Mitochondrial GPT2 plays a pivotal role in metabolic adaptation to the perturbation of mitochondrial glutamine metabolism

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197 · see citing works

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622 · see citing works

Regulation of glutathione synthesis

Lu, S. C.-L. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.05.005 · Cited by 2,131 · see citing works

From Krebs to clinic: glutamine metabolism to cancer therapy

Altman, B. J., Stine, Z. E., & Dang, C. V. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.71 · Cited by 2,119 · see citing works

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001 · see citing works

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Son, J., Lyssiotis, C. A., Ying, H., Wang, X., Hua, S., Ligorio, M., Perera, R. M., Ferrone, C. R., Mullarky, E., Shyh-Chang, N., et al. (2013) · Nature · doi:10.1038/nature12040 · Cited by 1,990 · see citing works

Glutamine addiction: a new therapeutic target in cancer

Wise, D. R., & Thompson, C. B. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.05.003 · Cited by 1,770 · see citing works

ROS homeostasis and metabolism: a dangerous liason in cancer cells

Panieri, E., & Santoro, M. M. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.105 · Cited by 1,156 · see citing works

Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer

Gross, M. I., Demo, S. D., Dennison, J. B., Chen, L., Chernov-Rogan, T., Goyal, B., Janes, J. R., Laidig, G. J., Lewis, E. R., Li, J., et al. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0870 · Cited by 1,068 · see citing works

Targeting metabolic transformation for cancer therapy

Tennant, D. A., Durán, R. V., & Gottlieb, E. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2817 · Cited by 1,057 · see citing works

The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

Ye, J., Kumanova, M., Hart, L. S., Sloane, K. L., Zhang, H., Panis, D. N. D., Bobrovnikova-Marjon, E. V., Diehl, J. A., Ron, D., & Koumenis, C. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.81 · Cited by 709 · see citing works

SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism

Jeong, S. M., Xiao, C., Finley, L. W. S., Lahusen, T., Souza, A. L., Pierce, K., Li, Y.-H., Wang, X., Laurent, G., German, N. J., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.02.024 · Cited by 445 · see citing works

Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion

Zhang, J., Fan, J., Venneti, S., Cross, J. R., Takagi, T., Bhinder, B., Djaballah, H., Kanai, M., Cheng, E. H., Judkins, A. R., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.018 · Cited by 439 · see citing works

Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)

Robinson, M. M., McBryant, S. J., Tsukamoto, T., Rojas, C. J., Ferraris, D. V., Hamilton, S. K., Hansen, J. C., & Curthoys, N. P. (2007) · Biochemical Journal · doi:10.1042/bj20070039 · Cited by 344 · see citing works

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

Biancur, D. E., Paulo, J. A., Małachowska, B., Quiles Del Rey, M., Sousa, C. M., Wang, X., Sohn, A. S. W., Chu, G. C., Gygi, S. P., Harper, J. W., et al. (2017) · Nature Communications · doi:10.1038/ncomms15965 · Cited by 315 · see citing works

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions

Sun, L., Song, L., Wan, Q., Wu, G., Li, X., Wang, Y., Wang, J., Liu, Z., Zhong, X., He, X., et al. (2015) · Cell Research · doi:10.1038/cr.2015.33 · Cited by 311 · see citing works

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

Hao, Y., Samuels, Y., Li, Q., Krokowski, D., Guan, B.-J., Wang, C., Jin, Z., Dong, B., Cao, B., Feng, X., et al. (2016) · Nature Communications · doi:10.1038/ncomms11971 · Cited by 290 · see citing works

Glutamine: pleiotropic roles in tumor growth and stress resistance

Shanware, N. P., Mullen, A. R., DeBerardinis, R. J., & Abraham, R. T. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0731-9 · Cited by 176 · see citing works

Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase

Toda, K., Kawada, K., Iwamoto, M., Inamoto, S., Sasazuki, T., Shirasawa, S., Hasegawa, S., & Sakai, Y. (2016) · Neoplasia · doi:10.1016/j.neo.2016.09.004 · Cited by 113 · see citing works

Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition

Yang, S., Hwang, S., Kim, M., Seo, S. B., Lee, J., & Jeong, S. M. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0089-1 · Cited by 106 · see citing works

Mitochondrial dysfunction enhances cisplatin resistance in human gastric cancer cells via the ROS-activated GCN2-eIF2α-ATF4-xCT pathway

