Traumatic brain injury increases levels of miR‐21 in extracellular vesicles: implications for neuroinflammation
Open accessAbstract
Traumatic brain injury (TBI) is an important health concern and effective treatment strategies remain elusive. Understanding the complex multicellular response to TBI may provide new avenues for intervention. In the context of TBI, cell-cell communication is critical. One relatively unexplored form of cell-cell communication in TBI is extracellular vesicles (EVs). These membrane-bound vesicles can carry many different types of cargo between cells. Recently, miRNA in EVs have been shown to mediate neuroinflammation and neuronal injury. To explore the role of EV-associated miRNA in TBI, we isolated EVs from the brain of injured mice and controls, purified RNA from brain EVs, and performed miRNA sequencing. We found that the expression of miR-212 decreased, while miR-21, miR-146, miR-7a, and miR-7b were significantly increased with injury, with miR-21 showing the largest change between conditions. The expression of miR-21 in the brain was primarily localized to neurons near the lesion site. Interestingly, adjacent to these miR-21-expressing neurons were activated microglia. The concurrent increase in miR-21 in EVs with the elevation of miR-21 in neurons, suggests that miR-21 is secreted from neurons as potential EV cargo. Thus, this study reveals a new potential mechanism of cell-cell communication not previously described in TBI.
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By carrying pro-inflammatory or anti-inflammatory molecules, EVs can either exacerbate or mitigate secondary injury mechanisms, affecting progression of neuronal damage and cognitive deficits post-TBI.
“By carrying molecules with pro-inflammatory or anti-inflammatory actions, EVs can either exacerbate or mitigate secondary injury mechanisms, thereby affecting the progression of neuronal damage and the development of cognitive deficits post-TBI [180].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [180]
The Discussion (page unavailable) describes EV-associated miRNAs that may promote neuronal injury and suggests that EV-carried miR-146 could reduce neuroinflammation after TBI. The Conclusion (page unavailable) says changes in EV miRNAs likely affect TBI progression, but their effects after TBI remain to be tested. The paper does not establish that EVs exacerbate or mitigate secondary injury, or link them to cognitive deficits after TBI. (LLM, conf=0.87)
Experimental — accuracy not yet measuredThe molecular cargo of EVs, especially those released from injured brain cells, can modulate the immune response within the CNS, potentially influencing the trajectory of injury and subsequent recovery.
“The molecular cargo of EVs, especially those released from injured brain cells, can modulate the immune response within the CNS, potentially influencing the trajectory of injury and subsequent recovery processes.”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [180]
The Abstract (page unavailable) says EV miRNA can mediate neuroinflammation and neuronal injury, and the Conclusion says injury-related changes in EV miRNA likely affect TBI progression. The Conclusion also says whether neuronal EV miR-21 activates nearby microglia still needs testing. The paper does not link EV cargo to subsequent recovery processes. (LLM, conf=0.83)
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Cites
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317 · see citing works
Membrane vesicles as conveyors of immune responses
Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,869 · see citing works
Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells
Mittelbrunn, M., Gutiérrez‐Vázquez, C., Villarroya‐Beltri, C., González, S., Sánchez‐Cabo, F., González, M. A., Bernad, A., & Sánchez‐Madrid, F. (2011) · Nature Communications · doi:10.1038/ncomms1285 · Cited by 1,768 · see citing works
MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
Fabbri, M., Paone, A., Calore, F., Galli, R., Gaudio, E., Santhanam, R., Lovat, F., Fadda, P., Mao, C., Nuovo, G. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209414109 · Cited by 1,558 · see citing works
Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes.
