Th17 cell pathogenicity in autoimmune disease

Park, Eunchong; Ciofani, Maria

doi:10.1038/s12276-025-01535-9

Cited by 75Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyRheumatoid Arthritis Research and Therapies

Th17 cell pathogenicity in autoimmune disease

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Park, Eunchong, Ciofani, Maria·2025·Experimental & Molecular Medicine

DOI 10.1038/s12276-025-01535-9PMC PMC12508148

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Abstract

T helper 17 (Th17) cells have been implicated in numerous inflammatory autoimmune diseases. Clinical benefits from targeting Th17 cell-related cytokines, such as IL-17 and IL-23, highlight how knowledge of Th17 cell development and effector function can be translated into treatments for inflammatory disease. Here we discuss the pathogenic roles of Th17 cells in autoimmune diseases such as multiple sclerosis, inflammatory bowel disease and psoriasis, with emphasis on the cytokines, transcriptional regulators and metabolites that influence Th17 cell differentiation and pathogenicity. Moreover, we address how intestinal environments and physiological responses affect Th17 cells in autoimmune diseases. We also examine current and emerging therapeutic strategies aimed at regulating Th17 cell-driven inflammation to mitigate autoimmune diseases.

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Factors such as VEGF induce endothelial activation, vascular dilation, and neovascularization in the papillary dermis, facilitating sustained leukocyte migration into the skin.
“Factors such as VEGF induce endothelial activation, vascular dilation, and neovascularization in the papillary dermis, facilitating sustained leukocyte migration into the skin [27].”
From The Cutaneous Immune Microenvironment in Selected Inflammatory Skin Diseases: Linking Histopathology, Mechanisms, and Targeted Therapy (2026) · cites this paper as [27]
The psoriasis passage in “Th17 cell pathogenicity in autoimmune diseases” (page unavailable) says that inflammatory cytokines and chemokines recruit neutrophils to inflamed skin. It does not attribute that recruitment to VEGF or describe endothelial activation, vascular dilation, neovascularization in the papillary dermis, or sustained migration. (LLM, conf=0.76)
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Increasing real-world evidence supports the durable efficacy and favorable long-term disease control achieved with selective IL-23 inhibitors.
“Increasing real-world evidence also supports the durable efficacy and favorable long-term disease control achieved with selective IL-23 inhibitors [27,28].”
From The Cutaneous Immune Microenvironment in Selected Inflammatory Skin Diseases: Linking Histopathology, Mechanisms, and Targeted Therapy (2026) · cites this paper as [27]
The “Antibodies: cytokine blockade” section says selective IL-23-blocking antibodies demonstrate therapeutic efficacy in autoimmune diseases, including psoriasis and IBD. It does not report increasing real-world evidence, durable efficacy, or long-term disease control; it also notes resistance to IL-23 blockade in some Th17 cell populations. No page number is available in our copy. (LLM, conf=0.87)
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Throughout the psoriatic process, continuous exchange between keratinocytes and immune cells maintains a loop in which IL-23 sustains pathogenic T cells, IL-17 and IL-22 perpetuate epidermal alterations, and TNF-α amplifies inflammation across multiple cell types.
“Throughout this process, continuous exchange between keratinocytes and immune cells maintains a loop in which IL-23 sustains pathogenic T cells, IL-17 and IL-22 perpetuate epidermal alterations, and TNF-α amplifies inflammation across multiple cell types.”
From The Cutaneous Immune Microenvironment in Selected Inflammatory Skin Diseases: Linking Histopathology, Mechanisms, and Targeted Therapy (2026) · cites this paper as [27]
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IL-22 Is Required for Imiquimod-Induced Psoriasiform Skin Inflammation in Mice
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Loss of STAT3 in CD4+ T Cells Prevents Development of Experimental Autoimmune Diseases
Liu, X., Lee, Y. S., Yu, C., & Egwuagu, C. E. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.6070 · Cited by 290 · see citing works
Leptin Metabolically Licenses T Cells for Activation To Link Nutrition and Immunity