Wang, S., Chen, M.-S., Chou, Y., Ueng, Y., Yin, P., Yeh, T.-S., & Lee, H. (2016) · Oncotarget · doi:10.18632/oncotarget.12356 · Cited by 93 · see citing works

Aspartate Rescues S-phase Arrest Caused by Suppression of Glutamine Utilization in KRas-driven Cancer Cells

Patel, D., Menon, D., Bernfeld, E., Mroz, V., Kalan, S., Loayza, D., & Foster, D. A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.710145 · Cited by 86 · see citing works

A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells

Byun, J., Choi, Y., Kim, J. H., Jeong, J. Y., Jeon, H., Kim, M. K., Hwang, I., Lee, S.-Y., Lee, Y. M., Lee, I., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.066 · Cited by 84 · see citing works

Glucose availability controls ATF4-mediated MITF suppression to drive melanoma cell growth

Ferguson, J., Smith, M. P., Zudaire, I., Wellbrock, C., & Arozarena, I. (2017) · Oncotarget · doi:10.18632/oncotarget.16514 · Cited by 76 · see citing works

Reducing the serine availability complements the inhibition of the glutamine metabolism to block leukemia cell growth

Polet, F., Corbet, C., Pinto, A., Rubio, L. I., Martherus, R., Bol, V., Drozak, X., Grégoire, V., Riant, O., & Féron, O. (2015) · Oncotarget · doi:10.18632/oncotarget.6426 · Cited by 66 · see citing works

Inhibition of amino acid transaminases by L-cycloserine

Wong, D. T., Fuller, R. W., & Molloy, B. B. (1973) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(73)90013-7 · Cited by 43 · see citing works

Enhanced mitochondrial glutamine anaplerosis suppresses pancreatic cancer growth through autophagy inhibition

Jeong, S. M., Hwang, S., Park, K., Yang, S., & Seong, R. H. (2016) · Scientific Reports · doi:10.1038/srep30767 · Cited by 37 · see citing works

Activating transcription factor 4 mediates up-regulation of alanine aminotransferase 2 gene expression under metabolic stress

Salgado, M. C. D. O., Metón, I., Anemaet, I. G., & Baanante, I. V. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.01.005 · Cited by 18 · see citing works

Glutamine reliance in cell metabolism

Yoo, H. C., Yu, Y. C., Sung, Y., & Han, J. M. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00504-8 · Cited by 1,021 · see citing works

Targeting glutamine metabolism as a therapeutic strategy for cancer

Jin, J., Byun, J., Choi, Y., & Park, K. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-00971-9 · Cited by 576 · see citing works

The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia

Weng, H., Huang, F., Yu, Z., Chen, Z., Prince, E., Kang, Y., Zhou, K., Li, W., Hu, J., Fu, C., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.10.004 · Cited by 336 · see citing works

Targeting mitochondrial metabolism for precision medicine in cancer

Sainero‐Alcolado, L., Liaño-Pons, J., Ruiz-Pérez, M. V., & Arsenian‐Henriksson, M. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01022-y · Cited by 330 · see citing works

Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management

Jin, P., Jiang, J., Zhou, L., Huang, Z., Nice, E. C., Huang, C., & Fu, L. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01313-4 · Cited by 282 · see citing works

Selective alanine transporter utilization creates a targetable metabolic niche in pancreatic cancer

Parker, S. J., Amendola, C. R., Hollinshead, K. E. R., Yu, Q., Yamamoto, K., Encarnación-Rosado, J., Rose, R. E., LaRue, M. M., Sohn, A. S. W., Biancur, D. E., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0959 · Cited by 175 · see citing works

CRISPR screens in physiologic medium reveal conditionally essential genes in human cells

Rossiter, N. J., Huggler, K. S., Adelmann, C. H., Keys, H. R., Soens, R. W., Sabatini, D. M., & Cantor, J. R. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.02.005 · Cited by 133 · see citing works

A glutamine tug-of-war between cancer and immune cells: recent advances in unraveling the ongoing battle

Wang, B., Pei, J., Xu, S.-N., Liu, J., & Yu, J.-M. (2024) · Journal of experimental & clinical cancer research : CR · doi:10.1186/s13046-024-02994-0 · Cited by 129 · see citing works

Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets

Nan, D., Yao, W., Huang, L., Liu, R., Chen, X., Xia, W., Sheng, H., Zhang, H., Liang, X., & Lü, Y. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-024-02018-6 · Cited by 95 · see citing works

