CoChat
Sign Up
Cited by 280Oral microbiology and periodontitis researchBacterial biofilms and quorum sensingDental materials and restorations

Advancing antimicrobial strategies for managing oral biofilm infections

Open access
Jiao, Yang, Tay, Franklin R., Niu, Li-na, Chen, Ji-hua·2019·International Journal of Oral Science
DOI 10.1038/s41368-019-0062-1PMC PMC6802668
Open this paper in CoChat — free accountOpen PDF

Abstract

Effective control of oral biofilm infectious diseases represents a major global challenge. Microorganisms in biofilms exhibit increased drug tolerance compared with planktonic cells. The present review covers innovative antimicrobial strategies for controlling oral biofilm-related infections published predominantly over the past 5 years. Antimicrobial dental materials based on antimicrobial agent release, contact-killing and multi-functional strategies have been designed and synthesized for the prevention of initial bacterial attachment and subsequent biofilm formation on the tooth and material surface. Among the therapeutic approaches for managing biofilms in clinical practice, antimicrobial photodynamic therapy has emerged as an alternative to antimicrobial regimes and mechanical removal of biofilms, and cold atmospheric plasma shows significant advantages over conventional antimicrobial approaches. Nevertheless, more preclinical studies and appropriately designed and well-structured multi-center clinical trials are critically needed to obtain reliable comparative data. The acquired information will be helpful in identifying the most effective antibacterial solutions and the most optimal circumstances to utilize these strategies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/s41368-019-0062-1

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Many antibacterial studies of PDA are based on single-species or simplified biofilm models.

    “Many antibacterial studies are based on single-species or simplified biofilm models, which cannot fully reflect the complexity of mature multispecies oral biofilms.82”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [82]

    The Cold atmospheric plasma section (page unavailable) describes an antibacterial study using single-species oral biofilms, while the Introduction describes mature biofilms as containing multiple species. The review does not establish that many antibacterial studies use single-species or simplified models, and it does not make that claim specifically about PDA studies. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Single-species or simplified biofilm models cannot fully reflect the complexity of mature multispecies oral biofilms.

    “Many antibacterial studies are based on single-species or simplified biofilm models, which cannot fully reflect the complexity of mature multispecies oral biofilms.82”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [82]

    The Introduction (page unavailable) describes mature biofilms as containing multiple microbial species and oral biofilms as arising from complex interactions. The Cold atmospheric plasma section (page unavailable) describes a study of single-species oral biofilms, but the review does not establish that many antibacterial studies use such models or explicitly assess how well they reflect mature multispecies biofilms. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The citation lists haven’t been fetched yet

References 175 · Cited by 280

Research works printed but not linked: 161

  1. [1]Flemming HC Biofilms: an emergent form of bacterial life Nat. Rev. Microbiol. 2016 14 563 575 10.1038/nrmicro.2016.94 27510863 · DOI · Paper page
  2. [2]Flemming HC Wuertz S Bacteria and archaea on Earth and their abundance in biofilms Nat. Rev. Microbiol. 2019 4 247 260 10.1038/s41579-019-0158-9 30760902 · DOI · Paper page
  3. [3]Bowen WH Burne RA Wu H Koo H Oral biofilms: pathogens, matrix, and polymicrobial interactions in microenvironments Trends Microbiol. 2018 26 229 242 10.1016/j.tim.2017.09.008 29097091 PMC5834367 · DOI · Paper page
  4. [4]David D Understanding biofilm resistance to antibacterial agents Nat. Rev. Drug Discov. 2003 2 114 122 10.1038/nrd1008 12563302 · DOI
  5. [5]Morgan-Sagastume F Larsen P Nielsen JL Nielsen PH Characterization of the loosely attached fraction of activated sludge bacteria Water Res. 2008 42 843 854 10.1016/j.watres.2007.08.026 17889248 · DOI
  6. [6]Stoodley P Sauer K Davies DG Costerton JW Biofilms as complex differentiated communities Annu. Rev. Microbiol. 2002 56 187 209 10.1146/annurev.micro.56.012302.160705 12142477 · DOI
