The DOI matches its Crossref record; 627 of the 627 references it cites were found in a registry or an index.
TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases
Open accessAbstract
Transient receptor potential (TRP) channels are sensors for a variety of cellular and environmental signals. Mammals express a total of 28 different TRP channel proteins, which can be divided into seven subfamilies based on amino acid sequence homology: TRPA (Ankyrin), TRPC (Canonical), TRPM (Melastatin), TRPML (Mucolipin), TRPN (NO-mechano-potential, NOMP), TRPP (Polycystin), TRPV (Vanilloid). They are a class of ion channels found in numerous tissues and cell types and are permeable to a wide range of cations such as Ca 2+, Mg 2+, Na+, K+, and others. TRP channels are responsible for various sensory responses including heat, cold, pain, stress, vision and taste and can be activated by a number of stimuli. Their predominantly location on the cell surface, their interaction with numerous physiological signaling pathways, and the unique crystal structure of TRP channels make TRPs attractive drug targets and implicate them in the treatment of a wide range of diseases. Here, we review the history of TRP channel discovery, summarize the structures and functions of the TRP ion channel family, and highlight the current understanding of the role of TRP channels in the pathogenesis of human disease. Most importantly, we describe TRP channel-related drug discovery, therapeutic interventions for diseases and the limitations of targeting TRP channels in potential clinical applications.
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Cites
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Cited by
Xiong, J., Xiao, R., Zhao, J., Zhao, Q., Luo, M., Li, F., Zhang, W., & Wu, M. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-023-04810-3 · Cited by 79
Direct modulation of TRPC ion channels by Gα proteins
Kang, H., Kim, J., Park, C. H., Jeong, B., & So, I. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1362987 · Cited by 14
Metadata
- Authors
- Zhang, M., Ma, Y., Ye, X., Zhang, N., Pan, L., & Wang, B.
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2023-07-05
- Volume
- 8
- Issue
- 1
- Pages
- 261-261
- ISSN
- 2059-3635 (ISSN-L)
- OpenAlex
- W4383101597
- Cited by
- 522
- References
- 627
- FWCI
- 78.85
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhang, M., Ma, Y., Ye, X., Zhang, N., Pan, L., & Wang, B. (2023). TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases. Signal Transduction and Targeted Therapy. https://doi.org/10.1038/s41392-023-01464-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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