Metabolic reprogramming in colorectal cancer: regulatory networks and therapy

Zhang, J., Zou, S., & Fang, L. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-00977-w · Cited by 69 · see citing works

Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection

West, E. E., Merle, N. S., Kamiński, M. M., Palacios, G. F., Kumar, D., Wang, L., Bibby, J. A., Overdahl, K. E., Jarmusch, A. K., Freeley, S. J., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.07.014 · Cited by 56 · see citing works

Programming a Ferroptosis‐to‐Apoptosis Transition Landscape Revealed Ferroptosis Biomarkers and Repressors for Cancer Therapy

Vinik, Y., Maimon, A., Dubey, V., Raj, H., Abramovich, I., Malitsky, S., Itkin, M., Ma’ayan, A., Westermann, F., Gottlieb, E., et al. (2024) · Advanced Science · doi:10.1002/advs.202307263 · Cited by 49 · see citing works

The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells

Wang, Z., Hu, H., Heitink, L. S., Rogers, K. L., You, Y., Tan, T., Suen, C. S. N. L. W., Garnham, A. L., Chen, H., Lieschke, E., et al. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01122-3 · Cited by 49 · see citing works

Succinate Dehydrogenase and Human Disease: Novel Insights into a Well-Known Enzyme

Esteban-Amo, M. J., Jiménez-Cuadrado, P., Serrano‐Lorenzo, P., de la Fuente, M. Á., & Simarro, M. (2024) · Biomedicines · doi:10.3390/biomedicines12092050 · Cited by 49 · see citing works

Mitochondria Deregulations in Cancer Offer Several Potential Targets of Therapeutic Interventions

Musicco, C., Signorile, A., Pesce, V., Polosa, P. L., & Cormio, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310420 · Cited by 43 · see citing works

Metabolic Roles of HIF1, c-Myc, and p53 in Glioma Cells

Trejo‐Solís, C., Castillo‐Rodríguez, R. A., Serrano-García, N., Silva‐Adaya, D., Vargas-Cruz, S., Chávez-Cortéz, E. G., Gallardo‐Pérez, J. C., Zavala-Vega, S., Cruz-Salgado, A., & Magaña-Maldonado, R. (2024) · Metabolites · doi:10.3390/metabo14050249 · Cited by 40 · see citing works

Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2–dependent glutaminolysis pathway

Wei, P., Bott, A. J., Cluntun, A. A., Morgan, J. T., Cunningham, C. N., Schell, J. C., Ouyang, Y., Ficarro, S. B., Marto, J. A., Danial, N. N., et al. (2022) · Science Advances · doi:10.1126/sciadv.abq0117 · Cited by 38 · see citing works

A photo-oxidation driven proximity labeling strategy enables profiling of mitochondrial proteome dynamics in living cells

Wang, H., Wang, Z., Gao, H., Liu, J., Qiao, Z., Zhao, B., Liang, Z., Jiang, B., Zhang, L., & Zhang, Y. (2022) · Chemical Science · doi:10.1039/d2sc04087e · Cited by 36 · see citing works

Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions

Pandya, S. R., Singh, H., Desimone, M. F., Singh, J., George, N., & Jasani, S. (2023) · Materials Advances · doi:10.1039/d3ma00629h · Cited by 36 · see citing works

Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5α-dihydrotestosterone regulation

Cardoso, H. J., Figueira, M. I., Vaz, C. V., Carvalho, T. M. A., Brás, L. A., Madureira, P. A., Oliveira, P. J., Sardão, V. A., & Socorro, S. (2021) · Cellular Oncology · doi:10.1007/s13402-020-00575-9 · Cited by 34 · see citing works

Pyruvate transamination and NAD biosynthesis enable proliferation of succinate dehydrogenase-deficient cells by supporting aerobic glycolysis

Ricci, L., Stanley, F. U., Eberhart, T., Mainini, F., Sumpton, D. P., & Cardaci, S. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05927-5 · Cited by 32 · see citing works

Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver Disease

Chen, T., Dalton, G. D., Oh, S., Maeso‐Díaz, R., Du, K., Meyers, R. A., Guy, C. D., Abdelmalek, M. F., Henao, R., Guarnieri, P., et al. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.12.008 · Cited by 31 · see citing works