  7. [7]Mira A Simon-Soro A Curtis MA Role of microbial communities in the pathogenesis of periodontal diseases and caries J. Clin. Periodontol. 2017 44 Suppl. 18 S23 S38 10.1111/jcpe.12671 28266108 · DOI
  8. [8]Lin NJ Biofilm over teeth and restorations: what do we need to know? Dent. Mater. 2017 33 667 680 10.1016/j.dental.2017.03.003 28372810 · DOI
  9. [9]Allaker RP The use of nanoparticles to control oral biofilm formation J. Dent. Res. 2010 89 1175 1186 10.1177/0022034510377794 20739694 · DOI
  10. [10]Cloutier M Mantovani D Rosei F Antibacterial coatings: challenges, perspectives, and opportunities Trends Biotechnol. 2015 33 637 652 10.1016/j.tibtech.2015.09.002 26463723 · DOI
  11. [11]Colton MB Ehrlich E Bactericidal effect obtained by addition of antibiotics to dental cements and direct filling resins J. Am. Dent. Assoc. 1953 47 524 531 10.14219/jada.archive.1953.0206 13108496 · DOI
  12. [12]Campoccia D Montanaro L Arciola CR A review of the biomaterials technologies for infection-resistant surfaces Biomaterials 2013 34 8533 8554 10.1016/j.biomaterials.2013.07.089 23953781 · DOI
  13. [13]Darouiche RO A comparison of two antimicrobial-impregnated central venous catheters. Catheter Study Group N. Engl. J. Med. 1999 340 1 8 10.1056/NEJM199901073400101 9878638 · DOI
  14. [14]Padovani GC Advances in dental materials through nanotechnology: facts, perspectives and toxicological aspects Trends Biotechnol. 2015 33 621 636 10.1016/j.tibtech.2015.09.005 26493710 · DOI
  15. [15]Melo MA Guedes SF Xu HH Rodrigues LK Nanotechnology-based restorative materials for dental caries management Trends Biotechnol. 2013 31 459 467 10.1016/j.tibtech.2013.05.010 23810638 PMC3845439 · DOI
  16. [16]Cheng L Nanotechnology strategies for antibacterial and remineralizing composites and adhesives to tackle dental caries Nanomedicine 2015 10 627 641 10.2217/nnm.14.191 25723095 PMC4347904 · DOI
  17. [17]Liu Y Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control Chem. Soc. Rev. 2019 48 428 446 10.1039/C7CS00807D 30601473 · DOI · Paper page
  18. [18]Nicolas B Nitric oxide signaling in Pseudomonas aeruginosa biofilms mediates phosphodiesterase activity, decreased cyclic di-GMP levels, and enhanced dispersal J. Bacteriol. 2009 191 7333 7342 10.1128/JB.00975-09 19801410 PMC2786556 · DOI
  19. [19]Taylor PW Hamilton-Miller JM Stapleton PD Antimicrobial properties of green tea catechins Food Sci. Technol. Bull. 2005 2 71 81 19844590 PMC2763290
  20. [20]Quah SY Wu S Lui JN Sum CP Tan KS N-acetylcysteine inhibits growth and eradicates biofilm of Enterococcus faecalis J. Endod. 2012 38 81 85 10.1016/j.joen.2011.10.004 22152626 · DOI
  21. [21]Park K Controlled drug delivery systems: past forward and future back J. Control. Release 2014 190 3 8 10.1016/j.jconrel.2014.03.054 24794901 PMC4142099 · DOI
  22. [22]Jiao Y Quaternary ammonium-based biomedical materials: state-of-the-art, toxicological aspects and antimicrobial resistance Prog. Polym. Sci. 2017 71 53 90 10.1016/j.progpolymsci.2017.03.001 PMC7111226 32287485 · DOI · Paper page
  23. [23]Munozbonilla A Muñoz-Bonilla A Fernández-García M Polymeric materials with antimicrobial activity Prog. Polym. Sci. 2012 37 281 339 10.1016/j.progpolymsci.2011.08.005 · DOI · Paper page
  24. [24]Tezel U Pavlostathis SG Quaternary ammonium disinfectants: microbial adaptation, degradation and ecology Curr. Opin. Biotechnol. 2015 33 296 304 10.1016/j.copbio.2015.03.018 25864173 · DOI
  25. [25]Krasimir V Jessica C Griesser HJ Antibacterial surfaces for biomedical devices Expert Rev. Med. Devices 2009 6 553 567 10.1586/erd.09.36 19751126 · DOI
  26. [28]Beyth N Surface antimicrobial activity and biocompatibility of incorporated polyethylenimine nanoparticles Biomaterials 2008 29 4157 4163 10.1016/j.biomaterials.2008.07.003 18678404 · DOI
  27. [29]Imazato S Russell RR McCabe JF Antibacterial activity of MDPB polymer incorporated in dental resin J. Dent. 1994 23 1437 1443 7782530
  28. [33]Li F Effects of a dental adhesive incorporating antibacterial monomer on the growth, adherence and membrane integrity of Streptococcus mutans J. Dent. 2009 37 289 296 10.1016/j.jdent.2008.12.004 19185408 · DOI
  29. [34]Imazato S Ma S Chen JH Xu HH Therapeutic polymers for dental adhesives: loading resins with bio-active components Dent. Mater. 2014 30 97 104 10.1016/j.dental.2013.06.003 23899387 PMC4312699 · DOI
  30. [35]Makvandi P Jamaledin R Jabbari M Nikfarjam N Borzacchiello A Antibacterial quaternary ammonium compounds in dental materials: a systematic review Dent. Mater. 2018 34 851 867 10.1016/j.dental.2018.03.014 29678327 · DOI
  31. [36]Cocco AR Rosa WL Silva AF Lund RG Piva E A systematic review about antibacterial monomers used in dental adhesive systems: current status and further prospects Dent. Mater. 2015 31 1345 1362 10.1016/j.dental.2015.08.155 26345999 · DOI
