Cited by 6,012Genomics and Chromatin DynamicsEpigenetics and DNA MethylationChromatin Remodeling and Cancer

Regulation of chromatin by histone modifications

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Bannister, Andrew J, Kouzarides, Tony·2011·Cell Research

Abstract

Chromatin is not an inert structure, but rather an instructive DNA scaffold that can respond to external cues to regulate the many uses of DNA. A principle component of chromatin that plays a key role in this regulation is the modification of histones. There is an ever-growing list of these modifications and the complexity of their action is only just beginning to be understood. However, it is clear that histone modifications play fundamental roles in most biological processes that are involved in the manipulation and expression of DNA. Here, we describe the known histone modifications, define where they are found genomically and discuss some of their functional consequences, concentrating mostly on transcription where the majority of characterisation has taken place.

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Crossref · 10.1038/cr.2011.22

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  • The acetylation state of histones is regulated by histone acetyltransferases, which add acetyl groups to histone tails at lysine residues, and histone deacetylases, which remove these acetyl groups.

    “The acetylation state of histones is regulated by the following two classes of enzymes: histone acetyltransferases (HATs), which add acetyl groups to histone tails at lysine residues, and histone deacetylases (HDACs), which removes these acetyl groups.”
  • D-2-hydroxyglutarate (D2HG) inhibits numerous demethylases, leading to changes in genomic and transcriptomic methylation profiles as well as gene expression and genome topology.

    “D-2-hydroxyglutarate (D2HG) is one such oncometabolite, which inhibits numerous demethylases, leading to changes in genomic and transcriptomic methylation profiles as well as gene expression and genome topology 32,90-92 .”

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2 of the 130 references couldn’t be matched to a known paper.

Research works printed but not linked: 5

  1. Dawson MA, Bannister AJ, Gottgens B, et al. JAK2 phos- phorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 2009; 461:819-822.
  2. Bannister AJ, Schneider R, Kouzarides T. Histone methyla- tion: dynamic or static? Cell 2002; 109:801-806.
  3. Adams-Cioaba MA, Min J. Structure and function of his- tone methylation binding proteins. Biochem Cell Biol 2009; 87:93-105.
  4. Berger SL, Kouzarides T, Shiekhattar R, Shilatifard A. An operational definition of epigenetics. Genes Dev 2009; 23:781-783. 127
  5. Kouzarides T, Berger SL. Chromatin modifications and their mechanism of action. In: Allis CD, Jenuwein T, Reinberg D, eds. Epigenetics, New York: Cold Spring Harbor Laboratory Press, 2007:191-210.

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Authors
Bannister, A. J., & Kouzarides, T.
Affiliations
University of Cambridge (GB)
Corresponding author
Kouzarides, Tony
Venue
Cell Research
Published
2011-02-15
Volume
21
Issue
3
Pages
381-395
ISSN
  • 1001-0602 (ISSN-L)
  • 1748-7838
OpenAlex
W2147524392
Cited by
6,012
References
130
Citations by year
2026: 322 · 2025: 536 · 2024: 558 · 2023: 510 · 2022: 523 · 2021: 490 · 2020: 502 · 2019: 427 · 2018: 404 · 2017: 383 · 2016: 348 · 2015: 283 · 2014: 253 · 2013: 219 · 2012: 176
FWCI
20.90
Type
journal article
Language
en
Open access
Locations
  • Cell Research (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
chromatin regulation, histone modifications, transcriptional regulation, epigenetics
MeSH terms
Chromatin, Heterochromatin, Histones, Protein Processing, Post-Translational, Histone Demethylases

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