Montecalvo, A., Larregina, A. T., Shufesky, W. J., Beer Stolz, D., Sullivan, M. L. G., Karlsson, J. M., Baty, C. J., Gibson, G. A., Erdos, G., Wang, Z., et al. (2012) · Blood · doi:10.1182/blood-2011-02-338004 · Cited by 1,262 · see citing works
<i>miR-146a</i> is a significant brake on autoimmunity, myeloproliferation, and cancer in mice
Boldin, M. P., Taganov, K. D., Rao, D. S., Yang, L., Zhao, J. L., Kalwani, M., Garcia-Flores, Y., Luong, M., Devrekanli, A., Xu, J., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20101823 · Cited by 861 · see citing works
The Role of Markers of Inflammation in Traumatic Brain Injury
Woodcock, T. M., & Morganti-Kossmann, M. C. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00018 · Cited by 719 · see citing works
Exosome-delivered microRNAs modulate the inflammatory response to endotoxin
Alexander, M., Hu, R., Runtsch, M. C., Kagele, D. A., Mosbruger, T. L., Tolmachova, T., Seabra, M. C., Round, J. L., Ward, D. M., & O’Connell, R. M. (2015) · Nature Communications · doi:10.1038/ncomms8321 · Cited by 707 · see citing works
An unconventional role for miRNA: let-7 activates toll-like receptor 7 and causes neurodegeneration
Lehmann, S. M., Krüger, C., Park, B., Derkow, K., Rosenberger, K., Baumgart, J., Trimbuch, T., Eom, G., Hinz, M., Kaul, D., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3113 · Cited by 697 · see citing works
Zaloshnja, E., Miller, T. R., Langlois, J. A., & Selassie, A. W. (2008) · Journal of Head Trauma Rehabilitation · doi:10.1097/01.htr.0000341435.52004.ac · Cited by 609 · see citing works
SMITH, D. H., SOARES, H. D., PIERCE, J. S., PERLMAN, K. G., SAATMAN, K. E., MEANEY, D. F., DIXON, C. E., & McINTOSH, T. K. (1995) · Journal of Neurotrauma · doi:10.1089/neu.1995.12.169 · Cited by 451 · see citing works
Bellingham, S. A., Coleman, B. M., & Hill, A. F. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks832 · Cited by 440 · see citing works
Pérez‐González, R., Gauthier, S. A., Kumar, A. R., & Levy, E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.404467 · Cited by 385 · see citing works
Gyoneva, S., & Ransohoff, R. M. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.04.003 · Cited by 344 · see citing works
Wang, W.-X., Huang, Q., Hu, Y., Stromberg, A. J., & Nelson, P. T. (2011) · Acta Neuropathologica · doi:10.1007/s00401-010-0756-0 · Cited by 339 · see citing works
miR-212/132 expression and functions: within and beyond the neuronal compartment
Wanet, A., Tacheny, A., Arnould, T., & Renard, P. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks151 · Cited by 331 · see citing works
Identification of RNA Sequence Motifs Stimulating Sequence-Specific TLR8-Dependent Immune Responses
Forsbach, A., Némorin, J.-G., Montino, C., Müller, C., Samulowitz, U., Vicari, A. P., Jurk, M., Mutwiri, G., Krieg, A. Μ., Lipford, G. B., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.6.3729 · Cited by 316 · see citing works
Mattson, M. P., & Scheff, S. W. (1994) · Journal of Neurotrauma · doi:10.1089/neu.1994.11.3 · Cited by 308 · see citing works
Motor and cognitive function evaluation following experimental traumatic brain injury
Fujimoto, S. T., Longhi, L. G., Saatman, K. E., & McIntosh, T. K. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.06.002 · Cited by 301 · see citing works
Craniotomy: True Sham for Traumatic Brain Injury, or a Sham of a Sham?
