Cited by 114Pancreatic and Hepatic Oncology ResearchWnt/β-catenin signaling in development and cancerCancer Cells and Metastasis

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NMIIA promotes tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway and EMT in pancreatic cancer

Zhou, Pingting, Li, Yanyan, Li, Bo, Zhang, Meichao, Liu, Yuanhua, Yao, Yuan, Li, Dong·2019·Oncogene

DOI 10.1038/s41388-019-0806-6

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Abstract

Non-muscle myosin IIA (NMIIA) protein plays an important role in cell cytokinesis and cell migration. The role and underlying regulatory mechanisms of NMIIA in pancreatic cancer (PC) remain elusive. We found that NMIIA is highly expressed in PC tissues and contributes to PC poor progression by using open microarray datasets from the Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA), and PC tissue arrays. NMIIA regulates β-catenin mediated EMT to promote the proliferation, migration, invasion, and sphere formation of PC cells in vitro and in vivo. NMIIA controls the β-catenin transcriptional activity by interacting with β-catenin. Moreover, MEK/ERK signaling is critical in MLC2 (Ser19) phosphorylation, which can mediate NMIIA activity and regulate Wnt/β-catenin signaling. These findings highlight the significance of NMIIA in tumor regression and implicate NMIIA as a promising candidate for PC treatment.