Glutaminase Inhibition on NSCLC Depends on Extracellular Alanine Exploitation

Caiola, E., Colombo, M., Sestito, G., Lupi, M., Marabese, M., Pastorelli, R., Broggini, M., & Brunelli, L. (2020) · Cells · doi:10.3390/cells9081766 · Cited by 29 · see citing works

Elucidation of an mTORC2-PKC-NRF2 pathway that sustains the ATF4 stress response and identification of Sirt5 as a key ATF4 effector

Li, R., Wilson, K. F., & Cerione, R. A. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01156-5 · Cited by 25 · see citing works

The Involvement of Long Non-Coding RNAs in Glutamine-Metabolic Reprogramming and Therapeutic Resistance in Cancer

Roh, J.-J., Im, M., Chae, Y., Kang, J., & Kim, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314808 · Cited by 25 · see citing works

Co-inhibition of glutaminolysis and one-carbon metabolism promotes ROS accumulation leading to enhancement of chemotherapeutic efficacy in anaplastic thyroid cancer

Hwang, Y., Yun, H. J., Jeong, J. W., Kim, M., Joo, S., Lee, H., Chang, H., Kim, S., & Fang, S. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06041-2 · Cited by 25 · see citing works

YAP governs cellular adaptation to perturbation of glutamine metabolism by regulating ATF4-mediated stress response

Kim, M., Hwang, S., Kim, B.-J., Shin, S., Yang, S., Gwak, J., & Jeong, S. M. (2023) · Oncogene · doi:10.1038/s41388-023-02811-6 · Cited by 21 · see citing works

Glutamine metabolism in tumor metastasis: Genes, mechanisms and the therapeutic targets

Zhong, X., He, Z., Li, Y., Fan, Y., Yu, T., Kang, Y., & Bi, Q. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e20656 · Cited by 20 · see citing works

Altered Transcription Factor Binding and Gene Bivalency in Islets of Intrauterine Growth Retarded Rats

Lien, Y., Wang, Z. P., Lu, X. M., & Simmons, R. A. (2020) · Cells · doi:10.3390/cells9061435 · Cited by 20 · see citing works

Screening mitochondria-related biomarkers in skin and plasma of atopic dermatitis patients by bioinformatics analysis and machine learning

Yu, H., Lin, J., Yuan, J., Sun, X., Wang, C., & Bai, B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1367602 · Cited by 19 · see citing works

miR-124 coordinates metabolic regulators acting at early stages of human neurogenesis

Son, G., Na, Y., Kim, Y., Son, J.-H., Clemenson, G. D., Schafer, S. T., Yoo, J.-Y., Parylak, S., Paquola, A. C. M., Do, H., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-07089-2 · Cited by 19 · see citing works

GPT2 Is Induced by Hypoxia-Inducible Factor (HIF)-2 and Promotes Glioblastoma Growth

Zhang, B., Chen, Y., Bao, L., & Luo, W. (2022) · Cells · doi:10.3390/cells11162597 · Cited by 17 · see citing works

PIK3CA mutation affects the proliferation of colorectal cancer cells through the PI3K-MEK/PDK1-GPT2 pathway

Chen, W., Dai, G., Qian, Y., Lian, W., He, X., Liu, H., Gao, Y., Tang, X., & Dong, B. (2021) · Oncology Reports · doi:10.3892/or.2021.8222 · Cited by 16 · see citing works

Unraveling mitochondrial pyruvate dysfunction to mitigate hyperlactatemia and lethality in sepsis

Nuyttens, L., Heyerick, M., Heremans, G., Moens, E., Roes, M., Dender, C. V., Bus, L. D., Decruyenaere, J. M. A., Waele, J. J. D., Vandewalle, J., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116032 · Cited by 22 · see citing works

Suppression of fatty acid oxidation supports pancreatic cancer growth and survival under hypoxic conditions through autophagy induction

Kim, B.-J., Gwak, J., Kim, M., Yang, S., Hwang, S., Shin, S., Kim, J. H., Son, J., & Jeong, S. M. (2023) · Cancer Gene Therapy · doi:10.1038/s41417-023-00598-y · Cited by 15 · see citing works

Multi–Omics Analysis of Key microRNA–mRNA Metabolic Regulatory Networks in Skeletal Muscle of Obese Rabbits

Li, Y., Wang, J., Elzo, M. A., Gan, M., Tang, T., Shao, J., Lai, T., Ma, Y., Jia, X., & Lai, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084204 · Cited by 14 · see citing works

Mitochondrial enzyme GPT2 regulates metabolic mechanisms required for neuron growth and motor functionin vivo

