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Cited by 413RNA and protein synthesis mechanismsImmune Response and InflammationCancer Immunotherapy and Biomarkers

Unique roles of tryptophanyl-tRNA synthetase in immune control and its therapeutic implications

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Jin, Mirim·2019·Experimental & Molecular Medicine
DOI 10.1038/s12276-018-0196-9PMC PMC6321835
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Abstract

Tryptophanyl tRNA synthetase (WRS) is an essential enzyme as it catalyzes the ligation of tryptophan to its cognate tRNA during translation. Interestingly, mammalian WRS has evolved to acquire domains or motifs for novel functions beyond protein synthesis; WRS can also further expand its functions via alternative splicing and proteolytic cleavage. WRS is localized not only to the nucleus but also to the extracellular space, playing a key role in innate immunity, angiogenesis, and IFN-γ signaling. In addition, the expression of WRS varies significantly in different tissues and pathological states, implying that it plays unique roles in physiological homeostasis and immune defense. This review addresses the current knowledge regarding the evolution, structural features, and context-dependent functions of WRS, particularly focusing on its roles in immune regulation.

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  • Amyloid pathology typically develops early in AD whereas tau pathology occurs later but correlates more accurately with AD progression and cognitive impairment.

    “Amyloid pathology typically develops early in AD whereas tau pathology occurs later but correlates more accurately with AD progression and cognitive impairment3–5.”

    From <i>APOE3</i> - <i>R136S</i> mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition (2024) · cites this paper as [4]

    The Introduction discusses aminoacyl-tRNA synthetases, and the retrieved WRS signaling and clinical relevance passages discuss tryptophanyl-tRNA synthetase rather than Alzheimer’s disease. Searches for amyloid, tau, AD progression, and cognitive impairment found no passage addressing the claimed timing or correlation of these pathologies. (LLM, conf=0.76)

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Authors
Jin, M.
Affiliations
Gachon University (KR)
Corresponding author
Jin, Mirim
ORCID
Jin, Mirim
Venue
Experimental & Molecular Medicine
Publisher
Springer Science and Business Media LLC
Published
2019-01
Volume
51
Issue
1
Pages
1-10
ISSN
  • 1226-3613 (ISSN-L)
  • 2092-6413
DOI
10.1038/s12276-018-0196-9
PMC
PMC6321835
OpenAlex
W2907665228
Cited by
413
References
0
Citations by year
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FWCI
3.78
Type
journal article
Language
en
Open access
Licence
Locations
  • Experimental & Molecular Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Research Foundation of Korea (NRF2015M3A6A4065732)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords
tryptophanyl-tRNA synthetase, immune regulation, innate immunity, angiogenesis, interferon-gamma signaling, alternative splicing, proteolytic cleavage, enzyme evolution, therapeutic target
MeSH terms
Animals, Humans, Immune System Diseases, Tryptophan-tRNA Ligase, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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