Direct modulation of TRPC ion channels by Gα proteins

The smooth muscle cell in culture

Chamley-Campbell, J. H., CAMPBELL, G. R., & Ross, R. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.1.1 · Cited by 1,560 · see citing works

Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

Rosas-Ballina, M., Olofsson, P. S., Ochani, M., Valdés-Ferrer, S. I., Levine, Y. A., Reardon, C., Tusche, M. W., Pavlov, V. A., Andersson, U., Chavan, S., et al. (2011) · Science · doi:10.1126/science.1209985 · Cited by 1,551 · see citing works

Characteristics of the Cholecystokinin-Induced Depolarization of Pacemaking Activity in Cultured Interstitial Cells of Cajal from Murine Small Intestine

Lee, J. H., Kim, S.-Y., Kwon, Y. K., Kim, B. J., & So, I. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350075 · Cited by 1,380 · see citing works

Muscarinic Receptor Subtypes

Hulme, E. C., Birdsall, N. J. M., & Buckley, N. J. (1990) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.30.040190.003221 · Cited by 1,344 · see citing works

G Protein Pathways

Neves, S. R., Ram, P. T., & Iyengar, R. (2002) · Science · doi:10.1126/science.1071550 · Cited by 1,300 · see citing works

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

Logothetis, D. E., Kurachi, Y., Galper, J., Neer, E. J., & Clapham, D. E. (1987) · Nature · doi:10.1038/325321a0 · Cited by 1,208 · see citing works

Heterotrimeric G protein activation by G-protein-coupled receptors

Oldham, W. M., & Hamm, H. E. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2299 · Cited by 1,174 · see citing works

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

Lüscher, C., & Slesinger, P. A. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2834 · Cited by 617 · see citing works

Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4−/− mice

Freichel, M., Suh, S. H., Pfeifer, A., Schweig, U., Trost, C., Weißgerber, P., Biel, M., Philipp, S. E., Freise, D., Droogmans, G., et al. (2001) · Nature Cell Biology · doi:10.1038/35055019 · Cited by 577 · see citing works

Nitric oxide activates TRP channels by cysteine S-nitrosylation

Yoshida, T., Inoue, R., Morii, T., Takahashi, N., Yamamoto, S., Hara, Y., Tominaga, M., Shimizu, S., Sato, Y., & Mori, Y. (2006) · Nature Chemical Biology · doi:10.1038/nchembio821 · Cited by 566 · see citing works

TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling

Kuwahara, K., Wang, Y., McAnally, J., Richardson, J. A., Bassel‐Duby, R., Hill, J. A., & Olson, E. N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27702 · Cited by 561 · see citing works

Advances in TRP channel drug discovery: from target validation to clinical studies

Koivisto, A., Belvisi, M. G., Gaudet, R., & SZALLASI, A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00268-4 · Cited by 549 · see citing works

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

Zhang, M., Ma, Y., Ye, X., Zhang, N., Pan, L., & Wang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01464-x · Cited by 548 · see citing works

PIP2 Activates KCNQ Channels, and Its Hydrolysis Underlies Receptor-Mediated Inhibition of M Currents

Zhang, H., Craciun, L. C., Mirshahi, T., Rohács, T., Lopes, C. M. B., Jin, T., & Logothetis, D. E. (2003) · Neuron · doi:10.1016/s0896-6273(03)00125-9 · Cited by 523 · see citing works

TRPC5 is a regulator of hippocampal neurite length and growth cone morphology

Greka, A., Navarro, B., Oancea, E., Duggan, A., & Clapham, D. E. (2003) · Nature Neuroscience · doi:10.1038/nn1092 · Cited by 382 · see citing works

Impairment of Store-Operated Ca 2+ Entry in TRPC4 −/− Mice Interferes With Increase in Lung Microvascular Permeability

Tiruppathì, C., Freichel, M., Vogel, S. M., Paria, B. C., Mehta, D., Flockerzi, V., & Malik, A. B. (2002) · Circulation Research · doi:10.1161/01.res.0000023391.40106.a8 · Cited by 370 · see citing works

Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice

Gomeza, J., Shannon, H. E., Kostenis, E., Felder, C. C., Zhang, L., Brodkin, J. D., Grinberg, A., SHENG, H. Z., & Wess, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1692 · Cited by 348 · see citing works

mRNA distribution analysis of human TRPC family in CNS and peripheral tissues

Riccio, A., Medhurst, A. D., Mattei, C., Kelsell, R. E., Calver, A. R., Randall, A. D., Benham, C. D., & Pangalos, M. N. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00527-2 · Cited by 327 · see citing works

X-ray structure of the mammalian GIRK2–βγ G-protein complex

Whorton, M. R., & MacKinnon, R. (2013) · Nature · doi:10.1038/nature12241 · Cited by 298 · see citing works

Induction of photoreceptor voltage noise in the dark in Drosophila mutant

Minke, B., Wu, C., & Pak, W. L. (1975) · Nature · doi:10.1038/258084a0 · Cited by 276 · see citing works

Acetylcholine activates an inward current in single mammalian smooth muscle cells

Benham, C. D., Bolton, T. B., & Lang, R. J. (1985) · Nature · doi:10.1038/316345a0 · Cited by 269 · see citing works

