The DOI matches its Crossref record; 326 of the 326 references it cites were found in a registry or an index.
The IL-17 family in diseases: from bench to bedside
Open accessAbstract
The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and recently, all of its related receptors have been discovered. IL-17 was first discovered approximately 30 years ago. Members of this family have various biological functions, including driving an inflammatory cascade during infections and autoimmune diseases, as well as boosting protective immunity against various pathogens. IL-17 is a highly versatile proinflammatory cytokine necessary for vital processes including host immune defenses, tissue repair, inflammatory disease pathogenesis, and cancer progression. However, how IL-17 performs these functions remains controversial. The multifunctional properties of IL-17 have attracted research interest, and emerging data have gradually improved our understanding of the IL-17 signaling pathway. However, a comprehensive review is required to understand its role in both host defense functions and pathogenesis in the body. This review can aid researchers in better understanding the mechanisms underlying IL-17’s roles in vivo and provide a theoretical basis for future studies aiming to regulate IL-17 expression and function. This review discusses recent progress in understanding the IL-17 signaling pathway and its physiological roles. In addition, we present the mechanism underlying IL-17’s role in various pathologies, particularly, in IL-17-induced systemic lupus erythematosus and IL-17-related tumor cell transformation and metastasis. In addition, we have briefly discussed promising developments in the diagnosis and treatment of autoimmune diseases and tumors.
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Cites
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“Experiments with mice administered IL-17-blocking antibodies revealed that a certain level of IL-17 effectively prevented candidiasis.(103,104) IL17 also boosts immunity against other fungi.”
BackgroundInterleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
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IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis
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Cited by
Th17 cell pathogenicity in autoimmune disease
Park, E., & Ciofani, M. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01535-9 · Cited by 75
Targeting interleukin-17 as a novel treatment option for fibrotic diseases
Sisto, M., & Lisi, S. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm13010164 · Cited by 22
Metadata
- Authors
- Huangfu, L., Li, R., Huang, Y., & Wang, S.
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2023-10-11
- Volume
- 8
- Issue
- 1
- Pages
- 402-402
- ISSN
- 2059-3635 (ISSN-L)
- OpenAlex
- W4387477955
- Cited by
- 452
- References
- 326
- FWCI
- 39.63
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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