CPT: Pharmacometrics and Systems Pharmacology

How to improve R&D productivity: the pharmaceutical industry's grand challenge

Paul, S. M., Mytelka, D. S., Dunwiddie, C. T., Persinger, C. C., Munos, B. H., Lindborg, S. R., & Schacht, A. L. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3078 · Cited by 3,566 · see citing works

A Whole-Cell Computational Model Predicts Phenotype from Genotype

Karr, J. R., Sanghvi, J. C., Macklin, D. N., Gutschow, M. V., Jacobs, J. M., Bolival, B., Assad-Garcia, N., Glass, J. I., & Covert, M. W. (2012) · Cell · doi:10.1016/j.cell.2012.05.044 · Cited by 1,300 · see citing works

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

Morgan, P., Van Der Graaf, P. H., Arrowsmith, J., Feltner, D. E., Drummond, K. S., Wegner, C. D., & Street, S. D. A. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2011.12.020 · Cited by 692 · see citing works

BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models

Li, C., Donizelli, M., Rodriguez, N., Dharuri, H., Endler, L., Chelliah, V., Li, L., He, E., Henry, A., Stefan, M. I., et al. (2010) · BMC Systems Biology · doi:10.1186/1752-0509-4-92 · Cited by 597 · see citing works

Basic Concepts in Population Modeling, Simulation, and Model‐Based Drug Development

Mould, D., & Upton, R. N. (2012) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2012.4 · Cited by 552 · see citing works

Model-based Drug Development

Lalonde, R. L., Kowalski, K., Hutmacher, M. M., Ewy, W., Nichols, D., Milligan, P. A., Corrigan, B., Lockwood, P. A., Marshall, S. A., Benincosa, L. J., et al. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100235 · Cited by 452 · see citing works

Physiologically Based Pharmacokinetics Joined with In Vitro–In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology

Rostami-Hodjegan, A. (2012) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2012.65 · Cited by 331 · see citing works

Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development

van der Graaf, P. H., & Benson, N. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0467-9 · Cited by 248 · see citing works

Systems Biology: An Approach

Kohl, P. K., Crampin, E. J., Quinn, T. A., & Noble, D. (2010) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2010.92 · Cited by 232 · see citing works

Rescuing drug discovery: in vivo systems pathology and systems pharmacology

van der Greef, J., & McBurney, R. N. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1904 · Cited by 209 · see citing works

Merging Systems Biology with Pharmacodynamics

Iyengar, R., Zhao, S., Chung, S., Mager, D. E., & Gallo, J. M. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003563 · Cited by 155 · see citing works

Impact of Pharmacometric Analyses on New Drug Approval and Labelling Decisions

Lee, J. Y., Garnett, C. E., Gobburu, J. V. S., Bhattaram, V. A., Brar, S. S., Earp, J. C., Jadhav, P. R., Krudys, K. M., Lesko, L. J., Li, F., et al. (2011) · Clinical Pharmacokinetics · doi:10.2165/11593210-000000000-00000 · Cited by 151 · see citing works

Pharmacometrics : the science of quantitative pharmacology

Ette, E., & Williams, P. J. (2007) · Wiley eBooks · doi:10.1002/0470087978 · Cited by 151 · see citing works

Pharmacometrics: A Multidisciplinary Field to Facilitate Critical Thinking in Drug Development and Translational Research Settings

Barrett, J. S., Fossler, M. J., Cadieu, K. D., & Gastonguay, M. R. (2008) · The Journal of Clinical Pharmacology · doi:10.1177/0091270008315318 · Cited by 132 · see citing works

A PBPK Model to Predict Disposition of CYP3A‐Metabolized Drugs in Pregnant Women: Verification and Discerning the Site of CYP3A Induction

Ke, A., Nallani, S., Zhao, P., Rostami‐Hodjegan, A., & Unadkat, J. D. (2012) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2012.2 · Cited by 93 · see citing works

Systems pharmacology and genome medicine: a future perspective

Wist, A. D., Berger, S. I., & Iyengar, R. (2009) · Genome Medicine · doi:10.1186/gm11 · Cited by 82 · see citing works

Translational Bioinformatics: Linking the Molecular World to the Clinical World

Altman, R. B. (2012) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2012.49 · Cited by 48 · see citing works