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IGFBP2 drives epithelial-mesenchymal transition in hepatocellular carcinoma via activating the Wnt/β-catenin pathway
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Background
RETRACTED: ENKUR recruits FBXW7 to ubiquitinate and degrade MYH9 and further suppress MYH9‐induced deubiquitination of β‐catenin to block gastric cancer metastasis
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Retracted
NRF1-regulated CircNSUN2 promotes lymphoma progression through activating Wnt signaling pathway via stabilizing HMGA1
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“They were FOXP3 [18], LGR5 [19], NMIIA [20], RORA [21], WDR74 [22], HMGA1 [18,23] and HMGA2 [10].”
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Self-citation
NEK2 promotes esophageal squamous cell carcinoma cell proliferation, migration and invasion through the Wnt/β-catenin signaling pathway
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“Interestingly, RNF43 has a negative regulatory action on the Wnt signaling, which is closely related to the underlying mechanism of pancreatic cancer with metastases (27, 28).”
Background
The role of liquid-liquid phase separation in defining cancer EMT
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MYH9 facilitates autoregulation of adipose tissue depot development
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From Motor Proteins to Oncogenic Factors: The Evolving Role of Kinesin Superfamily Proteins in Breast Cancer Development
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Background
ASIC1a contributes to the epithelial–mesenchymal transformation of breast cancer by activating the Ca2+/β‐catenin pathway
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Background
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Background
One Novel BiP/GRP78 Inhibitor YUM70 Induces GSDME Dependent Pyroptosis and Enhances Sensitivity To EGFR Inhibitors in cholangiocarcinoma and hepatocellular carcinomaPreprint
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Self-citation
DNASE1L3 functions as a significant metastatic suppressor by attenuating MYH9/β-catenin/c-Jun/LncRNA-KDM4A-induced E-cadherin ubiquitination degradation in nasopharyngeal carcinoma
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Serala, K., Bai, J., & Prince, S. (2024) · Preprints.org · doi:10.20944/preprints202402.1726.v1
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Potential regulatory mechanisms of hsa_circ_0131457/miR-636/SFRP2 inhibition of tumor progression in pancreatic ductus adenocarcinomaPreprint
Kong, P., Yang, H., Dong, Y., Tong, Q., Dong, X., Yi, M.-A., & Yan, D. (2023) · Research Square · doi:10.21203/rs.3.rs-2604123/v1
Additional file 2 of CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2
Meng, L., Zhang, Y., Wu, P., Li, D., Lu, Y., Shen, P., Yang, T., Shi, G., Chen, Q., Yuan, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19959658
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Additional file 1 of CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2
Meng, L., Zhang, Y., Wu, P., Li, D., Lu, Y., Shen, P., Yang, T., Shi, G., Chen, Q., Yuan, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19959652
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Additional file 3 of CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2
Meng, L., Zhang, Y., Wu, P., Li, D., Lu, Y., Shen, P., Yang, T., Shi, G., Chen, Q., Yuan, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19959661
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Additional file 6 of CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2
Meng, L., Zhang, Y., Wu, P., Li, D., Lu, Y., Shen, P., Yang, T., Shi, G., Chen, Q., Yuan, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19959673
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Additional file 5 of CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2
Meng, L., Zhang, Y., Wu, P., Li, D., Lu, Y., Shen, P., Yang, T., Shi, G., Chen, Q., Yuan, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19959670
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Additional file 4 of CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2
Meng, L., Zhang, Y., Wu, P., Li, D., Lu, Y., Shen, P., Yang, T., Shi, G., Chen, Q., Yuan, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19959667
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Additional file 4 of Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/β-catenin pathway
Li, Z., Yang, H.-Y., Zhang, X.-L., Zhang, X., Huang, Y.-Z., Dai, X.-Y., Shi, L., Zhou, G.-R., Wei, J.-F., & Ding, Q. (2022) · Figshare · doi:10.6084/m9.figshare.19728217
Additional file 3 of Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/β-catenin pathway
Li, Z., Yang, H.-Y., Zhang, X.-L., Zhang, X., Huang, Y.-Z., Dai, X.-Y., Shi, L., Zhou, G.-R., Wei, J.-F., & Ding, Q. (2022) · Figshare · doi:10.6084/m9.figshare.19728214
Additional file 1 of Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/β-catenin pathway
Li, Z., Yang, H.-Y., Zhang, X.-L., Zhang, X., Huang, Y.-Z., Dai, X.-Y., Shi, L., Zhou, G.-R., Wei, J.-F., & Ding, Q. (2022) · Figshare · doi:10.6084/m9.figshare.19728208
Additional file 5 of Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/β-catenin pathway
Li, Z., Yang, H.-Y., Zhang, X.-L., Zhang, X., Huang, Y.-Z., Dai, X.-Y., Shi, L., Zhou, G.-R., Wei, J.-F., & Ding, Q. (2022) · Figshare · doi:10.6084/m9.figshare.19728220
Additional file 10 of Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/β-catenin pathway
Li, Z., Yang, H.-Y., Zhang, X.-L., Zhang, X., Huang, Y.-Z., Dai, X.-Y., Shi, L., Zhou, G.-R., Wei, J.-F., & Ding, Q. (2022) · Figshare · doi:10.6084/m9.figshare.19728205
Additional file 2 of Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/β-catenin pathway
Li, Z., Yang, H.-Y., Zhang, X.-L., Zhang, X., Huang, Y.-Z., Dai, X.-Y., Shi, L., Zhou, G.-R., Wei, J.-F., & Ding, Q. (2022) · Figshare · doi:10.6084/m9.figshare.19728211
Additional file 1 of IGFBP2 drives epithelial-mesenchymal transition in hepatocellular carcinoma via activating the Wnt/β-catenin pathway
Chen, X., Zhang, Y., Zhang, P., Wei, M., Tian, T., Guan, Y., Han, C., Wei, W., & Ma, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26639319
Additional file 7 of CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2
Meng, L., Zhang, Y., Wu, P., Li, D., Lu, Y., Shen, P., Yang, T., Shi, G., Chen, Q., Yuan, H., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19959676
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Authors: Zhou, P., Li, Y., Li, B., Zhang, M., Liu, Y., Yao, Y., & Li, D.
Affiliations: Shanghai Jiao Tong University (CN)
Second Military Medical University (CN)
Nanjing Medical University (CN)
Corresponding author: Liu, Yuanhua
Li, Dong
ORCID: Zhou, Pingting
Li, Yanyan
Li, Bo
Zhang, Meichao
Liu, Yuanhua
Li, Dong
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2019-04-09
Volume: 38
Issue: 27
Pages: 5500-5515
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/s41388-019-0806-6
OpenAlex: W2939437655
Cited by: 108
References: 63
Citations by year: 2026: 5 · 2025: 3 · 2024: 13 · 2023: 14 · 2022: 34 · 2021: 19 · 2020: 16 · 2019: 4
FWCI: 8.32
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China
Innovation Program for Ph.D. students in Shanghai Jiaotong University School of Medicine
Topics: Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: non-muscle myosin IIA, pancreatic cancer, Wnt/β-catenin signaling, epithelial-mesenchymal transition, tumor growth, metastasis, MEK/ERK signaling, myosin light chain 2 phosphorylation, cell proliferation, cell migration and invasion, tumor sphere formation
MeSH terms: Humans, Neoplasm Invasiveness, Neoplasm Metastasis, Pancreatic Neoplasms, Myosin Heavy Chains, Cell Proliferation, beta Catenin, Epithelial-Mesenchymal Transition, Wnt Signaling Pathway

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NMIIA promotes tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway and EMT in pancreatic cancer

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