Baytaş, O., Davidson, S. M., DeBerardinis, R. J., & Morrow, E. M. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab269 · Cited by 13 · see citing works

Targeting cellular adaptive responses to glutaminolysis perturbation for cancer therapy

Kim, M., Hwang, S., & Jeong, S. M. (2024) · Molecules and Cells · doi:10.1016/j.mocell.2024.100096 · Cited by 12 · see citing works

Mitochondrial glutamine metabolism regulates sensitivity of cancer cells after chemotherapy via amphiregulin

Hwang, S., Yang, S., Kim, M., Hong, Y., Kim, B.-J., Lee, E. K., & Jeong, S. M. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00792-7 · Cited by 12 · see citing works

Loss of mitochondrial enzyme GPT2 causes early neurodegeneration in locus coeruleus

Baytaş, O., Kauer, J. A., & Morrow, E. M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105831 · Cited by 11 · see citing works

Cottonseed hydrolysate supplementation alters metabolic and proteomics responses in Chinese hamster ovary cell cultures

Dhara, V. G., Kumar, S., Devine, L. R., Naik, H. M., Cole, R. N., More, A. J., Lau, E. C., & Betenbaugh, M. J. (2023) · Biotechnology Journal · doi:10.1002/biot.202200243 · Cited by 12 · see citing works

Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition

Holt, A. K., Najumudeen, A. K., Collard, T. J., Li, H., Millett, L. M., Hoskin, A. J., Legge, D., Mortensson, E., Flanagan, D. J., Jones, N., et al. (2023) · Cancer & Metabolism · doi:10.1186/s40170-023-00318-y · Cited by 11 · see citing works

System analysis based on glutamine catabolic-related enzymes identifies GPT2 as a novel immunotherapy target for lung adenocarcinoma

Wang, B., Pei, J., Xu, S., Liu, J., & Yu, J. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.107415 · Cited by 11 · see citing works

The Ku70-SIX1-GPT2 axis regulates alpha-ketoglutarate metabolism to drive progression of prostate cancer

Huang, H., Zhuang, X., Yin, S., Sun, W., Cheng, J., Peng, E.-Y., Xiang, Y., He, X., Tang, M., Li, Y., et al. (2024) · Oncogene · doi:10.1038/s41388-024-03209-8 · Cited by 10 · see citing works

Mitochondrial Glutamine Metabolism Determines Senescence Induction After Chemotherapy

KIM, B., Gwak, J., Lee, E. K., & Jeong, S. M. (2020) · Anticancer Research · doi:10.21873/anticanres.14712 · Cited by 10 · see citing works

Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy

Yao, Y., Chen, C., Li, B., & Gao, W. (2025) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-025-03949-w · Cited by 8 · see citing works

Metabolic Targets in CRC: The Emerging Role of Cytochrome P450 Inhibitors

Alshakarchi, H. I., Azari, H., Jeddoa, Z. M. A., Jafar, N. N. A., Khazaei, Y., Gataa, I. S., Ferns, G. A., & Avan, A. (2025) · Current Pharmaceutical Design · doi:10.2174/0113816128341167250520063502 · Cited by 8 · see citing works

GPT2 mutations in autosomal recessive developmental disability: extending the clinical phenotype and population prevalence estimates

Ouyang, Q., Kavanaugh, B. C., Joesch-Cohen, L. M., Dubois, B., Wu, Q., Schmidt, M., Baytaş, O., Pastore, S. F., Harripaul, R., Mishra, S., et al. (2019) · Human Genetics · doi:10.1007/s00439-019-02057-x · Cited by 8 · see citing works

Changes in microRNAs Expression Profile of Mimetic Aging Mice Treated with Melanin from Sepiella japonica Ink

Han, M., Zhao, Y., Song, W., Wang, C., Mu, C., & Li, R. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c00291 · Cited by 8 · see citing works

Systematic analysis of glutamine metabolism family genes and exploration of the biological role of GPT in colorectal cancer

Dai, W., Mo, W., Xu, W., Han, D., & Xu, X. (2023) · Aging · doi:10.18632/aging.205079 · Cited by 7 · see citing works

Mitochondria at the intersections of RNA modifications and metabolism reprogramming implications in cell death, tumor microenvironment, and immunotherapy

Zhang, J., Zhang, H., Chen, L., Wu, Y., Xie, J., Yang, Y., Chen, A., Shahatiaili, A., Muhammad, S., Yang, W., et al. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01762-7 · Cited by 7 · see citing works

