The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
IgA and the intestinal microbiota: the importance of being specific
Open accessAbstract
Secretory IgA has long been a divisive molecule. Some immunologists point to the mild phenotype of IgA deficiency to justify ignoring it, while some consider its abundance and evolutionary history as grounds for its importance. Further, there is extensive and growing disagreement over the relative importance of affinity-matured, T cell-dependent IgA vs. "natural" and T cell-independent IgA in both microbiota and infection control. As with all good arguments, there is good data supporting different opinions. Here we revisit longstanding questions in IgA biology. We start the discussion from the question of intestinal IgA antigen specificity and critical definitions regarding IgA induction, specificity, and function. These definitions must then be tessellated with the cellular and molecular pathways shaping IgA responses, and the mechanisms by which IgA functions. On this basis we propose how IgA may contribute to the establishment and maintenance of beneficial interactions with the microbiota.
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Victora, G. D., & Nussenzweig, M. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075032 · Cited by 1,878
Gut inflammation provides a respiratory electron acceptor for Salmonella
Winter, S. E., Thiennimitr, P., Winter, M. G., Butler, B. P., Huseby, D. L., Crawford, R. W., Russell, J. M., Bevins, C. L., Adams, L. G., Tsolis, R. M., et al. (2010) · Nature · doi:10.1038/nature09415 · Cited by 1,290
Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease
Palm, N. W., de Zoete, M. R., Cullen, T. W., Barry, N. A., Stefanowski, J., Hao, L., Degnan, P. H., Hu, J., Peter, I., Zhang, W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.006 · Cited by 1,286
A Primitive T Cell-Independent Mechanism of Intestinal Mucosal IgA Responses to Commensal Bacteria
Macpherson, A. J., Gatto, D., Sainsbury, E., Harriman, G. R., Hengartner, H., & Zinkernagel, R. M. (2000) · Science · doi:10.1126/science.288.5474.2222 · Cited by 1,113
B Cell Responses: Cell Interaction Dynamics and Decisions
Cyster, J. G., & Allen, C. D. C. (2019) · Cell · doi:10.1016/j.cell.2019.03.016 · Cited by 971
Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses
Hapfelmeier, S., Lawson, M. A. E., Slack, E., Kirundi, J. K., Stoel, M., Heikenwalder, M., Cahenzli, J., Velykoredko, Y., Balmer, M. L., Endt, K., et al. (2010) · Science · doi:10.1126/science.1188454 · Cited by 835
Self-citationDengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibody
Halstead, S., & O'Rourke, E. (1977) · The Journal of Experimental Medicine · doi:10.1084/jem.146.1.201 · Cited by 804
Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota
Smith, K., McCoy, K. D., & Macpherson, A. J. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2006.10.002 · Cited by 785
The regulation of IgA class switching
Cerutti, A. (2008) · Nature Reviews Immunology · doi:10.1038/nri2322 · Cited by 756
Dynamic modulation of the gut microbiota and metabolome by bacteriophages in a mouse model
Hsu, B. B., Gibson, T. E., Yeliseyev, V., Liu, Q., Lyon, L., Bry, L., Silver, P. A., & Gerber, G. K. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.05.001 · Cited by 573
Cited by
Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes
Scheithauer, T. P. M., Rampanelli, E., Nieuwdorp, M., Vallance, B. A., Verchere, C. B., van Raalte, D. H., & Herrema, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.571731 · Cited by 673
Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives
Dempsey, E., & Corr, S. C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.840245 · Cited by 579
Implication of Intestinal Barrier Dysfunction in Gut Dysbiosis and Diseases
Stolfi, C., Maresca, C., Monteleone, G., & Laudisi, F. (2022) · Biomedicines · doi:10.3390/biomedicines10020289 · Cited by 339
The gut microbiome and hypertension
O’Donnell, J. A., Zheng, T., Meric, G., & Marques, F. Z. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00654-0 · Cited by 281
Diversity and dynamism of IgA−microbiota interactions
Huus, K. E., Petersen, C., & Finlay, B. B. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00506-1 · Cited by 198
Metadata
- Authors
- Pabst, O., & Slack, E.
- Venue
- Mucosal Immunology
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 13
- Issue
- 1
- Pages
- 12-21
- ISSN
- 1933-0219 (ISSN-L)
- OpenAlex
- W2988261311
- Cited by
- 484
- References
- 68
- FWCI
- 13.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
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