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Cited by 1,765Immune cells in cancerCytokine Signaling Pathways and InteractionsInflammatory mediators and NSAID effects

Chronic inflammation and cytokines in the tumor microenvironment

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Landskron, Glauben, De la Fuente, Marjorie, Thuwajit, Peti, Thuwajit, Chanitra, Hermoso, Marcela A.·2014·Journal of Immunology Research
DOI 10.1155/2014/149185PMC PMC4036716
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Abstract

Acute inflammation is a response to an alteration induced by a pathogen or a physical or chemical insult, which functions to eliminate the source of the damage and restore homeostasis to the affected tissue. However, chronic inflammation triggers cellular events that can promote malignant transformation of cells and carcinogenesis. Several inflammatory mediators, such as TNF- α , IL-6, TGF- β , and IL-10, have been shown to participate in both the initiation and progression of cancer. In this review, we explore the role of these cytokines in important events of carcinogenesis, such as their capacity to generate reactive oxygen and nitrogen species, their potential mutagenic effect, and their involvement in mechanisms for epithelial mesenchymal transition, angiogenesis, and metastasis. Finally, we will provide an in-depth analysis of the participation of these cytokines in two types of cancer attributable to chronic inflammatory disease: colitis-associated colorectal cancer and cholangiocarcinoma.

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Authors
Landskron, G., De la Fuente, M., Thuwajit, P., Thuwajit, C., & Hermoso, M. A.
Affiliations
  • University of Chile (CL)
  • Disciplinary Program, Institute of Biomedical Sciences, School of Medicine, University of Chile, Independencia 1027, 8380453 Santiago, Chile
  • Siriraj Hospital (TH)
Corresponding author
Hermoso, Marcela A.
ORCID
Venue
Journal of Immunology Research
Publisher
Wiley
Published
2014
Volume
2014
Pages
1-19
ISSN
  • 2314-7156 (ISSN-L)
  • 2314-8861
DOI
10.1155/2014/149185
PMC
PMC4036716
OpenAlex
W2164664027
Cited by
1,765
References
20
Citations by year
2026: 74 · 2025: 124 · 2024: 150 · 2023: 166 · 2022: 191 · 2021: 207 · 2020: 207 · 2019: 162 · 2018: 158 · 2017: 102 · 2016: 108 · 2015: 89 · 2014: 25
FWCI
10.54
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Immunology Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Universidad de Chile (submittedVersion, cc-by-nc-nd)
  • Greater South Information System
Funders
  • FONDECYT (1120577, REDES130037)
  • CONICYT (1120577, REDES130037)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Keywords
chronic inflammation, tumor microenvironment, cytokines, carcinogenesis, TNF-α, interleukin-6, TGF-beta, IL-10, reactive oxygen species, reactive nitrogen species, mutagenesis, epithelial-mesenchymal transition, angiogenesis, metastasis, colitis-associated colorectal cancer, cholangiocarcinoma
MeSH terms
Bile Duct Neoplasms, Bile Ducts, Intrahepatic, Chronic Disease, Colitis, Humans, Inflammation, Tumor Necrosis Factor-alpha, Colorectal Neoplasms, Interleukin-6, Gene Expression, Transforming Growth Factor beta, Interleukin-10, Cholangiocarcinoma, Oxidative Stress, Tumor Microenvironment, Carcinogenesis

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