Muscarinic receptors in the Mammalian Heart

Dhein, S., van Koppen, C. J., & Brodde, O.-E. (2001) · Pharmacological Research · doi:10.1006/phrs.2001.0835 · Cited by 264 · see citing works

Lanthanides Potentiate TRPC5 Currents by an Action at Extracellular Sites Close to the Pore Mouth

Jung, S., Muehle, A., Schaefer, M., Strotmann, R., Schultz, G., & Plant, T. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211484200 · Cited by 259 · see citing works

The non-excitable smooth muscle: Calcium signaling and phenotypic switching during vascular disease

House, S. J., Potier‐Cartereau, M., Bisaillon, J. M., Singer, H. A., & Trebak, M. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0491-8 · Cited by 257 · see citing works

Vagus Nerve Stimulation and the Cardiovascular SystemPreprint

Capilupi, M. J., Kerath, S. M., & Becker, L. B. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a034173 · Cited by 257 · see citing works

Melanocortin 4 Receptors Reciprocally Regulate Sympathetic and Parasympathetic Preganglionic Neurons

Sohn, J.-W., Harris, L. E., Berglund, E. D., Liu, T., Vong, L., Lowell, B. B., Balthasar, N., Williams, K. W., & Elmquist, J. K. (2013) · Cell · doi:10.1016/j.cell.2012.12.022 · Cited by 218 · see citing works

Acetylcholine activates nonselective cation channels in guinea pig ileum through a G protein

Inoue, R., & Isenberg, G. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.6.c1173 · Cited by 218 · see citing works

Serotonin 2C Receptor Activates a Distinct Population of Arcuate Pro-opiomelanocortin Neurons via TRPC Channels

Sohn, J., Xu, Y., Jones, J. E., Wickman, K., Williams, K. W., & Elmquist, J. K. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.012 · Cited by 196 · see citing works

Deletion of TRPC4 and TRPC6 in Mice Impairs Smooth Muscle Contraction and Intestinal Motility In Vivo

Tsvilovskyy, V., Zholos, A. V., Aberle, T., Philipp, S. E., Dietrich, A., Zhu, M. X., Birnbaumer, L., Freichel, M., & Flockerzi, V. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.06.046 · Cited by 194 · see citing works

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models

Zhou, Y., Castonguay, P., Sidhom, E.-H., Clark, A. R., Dvela‐Levitt, M., Kim, S., Sieber, J., Wieder, N. W., Jung, J. Y., Andreeva, S. G., et al. (2017) · Science · doi:10.1126/science.aal4178 · Cited by 189 · see citing works

(−)‐Englerin A is a Potent and Selective Activator of TRPC4 and TRPC5 Calcium Channels

Akbulut, Y., Gaunt, H. J., Muraki, K., Ludlow, M. J., Amer, M. S., Bruns, A. F., Vasudev, N. S., Radtke, L., Willot, M., Hahn, S., et al. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201411511 · Cited by 186 · see citing works

Antibodies and venom peptides: new modalities for ion channels

Wulff, H., Christophersen, P., Colussi, P. A., Chandy, K. G., & Yarov-Yarovoy, V. M. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0013-8 · Cited by 185 · see citing works

Muscarinic regulation of cardiac ion channels

Harvey, R. D., & Belevych, A. E. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705338 · Cited by 175 · see citing works

Isoform-specific Inhibition of TRPC4 Channel by Phosphatidylinositol 4,5-Bisphosphate

Otsuguro, K., Tang, J., Tang, Y., Xiao, R., Freichel, M., Tsvilovskyy, V., Ito, S., Flockerzi, V., Zhu, M. X., & Zholos, A. V. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707306200 · Cited by 168 · see citing works

Molecular markers expressed in cultured and freshly isolated interstitial cells of Cajal

Epperson, A., Hatton, W. J., Callaghan, B. P., Doherty, P. D., Walker, R. L., Sanders, K. M., Ward, S. M., & Horowitz, B. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.2.c529 · Cited by 167 · see citing works

Membrane potentials of smooth muscle fibres of the taenia coli of the guinea‐pig

Bülbring, E. (1954) · The Journal of Physiology · doi:10.1113/jphysiol.1954.sp005159 · Cited by 167 · see citing works

Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice

Tzavara, E. T., Bymaster, F. P., Felder, C. C., Wade, M. R., Gomeza, J., Wess, J., McKinzie, D. L., & Nomikos, G. G. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001270 · Cited by 163 · see citing works

Intracellular calcium ions modulate acetylcholine‐induced inward current in guinea‐pig ileum.

Inoue, R., & Isenberg, G. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018056 · Cited by 157 · see citing works

Structure of the mouse TRPC4 ion channel

Duan, J., Li, J., Zeng, B., Chen, G., Peng, X., Zhang, Y., Wang, J., Clapham, D. E., Li, Z., & Zhang, J. (2018) · Nature Communications · doi:10.1038/s41467-018-05247-9 · Cited by 146 · see citing works

Molecular analysis of smooth muscle development in the mouse

McHugh, K. M. (1995) · Developmental Dynamics · doi:10.1002/aja.1002040306 · Cited by 138 · see citing works

Direct G Protein Activation of Ion Channels?