  32. [37]Huang L Antibacterial effect of a resin incorporating a novel polymerizable quaternary ammonium salt MAE-DB against Streptococcus mutans J. Biomed. Mater. Res. Part B 2012 100 1353 1358 10.1002/jbm.b.32703 22566399 · DOI · Paper page
  33. [39]Cheng L Tetracalcium phosphate composite containing quaternary ammonium dimethacrylate with antibacterial properties J. Biomed. Mater. Res. Part B 2012 100 726 734 10.1002/jbm.b.32505 PMC3373275 22190356 · DOI
  34. [40]Antonucci JM Synthesis and characterization of dimethacrylates containing quaternary ammonium functionalities for dental applications Dent. Mater. 2012 28 219 228 10.1016/j.dental.2011.10.004 22035983 PMC3259208 · DOI · Paper page
  35. [42]Liang J The anti-caries effects of dental adhesive resin influenced by the position of functional groups in quaternary ammonium monomers Dent. Mater. 2017 34 400 411 10.1016/j.dental.2017.11.021 29269159 · DOI
  36. [43]Zhou W Improved secondary caries resistance via augmented pressure displacement of antibacterial adhesive Sci. Rep. 2016 6 22269 10.1038/srep22269 26928742 PMC4772086 · DOI
  37. [44]Zhou, W. et al. Caries-resistant bonding layer in dentin. Sci. Rep.6, 32740 (2016). PMC5013435 27599621
  38. [45]Wu T Evaluation of novel anticaries adhesive in a secondary caries animal model Caries Res. 2018 52 14 21 10.1159/000481832 29232675 · DOI
  39. [46]Imazato S Tay FR Kaneshiro AV Takahashi Y Ebisu S An in vivo evaluation of bonding ability of comprehensive antibacterial adhesive system incorporating MDPB Dent. Mater. 2007 23 170 176 10.1016/j.dental.2006.01.005 16469372 · DOI · Paper page
  40. [47]Silva ON Exploring the pharmacological potential of promiscuous host-defense peptides: from natural screenings to biotechnological applications Front. Microbiol. 2011 2 232 22125552 PMC3222093
  41. [48]Lima SMF Antimicrobial peptide-based treatment for endodontic infections—biotechnological innovation in endodontics Biotechnol. Adv. 2015 33 203 213 10.1016/j.biotechadv.2014.10.013 25447423 · DOI
  42. [49]Brogden KA Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat. Rev. Microbiol. 2005 3 238 250 10.1038/nrmicro1098 15703760 · DOI · Paper page
  43. [50]Di Luca M Maccari G Nifosì R Treatment of microbial biofilms in the post-antibiotic era: prophylactic and therapeutic use of antimicrobial peptides and their design by bioinformatics tools FEMS Immunol. Med. Microbiol. 2014 70 257 270 24515391
  44. [51]P orto WF Pires AS Franco OL Computational tools for exploring sequence databases as a resource for antimicrobial peptides Biotechnol. Adv. 2017 35 337 349 10.1016/j.biotechadv.2017.02.001 28216008 · DOI
  45. [52]Fjell CD Hiss JA Hancock RE Schneider G Designing antimicrobial peptides: form follows function Nat. Rev. Drug Discov. 2012 11 37 51 10.1038/nrd3591 22173434 · DOI
  46. [53]Onaizi SA Leong SS Tethering antimicrobial peptides: current status and potential challenges Biotechnol. Adv. 2011 29 67 74 10.1016/j.biotechadv.2010.08.012 20817088 · DOI
  47. [54]Kazemzadeh-Narbat M Antimicrobial peptides on calcium phosphate-coated titanium for the prevention of implant-associated infections Biomaterials 2010 31 9519 9526 10.1016/j.biomaterials.2010.08.035 20970848 · DOI
  48. [55]Moussa DG Fok A Aparicio C Hydrophobic and antimicrobial dentin: a peptide-based 2-tier protective system for dental resin composite restorations Acta Biomater. 2019 88 251 265 10.1016/j.actbio.2019.02.007 30753942 PMC6474255 · DOI
  49. [56]Tiller JC Liao CJ Lewis K Klibanov AM Designing surfaces that kill bacteria on contact Proc. Natl Acad. Sci. USA 2001 98 5981 5985 10.1073/pnas.111143098 11353851 PMC33409 · DOI
  50. [57]Li, F., Weir, M. D., Fouad, A. F. & Xu, H. H. Effect of salivary pellicle on antibacterial activity of novel antibacterial dental adhesives using a dental plaque microcosm biofilm model. Dent. Mater.30, 182–191 (2014). PMC4023513 24332270
  51. [58]Jiao Y Methacryloxylethyl cetyl ammonium chloride induces DNA damage and apoptosis in human dental pulp cells via generation of oxidative stress Int. J. Biol. Sci. 2016 12 580 593 10.7150/ijbs.14578 27143955 PMC4852205 · DOI · Paper page
  52. [59]Behzadi S Cellular uptake of nanoparticles: journey inside the cell Chem. Soc. Rev. 2017 46 4218 4244 10.1039/C6CS00636A 28585944 PMC5593313 · DOI · Paper page
  53. [60]Yu Q Wu Z Chen H Dual-function antibacterial surfaces for biomedical applications Acta Biomater. 2015 16 1 13 10.1016/j.actbio.2015.01.018 25637065 · DOI · Paper page
  54. [61]Wei T Yu Q Chen H Responsive and synergistic antibacterial coatings: fighting against bacteria in a smart and effective way Adv. Healthc. Mater. 2019 8 e1801381 10.1002/adhm.201801381 30609261 · DOI