New approaches to modeling complex biochemistry

Bachman, J. A., & Sorger, P. K. (2011) · Nature Methods · doi:10.1038/nmeth0211-130 · Cited by 40 · see citing works

Open science and reproducible research

Groves, T., & Godlee, F. (2012) · British medical journal · doi:10.1136/bmj.e4383 · Cited by 37 · see citing works

Multiscale Modeling in Drug Discovery and Development: Future Opportunities and Present Challenges

Vicini, P. (2010) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2010.87 · Cited by 37 · see citing works

Modeling Interindividual Variability in Physiologically Based Pharmacokinetics and Its Link to Mechanistic Covariate Modeling

Huisinga, W., Solms, A., Fronton, L., & Pilari, S. (2012) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2012.3 · Cited by 36 · see citing works

Bridging Clinical Outcomes of Canakinumab Treatment in Patients With Rheumatoid Arthritis With a Population Model of IL‐1β Kinetics

Ait‐Oudhia, S., Lowe, P. J., & Mager, D. E. (2012) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2012.6 · Cited by 31 · see citing works

A Semi‐Mechanistic Metabolism Model of CYP3A Substrates in Pregnancy: Predicting Changes in Midazolam and Nifedipine Pharmacokinetics

Quinney, S. K., Mohamed, A., Hébert, M. F., Haas, D. M., Clark, S., Umans, J., Caritis, S. N., & Li, L. (2012) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2012.5 · Cited by 28 · see citing works

Pharmacokinetic–Pharmacodynamic Modeling of Severity Levels of Extrapyramidal Side Effects With Markov Elements

Reddy, V. P., Petersson, K., Suleiman, A., Vermeulen, A., Proost, J., & Friberg, L. E. (2012) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2012.9 · Cited by 26 · see citing works

Pharmacometrics for Regulatory Decision Making

Manolis, E., & Herold, R. (2011) · Clinical Pharmacokinetics · doi:10.2165/11594340-000000000-00000 · Cited by 18 · see citing works

Integrative and Organ Systems Pharmacology: A New Initiative from the National Institute of General Medical Sciences

Preusch, P. C. (2004) · Molecular Interventions · doi:10.1124/mi.4.2.1 · Cited by 15 · see citing works

Reflections on drug research

Black, J. W. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01019.x · Cited by 13 · see citing works

Open Access: A New Model for Publishing in the Pharmacological Sciences

Conway, M. (2012) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2012.7 · Cited by 4 · see citing works

Model-Based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development

Milligan, P. A., Brown, M. J., Marchant, B., Martin, S. W., van der Graaf, P. H., Benson, N., Nucci, G., Nichols, D. J., Boyd, R. A., Mandema, J. W., et al. (2013) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2013.54 · Cited by 238 · see citing works

Is Polypharmacy Associated with Frailty in Older People? Results From the ESTHER Cohort Study

Saum, K.-U., Schöttker, B., Meid, A. D., Holleczek, B., Haefeli, W. E., Hauer, K. A., & Brenner, H. (2016) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14718 · Cited by 204 · see citing works

Effect of Kidney Function on Drug Kinetics and Dosing in Neonates, Infants, and Children

Rodieux, F., Wilbaux, M., van den Anker, J. N., & Pfister, M. (2015) · Clinical Pharmacokinetics · doi:10.1007/s40262-015-0298-7 · Cited by 141 · see citing works

Emergency re‐admissions to hospital due to adverse drug reactions within 1 year of the index admission

Davies, E. C., Green, C. F., Mottram, D. R., Rowe, P., & Pirmohamed, M. (2010) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2010.03751.x · Cited by 125 · see citing works

Identifying demographic, social and clinical predictors of biologic therapy effectiveness in psoriasis: a multicentre longitudinal cohort study

Warren, R. B., Marsden, A., Tomenson, B., Mason, K. J., Soliman, M. M., Burden, A. D., Reynolds, N. J., Stocken, D. D., Emsley, R., Griffiths, C. E. M., et al. (2018) · British Journal of Dermatology · doi:10.1111/bjd.16776 · Cited by 116 · see citing works

Polypharmacy among inpatients aged 70 years or older in Australia

Hubbard, R. E., Peel, N. M., Scott, I. A., Martin, J. H., Smith, A. J., Pillans, P. I., Poudel, A., & Gray, L. (2015) · The Medical Journal of Australia · doi:10.5694/mja13.00172 · Cited by 108 · see citing works