Clapham, D. E. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.002301 · Cited by 130 · see citing works

Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory

Bröker‐Lai, J., Kollewe, A., Schindeldecker, B., Pohle, J., Nguyễn, V., Mathar, I., Guzman, R. E., Schwarz, Y. N., Lai, A., Weißgerber, P., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201696369 · Cited by 126 · see citing works

GTP‐binding protein involvement in membrane currents evoked by carbachol and histamine in guinea‐pig ileal muscle.

Komori, S., Kawai, M., Takewaki, T., & Ohashi, H. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019118 · Cited by 125 · see citing works

Muscarinic receptor subtypes controlling the cationic current in guinea‐pig ileal smooth muscle

Zholos, A. V., & Bolton, T. B. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701438 · Cited by 113 · see citing works

Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function

Duan, J., Li, J., Chen, G.-L., Ge, Y., Liu, J., Xie, K., Peng, X., Zhou, W., Zhong, J., Zhang, Y., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw7935 · Cited by 112 · see citing works

Potentiation of TRPC5 by Protons

Semtner, M., Schaefer, M., Pinkenburg, O., & Plant, T. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702577200 · Cited by 111 · see citing works

Dynamic NHERF interaction with TRPC4/5 proteins is required for channel gating by diacylglycerol

Storch, U., Forst, A. W., Pardatscher, F. M., Erdogmus, S., Philipp, M., Gregoritza, M., y Schnitzler, M. M., & Gudermann, T. W. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612263114 · Cited by 109 · see citing works

Role of G‐proteins in muscarinic receptor inward and outward currents in rabbit jejunal smooth muscle.

Komori, S., & Bolton, T. B. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018178 · Cited by 107 · see citing works

Nonadrenergic neural vasodilator mechanisms.

Bevan, J. A., & Brayden, J. E. (1987) · Circulation Research · doi:10.1161/01.res.60.3.309 · Cited by 106 · see citing works

Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation

Carson, C., Raman, P., Tullai, J., Xu, L., Hénault, M., Thomas, E., Yeola, S. W., Lao, J., McPate, M. J., Verkuyl, J. M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127498 · Cited by 103 · see citing works

Odontoblast TRPC5 channels signal cold pain in teeth

Bernal, L., Sotelo-Hitschfeld, P., König, C., Sinica, V., Wyatt, A. K., Winter, Z., Hein, A., Touška, F., Reinhardt, S., Tragl, A., et al. (2021) · Science Advances · doi:10.1126/sciadv.abf5567 · Cited by 102 · see citing works

Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington’s disease

Hong, C., Seo, H., Kwak, M., Jeon, J., Jang, J., Jeong, E. M., Myeong, J., Hwang, Y. J., Ha, K., Kang, M. J., et al. (2015) · Brain · doi:10.1093/brain/awv188 · Cited by 101 · see citing works

Full-length Gαq–phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain

Lyon, A. M., Dutta, S., Boguth, C. A., Skiniotis, G., & Tesmer, J. J. G. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2497 · Cited by 100 · see citing works

TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons

Gao, Y., Yao, T. S., Deng, Z., Sohn, J., Sun, J. M., Huang, Y., Kong, X., Yu, K.-J., Wang, R.-T., Chen, H., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.072 · Cited by 100 · see citing works

Selective Gαi Subunits as Novel Direct Activators of Transient Receptor Potential Canonical (TRPC)4 and TRPC5 Channels

Jeon, J.-P., Hong, C., Park, E., Jeon, J., Cho, N., Kim, I. G., Choe, H., Muallem, S., Kim, H. J., & So, I. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.326553 · Cited by 99 · see citing works

Heteromeric Canonical Transient Receptor Potential 1 and 4 Channels Play a Critical Role in Epileptiform Burst Firing and Seizure-Induced Neurodegeneration

Phelan, K. D., Mock, M. M., Kretz, O., Shwe, U. T., Kozhemyakin, M. B., Greenfield, L. J., Dietrich, A., Birnbaumer, L., Freichel, M., Flockerzi, V., et al. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.075341 · Cited by 96 · see citing works

G-Protein Coupled Receptors (GPCRs): Signaling Pathways, Characterization, and Functions in Insect Physiology and Toxicology

Liu, N., Wang, Y., Li, T., & Feng, X. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105260 · Cited by 96 · see citing works

Dissociation of Heterotrimeric G Proteins in Cells

Lambert, N. A. (2008) · Science Signaling · doi:10.1126/scisignal.125re5 · Cited by 94 · see citing works

Transcriptome of interstitial cells of Cajal reveals unique and selective gene signatures

Lee, M. Y., Ha, S. E., Park, C., Park, P. J., Fuchs, R., Wei, L., Jorgensen, B. G., Redelman, D. D., Ward, S. M., Sanders, K. M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176031 · Cited by 94 · see citing works

Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

Song, K., Wei, M., Guo, W., Li, Q., Kang, Y., Wu, J.-X., & Chen, L. (2021) · eLife · doi:10.7554/elife.63429 · Cited by 94 · see citing works

TRP channels: a journey towards a molecular understanding of pain

Rosenbaum, T., Morales‐Lázaro, S. L., & Islas, L. D. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00611-7 · Cited by 91 · see citing works

Activities of neurons within the rat dorsolateral septal nucleus (DLSN)

Gallagher, J. P., Zheng, F., Hasuo, H., & Shinnick-Gallagher, P. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)98600-a · Cited by 82 · see citing works