Cole, J. T., Yarnell, A. M., Kean, W. S., Gold, E. M., Lewis, B. K., Ren, M., McMullen, D. C., Jacobowitz, D. M., Pollard, H. B., O’Neill, J. T., et al. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2010.1427 · Cited by 300 · see citing works
Kim, A. H., Reimers, M., Maher, B., Williamson, V., McMichael, O., McClay, J. L., van den Oord, E. J. C. G., Riley, B. P., Kendler, K. S., & Vladimirov, V. I. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.07.002 · Cited by 298 · see citing works
Progressive inflammation‐mediated neurodegeneration after traumatic brain or spinal cord injury
Faden, A. I., Wu, J., Stoica, B. A., & Loane, D. J. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13179 · Cited by 287 · see citing works
The emerging roles of microRNAs in CNS injuries
Bhalala, O. G., Srikanth, M., & Kessler, J. A. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.67 · Cited by 274 · see citing works
MicroRNA‐21 protects neurons from ischemic death
Buller, B., Liu, X., Wang, X., Zhang, R. L., Zhang, L., Hozeska‐Solgot, A., Chopp, M., & Zhang, Z. G. (2010) · The FEBS Journal · doi:10.1111/j.1742-4658.2010.07818.x · Cited by 242 · see citing works
MicroRNA-21 Regulates Astrocytic Response Following Spinal Cord Injury
Bhalala, O. G., Pan, L., Sahni, V., McGuire, T. L., Gruner, K., Tourtellotte, W. G., & Kessler, J. A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3860-12.2012 · Cited by 220 · see citing works
Redell, J. B., Liu, Y., & Dash, P. K. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21945 · Cited by 214 · see citing works
Hu, G., Yao, H., Chaudhuri, A. D., Duan, M., Yelamanchili, S. V., Wen, H., Cheney, P. D., Fox, H. S., & Buch, S. J. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.114 · Cited by 203 · see citing works
Self-citationMicroarray based analysis of microRNA expression in rat cerebral cortex after traumatic brain injury
Lei, P., Li, Y., Chen, X., Yang, S., & Zhang, J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.05.074 · Cited by 193 · see citing works
Axotomy-Induced miR-21 Promotes Axon Growth in Adult Dorsal Root Ganglion Neurons
Strickland, I. T., Richards, L. J., Holmes, F. E., Wynick, D., Uney, J. B., & Wong, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023423 · Cited by 169 · see citing works
miR-21 improves the neurological outcome after traumatic brain injury in rats
Ge, X.-T., Lei, P., Wang, H.-C., Zhang, A.-L., Han, Z.-L., Chen, X., Li, S.-H., Jiang, R.-C., Kang, C.-S., & Zhang, J.-N. (2014) · Scientific Reports · doi:10.1038/srep06718 · Cited by 167 · see citing works
TLR7: A new sensor of viral infection
Crozat, K., & Beutler, B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401347101 · Cited by 163 · see citing works
Tissue-specific control of brain-enriched miR-7 biogenesis
Choudhury, N. R., de Lima Alves, F., de Andrés-Aguayo, L., Graf, T., Cáceres, J. F., Rappsilber, J., & Michlewski, G. (2013) · Genes & Development · doi:10.1101/gad.199190.112 · Cited by 158 · see citing works
Yelamanchili, S. V., Lamberty, B. G., Rennard, D. A., Morsey, B., Hochfelder, C. G., Meays, B. M., Levy, E., & Fox, H. S. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005032 · Cited by 139 · see citing works
Self-citationNeuroinflammation: beneficial and detrimental effects after traumatic brain injury
Finnie, J. (2013) · InflammoPharmacology · doi:10.1007/s10787-012-0164-2 · Cited by 136 · see citing works
CDC Grand Rounds: Reducing Severe Traumatic Brain Injury in the United States
Wright, D. W., Kellermann, A. L., McGuire, L., Chen, B., & Popović, T. (2013) · PubMed Central · Cited by 136 · see citing works
Han, Z., Chen, F., Ge, X., Tan, J., Lei, P., & Zhang, J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.07.045 · Cited by 128 · see citing works
A Coat of Many Colors: Neuroimmune Crosstalk in Human Immunodeficiency Virus Infection
Kraft-Terry, S. D., Buch, S. J., Fox, H. S., & Gendelman, H. E. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.042 · Cited by 114 · see citing works
Self-citationYelamanchili, S. V., Chaudhuri, A. D., Chen, L.-N., Xiong, H., & Fox, H. S. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.56 · Cited by 108 · see citing works
Self-citationMicroRNA-7 Protects against 1-Methyl-4-Phenylpyridinium-Induced Cell Death by Targeting RelA
Choi, D. C., Chae, Y.-J., Kabaria, S., Chaudhuri, A. D., Jain, M. R., Li, H., Mouradian, M. M., & Junn, E. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0985-14.2014 · Cited by 103 · see citing works
Zhang, L., Dong, L., Li, Y., Hong, Z., & Wei, W. (2012) · Glia · doi:10.1002/glia.22404 · Cited by 103 · see citing works
Lagraoui, M., Latoche, J. R., Cartwright, N. G., Sukumar, G., Dalgard, C. L., & Schaefer, B. C. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00155 · Cited by 100 · see citing works
Traumatic Brain Injury Dysregulates MicroRNAs to Modulate Cell Signaling in Rat Hippocampus
Liu, L., Sun, T., Liu, Z., Chen, X., Zhao, L., Qu, G., & Li, Q. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103948 · Cited by 98 · see citing works
Sakai, A., & Suzuki, H. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.04.089 · Cited by 97 · see citing works
CDC grand rounds: reducing severe traumatic brain injury in the United States.