Parsing interindividual drug variability: an emerging role for systems pharmacology

Turner, R. M., Park, B. K., & Pirmohamed, M. (2015) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1302 · Cited by 91 · see citing works

Implementation of Quantitative and Systems Pharmacology in Large Pharma

Visser, S. A. G., de Alwis, D. P., Kerbusch, T., Stone, J. A., & Allerheiligen, S. R. B. (2014) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2014.40 · Cited by 91 · see citing works

Mortality from adverse drug reactions in adult medical inpatients at four hospitals in South Africa: a cross‐sectional survey

Mouton, J. P., Mehta, U. C., Parrish, A., Wilson, D., Stewart, A., Njuguna, C. W., Kramer, N., Maartens, G., Blockman, M., & Cohen, K. (2014) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12567 · Cited by 90 · see citing works

A model qualification method for mechanistic physiological QSP models to support model‐informed drug development

Friedrich, C. (2016) · CPT: Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12056 · Cited by 87 · see citing works

Opioid Stewardship in Otolaryngology: State of the Art Review

Cramer, J. D., Wisler, B., & Gouveia, C. J. (2018) · Otolaryngology · doi:10.1177/0194599818757999 · Cited by 84 · see citing works

Pharmacometric Approaches to Personalize Use of Primarily Renally Eliminated Antibiotics in Preterm and Term Neonates

Wilbaux, M., Fuchs, A., Samardžić, J., Rodieux, F., Csajka, C., Allegaert, K., van den Anker, J. N., & Pfister, M. (2016) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.705 · Cited by 80 · see citing works

Systematic review of predictive risk models for adverse drug events in hospitalized patients

Falconer, N., Barras, M. A., & Cottrell, N. (2018) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13514 · Cited by 78 · see citing works

Stem cell‐derived hepatocytes as a predictive model for drug‐induced liver injury: are we there yet?

Kia, R., Sison-Young, R. L. C., Heslop, J. A., Kitteringham, N. R., Hanley, N. A., MILLS, J. S., Park, B. K., & Goldring, C. E. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04360.x · Cited by 74 · see citing works

The Role of Modeling and Simulation in Development and Registration of Medicinal Products: Output From the EFPIA/EMA Modeling and Simulation Workshop

Manolis, E., Rohou, S., Hemmings, R., Salmonson, T., Karlsson, M., & Milligan, P. (2013) · CPT: Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2013.7 · Cited by 70 · see citing works

Multiscale Modeling in the Clinic: Drug Design and Development

Clancy, C. E., An, G., Cannon, W. R., Liu, Y., May, E. E., Ortoleva, P., Popel, A. S., Sluka, J. P., Su, J., Vicini, P., et al. (2016) · Annals of Biomedical Engineering · doi:10.1007/s10439-016-1563-0 · Cited by 62 · see citing works

Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network

Cucurull‐Sanchez, L., Chappell, M. J., Chelliah, V., Amy Cheung, S. Y., Derks, G., Penney, M., Phipps, A., Malik‐Sheriff, R. S., Timmis, J., Tindall, M. J., et al. (2019) · CPT: Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12381 · Cited by 61 · see citing works

Prevalence, nature and potential preventability of adverse drug events – a population‐based medical record study of 4970 adults

Hakkarainen, K. M., Gyllensten, H., Jönsson, A. K., Sundell, K. A., Petzold, M., & Hägg, S. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12314 · Cited by 63 · see citing works

Developing consensus on hospital prescribing indicators of potential harms amenable to decision support

Thomas, S. K., McDowell, S. E., Hodson, J. A., Nwulu, U., Howard, R. L., Avery, A. J., Slee, A., & Coleman, J. J. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12087 · Cited by 62 · see citing works

Drug‐related deaths in hospital inpatients: A retrospective cohort study

Montané, E., Arellano, A. L., Sanz, Y., Roca, J., & Farré, M. (2017) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13471 · Cited by 56 · see citing works

The Use of Biomarkers in Human Pharmacology (Phase I) Studies

Cohen, A. F., Burggraaf, J., van Gerven, J. M. A., Moerland, M., & Groeneveld, G. J. (2015) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135918 · Cited by 55 · see citing works

A mathematical model of the human menstrual cycle for the administration of GnRH analogues

