Cited by 581Probiotics and Fermented FoodsReproductive tract infections researchGut microbiota and health

Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives

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Dempsey, Elaine, Corr, Sinéad C.·2022·Frontiers in Immunology

Abstract

In recent decades, probiotic bacteria have become increasingly popular as a result of mounting scientific evidence to indicate their beneficial role in modulating human health. Although there is strong evidence associating various Lactobacillus probiotics to various health benefits, further research is needed, in particular to determine the various mechanisms by which probiotics may exert these effects and indeed to gauge inter-individual value one can expect from consuming these products. One must take into consideration the differences in individual and combination strains, and conditions which create difficulty in making direct comparisons. The aim of this paper is to review the current understanding of the means by which Lactobacillus species stand to benefit our gastrointestinal health.

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Crossref · 10.3389/fimmu.2022.840245

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  • To exert beneficial gastrointestinal effects, lactobacilli must withstand harsh gastrointestinal conditions including gastric acidity and bile salts.

    “To exert these beneficial effects, they must withstand the harsh conditions of the gastrointestinal tract, including gastric acidity and bile salts [1].”

    From Bile Salt Hydrolase Activity in the Food-Derived Strain Levilactobacillus brevis M3R3: Genomic and Functional Characterization (2026) · cites this paper as [1]

    The Introduction (page unavailable) says an efficacious probiotic must survive the gastrointestinal tract and resist the stomach’s low pH; it identifies Lactobacillus species as widely used probiotics. Our copy does not state that resistance to bile salts is required, so that specific part of the claim is unsupported. (LLM, conf=0.88)

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Authors
Dempsey, E., & Corr, S. C.
Affiliations
Trinity College Dublin (IE)
Corresponding author
Corr, Sinéad C.
Venue
Frontiers in Immunology
Published
2022-04-06
Volume
13
Pages
840245-840245
ISSN
1664-3224 (ISSN-L)
OpenAlex
W4225650845
Cited by
579
References
164
Citations by year
2026: 145 · 2025: 220 · 2024: 139 · 2023: 59 · 2022: 16
FWCI
10.03
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion, cc-by-nc-sa)
  • Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion, cc-by)
Funders
Science Foundation Ireland
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
Lactobacillus, probiotics, gut health, probiotic mechanisms of action, interindividual variability, strain differences, gut microbiota, health benefits
MeSH terms
Bacteria, Humans, Lactobacillus, Probiotics, Gastrointestinal Tract

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