Receptor-induced depletion of phosphatidylinositol 4,5-bisphosphate inhibits inwardly rectifying K + channels in a receptor-specific manner

Cho, H., Lee, D., Lee, S., & Ho, W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408844102 · Cited by 82 · see citing works

Low mobility of phosphatidylinositol 4,5-bisphosphate underlies receptor specificity of Gq-mediated ion channel regulation in atrial myocytes

Cho, H., Kim, Y. A., Yoon, J., Lee, D., Kim, J. H., Lee, S., & Ho, W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408851102 · Cited by 82 · see citing works

Actions of neurotransmitters and other messengers on Ca2+ channels and K+ channels in smooth muscle cells

Beech, D. J. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(97)87271-3 · Cited by 81 · see citing works

TRPC4 in Rat Dorsal Root Ganglion Neurons Is Increased after Nerve Injury and Is Necessary for Neurite Outgrowth

Wu, D., Huang, W. L., Richardson, P. M., Priestley, J. V., & Liu, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703177200 · Cited by 80 · see citing works

A Cytosolic Residue Mediates Mg2+Block and Regulates Inward Current Amplitude of a Transient Receptor Potential Channel

Obukhov, A. G., & Nowycky, M. C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4451-04.2005 · Cited by 77 · see citing works

A TRPC5-regulated calcium signaling pathway controls dendrite patterning in the mammalian brainPreprint

Puram, S. V., Riccio, A., Koirala, S., Ikeuchi, Y., Kim, A. H., Corfas, G., & Bonni, A. (2011) · Genes & Development · doi:10.1101/gad.174060.111 · Cited by 76 · see citing works

Desensitization of canonical transient receptor potential channel 5 by protein kinase C

Zhu, M. H., Chae, M. R., Kim, H. J., Lee, Y., Kim, M. J., Jin, N., Yang, D. K., So, I., & Kim, K. W. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00440.2004 · Cited by 76 · see citing works

Critical roles of G i/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels

Thakur, D., Tian, J., Jeon, J., Xiong, J., Huang, Y., Flockerzi, V., & Zhu, M. X. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522294113 · Cited by 72 · see citing works

TRPC4 Is an Essential Component of the Nonselective Cation Channel Activated by Muscarinic Stimulation in Mouse Visceral Smooth Muscle Cells

Lee, K. P., Jun, J. Y., Chang, I. Y., Suh, S.-H., So, I., & Kim, K. W. (2005) · Molecules and Cells · doi:10.1016/s1016-8478(23)13250-x · Cited by 72 · see citing works

Structural basis of TRPC4 regulation by calmodulin and pharmacological agents

Vinayagam, D., Quentin, D., Yu-Strzelczyk, J., Sitsel, O., Merino, F., Stabrin, M., Hofnagel, O., Yu, M., Ledeboer, M. W., Nagel, G., et al. (2020) · eLife · doi:10.7554/elife.60603 · Cited by 71 · see citing works

Functions of Muscarinic Receptor Subtypes in Gastrointestinal Smooth Muscle: A Review of Studies with Receptor-Knockout Mice

Tanahashi, Y., Komori, S., Matsuyama, H., Kitazawa, T., & Unno, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020926 · Cited by 71 · see citing works

Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site

Wright, D. J., Simmons, K. J., Johnson, R. M., Beech, D. J., Muench, S. P., & Bon, R. S. (2020) · Communications Biology · doi:10.1038/s42003-020-01437-8 · Cited by 66 · see citing works

Activation of M2 muscarinic receptors in guinea-pig ileum opens cationic channels modulated by M3 muscarinic receptors

Bolton, T. B., & Zholos, A. V. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00056-8 · Cited by 65 · see citing works

Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice

Yang, L.-P., Jiang, F.-J., Wu, G.-S., Deng, K., Wen, M., Zhou, X., Hong, X., Zhu, M. X., & Luo, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136255 · Cited by 63 · see citing works

Oscillations of receptor-operated cationic current and internal calcium in single guinea-pig ileal smooth muscle cells

Komori, S., Kawai, M., Pacaud, P., Ohashi, H., & Bolton, T. B. (1993) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00374905 · Cited by 63 · see citing works

Cardiac effects of muscarinic receptor antagonists used for voiding dysfunction

Andersson, K., Campeau, L., & Olshansky, B. (2010) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2010.03813.x · Cited by 62 · see citing works

Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice

Zhou, Q., Fu, X., Xu, J., Dong, S., Liu, C., Cheng, D., Gao, C., Huang, M., Liu, Z., Ni, X., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.11.008 · Cited by 56 · see citing works

G-protein–gated TRP-like Cationic Channel Activated by Muscarinic Receptors

Zholos, A. V., Zholos, A. A., & Bolton, T. B. (2004) · The Journal of General Physiology · doi:10.1085/jgp.200309002 · Cited by 55 · see citing works

Cloning, expression and characterization of a novel human Ras-related protein that is regulated by glucocorticoid hormone

Tu, Y., & Wu, C. (1999) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(99)00197-9 · Cited by 51 · see citing works

PIP2 regulation of TRPC5 channel activation and desensitization

Ningoo, M., Plant, L. D., Greka, A., & Logothetis, D. E. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100726 · Cited by 51 · see citing works

Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes

Kollewe, A., Schwarz, Y. N., Oleinikov, K., Raza, A., Haupt, A., Wartenberg, P., Wyatt, A. K., Boehm, U., Ectors, F., Bildl, W., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.029 · Cited by 51 · see citing works

NMR Analyses of the Gβγ Binding and Conformational Rearrangements of the Cytoplasmic Pore of G Protein-activated Inwardly Rectifying Potassium Channel 1 (GIRK1)

Yokogawa, M., Osawa, M., Takeuchi, K., Mase, Y., & Shimada, I. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.160754 · Cited by 47 · see citing works

Ca2+ inhibition of inositol trisphosphate‐induced Ca2+ release in single smooth muscle cells of guinea‐pig small intestine.

