatigue, muscle oxidative capacity, muscle cross-sectional area, spiny mouse, prenatal nutrition
- MeSH terms
- Animals, Animals, Newborn, Asphyxia Neonatorum, Creatine, Disease Models, Animal, Female, Hindlimb, Male, Muscle Contraction, Oxidation-Reduction, Pregnancy, Muscle, Skeletal, Muscle Fatigue, Murinae
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