The anorexigenic peptide neurotensin relates to insulin sensitivity in obese patients after BPD or RYGB metabolic surgery
Abstract
Neurotensin is a peptide with effects on appetite and intestinal lipid absorption. Experimental data suggest a role in glucose homeostasis, while human data is missing. Here, 20 morbidly obese subjects either underwent biliopancreatic diversion with duodenal switch (BPD), or Roux-en-Y gastric bypass (RYGB) in a randomized fashion. Before and 1 year after surgery, anthropometric data, body composition, clinical biochemistry, insulin sensitivity by means of euglycemic hyperinsulinemic clamps (HEC) and fasting plasma proneurotensin 1-117 were analyzed. Plasma proneurotensin increased significantly more 1 year after BDP than RYGB (P = 0.028), while weight loss was comparable. After metabolic surgery, proneurotensin correlated positively with insulin sensitivity (M-value) (r = 0.55, P < 0.001), while an inverse relationship with fasting glucose, HOMA-IR and HbA1c was observed (P < 0.05 for all components). After adjustment for age and gender, proneurotensin and BMI remained independently related with delta of M-value (β = 0.46 and β = 0.51, P < 0.05, resp.). From these data we conclude that proneurotensin positively correlates with insulin sensitivity uniquely after weight loss induced by metabolic surgery in humans. BDP leads to a stronger increase in the anorexigenic peptide compared to RYGB.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Gastrointestinal derived signals play a key role in weight loss maintenance.
“Gastrointestinal derived signals play a key role in weight loss maintenance.”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [124]
Proglucagon-derived hormones such as GLP-1, GLP-2, glicentin/oxyntomodulin, and nonproglucagon-derived peptides such as PYY and neurotensin increase in bariatric studies.
“Proglucagon-derived hormones such as GLP-1, GLP-2, glicentin/oxyntomodulin, and nonproglucagon-derived peptides such as PYY and neurotensin, have also been demonstrated to increase in bariatric studies [123-125].”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [124]
Cites
Mingrone, G., Panunzi, S., De Gaetano, A., Guidone, C., Iaconelli, A., Nanni, G., Castagneto, M., Bornstein, S., & Rubino, F. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00075-6 · Cited by 1,220 · see citing works
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
Kumashiro, N., Erion, D. M., Zhang, D., Kahn, M., Beddow, S. A., Chu, X., Still, C. D., Gerhard, G. S., Han, X., Dziura, J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113359108 · Cited by 585 · see citing works
An obligatory role for neurotensin in high-fat-diet-induced obesity
Li, J., Song, J., Zaytseva, Y. Y., Liu, Y., Rychahou, P. G., Jiang, K., Starr, M. E., Kim, J. T., Harris, J. W., Yiannikouris, F. B., et al. (2016) · Nature · doi:10.1038/nature17662 · Cited by 260 · see citing works
Melander, O., Maisel, A. S., Almgren, P., Manjer, J., Belting, M., Hedblad, B., Engström, G., Kilger, U., Nilsson, P. M., Bergmann, A., et al. (2012) · JAMA · doi:10.1001/jama.2012.12998 · Cited by 149 · see citing works
Postprandial changes in gut regulatory peptides in gastric bypass patients
Holdstock, C., Zethelius, B., Sundbom, M., Karlsson, F. A., & Engström, B. E. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.157 · Cited by 75 · see citing works
Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery
Ratner, C., Skov, L. J., Raida, Z., Bächler, T., Bellmann‐Sickert, K., Foll, C. L., Sivertsen, B., Dalbøge, L. S., Hartmann, B., Beck‐Sickinger, A. G., et al. (2016) · Endocrinology · doi:10.1210/en.2016-1329 · Cited by 73 · see citing works