Röblitz, S., Stötzel, C., Deuflhard, P., Jones, H. M., Azulay, D.-O., van der Graaf, P. H., & Martin, S. W. (2013) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2012.11.020 · Cited by 54 · see citing works

Female patients are less satisfied with biological treatment for psoriasis and experience more side‐effects than male patients: results from the prospective BioCAPTURE registry

van der Schoot, L. S., van den Reek, J. M. P. A., Groenewoud, J. M. M., Otero, M. E., Njoo, M. D., Ossenkoppele, P. M., Mommers, J. M., Koetsier, M. I. A., Berends, M. A. M., Arnold, W. P., et al. (2019) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15733 · Cited by 54 · see citing works

Combination therapy with T cell engager and PD-L1 blockade enhances the antitumor potency of T cells as predicted by a QSP model

Ma, H., Wang, H., Sové, R. J., Wang, J., Giragossian, C., & Popel, A. S. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001141 · Cited by 51 · see citing works

Systems pharmacology of hepatic metabolism in zebrafish larvae

van Wijk, R. C., Krekels, E. H. J., Hankemeier, T., Spaink, H. P., & van der Graaf, P. H. (2016) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2017.04.003 · Cited by 46 · see citing works

Improving the assessment of adverse drug reactions using the Naranjo Algorithm in daily practice: The Japan Adverse Drug Events Study

Murayama, H., Sakuma, M., Takahashi, Y., & Morimoto, T. (2018) · Pharmacology Research & Perspectives · doi:10.1002/prp2.373 · Cited by 46 · see citing works

Prevalence and Characteristics of Moderate to Severe Pain among Hospitalized Older Adults

Deng, L. X., Patel, K., Miaskowski, C. A., Maravilla, I., Schear, S., Garrigues, S. K., Thompson, N., Auerbach, A. D., & Ritchie, C. S. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15459 · Cited by 40 · see citing works

Integrating Multiple Evidence Sources to Predict Adverse Drug Reactions Based on a Systems Pharmacology Model

Cao, D., Xiao, N., Li, Y., Zeng, W., Liang, Y., Lu, A., Xu, Q., & Af, C. (2015) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12002 · Cited by 38 · see citing works

The impact of serious adverse drug reactions: a population‐based study of a decade of hospital admissions in New South Wales, Australia

Walter, S. R., Day, R. O., Gallego, B., & Westbrook, J. I. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13124 · Cited by 38 · see citing works

PFIM 4.0, an extended R program for design evaluation and optimization in nonlinear mixed-effect models

Dumont, C., Lestini, G., Nagard, H. L., Mentré, F., Comets, E., Nguyen, T. T., & for the PFIM group (2018) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2018.01.008 · Cited by 38 · see citing works

Agent‐based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity

Hunt, C. A., Kennedy, R., Kim, S. H. J., & Ropella, G. E. P. (2013) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1222 · Cited by 37 · see citing works

Medication use and potentially high‐risk prescribing in older patients hospitalized for diabetes: a missed opportunity to improve care?

Caughey, G. E., Barratt, J. D., Shakib, S., Kemp, A., & Roughead, E. E. (2016) · Diabetic Medicine · doi:10.1111/dme.13148 · Cited by 37 · see citing works

The effect of prescriber education on medication‐related patient harm in the hospital: a systematic review

Bos, J. M., van den Bemt, P. M. L. A., Smet, P. A. G. M. D., & Kramers, C. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13200 · Cited by 37 · see citing works

Mathematical modeling and simulation in animal health. Part I: Moving beyond pharmacokinetics

Riviere, J. E., Gabrielsson, J., Fink, M., & Mochel, J. P. (2015) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/jvp.12278 · Cited by 31 · see citing works

Dose/Exposure‐Response Modeling to Support Dosing Recommendation for Phase III Development of Baricitinib in Patients with Rheumatoid Arthritis

Zhang, X., Chua, L., Ernest, C. S., Macias, W. L., Rooney, T. P., & Tham, L. S. (2017) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12251 · Cited by 30 · see citing works

Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety Assessment

Collins, T., Bergenholm, L., Abdulla, T., Yates, J. W. T., Evans, N. D., Chappell, M., & Mettetal, J. T. (2015) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.18 · Cited by 28 · see citing works

Junior doctor‐led ‘near‐peer’ prescribing education for medical students

Gibson, K. R., Qureshi, Z. U., Ross, M., & Maxwell, S. R. J. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12147 · Cited by 27 · see citing works