Systematic profiling of mitochondria-related transcriptome in tumorigenesis, prognosis, and tumor immune microenvironment of intrahepatic cholangiocarcinoma: a multi-center cohort study

Chen, B., Lü, M., Chen, Q., Zou, E., Bo, Z., Li, J., Zhao, R., Zhao, J., Yu, Z., Chen, G., et al. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2024.1430885 · Cited by 6 · see citing works

GPT2 mediates glutamine metabolism-driven metabolic alterations in platinum-resistant ovarian cancer cells

Ponton-Almodovar, A. L., Udumula, M. P., Khullar, V., Rashid, F., Rattan, R., Bernard, J. J., & Horibata, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-15707-0 · Cited by 4 · see citing works

Glutaminase I and glutamine transaminase–ω-amidase pathways in colorectal cancer: Metabolic reprogramming and emerging therapeutic strategies

Voor, S. F., Cooper, A. J. L., & Pinto, J. T. (2025) · Analytical Biochemistry · doi:10.1016/j.ab.2025.115989 · Cited by 4 · see citing works

Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism

Baytaş, O., Davidson, S. M., Kauer, J. A., & Morrow, E. M. (2024) · Molecular Brain · doi:10.1186/s13041-024-01154-x · Cited by 4 · see citing works

Identification of ferroptosis-related genes and predicted overall survival in patients with burns

Zhao, M., Zhang, Y., & Zhao, H. (2023) · Frontiers in Surgery · doi:10.3389/fsurg.2022.1060036 · Cited by 4 · see citing works

Exosomal GPT2 derived from triple‐negative breast cancer cells promotes metastasis by activating BTRC

Cui, M., Peng, J., Zhou, Y., Wang, X., & Cui, D. (2023) · Thoracic Cancer · doi:10.1111/1759-7714.14984 · Cited by 3 · see citing works

Liver regeneration–associated hepatocellular YAP1 activation prevents colorectal cancer liver metastasis through glutamine competition

Yu, Q., Yu, M., Xie, P., Guo, L., Zhao, Y., Xu, W., Li, X., Wu, M., Zhang, Z., Chen, Z., et al. (2025) · Science Advances · doi:10.1126/sciadv.adw6926 · Cited by 4 · see citing works

Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth

Sinha, S., Panda, A. K., das Neves, R. X., Nwosu, Z. C., Xu, K., van Beek, E., Desai, P. P., Sindiri, S., Chempati, S., Remmert, K., et al. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-1055 · Cited by 3 · see citing works

Metabolic signatures of lymphangioleiomyomatosis in biofluids: nuclear magnetic resonance (NMR)-based metabonomics of blood plasma: a case-control study

Gu, W., Pan, Y., Zhao, W., Liu, J., & Meng, Y. (2023) · Annals of Translational Medicine · doi:10.21037/atm-22-6420 · Cited by 3 · see citing works

TGF-β coordinates alanine synthesis and import for myofibroblast differentiation in pulmonary fibrosis

Li, F., Vigder, N., Ziehr, D. R., Kamiya, M., Nguyen, H. N., Faustino, D. E. F., Khalil, A. H., Lam, H. C., Steinhauser, M. L., Kim, E. Y., et al. (2026) · JCI Insight · doi:10.1172/jci.insight.199449 · Cited by 2 · see citing works

Genes Encoding Heat Shock Proteins Are Associated with Risk and Clinical Course of Severe COVID-19: A Pilot Study

Karpenko, A. R., Kobzeva, K., Orlov, Y., & Bushueva, O. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188967 · Cited by 3 · see citing works

Paternal uniparental disomy of chromosome 16 resulting in homozygosity of a GPT2 mutation causes intellectual and developmental disability

Liu, J., Chen, B., Liu, Y., Kong, J., Zhang, B., Han, L., Mei, D., Yun, C., Shang, Q., Xie, Z., et al. (2022) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2022.104554 · Cited by 2 · see citing works

A non-canonical role for glutamate decarboxylase 1 in cancer cell amino acid homeostasis, independent of the GABA shuntPreprint

Samborska, B., Griss, T., Ma, E. H., Jones, N., Williams, K. S., Sergushichev, A., Johnson, R. M., Esaulova, E., Loginicheva, E., Flynn, B. R., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.17.431489 · Cited by 2 · see citing works

