WNT signaling modulates PD-L1 expression in the stem cell compartment of triple-negative breast cancer

Castagnoli, Lorenzo; Cancila, Valeria; Cordoba-Romero, Sandra L.; Faraci, Simona; Talarico, Giovanna; Belmonte, Beatrice; Iorio, Marilena V.; Milani, Matteo; Volpari, Tatiana; Chiodoni, Claudia; Hidalgo-Miranda, Alfredo; Tagliabue, Elda; Tripodo, Claudio; Sangaletti, Sabina; Di Nicola, Massimo; Pupa, Serenella M.

doi:10.1038/s41388-019-0700-2

WNT signaling modulates PD-L1 expression in the stem cell compartment of triple-negative breast cancer

Triple-negative breast cancers (TNBCs) are characterized by a poor prognosis and lack of targeted treatments, and thus, new therapeutic strategies are urgently needed. Inhibitors against programmed death-1 (PD-1)/PD-1 ligand (PD-L1) have shown significant efficacy in various solid cancers, but th…