Panmictic and Clonal Evolution on a Single Patchy Resource Produces Polymorphic Foraging Guilds

Getz, W. M., Salter, R. M., Lyons, A. J., & Sippl-Swezey, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133732 · Cited by 26 · see citing works

Drug‐Related Inadvertent Deaths in a University Hospital – A Declining Trend

Lapatto‐Reiniluoto, O., Juntti‐Patinen, L., Niemi, M., Backman, J. T., & Neuvonen, P. J. (2015) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12435 · Cited by 25 · see citing works

Systems Pharmacology of the NGF Signaling Through p75 and TrkA Receptors

Toni, T., Dua, P., & van der Graaf, P. H. (2014) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2014.48 · Cited by 25 · see citing works

A multifaceted intervention to reduce drug‐related complications in surgical patients

Bos, J. M., van den Bemt, P. M. L. A., Kievit, W., Pot, J. L. W., Nagtegaal, J. E., Wieringa, A., van der Westerlaken, M. M. L., van der Wilt, G. J., Smet, P. A. G. M. D., & Kramers, C. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13141 · Cited by 25 · see citing works

Development and validation of the Adverse Inpatient Medication Event model (AIME)

Falconer, N., Barras, M. A., Abdel‐Hafez, A., Radburn, S., & Cottrell, N. (2020) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14560 · Cited by 24 · see citing works

A new approach to identify, classify and count drug‐related events

Bürkle, T., Müller, F., Patapovas, A., Sonst, A., Pfistermeister, B., Plank‐Kiegele, B., Dormann, H., & Maas, R. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12189 · Cited by 23 · see citing works

No differences between men and women in adverse drug reactions related to psychotropic drugs: a survey from F rance, I taly and S pain

D’Incau, P., Lapeyre‐Mestre, M., Carvajal, A., Donati, M., Valdivieso, I. S., Rodriguez, L., Sáinz-Gil, M., Escudero, A., & Conforti, A. (2013) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12032 · Cited by 24 · see citing works

Quantitative clinical pharmacology practice for optimal use of antibiotics during the neonatal period

Samardžić, J., Allegaert, K., Wilbaux, M., Pfister, M., & van den Anker, J. N. (2016) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2016.1147559 · Cited by 22 · see citing works

e‐SPC – delivering drug information in the 21st century: developing new approaches to deliver drug information to prescribers

Maxwell, S. R. J., Eichler, H., Bucsics, A., Haefeli, W. E., & Gustafsson, L. L. (2011) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2011.03981.x · Cited by 22 · see citing works

White Paper: Landscape on Technical and Conceptual Requirements and Competence Framework in Drug/Disease Modeling and Simulation

Vlasakakis, G., Comets, E., Keunecke, A., Gueorguieva, I., Magni, P., Terranova, N., Pasqua, O. E. D., de Lange, E. C. M., & Kloft, C. (2013) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2013.16 · Cited by 21 · see citing works

Monitoring medicines use: the role of the clinical pharmacologist

Williams, D. J. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04316.x · Cited by 21 · see citing works

Quality of life in children with adverse drug reactions: a narrative and systematic review

Pozzo‐Magaña, B. R. D., Rieder, M. J., & Lazo‐Langner, A. (2014) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12423 · Cited by 21 · see citing works

Systems pharmacology of the nerve growth factor pathway: use of a systems biology model for the identification of key drug targets using sensitivity analysis and the integration of physiology and pharmacology

Benson, N., Matsuura, T., Smirnov, S., Demin, O., Jones, H. M., Dua, P., & van der Graaf, P. H. (2013) · Interface Focus · doi:10.1098/rsfs.2012.0071 · Cited by 20 · see citing works

Analysis of the coding sequence for the GM-CSF receptor alpha and beta chains in patients with juvenile chronic myeloid leukemia (JCML).

Freeburn, R. W., Gale, R. E., Wagner, H. M., & Linch, D. C. (1997) · PubMed · Cited by 19 · see citing works

Application of pharmacometrics and quantitative systems pharmacology to cancer therapy: The example of luminal a breast cancer.