  55. [62]Damm C Münstedt H Rosch A Long-term antimicrobial polyamide 6/silver-nanocomposites J. Mater. Sci. 2007 42 6067 6073 10.1007/s10853-006-1158-5 · DOI
  56. [63]Espinosa-Cristóbal LF Adherence inhibition of Streptococcus mutans on dental enamel surface using silver nanoparticles Mater. Sci. Eng. C 2013 33 2197 2202 10.1016/j.msec.2013.01.039 23498248 · DOI
  57. [64]Cheng L Effects of antibacterial primers with quaternary ammonium and nano-silver on Streptococcus mutans impregnated in human dentin blocks Dent. Mater. 2013 29 462 472 10.1016/j.dental.2013.01.011 23422420 PMC3631006 · DOI · Paper page
  58. [65]Zhang K Effect of quaternary ammonium and silver nanoparticle-containing adhesives on dentin bond strength and dental plaque microcosm biofilms Dent. Mater. 2012 28 842 852 10.1016/j.dental.2012.04.027 22592165 PMC3393841 · DOI · Paper page
  59. [66]Cheng L Anti-biofilm dentin primer with quaternary ammonium and silver nanoparticles J. Dent. Res. 2012 91 598 604 10.1177/0022034512444128 22492276 PMC3348066 · DOI · Paper page
  60. [67]Peulen TO Wilkinson KJ Diffusion of nanoparticles in a biofilm Environ. Sci. Technol. 2011 45 3367 3373 10.1021/es103450g 21434601 · DOI
  61. [68]Cheng L Antibacterial amorphous calcium phosphate nanocomposites with a quaternary ammonium dimethacrylate and silver nanoparticles Dent. Mater. 2012 28 561 572 10.1016/j.dental.2012.01.005 22305716 PMC3322309 · DOI · Paper page
  62. [69]Fan C Development of an antimicrobial resin—a pilot study Dent. Mater. 2011 27 322 328 10.1016/j.dental.2010.11.008 21112619 · DOI
  63. [70]Cheng L Effect of amorphous calcium phosphate and silver nanocomposites on dental plaque microcosm biofilms J. Biomed. Mater. Res. B 2012 100 1378 1386 10.1002/jbm.b.32709 PMC3373271 22566464 · DOI
  64. [71]Feng X Application of dental nanomaterials: potential toxicity to the central nervous system Int. J. Nanomed. 2015 10 3547 3565 10.2217/nnm.15.178 PMC4437601 25999717 · DOI
  65. [72]Storm WL Dual action antimicrobial surfaces via combined nitric oxide and silver release J. Biomed. Mater. Res. Part A 2015 103 1974 1984 10.1002/jbm.a.35331 25205657 · DOI
  66. [73]Samani, S., Hossainalipour, S. M., Tamizifar, M. & Rezaie, H. R. In vitro antibacterial evaluation of sol-gel-derived Zn−, Ag−, and (Zn+Ag)-doped hydroxyapatite coatings against methicillin-resistant Staphylococcus aureus. J. Biomed. Mater. Res. A101, 222–230 (2012). 22847909
  67. [74]Fayaz AM Biogenic synthesis of silver nanoparticles and their synergistic effect with antibiotics: a study against Gram-positive and Gram-negative bacteria Nanomedicine 2010 6 103 109 10.1016/j.nano.2009.04.006 19447203 · DOI
  68. [75]Ma S Adhesive materials with bioprotective/biopromoting functions Curr. Oral Health Rep. 2014 1 213 221 10.1007/s40496-014-0027-6 · DOI
  69. [76]Zhao J Liu Y Sun W Yang X First detection, characterization, and application of amorphous calcium phosphate in dentistry J. Dent. Sci. 2012 7 316 323 10.1016/j.jds.2012.09.001 · DOI
  70. [77]Cheng L Antibacterial and physical properties of calcium-phosphate and calcium-fluoride nanocomposites with chlorhexidine Dent. Mater. 2012 28 573 583 10.1016/j.dental.2012.01.006 22317794 PMC3322264 · DOI
  71. [78]Cheng L Dental plaque microcosm biofilm behavior on calcium phosphate nanocomposite with quaternary ammonium Dent. Mater. 2012 28 853 862 10.1016/j.dental.2012.04.024 22578992 PMC3393817 · DOI · Paper page
  72. [79]Liu Y Antibacterial and remineralizing orthodontic adhesive containing quaternary ammonium resin monomer and amorphous calcium phosphate nanoparticles J. Dent. 2018 72 53 63 10.1016/j.jdent.2018.03.004 29534887 · DOI
  73. [80]Li F Wang P Weir MD Fouad AF Xu HH Evaluation of antibacterial and remineralizing nanocomposite and adhesive in rat tooth cavity model Acta Biomater. 2014 10 2804 2813 10.1016/j.actbio.2014.02.033 24583320 PMC4312698 · DOI · Paper page
  74. [82]Al-Shammery Deema Michelogiannakis Dimitrios Ahmed Zain Uddin Ahmed Hameeda Bashir Rossouw P. Emile Romanos Georgios E. Javed Fawad Scope of antimicrobial photodynamic therapy in Orthodontics and related research: A review Photodiagnosis and Photodynamic Therapy 2019 25 456 459 10.1016/j.pdpdt.2019.02.011 30753923 · DOI
  75. [83]Hu X Huang YY Wang Y Wang X Hamblin MR Antimicrobial photodynamic therapy to control clinically relevant biofilm infections Front. Microbiol. 2018 9 1299 10.3389/fmicb.2018.01299 29997579 PMC6030385 · DOI
  76. [84]Takasaki AA Application of antimicrobial photodynamic therapy in periodontal and peri-implant diseases Periodontol. 2000 2009 51 109 140 10.1111/j.1600-0757.2009.00302.x 19878472 · DOI