Zholos, A. V., Komori, S., Ohashi, H., & Bolton, T. B. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020421 · Cited by 47 · see citing works

Systematic analysis and prediction of genes associated with monogenic disorders on human chromosome X

Leitão, E., Schröder, C., Parenti, I., Dalle, C., Rastetter, A., Kühnel, T., Kuechler, A., Kaya, S., Gérard, B., Schaefer, E., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34264-y · Cited by 47 · see citing works

Effects of G‐protein‐specific antibodies and Gβγ subunits on the muscarinic receptor‐operated cation current in guinea‐pig ileal smooth muscle cells

Yan, H. ‐., Okamoto, H. H., Unno, T., Tsytsyura, Y., Prestwich, S. A., Komori, S., Zholos, A. V., & Bolton, T. B. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705289 · Cited by 46 · see citing works

Interaction Sites of the G Protein β Subunit with Brain G Protein-coupled Inward Rectifier K+ Channel

Albsoul-Younes, A. M., Sternweis, P. M., Zhao, P., Nakata, H., Nakajima, S., Nakajima, Y., & Kozasa, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011231200 · Cited by 44 · see citing works

The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels

Kim, H., Kim, J., Jeon, J.-P., Myeong, J., Wie, J., Hong, C., Kim, H. J., Jeon, J., & So, I. (2012) · Channels · doi:10.4161/chan.21198 · Cited by 44 · see citing works

Activation of TRPC4β by Gαi subunit increases Ca2+ selectivity and controls neurite morphogenesis in cultured hippocampal neuron

Jeon, J.-P., Roh, S., Wie, J., Kim, J., Kim, H., Lee, K. P., Yang, D., Jeon, J., Cho, N., Kim, I. G., et al. (2013) · Cell Calcium · doi:10.1016/j.ceca.2013.07.006 · Cited by 41 · see citing works

Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells

Kim, M. T., Kim, B. J., Lee, J. H., Kwon, S. C., Yeon, D. S., Yang, D. K., So, I., & Kim, K. W. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00602.2004 · Cited by 41 · see citing works

Trpc5 deficiency causes hypoprolactinemia and altered function of oscillatory dopamine neurons in the arcuate nucleus

Blum, T. S., Moreno-Pérez, A., Pyrski, M. M., Bufe, B., Arifovic, A., Weißgerber, P., Freichel, M., Zufall, F., & Leinders‐Zufall, T. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1905705116 · Cited by 41 · see citing works

Existence of functional M 3 -muscarinic receptors in the human heart

Willmy-Matthes, P., Leineweber, K., Wangemann, T., Silber, R.-E., & Brodde, O. (2003) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-003-0796-2 · Cited by 40 · see citing works

G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization

Liang, B., Nissen, J. D., Laursen, M., Wang, X., Skibsbye, L., Hearing, M. C., Andersen, M. N., Rasmussen, H. B., Wickman, K., Grunnet, M., et al. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt240 · Cited by 38 · see citing works

Smooth muscle from aganglionic bowel in Hirschsprung's disease impairs neuronal development in vitro

Langer, J. C., Betti, P.-A., & Blennerhassett, M. G. (1994) · Cell and Tissue Research · doi:10.1007/bf00354798 · Cited by 38 · see citing works

Dual action of the Gαq-PLCβ-PI(4,5)P2 pathway on TRPC1/4 and TRPC1/5 heterotetramers

Myeong, J., Ko, J., Kwak, M., Kim, J., Woo, J., Ha, K., Hong, C., Yang, D., Kim, H. J., Jeon, J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-30625-0 · Cited by 38 · see citing works

The specific activation of TRPC4 by Gi protein subtype

Jeon, J., Lee, K. P., Park, E., Sung, T. S., Kim, B. J., Jeon, J., & So, I. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.012 · Cited by 37 · see citing works

Nonselective Cation Channels Activated by the Stimulation of Muscarinic Receptors in Mammalian Gastric Smooth Muscle.

