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Cited by 51

The protective effect of microRNA-21 in neurons after spinal cord injury

Zhang, Tao, Ni, Shuangfei, Luo, Zixiang, Lang, Ye, Hu, Jianzhong, Lu, Hongbin·2019·Spinal Cord
DOI 10.1038/s41393-018-0180-1PMC PMC6358587
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  • miR-21 is significantly upregulated after spinal cord injury, causes downregulation of targets FasL and PTEN, and its expression is directly related to secondary cell death following injury.

    “Several groups have identified miR-21 as significantly upregulated after spinal cord injury, causing downregulation of targets FasL and PTEN, and its expression is directly related to secondary cell death following injury16–18.”

    From CNS microRNA profiles: a database for cell type enriched microRNA expression across the mouse central nervous system (2020) · cites this paper as [18]

    The Results section ('miR-21 was upregulated in injured spinal cord neurons'; page not provided) reports significant upregulation after rat spinal cord injury. The Discussion reports that reducing miR-21 increased apoptosis and Fasl and PTEN expression, but this study demonstrates downregulation of PDCD4—not Fasl or PTEN—when miR-21 is overexpressed. It links miR-21 to neuronal apoptosis, but does not establish the claimed direct relationship between its expression and secondary cell death generally. (LLM, conf=0.86)

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  • By in situ hybridization, miR-21 was expressed in neurons after injury but the majority of its expression seems to occur in other cell types.

    “By in situ hybridization, miR-21 was expressed in neurons after injury but the majority of its expression seems to occur in other cell types18.”

    From CNS microRNA profiles: a database for cell type enriched microRNA expression across the mouse central nervous system (2020) · cites this paper as [18]

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Research works printed but not linked: 29

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  6. [6]Jiang LP He CY Zhu ZT Role of microRNA-21 in radiosensitivity in non-small cell lung cancer cells by targeting PDCD4 gene Oncotarget 2017 8 23675 89 28423589 PMC5410336
  7. [7]Zhang L Dong LY Li YJ Hong Z Wei WS miR-21 represses FasL in microglia and protects against microglia-mediated neuronal cell death following hypoxia/ischemia Glia 2012 60 1888 95 10.1002/glia.22404 22907769 · DOI · Paper page
  8. [8]Ge X Han Z Chen F Wang H Zhang B Jiang R MiR-21 alleviates secondary blood-brain barrier damage after traumatic brain injury in rats Brain Res 2015 1603 150 7 10.1016/j.brainres.2015.01.009 25598202 · DOI · Paper page
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Authors
Zhang, T., Ni, S., Luo, Z., Lang, Y., Hu, J., & Lu, H.
Venue
Spinal Cord
Publisher
Springer Science and Business Media LLC
Published
2018-08-08
Volume
57
Issue
2
Pages
141-149
ISSN
  • 1362-4393
  • 1476-5624
DOI
10.1038/s41393-018-0180-1
PMC
PMC6358587
Cited by
51
References
4
Language
en
Licence
creativecommons.org/licenses/by/4.0 (tdm)
Funders
National Natural Science Foundation of China (National Science Foundation of China) (81371956, 81672174)

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