Circulating Proneurotensin Concentrations and Cardiovascular Disease Events in the Community
Januzzi, J. L., Lyass, A., Liu, Y., Gaggin, H. K., Trebnick, A., Maisel, A. S., D’Agostino, R. B., Wang, T. J., Massaro, J. M., & Vasan, R. S. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307847 · Cited by 56 · see citing works
Effect of Gastric Bypass and Gastric Banding on Proneurotensin Levels in Morbidly Obese Patients
Christ‐Crain, M., Stoeckli, R., Ernst, A. S., Morgenthaler, N. G., Bilz, S., Korbonits, M., Struck, J., Bergmann, A., Müller-Stich, B. P., & Keller, U. B. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0256 · Cited by 55 · see citing works
Proneurotensin 1–117, a stable neurotensin precursor fragment identified in human circulation
Ernst, A. S., Hellmich, S., & Bergmann, A. (2006) · Peptides · doi:10.1016/j.peptides.2006.01.021 · Cited by 54 · see citing works
Neurotensin stimulates [3H]oleic acid translocation across rat small intestine
Armstrong, M., PARKER, M., Ferris, C. F., & Leeman, S. E. (1986) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1986.251.6.g823 · Cited by 53 · see citing works
Basso, N., Soricelli, E., Castagneto-Gissey, L., Casella, G., Albanese, D., Fava, F., Donati, C., Tuohy, K., Angelini, G., La Neve, F., et al. (2016) · Diabetes · doi:10.2337/db16-0039 · Cited by 53 · see citing works
The metabolic vascular syndrome - guide to an individualized treatment
Hanefeld, M., Pistrosch, F., Bornstein, S. R., & Birkenfeld, A. L. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9345-4 · Cited by 41 · see citing works
Obesity-related insulin resistance: implications for the surgical patient
Tewari, N., Awad, S., Macdonald, I., & Lobo, D. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.100 · Cited by 39 · see citing works
Characteristics of hepatic insulin‐sensitive nonalcoholic fatty liver disease
Shigiyama, F., Kumashiro, N., Furukawa, Y., Funayama, T., Takeno, K., Wakui, N., Ikehara, T., Nagai, H., Taka, H., Fujimura, T., et al. (2017) · Hepatology Communications · doi:10.1002/hep4.1077 · Cited by 25 · see citing works
Effects of biliopancreatic diversion on diurnal leptin, insulin and free fatty acid levels
Raffaelli, M., Iaconelli, A., Nanni, G., Guidone, C., Callari, C., Fernández‐Real, J. M., Bellantone, R. D. A., & Mingrone, G. (2015) · British journal of surgery · doi:10.1002/bjs.9780 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects
Biobaku, F., Ghanim, H., Monte, S. V., Caruana, J. A., & Dandona, P. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa049 · Cited by 68 · see citing works
The Role of Central Neurotensin in Regulating Feeding and Body Weight
Ramirez‐Virella, J., & Leinninger, G. M. (2021) · Endocrinology · doi:10.1210/endocr/bqab038 · Cited by 62 · see citing works
Pereira, S. S., Guimarães, M., Almeida, R., Pereira, A. M., Lobato, C. B., Hartmann, B., Hilsted, L., Holst, J. J., Nora, M. C., & Monteiro, M. P. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0282-z · Cited by 52 · see citing works
The role of gut hormones in the pathogenesis and management of obesity
Makaronidis, J., & Batterham, R. L. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.04.007 · Cited by 21 · see citing works
Circulating pro-neurotensin levels predict bodyweight gain and metabolic alterations in children
Barchetta, I., Bertoccini, L., Sentinelli, F., Bailetti, D., Marini, G., Cimini, F. A., Ceccarelli, V., Struck, J., Schulte, J., Loche, S., et al. (2020) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.11.025 · Cited by 20 · see citing works
The role of gut hormones in obesity
Mok, J., Makaronidis, J., & Batterham, R. L. (2018) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2018.09.005 · Cited by 18 · see citing works