So, I., & Kim, K. W. (2003) · Journal of Smooth Muscle Research · doi:10.1540/jsmr.39.231 · Cited by 36 · see citing works

Contribution of TRPC Channels in Neuronal Excitotoxicity Associated With Neurodegenerative Disease and Ischemic Stroke

Jeon, J., Bu, F., Sun, G., Tian, J., Ting, S., Li, J., Aronowski, J. A., Birnbaumer, L., Freichel, M., & Zhu, M. X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.618663 · Cited by 36 · see citing works

Regulation of neuropathic pain behavior by amygdaloid TRPC4/C5 channels

Wei, H., Sagalajev, B., Yüzer, M. A., Koivisto, A., & Pertovaara, A. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.09.033 · Cited by 35 · see citing works

Molecular architecture of the Gαi-bound TRPC5 ion channel

Won, J., Kim, J., Jeong, H., Kim, J., Feng, S., Jeong, B., Kwak, M., Ko, J., Im, W., So, I., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38281-3 · Cited by 35 · see citing works

Regulation of TRP-like muscarinic cation current in gastrointestinal smooth muscle with special reference to PLC/InsP3/Ca2+ system

Zholos, A. V. (2006) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2006.00392.x · Cited by 33 · see citing works

Protein kinase C mediates the desensitization of CCh-activated nonselective cationic current in guinea-pig gastric myocytes

Kim, Y. C., Kim, S. J., Sim, J. H., Jun, J. Y., Kang, T. M., Suh, S. H., So, I., & Kim, K. W. (1998) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050597 · Cited by 32 · see citing works

Ca2+ influx through carbachol‐activated non‐selective cation channels in guinea‐pig gastric myocytes

Kim, S. J., Koh, E., Kang, T. M., Kim, Y. C., So, I., Isenberg, G., & Kim, K. W. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.749ba.x · Cited by 32 · see citing works

Gq-coupled muscarinic receptor enhancement of KCNQ2/3 channels and activation of TRPC channels in multimodal control of excitability in dentate gyrus granule cells

Carver, C. M., & Shapiro, M. S. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1781-18.2018 · Cited by 31 · see citing works

Structural identification of riluzole-binding site on human TRPC5

Yang, Y., Wei, M., & Chen, L. (2022) · Cell Discovery · doi:10.1038/s41421-022-00410-5 · Cited by 31 · see citing works

TRPC1/4/5 channels contribute to morphine‐induced analgesic tolerance and hyperalgesia by enhancing spinal synaptic potentiation and structural plasticity

Chu, W., Wang, F., Sun, Z., Ma, S., Wang, X., Han, W., Wang, F., Bai, Z., Wu, S., Freichel, M., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202000154rr · Cited by 30 · see citing works

Molecular determinants of PKA-dependent inhibition of TRPC5 channel

Sung, T. S., Jeon, J.-P., Kim, B. J., Hong, C., Kim, S. Y., Kim, J., Jeon, J., Kim, H. J., Suh, C. K., Kim, S. J., et al. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00351.2010 · Cited by 28 · see citing works

Interaction of G Protein β Subunit with Inward Rectifier K+ Channel Kir3

Zhao, Q., Kawano, T., Nakata, H., Nakajima, Y., Nakajima, S., & Kozasa, T. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.5.1085 · Cited by 27 · see citing works

Muscarinic cationic current in gastrointestinal smooth muscles: signal transduction and role in contraction

Unno, T., Matsuyama, H., Okamoto, H. H., Sakamoto, T., Yamamoto, M. P., Tanahashi, Y., Yan, H., & Komori, S. (2006) · Autonomic and Autacoid Pharmacology · doi:10.1111/j.1474-8673.2006.00366.x · Cited by 26 · see citing works

Dual depolarization responses generated within the same lateral septal neurons by TRPC4-containing channels

Tian, J., Thakur, D., Lu, Y., Zhu, Y., Freichel, M., Flockerzi, V., & Zhu, M. X. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1362-5 · Cited by 25 · see citing works

Gαi-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation

Kwak, M., Hong, C., Myeong, J., Park, E. Y. J., Jeon, J., & So, I. (2018) · Scientific Reports · doi:10.1038/s41598-018-21873-1 · Cited by 21 · see citing works

Structure–Function Relationship and Physiological Roles of Transient Receptor Potential Canonical (TRPC) 4 and 5 Channels

Kim, J., Ko, J., Hong, C., & So, I. (2019) · Cells · doi:10.3390/cells9010073 · Cited by 21 · see citing works

TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect G q/11 –G i/o coincidence signals of variable strengths

Tian, J., Yang, J., Joslin, W. C., Flockerzi, V., Prescott, S. A., Birnbaumer, L., & Zhu, M. X. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2120870119 · Cited by 21 · see citing works

TRPC Channels and Epilepsy

Zheng, F. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-1088-4_11 · Cited by 20 · see citing works

Molecular mechanisms of cholinergic neurotransmission in visceral smooth muscles with a focus on receptor-operated TRPC4 channel and impairment of gastrointestinal motility by general anaesthetics and anxiolytics

Zholos, A. V., Melnyk, M. I., & Dryn, D. O. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109776 · Cited by 19 · see citing works

Intracellular acidification facilitates receptor‐operated TRPC4 activation through PLCδ1 in a Ca2+‐dependent manner

Thakur, D., Wang, Q., Jeon, J., Tian, J., & Zhu, M. X. (2020) · The Journal of Physiology · doi:10.1113/jp279658 · Cited by 18 · see citing works

Blockade of TRPC Channels Limits Cholinergic-Driven Hyperexcitability and Seizure Susceptibility After Traumatic Brain Injury

Carver, C. M., DeWitt, H. R., Stoja, A. P., & Shapiro, M. S. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.681144 · Cited by 18 · see citing works