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Safety and clinical activity of autologous RNA chimeric antigen receptor T-cell therapy in myasthenia gravis (MG-001): a prospective, multicentre, open-label, non-randomised phase 1b/2a study
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IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype
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Epigenetic Instability of Cytokine and Transcription Factor Gene Loci Underlies Plasticity of the T Helper 17 Cell Lineage
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IκBζ regulates TH17 development by cooperating with ROR nuclear receptors
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Gut microorganisms act together to exacerbate inflammation in spinal cords
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Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity
Schnell, A., Huang, L., Singer, M., Singaraju, A., Barilla, R. M., Regan, B. M. L., Bollhagen, A., Thakore, P. I., Dionne, D., Delorey, T. M., et al. (2021) · Cell · doi:10.1016/j.cell.2021.11.018 · Cited by 268 · see citing works
The Inducible Costimulator (ICOS) Is Critical for the Development of Human T H 17 Cells
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CLOCK:BMAL1 is a pioneer-like transcription factorPreprint
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Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells
McGinley, A. M., Sutton, C. E., Edwards, S. C., Leane, C. M., DeCourcey, J., Teijeiro, A., Hamilton, J. A., Boon, L., Djouder, N., & Mills, K. H. G. (2020) · Immunity · doi:10.1016/j.immuni.2020.01.002 · Cited by 248 · see citing works
IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein.
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Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE
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MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis
Murugaiyan, G., da Cunha, A. P., Ajay, A. K., Joller, N., Garo, L. P., Kumaradevan, S., Yosef, N., Vaidya, V. S., & Weiner, H. L. (2015) · Journal of Clinical Investigation · doi:10.1172/jci74347 · Cited by 239 · see citing works
TGF-β Promotes Th17 Cell Development through Inhibition of SOCS3
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Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation
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Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity
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“…stem-like TCF-1 + SLAMF6 + IL-17A + Th17 cell population as a reservoir of precursors for the generation of encephalito-genic GM-CSF + IFN γ + CXCR6 + ex-Th17 cells during EAE 54 – 56 , highlighting the dynamic nature of Th17 cell identity and effector transdifferentiation during autoimmunity.”
Differential Regulation of Human Treg and Th17 Cells by Fatty Acid Synthesis and Glycolysis
Cluxton, D., Petrasca, A., Moran, B., & Fletcher, J. M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00115 · Cited by 209 · see citing works
IL-23 and IL-1β Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation
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The Transcription Factors T-bet and Runx Are Required for the Ontogeny of Pathogenic Interferon-γ-Producing T Helper 17 Cells
Wang, Y., Godec, J., Ben-Aissa, K., Cui, K., Zhao, K., Pucsek, A. B., Lee, Y. K., Weaver, C. T., Yagi, R., & Lazarevic, V. (2014) · Immunity · doi:10.1016/j.immuni.2014.01.002 · Cited by 206 · see citing works
STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation
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CD40–CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4 + T cells
Iezzi, G., Sonderegger, I., Ampenberger, F., Schmitz, N., Marsland, B. J., & Köpf, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810769106 · Cited by 202 · see citing works
Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β
Komuczki, J., Tuzlak, S., Friebel, E., Hartwig, T., Spath, S., Rosenstiel, P., Waisman, A., Opitz, L., Oukka, M., Schreiner, B., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.006 · Cited by 201 · see citing works
Segmented Filamentous Bacteria Provoke Lung Autoimmunity by Inducing Gut-Lung Axis Th17 Cells Expressing Dual TCRs
Bradley, C. P., Teng, F., Felix, K. M., Sano, T., Naskar, D., Block, K. E., Huang, H., Knox, K. S., Littman, D. R., & Wu, H.-J. J. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.10.007 · Cited by 197 · see citing works
Role of SMAD and Non-SMAD Signals in the Development of Th17 and Regulatory T Cells