Brethvad, A. O., Zakariassen, H. L., Holt, J., Lundgren, J. R., Jakobsen, A., Hartmann, B., Lehmann, E. W., Kissow, H., Holst, J. J., Madsbad, S., et al. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155534 · Cited by 11 · see citing works
Sentinelli, F., Barchetta, I., Cimini, F. A., Dule, S., Bailetti, D., Cossu, E., Barbonetti, A., Totaro, M., Melander, O., Cavallo, M. G., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076460 · Cited by 7 · see citing works
Ferreira, F. P., Pereira, S. S., Costa, M. M., Guimarães, M., Albrechtsen, N. J. W., Holst, J. J., Nora, M. C., & Monteiro, M. P. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04698-z · Cited by 6 · see citing works
Perry, R. A., Craig, S. L., Gault, V. A., Flatt, P. R., & Irwin, N. (2021) · Bioscience Reports · doi:10.1042/bsr20211275 · Cited by 4 · see citing works
The Effects of Calorie Restriction and Bariatric Surgery on Circulating Proneurotensin Levels
Miskelly, M. G., Berggren, J., Svensson, M., Koffert, J., Honka, H., Kauhanen, S. P., Nuutila, P., Hedenbro, J., Lindqvist, A., Melander, O., et al. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae147 · Cited by 2 · see citing works
Bennet, L., Fawad, A., Struck, J., Lönn, S. L., Bergmann, A., & Melander, O. (2022) · BMC Endocrine Disorders · doi:10.1186/s12902-022-01183-4 · Cited by 2 · see citing works
Cingöz, G., Özyurt, G., Uzun, H., Doruk, Ö. G., Küme, T., Dündar, B. N., & Çatlı, G. (2021) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2021-0031 · Cited by 1 · see citing works
Alves, M. D. P., de Souza, C. V., & Reis, L. B. D. S. M. (2022) · Health Residencies Journal - HRJ · doi:10.51723/hrj.v3i15.453 · Cited by 2 · see citing works
処理ブロック内での分離フィルタの更新回数による2段階雑音低減法の性能(一般, STRAIGHTスペシャルセッション(SS))
Hamid, M. E., 啓太, 小., & 深林, 太. (2006) · Scientific Programming
Fawad, A., Struck, J., Larsson, S. L., Bergmann, A., Melander, O., & Bennet, L. (2022) · Research Square · doi:10.21203/rs.3.rs-698522/v2
Duodenal Switch: Mechanisms of Functioning
Sánchez-Pernaute, A., Rubio, M. Á., & Aguirre, M. E. P. (2023) · Springer eBooks · doi:10.1007/978-3-031-25828-2_2
Bariatrik Cerrahi Geçirmiş Hastaların Kardiyometabolik Risk Belirteçlerinin Değerlendirilmesi
Kızıltan, G., & Başerdem, N. (2025) · Sağlık Bilimlerinde Değer · doi:10.33631/sabd.1396786
- Authors
- von Loeffelholz, C., Gissey, L. C., Schumann, T., Henke, C., Kurzbach, A., Struck, J., Bergmann, A., Hanefeld, M., Schatz, U., Bornstein, S. R., Casella, G., Mingrone, G., & Birkenfeld, A. L.
- Affiliations
- University Hospital Carl Gustav Carus (DE)
- SphingoTec GmbH (Germany) (DE)
- Università Cattolica del Sacro Cuore (IT)
- Sapienza University of Rome (IT)
- King's College London (GB)
- Corresponding author
- Birkenfeld, Andreas L.
- ORCID
- Venue
- International Journal of Obesity
- Published
- 2018-05-24
- Volume
- 42
- Issue
- 12
- Pages
- 2057-2061
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W2803992310
- Cited by
- 18
- References
- 15
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Site cant be reached (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Sphingotec GmbH
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- neurotensin, insulin sensitivity, biliopancreatic diversion with duodenal switch, Roux-en-Y gastric bypass, bariatric surgery, morbid obesity, weight loss, insulin resistance, glucose homeostasis, anorexigenic peptides
- MeSH terms
- Adult, Blood Glucose, Female, Humans, Insulin Resistance, Male, Middle Aged, Neurotensin, Obesity, Morbid, Protein Precursors, Gastric Bypass, Biliopancreatic Diversion
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