Identification of two novel autism genes, TRPC4 and SCFD2, in Qatar simplex families through exome sequencing

Gupta, V. R., Ben‐Mahmoud, A., Ku, B., Velayutham, D., Jan, Z., Aden, A., Kubbar, A., Alshaban, F. A. W., Stanton, L. W., Jithesh, P. V., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1251884 · Cited by 16 · see citing works

Gαi/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents

Yoo, E.-S., Li, L., Jia, L., Lord, C. C., Lee, C. E., Birnbaum, S. G., Vianna, C. R., Berglund, E. D., Cunningham, K. A., Xu, Y., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109997 · Cited by 15 · see citing works

The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels

Wie, J., Kim, B. J., Myeong, J., Ha, K., Jeong, S. J., Yang, D., Kim, E., Jeon, J., & So, I. (2015) · Channels · doi:10.1080/19336950.2015.1058454 · Cited by 12 · see citing works

The Transient Receptor Potential Protein Homologue TRPC4/5 as a Candidate for the Nonselective Cationic Channel Activated by Muscarinic Stimulation in the Murine Stomach

Zhu, M. H., Lee, Y., Jin, N., So, I., & Kim, K. W. (2003) · Neurophysiology · doi:10.1023/b:neph.0000008790.75165.d6 · Cited by 12 · see citing works

Ras homolog enriched in striatum inhibits the functional activity of wild type thyrotropin, follicle-stimulating hormone, luteinizing hormone receptors and activating thyrotropin receptor mutations by altering their expression in COS-7 cells

Agretti, P., Marco, G. D., Pinchera, A., Vitti, P., Bernal, J., & Tonacchera, M. (2007) · Journal of Endocrinological Investigation · doi:10.1007/bf03346294 · Cited by 12 · see citing works

Intracellular spermine blocks TRPC4 channel via electrostatic interaction with C-terminal negative amino acids

Kim, J., Moon, S. H., Shin, Y.-C., Jeon, J., Park, K. J., Lee, K. P., & So, I. (2015) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-015-1753-x · Cited by 12 · see citing works

Functional responses of the hippocampus to hyperexcitability depend on directed, neuron‐specific KCNQ2 K+ channel plasticity

Carver, C. M., Hastings, S. D., Cook, M. E., & Shapiro, M. S. (2019) · Hippocampus · doi:10.1002/hipo.23163 · Cited by 12 · see citing works

Englerin A-sensing charged residues for transient receptor potential canonical 5 channel activation

Jeong, S., Ko, J., Kim, M., Park, K. C., Park, E. Y. J., Kim, J., Baik, Y., Wie, J., Cho, A. E., Jeon, J., et al. (2019) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2019.23.3.191 · Cited by 11 · see citing works

TRPC4 as a coincident detector of Gi/o and Gq/11 signaling: mechanisms and pathophysiological implications

Jeon, J., Tian, J., & Zhu, M. X. (2020) · Current Opinion in Physiology · doi:10.1016/j.cophys.2020.06.008 · Cited by 11 · see citing works

Analysis of Rhes Activation State and Effector Function

Bernal, J., & Crespo, P. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)07043-6 · Cited by 10 · see citing works

Analysis of interaction between intracellular spermine and transient receptor potential canonical 4 channel: multiple candidate sites of negatively charged amino acids for the inward rectification of transient receptor potential canonical 4

Kim, J., Moon, S. H., Kim, T.-W., Ko, J., Jeon, Y. K., Shin, Y.-C., Jeon, J., & So, I. (2020) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2020.24.1.101 · Cited by 9 · see citing works

Transient Receptor Potential Canonical 4 and 5 Channel Antagonist ML204 Depolarized Pacemaker Potentials of Interstitial Cells of Cajal

Lee, J. H., Wu, W., Huang, X., Jun, J. Y., & Choi, S. (2020) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm20064 · Cited by 7 · see citing works

Pharmacological Differences between Native Homomeric Transient Receptor Potential Canonical Type 4 Channels and Heteromeric Transient Receptor Potential Canonical Type 1/4 Channels in Lateral Septal Neurons

Phelan, K. D., Shwe, U. T., & Zheng, F. (2023) · Pharmaceuticals · doi:10.3390/ph16091291 · Cited by 6 · see citing works

Canonical Transient Receptor Potential Channels as Novel Targets for Antiepileptic Drugs

Zheng, F. (2022) · Epilepsy · doi:10.36255/exon-publications-epilepsy-trpc · Cited by 5 · see citing works

Inhibition of Canonical Transient Receptor Potential Channels 4/5 with Highly Selective and Potent Small-Molecule HC-070 Alleviates Mechanical Hypersensitivity in Rat Models of Visceral and Neuropathic Pain

Jalava, N., Kaskinoro, J., Chapman, H., Morales, M., Metsänkylä, H., Heinonen, S., & Koivisto, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043350 · Cited by 5 · see citing works

Negative self-regulation of transient receptor potential canonical 4 by the specific interaction with phospholipase C-δ1

Ko, J., Kim, J., Myeong, J., Kwak, M., & So, I. (2023) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2023.27.2.187 · Cited by 3 · see citing works

The TRPC5 receptor as pharmacological target for pain and metabolic disease

Khare, P., Chand, J., Ptáková, A., Liguori, R., Ferrazzi, F., Bishnoi, M., Vlachová, V., & Zimmermann, K. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108727 · Cited by 22 · see citing works