  77. [85]Konopka K Goslinski T Photodynamic therapy in dentistry J. Dent. Res. 2007 86 694 707 10.1177/154405910708600803 17652195 · DOI
  78. [86]Wilson M Lethal photosensitisation of oral bacteria and its potential application in the photodynamic therapy of oral infections Photochem. Photobiol. Sci. 2004 3 412 418 10.1039/b211266c 15122357 · DOI
  79. [87]Williams JA Pearson GJ Colles MJ Wilson M The effect of variable energy input from a novel light source on the photoactivated bactericidal action of toluidine blue O on Streptococcus mutans Caries Res. 2003 37 190 193 10.1159/000070443 12740542 · DOI
  80. [88]Zanin IC Gonçalves RB Junior AB Hope CK Pratten J Susceptibility of Streptococcus mutans biofilms to photodynamic therapy: an in vitro study J. Antimicrob. Chemother. 2005 56 324 330 10.1093/jac/dki232 15983029 · DOI
  81. [89]Burns T Wilson M Pearson GJ Effect of dentine and collagen on the lethal photosensitization of Streptococcus mutans Caries Res. 1995 29 192 197 10.1159/000262068 7621494 · DOI
  82. [90]Williams JA Pearson GJ Colles MJ Wilson M The photo-activated antibacterial action of toluidine blue O in a collagen matrix and in carious dentine Caries Res. 2004 38 530 536 10.1159/000080582 15528907 · DOI
  83. [91]Chan Y Lai CH Bactericidal effects of different laser wavelengths on periodontopathic germs in photodynamic therapy Lasers Med. Sci. 2003 18 51 55 10.1007/s10103-002-0243-5 12627274 · DOI
  84. [92]Wilson M Sarkar S Bulman JS Effect of blood on lethal photosensitization of bacteria in subgingival plaque from patients with chronic periodontitis Lasers Med. Sci. 1993 8 297 303 10.1007/BF02547854 8388448 · DOI
  85. [93]Wood S Metcalf D Devine D Robinson C Erythrosine is a potential photosensitizer for the photodynamic therapy of oral plaque biofilms J. Antimicrob. Chemother. 2006 57 680 684 10.1093/jac/dkl021 16464894 · DOI
  86. [94]Reynolds EC Remineralization of enamel subsurface lesions by casein phosphopeptide-stabilized calcium phosphate solutions J. Dent. Res. 1997 76 1587 1595 10.1177/00220345970760091101 9294493 · DOI
  87. [95]Müller P Guggenheim B Schmidlin PR Efficacy of gasiform ozone and photodynamic therapy on a multispecies oral biofilm in vitro Eur. J. Oral Sci. 2007 115 77 80 10.1111/j.1600-0722.2007.00418.x 17305720 · DOI
  88. [96]Pihlstrom BL Michalowicz BS Johnson NW Periodontal diseases Lancet 2005 366 1809 1820 10.1016/S0140-6736(05)67728-8 16298220 · DOI
  89. [97]Cobb Charles M. Clinical significance of non-surgical periodontal therapy: an evidence-based perspective of scaling and root planing Journal of Clinical Periodontology 2002 29 s2 22 32 10.1034/j.1600-051X.29.s2.4.x 12010523 · DOI · Paper page
  90. [98]Sherman PR The effectiveness of subgingival scaling and root planning. I. Clinical detection of residual calculus J. Periodontol. 1990 61 3 8 10.1902/jop.1990.61.1.3 2179512 · DOI
  91. [99]Roca I The global threat of antimicrobial resistance: science for intervention New Microbes New Infect. 2015 6 22 29 10.1016/j.nmni.2015.02.007 26029375 PMC4446399 · DOI · Paper page
  92. [100]Horev B PH-Activated nanoparticles for controlled topical delivery of farnesol to disrupt oral biofilm virulence ACS Nano 2015 9 2390 2404 10.1021/nn507170s 25661192 PMC4395463 · DOI
  93. [101]Dobson J Wilson M Sensitization of oral bacteria in biofilms to killing by light from a low-power laser Arch. Oral Biol. 1992 37 883 887 10.1016/0003-9969(92)90058-G 1334649 · DOI
  94. [102]Kömerik N In vivo killing of Porphyromonas gingivalis by toluidine blue-mediated photosensitization in an animal model Antimicrob. Agents Chemother. 2003 47 932 940 10.1128/AAC.47.3.932-940.2003 12604524 PMC149320 · DOI
  95. [103]Zhang J Photodynamic therapy versus systemic antibiotic for the treatment of periodontitis in a rat model J. Periodontol. 2019 90 798 807 30632612
  96. [104]de Oliveira RR Schwartz-Filho HO Novaes AB Jr Taba M Jr. Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: a preliminary randomized controlled clinical study J. Periodontol. 2007 78 965 973 10.1902/jop.2007.060494 17539707 · DOI
  97. [105]de Oliveira RR Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: cytokine profile in gingival crevicular fluid, preliminary results J. Periodontol. 2009 80 98 105 10.1902/jop.2009.070465 19228095 · DOI
  98. [106]Xue D Zhao Y Clinical effectiveness of adjunctive antimicrobial photodynamic therapy for residual pockets during supportive periodontal therapy: a systematic review and meta-analysis Photodiagn. Photodyn. Ther. 2017 17 127 133 10.1016/j.pdpdt.2016.11.011 27888165 · DOI
