SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism
Open accessAbstract
DNA damage elicits a cellular signaling response that initiates cell cycle arrest and DNA repair. Here, we find that DNA damage triggers a critical block in glutamine metabolism, which is required for proper DNA damage responses. This block requires the mitochondrial SIRT4, which is induced by numerous genotoxic agents and represses the metabolism of glutamine into tricarboxylic acid cycle. SIRT4 loss leads to both increased glutamine-dependent proliferation and stress-induced genomic instability, resulting in tumorigenic phenotypes. Moreover, SIRT4 knockout mice spontaneously develop lung tumors. Our data uncover SIRT4 as an important component of the DNA damage response pathway that orchestrates a metabolic block in glutamine metabolism, cell cycle arrest, and tumor suppression.
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During the DNA damage response, normal cells show decreased glutaminolysis controlled by SIRT4 suppressing GLUD1; absence of SIRT4 causes delayed DNA repair and chromosomal instability, suggesting a tumor suppressor effect.
“Moreover, evidence has shown that during the DNA damage response, normal cells show a decrease in glutaminolysis controlled by SIRT4 protein suppressing GLUD1. In the absence of SIRT4, a failure to undergo cell cycle arrest induced by DNA damage causes a delay in DNA repair and increased chromosomal instability, suggesting a tumor suppressor effect of SIRT4151.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [151]
Loss of SIRT4 enhances glutamine-dependent proliferation and genomic instability, contributing to tumorigenesis.
“Accordingly, loss of SIRT4 enhances glutamine-dependent proliferation and genomic instability, which simultaneously contribute to tumorigenesis151.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [151]
SIRT4 is upregulated as part of the DNA damage response via ATF4.
“Similarly, SIRT4 is upregulated as part of the DNA damage response via ATF4 (Jeong et al. 2013).”
From The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications (2018) · cites this paper as Jeong et al. 2013
SIRT4 controls tumorigenesis by inhibiting the high rate of glutamine metabolism associated with cancer growth.
“SIRT4 likewise appears to control tumorigenesis ((Jeong et al. 2013), (Csibi et al. 2013)) by inhibiting the high rate of glutamine metabolism associated with cancer growth;”
From The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications (2018) · cites this paper as Jeong et al. 2013
DHODH activity is elevated in response to DNA damage and upon genotoxic chemotherapy treatment to increase nucleotide synthesis for DNA repair.
“DHODH activity is also elevated in response to DNA damage and upon genotoxic chemotherapy treatment to increase nucleotide synthesis for DNA repair.76,77”
From The multifaceted contributions of mitochondria to cellular metabolism (2018) · cites this paper as [76]
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The role of mitochondrial sirtuins in health and disease
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Oncogenic regulation of tumor metabolic reprogramming
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SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK
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SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy
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SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis
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Self-citationThe Roles of Mitochondrial SIRT4 in Cellular Metabolism
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Metabolic Characterization of a Sirt5 deficient mouse model
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STAT3 Undergoes Acetylation-dependent Mitochondrial Translocation to Regulate Pyruvate Metabolism
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Sirtuins in stress response: guardians of the genome
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The Roles of Sirtuin Family Proteins in Cancer Progression
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SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma
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The roles of sirtuins family in cell metabolism during tumor development
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Coactivator SRC-2–dependent metabolic reprogramming mediates prostate cancer survival and metastasis
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- Authors
- Jeong, S. M., Xiao, C., Finley, L. W. S., Lahusen, T., Souza, A. L., Pierce, K., Li, Y.-H., Wang, X., Laurent, G., German, N. J., Xu, X., Li, C., Wang, R.-H., Lee, J., Csibi, A., Cerione, R., Blenis, J., Clish, C. B., Kimmelman, A., Deng, C.-X., & Haigis, M. C.
- Affiliations
- Harvard University (US)
- National Institutes of Health (US)
- Broad Institute (US)
- Cornell University (US)
- Corresponding author
- Deng, Chu-Xia
- Haigis, Marcia C.
- ORCID
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 23
- Issue
- 4
- Pages
- 450-463
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC3650305
- OpenAlex
- W2046120998
- Cited by
- 445
- References
- 56
- Citations by year
- 2026: 9 · 2025: 31 · 2024: 27 · 2023: 28 · 2022: 33 · 2021: 43 · 2020: 42 · 2019: 31 · 2018: 41 · 2017: 32 · 2016: 41 · 2015: 38 · 2014: 24 · 2013: 23
- FWCI
- 19.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG032375, AG032375)
- National Cancer Institute (R01CA157490)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- SIRT4, DNA damage response, glutamine metabolism, mitochondrial metabolism, TCA cycle, tumor suppression, genomic instability, cell cycle arrest, lung cancer, genotoxic stress, tumor suppressor
- MeSH terms
- Animals, DNA Damage, DNA Repair, Female, Glutamine, Humans, Male, Mitochondria, Neoplasms, Experimental, Signal Transduction, Mice, Knockout, Mitochondrial Proteins, Tumor Suppressor Proteins, Sirtuins, Cell Line, Tumor, Cell Growth Processes, Mice, Hep G2 Cells, HEK293 Cells
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