Lü, L., Wang, J., Zhang, F., Chai, Y., Brand, D. D., Wang, X., Horwitz, D. A., Shi, W., & Zheng, S. G. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903418 · Cited by 191 · see citing works
Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells
Oh, S., Mao, X., Vieira, S. M., Lee, J., Patel, D. R., Choi, E. J., Alvarado, A., Cottman‐Thomas, E., Maseda, D., Tsao, P., et al. (2023) · Nature Biotechnology · doi:10.1038/s41587-022-01637-z · Cited by 191 · see citing works
microRNA-301a regulation of a T-helper 17 immune response controls autoimmune demyelination
Mycko, M. P., Cichalewska, M., Machlańska, A., Ćwiklińska, H., Mariasiewicz, M., & Selmaj, K. W. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114325109 · Cited by 190 · see citing works
The role of transforming growth factor β in T helper 17 differentiation
Zhang, S. (2018) · Immunology · doi:10.1111/imm.12938 · Cited by 187 · see citing works
Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells
Gómez‐Rodríguez, J., Wohlfert, E. A., Handon, R., Meylan, F., Wu, J. Z., Anderson, S. M., Kirby, M., Belkaid, Y., & Schwartzberg, P. L. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131459 · Cited by 182 · see citing works
Elevated levels of Th17 cells and Th17-related cytokines are associated with disease activity in patients with inflammatory bowel disease
Jiang, W., Su, J., Zhang, X., Cheng, X., Zhou, J., Shi, R., & Zhang, H. (2014) · Inflammation Research · doi:10.1007/s00011-014-0768-7 · Cited by 181 · see citing works
The MicroRNA-183-96-182 Cluster Promotes T Helper 17 Cell Pathogenicity by Negatively Regulating Transcription Factor Foxo1 Expression
Ichiyama, K., González-Martín, A., Kim, B. S., Jin, H. Y., Jin, W., Xu, W. M., Sabouri-Ghomi, M., Xu, S., Zheng, P., Xiao, C., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.05.015 · Cited by 180 · see citing works
The role of Th17 cytokines in primary mucosal immunity
Kolls, J. K., & Khader, S. A. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.11.002 · Cited by 177 · see citing works
TGF-β1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression
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Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells
Jain, R., Chen, Y., Kanno, Y., Joyce-Shaikh, B., Vahedi, G., Hirahara, K., Blumenschein, W. M., Sukumar, S., Haines, C. J., Sadekova, S., et al. (2016) · Immunity · doi:10.1016/j.immuni.2015.11.009 · Cited by 167 · see citing works
Cutting Edge: Lung Mucosal Th17-Mediated Responses Induce Polymeric Ig Receptor Expression by the Airway Epithelium and Elevate Secretory IgA Levels
Jaffar, Z. H., Ferrini, M. E., Herritt, L., & Roberts, K. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900237 · Cited by 165 · see citing works
Leptin Receptor Signaling in T Cells Is Required for Th17 Differentiation
Reis, B. S., Lee, K., Fanok, M. H., Mascaraque, C., Amoury, M., Cohn, L. B., Rogoz, A., Dallner, O. S., Moraes‐Vieira, P. M., Domingos, A. I., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402996 · Cited by 162 · see citing works
Regulating the regulator: Factors that control levels and activity of the aryl hydrocarbon receptor
Harper, P. A., Riddick, D. S., & Okey, A. B. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.01.007 · Cited by 160 · see citing works
TGF‐β indirectly favors the development of human Th17 cells by inhibiting Th1 cells
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Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-β Therapy
Rasouli, J., Ćirić, B., Imitola, J., GONNELLA, P. A., Hwang, D. H., Mahajan, K. R., Mari, E. R., Safavi, F., Leist, T. P., Zhang, G., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403243 · Cited by 156 · see citing works
Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by Regulatory T Cells
Basdeo, S. A., Cluxton, D., Sulaimani, J., Moran, B., Canavan, M., Orr, C. K., Veale, D. J., Fearon, U., & Fletcher, J. M. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1600737 · Cited by 156 · see citing works
Profile of Cerebrospinal Fluid and Serum Cytokines in Patients with Relapsing-Remitting Multiple Sclerosis. A Correlation with Clinical Activity
Carrieri, P. B., Provitera, V., Rosa, T. D., Tartaglia, G. G., Gorga, F., & Perrella, O. (1998) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923979809034820 · Cited by 155 · see citing works
Leptin directly promotes T‐cell glycolytic metabolism to drive effector T‐cell differentiation in a mouse model of autoimmunity
Gerriets, V. A., Danzaki, K., Kishton, R. J., Eisner, W., Nichols, A., Saucillo, D. C., Shinohara, M. L., & MacIver, N. J. (2016) · European Journal of Immunology · doi:10.1002/eji.201545861 · Cited by 148 · see citing works