  99. [107]Yilmaz S Effect of galium arsenide diode laser on human periodontal disease: a microbiological and clinical study Lasers Surg. Med. 2002 30 60 66 10.1002/lsm.10010 11857606 · DOI
  100. [108]Fontana CR The antibacterial effect of photodynamic therapy in dental plaque-derived biofilms J. Periodontal Res. 2009 44 751 759 10.1111/j.1600-0765.2008.01187.x 19602126 PMC2784141 · DOI
  101. [109]Whiteley M Gene expression in Pseudomonas aeruginosa biofilms Nature 2001 413 860 864 10.1038/35101627 11677611 · DOI
  102. [110]Fimple JL Photodynamic treatment of endodontic polymicrobial infection in vitro J. Endod. 2008 34 728 734 10.1016/j.joen.2008.03.011 18498901 PMC2596687 · DOI
  103. [111]Garcez AS Nuñez SC Hamblin MR Ribeiro MS Antimicrobial effects of photodynamic therapy on patients with necrotic pulps and periapical lesion J. Endod. 2008 34 138 142 10.1016/j.joen.2007.10.020 18215668 PMC2808698 · DOI
  104. [112]Xu Y Endodontic antimicrobial photodynamic therapy: safety assessment in mammalian cell cultures J. Endod. 2009 35 1567 1572 10.1016/j.joen.2009.08.002 19840649 PMC2776084 · DOI
  105. [113]George S Kishen A Photophysical, photochemical, and photobiological characterization of methylene blue formulations for light-activated root canal disinfection J. Biomed. Opt. 2007 12 034029 10.1117/1.2745982 17614737 · DOI
  106. [114]Bonsor SJ Nichol R Reid TM Pearson GJ An alternative regimen for root canal disinfection Br. Dent. J. 2006 201 101 105 10.1038/sj.bdj.4813819 16865142 · DOI
  107. [115]Mizutani K Lasers in minimally invasive periodontal and peri-implant therapy Periodontol. 2000 2016 71 185 212 10.1111/prd.12123 27045437 · DOI
  108. [116]Bliss JM Bigelow CE Foster TH Haidaris CG Susceptibility of Candida species to photodynamic effects of photofrin Antimicrob. Agents Chemother. 2004 48 2000 2006 10.1128/AAC.48.6.2000-2006.2004 15155191 PMC415596 · DOI
  109. [117]Varela Kellesarian S Efficacy of antimicrobial photodynamic therapy in the disinfection of acrylic denture surfaces: a systematic review Photodiagn. Photodyn. Ther. 2017 17 103 110 10.1016/j.pdpdt.2016.12.001 27931875 · DOI
  110. [118]Zhang K Developing a new generation of therapeutic dental polymers to inhibit oral biofilms and protect teeth Materials 2018 11 pii: E1747 10.3390/ma11091747 PMC6165509 30227632 · DOI
  111. [119]Feng L NIR-driven graphitic-phase carbon nitride nanosheets for efficient bioimaging and photodynamic therapy J. Mater. Chem. B 2016 4 8000 8008 10.1039/C6TB02232D 32263789 · DOI
  112. [120]Gilmore BF Cold plasmas for biofilm control: opportunities and challenges Trends Biotechnol. 2018 36 627 638 10.1016/j.tibtech.2018.03.007 29729997 PMC12168448 · DOI
  113. [121]Isbary G Cold atmospheric plasma devices for medical issues Expert Rev. Med. Devices 2013 10 367 377 10.1586/erd.13.4 23668708 · DOI
  114. [122]Bourke P Ziuzina D Han L Cullen PJ Gilmore BF Microbiological interactions with cold plasma J. Appl. Microbiol. 2017 123 308 324 10.1111/jam.13429 28245092 · DOI
  115. [123]Lademann O Skin disinfection by plasma–tissue interaction: comparison of the effectivity of tissue-tolerable plasma and a standard antiseptic Skin Pharmacol. Physiol. 2011 24 284 288 10.1159/000329913 21709431 · DOI
  116. [124]Isbary G Successful and safe use of 2 min cold atmospheric argon plasma in chronic wounds: results of a randomized controlled trial Br. J. Dermatol. 2012 167 404 410 10.1111/j.1365-2133.2012.10923.x 22385038 PMC7161860 · DOI
  117. [125]Weiss MA Virucide properties of cold atmospheric plasma for future clinical applications J. Med. Virol. 2017 89 952 959 10.1002/jmv.24701 27696466 · DOI
  118. [126]Graves David B The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology Journal of Physics D: Applied Physics 2012 45 26 263001 10.1088/0022-3727/45/26/263001 · DOI
  119. [127]Gallagher MJ Rapid inactivation of airborne bacteria using atmospheric pressure dielectric barrier grating discharge IEEE Trans. Plasma Sci. 2007 35 1501 1510 10.1109/TPS.2007.905209 · DOI
  120. [128]Mendis DA Rosenberg M Azam F A note on the possible electrostatic disruption of bacteria IEEE Trans. Plasma Sci. 2000 28 1304 1306 10.1109/27.893321 · DOI
  121. [129]Liu Y Liu Q Yu QS Wang Y Nonthermal atmospheric plasmas in dental restoration J. Dent. Res. 2016 95 496 505 10.1177/0022034516629425 26848068 PMC4841281 · DOI
  122. [130]Chavez de Paz LE Redefining the persistent infection in root canals: possible role of biofilm communities J. Endod. 2007 33 652 662 10.1016/j.joen.2006.11.004 17509401 · DOI
  123. [131]Matsuo T An immunohistological study of the localization of bacteria invading root pulpal walls of teeth with periapical lesions J. Endod. 2003 29 194 200 10.1097/00004770-200303000-00008 12669880 · DOI