Fleisher, B., Brown, A. N., & Ait-Oudhia, S. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.07.015 · Cited by 17 · see citing works

Modeling and Simulation at the Interface of Nonclinical and Early Clinical Drug Development

Visser, S. A. G., Manolis, E., Danhof, M., & Kerbusch, T. (2013) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2013.3 · Cited by 17 · see citing works

Influence of the Size of Cohorts in Adaptive Design for Nonlinear Mixed Effects Models: An Evaluation by Simulation for a Pharmacokinetic and Pharmacodynamic Model for a Biomarker in Oncology

Lestini, G., Dumont, C., & Mentré, F. (2015) · Pharmaceutical Research · doi:10.1007/s11095-015-1693-3 · Cited by 16 · see citing works

Characterizing and Forecasting Individual Weight Changes in Term Neonates

Wilbaux, M., Kasser, S., Wellmann, S. M., Lapaire, O., van den Anker, J. N., & Pfister, M. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.02.044 · Cited by 15 · see citing works

On the stability of stationary solutions in diffusion models of oncological processes

Debbouche, A., Polovinkina, M. V., Половинкин, И. П., Valentim, C. A., & David, S. A. (2021) · The European Physical Journal Plus · doi:10.1140/epjp/s13360-020-01070-8 · Cited by 14 · see citing works

Evaluation of the Fisher information matrix in nonlinear mixed effect models using adaptive Gaussian quadrature

Nguyen, T. T., & Mentré, F. (2014) · Computational Statistics & Data Analysis · doi:10.1016/j.csda.2014.06.011 · Cited by 13 · see citing works

Altered glucose-dependent secretion of glucagon and ACTH is associated with insulin resistance, assessed by population analysis

Eriksson, J. W., Emad, R. A., Lundqvist, M., Abrahamsson, N., & Kjellsson, M. C. (2023) · Endocrine Connections · doi:10.1530/ec-22-0506 · Cited by 11 · see citing works

Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): from systems biology to systems pharmacology

Benson, N., van der Graaf, P. H., & Peletier, L. A. (2012) · Journal of Mathematical Biology · doi:10.1007/s00285-012-0620-z · Cited by 11 · see citing works

Drug‐Induced Blood Consumption: The Impact of Adverse Drug Reactions on Demand for Blood Components in German Departments of Internal Medicine

Rottenkolber, D., Schmiedl, S., Rottenkolber, M., Thürmann, P., & Hasford, J. (2012) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2012.00890.x · Cited by 9 · see citing works

Pharmacometrics and/or Systems Pharmacology

van der Graaf, P. H. (2018) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12376 · Cited by 9 · see citing works

Prescribing pattern insights from a longitudinal study of older adult inpatients with polypharmacy and chronic non‐cancer pain

Goetschi, A. N., Verloo, H., Wernli, B., Wertli, M. M., & Meyer‐Massetti, C. (2024) · European Journal of Pain · doi:10.1002/ejp.2298 · Cited by 8 · see citing works

A Multiscale Quantitative Systems Pharmacology Model for the Development and Optimization of mRNA Vaccines

Dasti, L., Giampiccolo, S., Pettinà, E., Fiandaca, G., Zangani, N., Leonardelli, L., Hedayioglu, F. D. L., Campanile, E., & Marchetti, L. (2025) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.70041 · Cited by 9 · see citing works

Systems‐based understanding of pharmacological responses with combinations of multidisciplinary methodologies

Kariya, Y., Honma, M., & Suzuki, H. (2013) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.1865 · Cited by 8 · see citing works

A Mechanistic Site-Of-Action Model: A Tool for Informing Right Target, Right Compound, And Right Dose for Therapeutic Antagonistic Antibody Programs

Kapitanov, G., Chabot, J., Narula, J., Roy, M., Neubert, H., Palandra, J., Farrokhi, V., Johnson, J. S., Webster, R., & Jones, H. M. (2021) · Frontiers in Bioinformatics · doi:10.3389/fbinf.2021.731340 · Cited by 8 · see citing works

Interpreting adverse drug reaction (ADR) reports as hospital patient safety incidents

Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2010) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2010.03671.x · Cited by 8 · see citing works

Advancing Pharmacometrics and Systems Pharmacology

Waldman, S. A., & Terzic, A. (2012) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2012.151 · Cited by 8 · see citing works

Infection Risk Associated with High‐Efficacy Disease‐Modifying Agents in Multiple Sclerosis: A Retrospective Cohort Study