Investigating the Impact of Ocean Acidification on Anti-Stress Mechanisms in Sepia esculenta Larvae Based on Transcriptome Profiling

Wang, Y., Liu, X., Lv, T., Wang, W., Sun, G., Yang, J., & Li, Z. (2024) · Journal of Ocean University of China · doi:10.1007/s11802-024-5772-0 · Cited by 1 · see citing works

SLAMF7 promotes TCRαβ+ double negative T cell antitumor activity through enhancing glutamine metabolism

Xu, N., Fang, P., Zhou, L., Han, X., Jiang, Y., Wang, X., Zhu, J., Li, B., Zhang, Z., Jin, H., et al. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03570-w · Cited by 1 · see citing works

Tributyltin Protumorigenic Effects Targeting Prostate Cancer Cell Metabolism, Proliferation, Migration, and Invasion

Feijó, M., Brás, L. A., Serra, C. D. M., Fonseca, L. R. S., Correia, S., Pereira, B. J., Duarte, A. P., Cardoso, H. J., Vaz, C. V., & Socorro, S. (2026) · Environmental Toxicology · doi:10.1002/tox.70029 · Cited by 1 · see citing works

Mitochondrial Glutamine Metabolism Modulates Chemotherapy Sensitivity in Cancer Cells through Amphiregulin Signaling

Novak, F. A., Hruby, J. M., & Kolar, P. E. (2025) · Archive of International Journal of Cancer and Allied Science · doi:10.51847/2brxgeyg9g · Cited by 1 · see citing works

Susan Mann, The Talented Women of the Zhang Family. Berkeley, University of California Press, 2007, xvi et 322 p.

Furth, C. (2008) · Perspectives chinoises

Exploration of Gene Expression Characters of Mouse M-1 Cells Treated by Qigong

Chen, Y.-M., Zhao, Y.-P., Wang, L., Feng, Q., Teng, J., Yu, Chen, Li, M.-M., Cai, Z.-Z., Li, C.-X., et al. (2021) · Journal of Yoga, Physical Therapy and Rehabilitation · doi:10.29011/2577-0756.001084

Additional file 2 of Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition

Holt, A. K., Najumudeen, A. K., Collard, T. J., Li, H., Millett, L. M., Hoskin, A. J., Legge, D., Mortensson, E., Flanagan, D. J., Jones, N., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24406923

Additional file 1 of Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition

Holt, A. K., Najumudeen, A. K., Collard, T. J., Li, H., Millett, L. M., Hoskin, A. J., Legge, D., Mortensson, E., Flanagan, D. J., Jones, N., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24406685

GPT2-mediated Glutamate to α-Ketoglutaric Acid Conversion in Cardiac Fibroblast Promotes Fibrosis

Chen, Y., Liao, F., Wang, J., Zhao, J., Xu, Y., Chen, Q., Hong, T., Lv, K., Li, Q., Chen, X., et al. (2026) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2026.101518

Stromal mitochondrial and cell death genes drive gastric cancer progression by remodeling the immune microenvironment

Wang, N., & Cai, W. (2026) · Gene Reports · doi:10.1016/j.genrep.2026.102595

GPT2 enhances colorectal cancer cell growth, movement, and invasion by altering gene expression patterns

Xu, X., Xie, P., Gan, H., Huang, Y., Liu, Z., & Lv, Q. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103912

Targeting cellular adaptive responses to glutaminolysis perturbation for cancer therapy

Kim, M., Hwang, S., & Jeong, S. M. (2024) · Molecules and Cells · doi:10.1016/j.mocell.2024.100096 · Cited by 12 · see citing works

Advancing Cancer Treatment by Targeting Glutamine Metabolism—A Roadmap

Halama, A., & Suhre, K. (2022) · Cancers · doi:10.3390/cancers14030553 · Cited by 92 · see citing works

Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells

Smith, B., Schafer, X., Ambeskovic, A., Spencer, C. M., Land, H., & Munger, J. C. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.045 · Cited by 168 · see citing works

Targeting fuel pocket of cancer cell metabolism: A focus on glutaminolysis

Sharma, S., Agnihotri, N., & Kumar, S. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114943 · Cited by 42 · see citing works

Glutamine at focus: versatile roles in cancer

Vitto, H. D., Pérez-Valencia, J. A., & Radosevich, J. A. (2015) · Tumor Biology · doi:10.1007/s13277-015-4671-9 · Cited by 48 · see citing works