Effects of early nutrition and growth on brain volumes, white matter microstructure, and neurodevelopmental outcome in preterm newborns
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BackgroundThis study aimed to investigate the effect of nutrition and growth during the first 4 weeks after birth on cerebral volumes and white matter maturation at term equivalent age (TEA) and on neurodevelopmental outcome at 2 years' corrected age (CA), in preterm infants.MethodsOne hundred thirty-one infants born at a gestational age (GA) <31 weeks with magnetic resonance imaging (MRI) at TEA were studied. Cortical gray matter (CGM) volumes, basal ganglia and thalami (BGT) volumes, cerebellar volumes, and total brain volume (TBV) were computed. Fractional anisotropy (FA) in the posterior limb of internal capsule (PLIC) was obtained. Cognitive and motor scores were assessed at 2 years' CA.ResultsCumulative fat and enteral intakes were positively related to larger cerebellar and BGT volumes. Weight gain was associated with larger cerebellar, BGT, and CGM volume. Cumulative fat and caloric intake, and enteral intakes were positively associated with FA in the PLIC. Cumulative protein intake was positively associated with higher cognitive and motor scores (all P<0.05).ConclusionOur study demonstrated a positive association between nutrition, weight gain, and brain volumes. Moreover, we found a positive relationship between nutrition, white matter maturation at TEA, and neurodevelopment in infancy. These findings emphasize the importance of growth and nutrition with a balanced protein, fat, and caloric content for brain development.
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Nutrition is one of the most important environmental factors that influence brain development.
“Nutrition is one of the most important environmental factors that influence brain development [58,59];”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [59]
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- Authors
- Coviello, C., Keunen, K., Kersbergen, K. J., Groenendaal, F., Leemans, A., Peels, B., Isgum, I., Viergever, M. A., de Vries, L. S., Buonocore, G., Carnielli, V. P., & Benders, M. J. N. L.
- Affiliations
- Utrecht University (NL)
- University of Siena (IT)
- Marche Polytechnic University (IT)
- Corresponding author
- Benders, Manon J N L
- ORCID
- Venue
- Pediatric Research
- Published
- 2017-10-25
- Volume
- 83
- Issue
- 1
- Pages
- 102-110
- ISSN
- 0031-3998 (ISSN-L)
- 1530-0447
- OpenAlex
- W2754145882
- Cited by
- 169
- References
- 41
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 25 · 2023: 24 · 2022: 27 · 2021: 30 · 2020: 14 · 2019: 15 · 2018: 6
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- www.nature.com
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pediatric Research (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Use Siena air (University of Siena) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (639‐072‐411, VIDI Grant 639.072.411)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- preterm infants, neonatal nutrition, enteral nutrition, brain growth, brain volume, white matter maturation, fractional anisotropy, posterior limb of internal capsule, cerebellar volume, weight gain, protein intake, dietary fat intake, energy intake, neurodevelopmental outcomes, cognitive development, motor development
- MeSH terms
- Basal Ganglia, Brain, Cognition, Female, Humans, Infant Nutritional Physiological Phenomena, Infant, Newborn, Infant, Premature, Magnetic Resonance Imaging, Male, Motor Skills, Retrospective Studies, Thalamus, Time Factors, Weight Gain, Multivariate Analysis, Anisotropy, Diffusion Tensor Imaging, White Matter, Gray Matter
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