Li, J., Hutton, G. J., Varisco, T. J., Lin, Y., Essien, E. J., & Aparasu, R. R. (2024) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.3492 · Cited by 7 · see citing works

A limited sampling strategy based on maximum a posteriori Bayesian estimation for a five-probe phenotyping cocktail

Nguyen, T. T., Bénech, H., Pruvost, A., & Lenuzza, N. (2015) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-015-1953-5 · Cited by 7 · see citing works

Adverse drug event reporting by pharmacists: a systematic literature review

Arabyat, R. M., Martínez, A. S., & Nusair, M. B. (2019) · Journal of Pharmaceutical Health Services Research · doi:10.1111/jphs.12332 · Cited by 7 · see citing works

Combining Isothermal and Adiabatic Mode Experiments for Kinetic Constant Estimation: Application to the Hydrogenation of 5-(Hydroxymethyl)furfural (5-HMF)

Leveneur, S. (2024) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.3c04346 · Cited by 6 · see citing works

Finding optimal design in nonlinear mixed effect models using multiplicative algorithms

Seurat, J., Tang, Y., Mentré, F., & Nguyen, T. T. (2021) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2021.106126 · Cited by 6 · see citing works

Practical QSP application from the preclinical phase to enhance the probability of clinical success: Insights from case studies in oncology

Oishi, M., Sayama, H., Toshimoto, K., Nakayama, T., & Nagasaka, Y. (2024) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2024.101020 · Cited by 6 · see citing works

Evaluation of Estimation Methods and Power of Tests of Discrete Covariates in Repeated Time-to-Event Parametric Models: Application to Gaucher Patients Treated by Imiglucerase

Vigan, M., Stirnemann, J., & Mentré, F. (2014) · The AAPS Journal · doi:10.1208/s12248-014-9575-x · Cited by 6 · see citing works

Systems Approaches Evolve Clinical Pharmacology

Waldman, S. A., van der Graaf, P., & Terzic, A. (2013) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2013.48 · Cited by 5 · see citing works

Drug‐Event Pairs as Indicators for the Detection of Adverse Drug Reactions during Hospitalization in Routinely Collected Electronic Data Sources

Wermund, A. M., Haerdtlein, A., Fehrmann, W., Weglage, C., Dreischulte, T., & Jaehde, U. (2025) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.3635 · Cited by 5 · see citing works

Mechanisms of a Sustained Anti‐inflammatory Drug Response in Alveolar Macrophages Unraveled with Mathematical Modeling

Nyman, E., Lindh, M., Lövfors, W., Simonsson, C., Persson, A., Eklund, D., Bäckström, E., Fridén, M., & Cedersund, G. (2020) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12568 · Cited by 5 · see citing works

Phxnlme: An R package that facilitates pharmacometric workflow of Phoenix NLME analyses

Lim, C. N., Liang, S., Feng, K., Chittenden, J. T., Henry, A., Mouksassi, S., & Birnbaum, A. K. (2016) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2016.12.002 · Cited by 4 · see citing works

Regulatory Modeling and Simulation Moves Into the Next Gear in Europe

van der Graaf, P. (2013) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2013.8 · Cited by 4 · see citing works

Conditional Non-parametric Bootstrap for Non-linear Mixed Effect Models

Comets, E., Rodrigues, C., Jullien, V., & Ursino, M. (2021) · Pharmaceutical Research · doi:10.1007/s11095-021-03052-6 · Cited by 4 · see citing works

Pharmacokinetic–Pharmacodynamic Modelling of Anesthetic Drugs

Proost, J. H. (2017) · Springer eBooks · doi:10.1007/978-3-319-47609-4_7 · Cited by 3 · see citing works

Computer Simulation and Modeling in Pharmacokinetics and Pharmacodynamics

Chawla, R., Rani, V., Mishra, M., & Kumar, K. (2022) · Springer eBooks · doi:10.1007/978-981-16-5180-9_8 · Cited by 3 · see citing works

Pharmacometrics and Systems Pharmacology Software Tutorials and Use: Comments and Guidelines for PSP Contributions

Vicini, P., Friberg, L. E., van der Graaf, P., & Rostami‐Hodjegan, A. (2013) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2013.60 · Cited by 3 · see citing works

Artificial Intelligence and Machine Learning in Clinical Research and Patient Remediation

