Il-1r1 drives leukemogenesis induced by Tet2 loss
Open accessAbstract
Loss of the ten-eleven translocation methylcytosine dioxygenase 2 ( Tet2 ) gene, which is commonly mutated in hematological malignancies, dysregulates inflammatory pathways, including the interleukin-1 (IL-1) pathway [ 1 , 2 , 3 ]. Roles for IL-1 signaling have been reported in terminally differentiated hematopoietic cells and in non-cell autonomous contexts [ 3 , 4 ]. However, our group demonstrated that inhibition of inflammatory pathways can suppress clonal hematopoiesis (CH), indicating potential direct roles for hematopoietic stem and progenitor cells (HSPCs) in inflammation [ 5 ]. As TET2 mutations are often present in HSPCs and provide these cells with a competitive advantage, dysregulation of the IL-1 pathway in HSPCs may contribute to leukemogenesis and may catalyze the progression of preleukemic states to malignancy [ 6 ].
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Progression of Tet2-/- hematopoiesis into myeloid malignancy is abrogated in the absence of Il1r1.
“Burns et al reported that progression of Tet2–/– hematopoiesis into myeloid malignancy is abrogated in the absence of Il1r1,56”
From Aging drives <i>Tet2</i> <i>+/−</i> clonal hematopoiesis via IL-1 signaling (2023) · cites this paper as [56]
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- Authors
- Burns, S. S., Kumar, R., Pasupuleti, S. K., So, K., Zhang, C., & Kapur, R.
- Affiliations
- Indiana University Indianapolis (US)
- Indiana University – Purdue University Indianapolis (US)
- Corresponding author
- Kapur, Reuben
- Venue
- Leukemia
- Published
- 2022-08-12
- Volume
- 36
- Issue
- 10
- Pages
- 2531-2534
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- PMC
- PMC9522579
- OpenAlex
- W4290839656
- Cited by
- 32
- References
- 16
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 10 · 2023: 8 · 2022: 2
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Leukemia (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IUScholarWorks (Indiana University) (submittedVersion, cc-by)
- Funders
- U.S. Department of Health & Human Services | National Institutes of Health (T32 DK007519, R01 CA173852, R01 CA134777, R01 HL146137, R01 HL140961)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- IL1R1, IL-1 signaling, TET2 mutation, leukemogenesis, clonal hematopoiesis, hematopoietic stem and progenitor cells, inflammation, preleukemic state, hematologic malignancies
- MeSH terms
- DNA-Binding Proteins, Leukemia, Signal Transduction, Dioxygenases, Receptors, Interleukin-1 Type I, Carcinogenesis
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