Down-regulation of Gfi-1 expression by TGF-β is important for differentiation of Th17 and CD103+ inducible regulatory T cells
Zhu, J., Davidson, T. S., Wei, G., Jankovic, D. L., Cui, K., Schones, D. E., Guo, L., Zhao, K., Shevach, E. M., & Paul, W. E. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081666 · Cited by 143 · see citing works
miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity
Li, B., Wang, X., Choi, I. Y., Wang, Y.-C., Liu, S. J., Pham, A. T., Moon, H., Smith, D. J., Rao, D. S., Boldin, M., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci94012 · Cited by 143 · see citing works
Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-β Is Mediated by Suppression of Eomesodermin
Ichiyama, K., Sekiya, T., Inoue, N., Tamiya, T., Kashiwagi, I., Kimura, A., Morita, R., Muto, G., Shichita, T., Takahashi, R., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.02.021 · Cited by 141 · see citing works
VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells
Schneider‐Hohendorf, T., Rossaint, J., Mohan, H., Böning, D., Breuer, J., Kuhlmann, T., Groß, C. C., Flanagan, K., Sorokin, L. M., Vestweber, D., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20140540 · Cited by 141 · see citing works
JunB promotes Th17 cell identity and restrains alternative CD4+ T-cell programs during inflammation
Carr, T. M., Wheaton, J. D., Houtz, G. M., & Ciofani, M. (2017) · Nature Communications · doi:10.1038/s41467-017-00380-3 · Cited by 141 · see citing works
T-bet and Eomesodermin Play Critical Roles in Directing T Cell Differentiation to Th1 versus Th17
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Excess IL-1 Signaling Enhances the Development of Th17 Cells by Downregulating TGF-β–Induced Foxp3 Expression
Ikeda, S., Saijo, S., Murayama, M. A., Shimizu, K., Akitsu, A., & Iwakura, Y. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1300387 · Cited by 129 · see citing works
Low-strength T-cell activation promotes Th17 responses
Purvis, H. A., Stoop, J. N., Mann, J., Woods Jon, S., Kozijn, A. E., Hambleton, S., Robinson, J. H., Isaacs, J. D., Anderson, A. E., & Hilkens, C. M. U. (2010) · Blood · doi:10.1182/blood-2010-03-272153 · Cited by 126 · see citing works
Transcription of Il17 and Il17f Is Controlled by Conserved Noncoding Sequence 2
Wang, X., Zhang, Y.-B., Yang, X. O., Nurieva, R., Chang, S. H., Ojeda, S. S., Kang, H. S., Schluns, K. S., Gui, J., Jetten, A. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2011.10.019 · Cited by 125 · see citing works
Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells
Montes, M., Zhang, X., Berthelot, L., Laplaud, D. A., Brouard, S., Jin, J., Rogan, S. C., Armao, D. M., Jewells, V. L., Soulillou, J., et al. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.08.030 · Cited by 123 · see citing works
Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling
Kibbie, J. J., Dillon, S. M., Thompson, T. A., Purba, C. M., McCarter, M. D., & Wilson, C. C. (2021) · Immunobiology · doi:10.1016/j.imbio.2021.152126 · Cited by 121 · see citing works
Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation
Yoon, J.-H., Sudo, K., Kuroda, M., Kato, M., Lee, I., Han, J. S., Nakae, S., Imamura, T., Kim, J., Ju, J. H., et al. (2015) · Nature Communications · doi:10.1038/ncomms8600 · Cited by 120 · see citing works
Smad3 Differentially Regulates the Induction of Regulatory and Inflammatory T Cell Differentiation
Martínez, G., Zhang, Z., Chung, Y., Reynolds, J. M., Lin, X., Jetten, A. M., Feng, X., & Dong, C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.c109.078238 · Cited by 118 · see citing works
The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation
Liu, Z., Cao, W., Xu, L., Chen, X., Zhan, Y., Yang, Q., Liu, S., Chen, P., Jiang, Y., Sun, X., et al. (2015) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjv022 · Cited by 114 · see citing works
Interplay Among Metabolism, Epigenetic Modifications, and Gene Expression in Cancer
Huo, M., Zhang, J., Huang, W., & Wang, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.793428 · Cited by 114 · see citing works
Regulation of CCL20 expression in astrocytes by IL‐6 and IL‐17
Meares, G. P., Ma, X., Qin, H., & Benveniste, E. N. (2012) · Glia · doi:10.1002/glia.22307 · Cited by 113 · see citing works
Reversing SKI–SMAD4-mediated suppression is essential for TH17 cell differentiation
Zhang, S., Takaku, M., Zou, L., Gu, A.-D., Chou, W.-C., Zhang, G., Wu, B., Kong, Q., Thomas, S. Y., Serody, J. S., et al. (2017) · Nature · doi:10.1038/nature24283 · Cited by 112 · see citing works
Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf
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The CCL20 and CCR6 axis in psoriasis
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Immunity's fourth dimension: approaching the circadian–immune connection
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Single-cell analysis of the human immune system reveals sex-specific dynamics of immunosenescence
Sopena-Rios, M., Ripoll-Cladellas, A., Omidi, F., Ballouz, S., Alquicira-Hernández, J., Oelen, R., Hewitt, A. W., Franke, L., van der Wijst, M. G. P., Powell, J. E., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01099-x · Cited by 10 · see citing works
The Double-Edged Sword of Type 17 Immunity in Wound Healing and Skin Barrier Repair: Microenvironment-Driven Functional Plasticity
Lu, Y., Xu, F., Qi, F., & Pan, Y. (2026) · Biomolecules · doi:10.3390/biom16030414 · Cited by 5 · see citing works
Biological activity study of a pine pollen extract rich in dihydroquercetin for the treatment of psoriasis
Xu, Q., Chen, Y., Dong, Y., Li, G., & Yan, M. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157597 · Cited by 3 · see citing works
Cell-Specific Extracellular Vesicles Targeting Strategies for Immune Modulation in Inflammatory Diseases
Lee, J., 권수안, Yang, Y., & Choi, J. H. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18060697 · Cited by 3 · see citing works
Lactobacilli Mitigate Gut Inflammation by Modulating T-Helper/T-Regulatory Cells and Suppressing Signaling Pathways in Food-Derived Models
Kulyar, M. F., Naqvi, S. U. A. S., Bernotienė, E., & Akhtar, M. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11135-2 · Cited by 3 · see citing works
ZIP3 is essential for the encephalitogenic function of pTh17 cells by regulating intracellular zinc levels
Drmic, D., Wang, L.-W., Noyer, L., Zhong, L., & Feske, S. (2026) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2026.127819 · Cited by 1 · see citing works
Context-specific roles for IL-17 in tuberculosis
Maseeme, M., Tezera, L. B., Noursadeghi, M., Leslie, A. J., & Pollara, G. (2026) · PLoS Pathogens · doi:10.1371/journal.ppat.1014054 · Cited by 2 · see citing works
Gut Microbial Functional Ecology and Microbiota-Derived Metabolites in Rheumatoid Arthritis Autoimmunity
Rong, X., Zhang, X., Tan, Y., & Lu, C. C. (2026) · Cells · doi:10.3390/cells15151398 · Cited by 2 · see citing works
The Cutaneous Immune Microenvironment in Selected Inflammatory Skin Diseases: Linking Histopathology, Mechanisms, and Targeted Therapy
Tinca, A. C., Cozac-Szoke, A. R., & Cotoi, O. S. (2026) · Dermatopathology · doi:10.3390/dermatopathology13020022 · Cited by 1 · see citing works
“Increasing real-world evidence also supports the durable efficacy and favorable long-term disease control achieved with selective IL-23 inhibitors [27,28].”
Dingxin Recipe III resolves atherosclerotic inflammation via revitalizing Regulatory T cell lineage fidelity associated with fatty acid oxidation metabolic reprogramming
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REVIEW The Role of IL-17 and Th17 Lymphocytes in Autoimmune Diseases
Tabarkiewicz, J., Pogoda, K., Karczmarczyk, A., Pożarowski, P., & Giannopoulos, K. (2014)

Authors: Park, E., & Ciofani, M.
Affiliations: AstraZeneca (United States) (US)
Duke University (US)
Corresponding author: Ciofani, Maria
ORCID: Park, Eunchong
Ciofani, Maria
Venue: Experimental & Molecular Medicine
Publisher: Springer Science and Business Media LLC
Published: 2025-09-01
Volume: 57
Issue: 9
Pages: 1913-1927
ISSN: 1226-3613 (ISSN-L)
2092-6413
DOI: 10.1038/s12276-025-01535-9
PMC: PMC12508148
OpenAlex: W4413865457
Cited by: 75
References: 280
Citations by year: 2026: 70 · 2025: 5
FWCI: 6.71
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Experimental & Molecular Medicine (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed (publishedVersion)
PubMed Central (publishedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (AI156186)
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (GM115474)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords: Th17 cells, autoimmune disease, IL-17, IL-23, Th17 cell differentiation, multiple sclerosis, inflammatory bowel disease, psoriasis, transcription factors, metabolites, intestinal environment, anti-inflammatory therapy
MeSH terms: Animals, Autoimmune Diseases, Cell Differentiation, Disease Susceptibility, Humans, Cytokines, Th17 Cells

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