  124. [132]Siqueira JF Efficacy of instrumentation techniques and irrigation regimens in reducing the bacterial population within root canals J. Endod. 2002 28 181 184 10.1097/00004770-200203000-00009 12017176 · DOI
  125. [133]Wang R The effect of an atmospheric pressure, dc nonthermal plasma microjet on tooth root canal, dentinal tubules infection and reinfection prevention Plasma Med. 2011 1 143 155 10.1615/PlasmaMed.2011003259 · DOI
  126. [134]Dahlén G Samuelsson W Molander A Reit C Identification and antimicrobial susceptibility of enterococci isolated from the root canal Oral Microbiol. Immunol. 2000 15 309 312 10.1034/j.1399-302x.2000.150507.x 11154422 · DOI
  127. [135]Sathorn C Parashos P Messer H Antibacterial efficacy of calcium hydroxide intracanal dressing: a systematic review and meta-analysis Int. Endod. J. 2007 40 2 10 10.1111/j.1365-2591.2006.01197.x 17209826 · DOI
  128. [136]Nakajo K Nakazawa F Iwaku M Hoshino E Alkali-resistant bacteria in root canal systems Oral Microbiol. Immunol. 2004 19 390 394 10.1111/j.1399-302x.2004.00174.x 15491465 · DOI
  129. [137]Jiang C Schaudinn C Jaramillo DE Webster P Costerton JW In vitro antimicrobial effect of a cold plasma jet against Enterococcus faecalis biofilms ISRN Dent. 2012 2012 295736 22461988 PMC3302053
  130. [138]Li Y Evaluation of cold plasma treatment and safety in disinfecting 3-week root canal Enterococcus faecalis biofilm in vitro J. Endod. 2015 41 1325 1330 10.1016/j.joen.2014.10.020 26027875 · DOI
  131. [139]Pan J Cold plasma therapy of a tooth root canal infected with Enterococcus faecalis biofilms in vitro J. Endod. 2013 39 105 110 10.1016/j.joen.2012.08.017 23228267 · DOI
  132. [140]Blumhagen A Plasma deactivation of oral bacteria seeded on hydroxyapatite disks as tooth enamel analogue Am. J. Dent. 2014 27 84 90 25000666 PMC4090609
  133. [141]Sladek REJ Stoffels E Walraven R Tielbeek PJA Koolhoven RA Plasma treatment of dental cavities: a feasibility study IEEE Trans. Plasma Sci. 2004 32 1540 1543 10.1109/TPS.2004.832636 · DOI
  134. [142]Rupf S Killing of adherent oral microbes by a non-thermal atmospheric plasma jet J. Med. Microbiol. 2010 59 206 212 10.1099/jmm.0.013714-0 19910483 · DOI
  135. [143]Duarte S Air plasma effect on dental disinfection Phys. Plasmas 2011 18 073503 10.1063/1.3606486 · DOI
  136. [144]Sladek RE Filoche SK Sissons CH Stoffels E Treatment of Streptococcus mutans biofilms with a nonthermal atmospheric plasma Lett. Appl. Microbiol. 2007 45 318 323 10.1111/j.1472-765X.2007.02194.x 17718846 · DOI
  137. [145]Liu D Bacterial-killing effect of atmospheric pressure non-equilibrium plasma jet and oral mucosa response J. Huazhong Univ. Sci. Technol. Med. Sci. 2011 31 852 856 10.1007/s11596-011-0690-y 22173512 · DOI
  138. [146]Molnar I Papp J Simon A Anghel SD Deactivation of Streptococcus mutans biofilms on a tooth surface using He dielectric barrier discharge at atmospheric pressure Plasma Sci. Technol. 2013 15 535 541 10.1088/1009-0630/15/6/09 · DOI
  139. [147]Campoccia D Montanaro L Arciola CR A review of the clinical implications of anti-infective biomaterials andinfection-resistant surfaces Biomaterials 2013 34 8018 8029 10.1016/j.biomaterials.2013.07.048 23932292 · DOI
  140. [148]Idlibi AN Destruction of oral biofilms formed in situ on machined titanium (Ti) surfaces by cold atmospheric plasma Biofouling 2013 29 369 379 10.1080/08927014.2013.775255 23574038 · DOI
  141. [149]Rupf S Removing biofilms from microstructured titanium ex vivo: a novel approach using atmospheric plasma technology PLoS ONE 2011 6 e25893 10.1371/journal.pone.0025893 22016784 PMC3189945 · DOI
  142. [150]Duske K Cold atmospheric plasma in combination with mechanical treatment improves osteoblast growth on biofilm covered titanium discs Biomaterials 2015 52 327 334 10.1016/j.biomaterials.2015.02.035 25818439 · DOI
  143. [151]Matthes R Osteoblast growth, after cleaning of biofilm-covered titanium discs with air-polishing and cold plasma J. Clin. Periodontol. 2017 44 672 680 10.1111/jcpe.12720 28303583 · DOI
  144. [152]Pei Y Biological activities and potential oral applications of n-acetylcysteine: progress and prospects Oxid. Med. Cell. Longev. 2018 2018 2835787 10.1155/2018/2835787 29849877 PMC5937417 · DOI
  145. [153]Xu FJ Neoh KG Kang ET Bioactive surfaces and biomaterials via atom transfer radical polymerization Prog. Polym. Sci. 2009 34 719 761 10.1016/j.progpolymsci.2009.04.005 · DOI
  146. [154]Wen T Becker ML “Click” reactions: a versatile toolbox for the synthesis of peptide-conjugates Chem. Soc. Rev. 2014 43 7013 7039 10.1039/C4CS00139G 24993161 · DOI