TRP channels and cancer modulation: a voyage beyond metabolic reprogramming, oxidative stress and the advent of nanotechnologies in targeted therapy

Giannaccari, M., Florindi, C., Bloise, N., Moccia, F. D., Lodola, F., & Visai, L. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03495-4 · Cited by 18 · see citing works

Exploring the therapeutic potential of TRPC channels in chronic pain: An investigation into their mechanisms, functions, and prospects

Ke, X., Cai, H., Chen, Y., & Chen, G. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.177206 · Cited by 8 · see citing works

Thermosensing ability of TRPC5: current knowledge and unsettled questions

Ptáková, A., & Vlachová, V. (2024) · The Journal of Physiological Sciences · doi:10.1186/s12576-024-00942-3 · Cited by 8 · see citing works

Phytoecdysteroids: Quantification in Selected Plant Species and Evaluation of Some Effects on Gastric Smooth Muscles

Todorova, V., Ivanova, S., Yotov, V., Zaytseva, E., Ardasheva, R., Turiyski, V., Prissadova, N., & Ivanov, K. (2024) · Molecules · doi:10.3390/molecules29215145 · Cited by 7 · see citing works

TRP channels at the crossroads of metabolism and immunity: ion–metabolite coupling in inflammation and disease

De-hua, L., Jiang, S., Wu, T., Cao, Z., Zhu, Z., Wu, N., Zhang, X., Long, M., Wang, J., & Wang, Z. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156486 · Cited by 6 · see citing works

Relevance of AKT and RAS Signaling Pathways for Antibody–Drug Conjugate Immunotherapies in Acute Lymphoblastic Leukemia

Ehm, P. A. H., & Rehbach, C. (2025) · Lymphatics · doi:10.3390/lymphatics3040033 · Cited by 3 · see citing works

Identification of iron metabolism-related genes in coronary heart disease and construction of a diagnostic model

Zhu, L., Zhang, J., Fan, W., Su, C., & Jin, Z. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1409605 · Cited by 2 · see citing works

The mutual interaction of TRPC5 channel with polycystin proteins

Kwak, M., Kang, H., Kim, J., Hong, Y., Jeong, B., Myeong, J., & So, I. (2024) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.24.265 · Cited by 1 · see citing works

TRPC1-5-5-5 heteromer as a sodium sensor

Kang, H., Kim, J., So, I., & Lee, B. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152265

Gd 3+ -doped carbon dots: modulation of mechanisms regulating gastrointestinal tract motility and the hepatobiliary system

Tsymbalyuk, О. V., Davydovska, T. L., Lysenko, V., Voiteshenko, I., Paliienko, K., Borisova, Т., Veselsky, S. P., Nyporko, A. Y., Pylypova, O. V., Fedirko, T. O., et al. (2025) · Biomaterials Science · doi:10.1039/d5bm01077b

BLOCKADE OF TRPC4 CHANNELS BY THE PICO145 INHIBITOR: AN EXPERIMENTAL AND MOLECULAR STUDY

Stratiichuk, R., Dryn, D. O., & Zholos, A. V. (2026) · Bulletin of Taras Shevchenko National University of Kyiv Series “Psychology” · doi:10.17721/1728.2748.2026.104.25-31

Untangling neuropathic pain: pathophysiological insights and future directions for targeted therapy

Verma, R., Singh, N., & Deol, P. K. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05478-4

Heat exposure remodels the gut microbiota to promote heat acclimation through a serotonin-mediated gut–brain axis

Li, S., Li, X., Wang, Y., Li, K., Shen, D., Luo, L., Jin, X., Li, Y., Nagaoka, K., & Li, C. (2026) · Environment International · doi:10.1016/j.envint.2026.110519

The specific activation of TRPC4 by Gi protein subtype

Jeon, J., Lee, K. P., Park, E., Sung, T. S., Kim, B. J., Jeon, J., & So, I. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.012 · Cited by 37 · see citing works

Selective Gαi Subunits as Novel Direct Activators of TRPC4 and TRPC5 Channels

Jeon, J., Hong, C., Park, E.-J., Jeon, J., Choe, H., Suh, C.-K., Kim, H., & So, I. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2011.11.2922

Selective Gαi Subunits as Novel Direct Activators of Transient Receptor Potential Canonical (TRPC)4 and TRPC5 Channels

Jeon, J.-P., Hong, C., Park, E., Jeon, J., Cho, N., Kim, I. G., Choe, H., Muallem, S., Kim, H. J., & So, I. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.326553 · Cited by 99 · see citing works

Close spatio-association of the transient receptor potential canonical 4 (TRPC4) channel with Gαi in TRPC4 activation process

Myeong, J., Kwak, M., Jeon, J.-P., Hong, C., Jeon, J., & So, I. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00374.2014 · Cited by 14 · see citing works

The Transient Receptor Potential Protein Homologue TRPC4/5 as a Candidate for the Nonselective Cationic Channel Activated by Muscarinic Stimulation in the Murine Stomach

Zhu, M. H., Lee, Y., Jin, N., So, I., & Kim, K. W. (2003) · Neurophysiology · doi:10.1023/b:neph.0000008790.75165.d6 · Cited by 12 · see citing works