Mishra, M., Dubey, V., Hackett, T. A., & Kashyap, M. K. (2023) · Springer eBooks · doi:10.1007/978-981-99-6472-7_3 · Cited by 2 · see citing works

Tutorials on the Foundations of Pharmacometrics and Systems Pharmacology

Friberg, L. E. (2013) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2013.27 · Cited by 2 · see citing works

Exploring the Therapeutic Potential of Defective Interfering Particles in Reducing the Replication of SARS-CoV-2

Locke, M., Grebennikov, D. S., SAZONOV, I. A., López‐García, M., Loguinova, M. Y., Meyerhans, A., Bocharov, G. A., & Molina-Parı́s, C. (2024) · Mathematics · doi:10.3390/math12121904 · Cited by 1 · see citing works

Pharmaceutical Inhalation Compounds Development by Using In Silico Modeling Tools

Patel, A., Parab, S., Gupta, S., Chintamaneni, P. K., & G., S. N. K. R. (2025) · Springer eBooks · doi:10.1007/978-981-96-4154-3_8 · Cited by 1 · see citing works

CPT: Pharmacometrics & Systems Pharmacology Publishes Its 100th Article

van der Graaf, P., & Friberg, L. E. (2014) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2014.4 · Cited by 1 · see citing works

Application of Quantitative Biomeasures in Early Drug Discovery

Fountain, S. T., & Vicini, P. (2016) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-319-40793-7_4 · Cited by 1 · see citing works

Pharmacometrics: Application in Drug Development and Clinical Practice

Mankar, S. D., Pawar, T., & Musale, P. (2023) · Asian Journal of Pharmaceutical Analysis · doi:10.52711/2231-5675.2023.00034 · Cited by 1 · see citing works

Systems pharmacology

Maher, T. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813762-8.00008-6 · Cited by 1 · see citing works

Pharmacogenetics of Drug Targets

Daly, A. K., & Arranz, M. J. (2012) · doi:10.1002/9781118116494.ch5

Cytochrome P450 Pharmacogenetics: From Bench to bedside

Shah, I. M., Breslin, C. J., & Mackay, S. P. (2012) · doi:10.1002/9781119967309.ch1

What Pharmacometricians (Should) Do

van der Graaf, P. (2013) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2013.21

Irreversible Pharmacodynamics

Russu, A., & Poggesi, I. (2016) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-319-44534-2_10

CPT: Pharmacometrics & Systems Pharmacology 2.0

Mentré, F. (2019) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12396

Peginterferon-α-2a/peginterferon-α-2b/ribavirin

(2015) · Reactions Weekly · doi:10.1007/s40278-015-3871-9

Quantitative approaches to drug safety: The 2022 PSP special issue

Sobie, E. A. (2022) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12804

Optimiser la prescription posologique des antibiotiques chez le nouveau-né : stratégies et applications cliniques

Leroux, S. (2016) · doi:10.70675/303f57d7zbbb8z4e10z8042za9d0c748ef0f

Optimisation du développement clinique de nouveaux anticancéreux par modélisation de données pharmacocinétiques et pharmacodynamiques précliniques

Pierrillas, P. B. (2016) · doi:10.70675/434b3248z2e9fz4f45z84a7zb5c3c24ce22d

CPT: Pharmacometrics & Systems Pharmacology – Inception, Maturation, and Future Vision

Yeo, K. R., Hennig, S., Krishnaswami, S., Strydom, N., Ayyar, V. S., French, J. L., Sinha, V. P., Sobie, E. A., Zhao, P., Friberg, L. E., et al. (2021) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12680 · Cited by 7 · see citing works

CPT: Pharmacometrics & Systems Pharmacology Publishes Its 100th Article

van der Graaf, P., & Friberg, L. E. (2014) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2014.4 · Cited by 1 · see citing works

Advancing Pharmacometrics and Systems Pharmacology

Waldman, S. A., & Terzic, A. (2012) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2012.151 · Cited by 8 · see citing works

Pharmacometrics and Systems Pharmacology 2030

Mentré, F., Friberg, L. E., Duffull, S. B., French, J., Lauffenburger, D. A., Li, L., Mager, D. E., Sinha, V. P., Sobie, E. A., & Zhao, P. (2019) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1683 · Cited by 27 · see citing works

Tutorials on the Foundations of Pharmacometrics and Systems Pharmacology

Friberg, L. E. (2013) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2013.27 · Cited by 2 · see citing works