  147. [155]Soukos NS Goodson JM Photodynamic therapy in the control of oral biofilms Periodontol. 2000 2011 55 143 166 10.1111/j.1600-0757.2010.00346.x 21134233 · DOI
  148. [156]Kuang X Chen V Xu X Novel approaches to the control of oral microbial biofilms Biomed. Res. Int. 2018 2018 6498932 10.1155/2018/6498932 30687755 PMC6330817 · DOI
  149. [158]Paladini F Pollini M Sannino A Ambrosio L Metal-based antibacterial substrates for biomedical applications Biomacromolecules 2015 16 1873 1885 10.1021/acs.biomac.5b00773 26082968 · DOI
  150. [160]Michl TD Nitric oxide releasing plasma polymer coating with bacteriostatic properties and no cytotoxic side effects Chem. Commun. 2015 51 7058 7060 10.1039/C5CC01722J 25807345 · DOI
  151. [161]Weber, D. J. & Rutala, W. A. Self-disinfecting surfaces: review of current methodologies and future prospects. Am. J. Infect. Control.41, S31–S35 (2013). 23622745
  152. [162]Yueh MF Tukey RH Triclosan: a widespread environmental toxicant with many biological effects Annu. Rev. Pharmacol. Toxicol. 2016 56 251 272 10.1146/annurev-pharmtox-010715-103417 26738475 PMC4774862 · DOI
  153. [163]Koo H Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol J. Antimicrob. Chemother. 2003 52 782 789 10.1093/jac/dkg449 14563892 · DOI
  154. [165]Nie B Ao H Zhou J Tang T Yue B Biofunctionalization of titanium with bacitracin immobilization shows potential for anti-bacteria, osteogenesis and reduction of macrophage inflammation Colloids Surf. B 2016 145 728 739 10.1016/j.colsurfb.2016.05.089 27289314 · DOI
  155. [166]Chen X Hirt H Li Y Gorr SU Aparicio C Antimicrobial GL13K peptide coatings killed and ruptured the wall of Streptococcus gordonii and prevented formation and growth of biofilms PLoS ONE 2014 9 e111579 10.1371/journal.pone.0111579 25372402 PMC4221044 · DOI
  156. [167]Dezoysa GH Sarojini V A feasibility study exploring the potential of novel battacin lipopeptides as antimicrobial coatings ACS Appl. Mater. Interfaces 2016 9 1373 1383 10.1021/acsami.6b15859 27992168 · DOI
  157. [168]Godoy-Gallardo M Antibacterial properties of hLf1-11 peptide onto titanium surfaces: a comparison study between silanization and surface initiated polymerization Biomacromolecules 2015 16 483 496 10.1021/bm501528x 25545728 · DOI
  158. [169]Chen R Willcox MD Ho KK Smyth D Kumar N Antimicrobial peptide melimine coating for titanium and its in vivo antibacterial activity in rodent subcutaneous infection models Biomaterials 2016 85 142 151 10.1016/j.biomaterials.2016.01.063 26871890 · DOI
  159. [170]Tan XW Effectiveness of antimicrobial peptide immobilization for preventing perioperative cornea implant-associated bacterial infection Antimicrob. Agents Chemother. 2014 58 5229 5238 10.1128/AAC.02859-14 24957820 PMC4135834 · DOI
  160. [171]Gao G The biocompatibility and biofilm resistance of implant coatings based on hydrophilic polymer brushes conjugated with antimicrobial peptides Biomaterials 2011 32 3899 3909 10.1016/j.biomaterials.2011.02.013 21377727 · DOI
  161. [172]Gao G Antibacterial surfaces based on polymer brushes: investigation on the influence of brush properties on antimicrobial peptide immobilization and antimicrobial activity Biomacromolecules 2011 12 3715 3727 10.1021/bm2009697 21902171 · DOI

Authors
Jiao, Y., Tay, F. R., Niu, L.-N., & Chen, J.-H.
Affiliations
  • Chinese PLA General Hospital (CN)
  • Augusta University (US)
  • Stomatology Hospital (CN)
Corresponding author
Niu, Li-na
ORCID
Venue
International Journal of Oral Science
Publisher
Springer Science and Business Media LLC
Published
2019-09
Volume
11
Issue
3
Pages
28-28
ISSN
  • 1674-2818 (ISSN-L)
  • 2049-3169
DOI
10.1038/s41368-019-0062-1
PMC
PMC6802668
OpenAlex
W2975557140
Cited by
280
References
175
Citations by year
2026: 25 · 2025: 42 · 2024: 48 · 2023: 68 · 2022: 41 · 2021: 31 · 2020: 24 · 2019: 1
FWCI
3.43
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Oral Science (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Natural Science Foundation of China (2017YFC0840100, IRT13051, 81720108011, 2018KA02)
  • Program for Changjiang Scholars and Innovative Research Team in University (IRT13051)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
  • Health Sciences › Dentistry › Orthodontics › Dental materials and restorations
Keywords
dental plaque, antimicrobial strategies, antimicrobial resistance, antimicrobial dental materials, contact killing, antimicrobial photodynamic therapy, cold atmospheric plasma, biofilm inhibition, dental caries, periodontal disease
MeSH terms
Anti-Infective Agents, Anti-Bacterial Agents, Bacterial Infections, Humans, Mouth, Plankton, Biofilms

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review