(2013) · PubMed · Cited by 89 · see citing works
Patz, S., Trattnig, C., Grünbacher, G., Ebner, B., Gülly, C., Novak, A., Rinner, B., Leitinger, G., Absenger, M., Tomescu, O. A., et al. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2012.2596 · Cited by 83 · see citing works
Hu, Z., Yu, D., Almeida-Suhett, C. P., Tu, K., Marini, A. M., Eiden, L. E., Braga, M. F. M., Zhu, J., & Li, Z. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039357 · Cited by 78 · see citing works
Temporal Profile of MicroRNA Expression in Contused Cortex after Traumatic Brain Injury in Mice
Meissner, L., Gallozzi, M., Balbi, M., Schwarzmaier, S., Tiedt, S., Terpolilli, N. A., & Plesnila, N. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2015.4077 · Cited by 68 · see citing works
Liu, H., Huang, C.-M., Hung, Y.-F., & Hsueh, Y. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.04.011 · Cited by 64 · see citing works
Carbachol increases intracellular free calcium in cultured rat microglia
Whittemore, E. R., Korotzer, A. R., Etebari, A., & Cotman, C. W. (1993) · Brain Research · doi:10.1016/0006-8993(93)90297-z · Cited by 59 · see citing works
Montalban, E., Mattugini, N., Ciarapica, R., Provenzano, C., Savino, M., Scagnoli, F., Prosperini, G., Carissimi, C., Fulci, V., Matrone, C., et al. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-014-8292-z · Cited by 56 · see citing works
Lescher, J., Paap, F., Schultz, V., Redenbach, L., Scheidt, U., Rosewich, H., Nessler, S., Fuchs, E., Gärtner, J., Brück, W., et al. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.02.012 · Cited by 52 · see citing works
Kuo, C.-Y., Liou, T., Chang, K., Chi, W., Escorpizo, R. S., Yen, C.-F., Liao, H., Chiou, H., Chiu, W., & Tsai, J.-T. (2015) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph120404116 · Cited by 51 · see citing works
MicroRNAs: Potential regulators involved in human anencephaly
Zhang, Z., Chang, H., Li, Y., Zhang, T., Zou, J., Zheng, X., & Wu, J. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.11.023 · Cited by 48 · see citing works
Bergman, P., James, T., Kular, L., Ruhrmann, S., Kramarova, T. V., Kvist, A., Šupić, G., Gillett, A., Pivarcsi, A., & Jagodic, M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1200728 · Cited by 46 · see citing works
Differential response of miRNA-21 and its targets after traumatic brain injury in aging mice
Sandhir, R., Gregory, E. J., & Berman, N. E. J. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.09.009 · Cited by 46 · see citing works
Chaudhuri, A. D., Yelamanchili, S. V., & Fox, H. S. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00160 · Cited by 44 · see citing works
Self-citationO'Connor, C., Heath, D., Cernak, I., Nimmo, A., & Vink, R. (2003) · Journal of Neurotrauma · doi:10.1089/089771503770195830 · Cited by 42 · see citing works
Upregulation of cathepsin D in the caudate nucleus of primates with experimental parkinsonism
Yelamanchili, S. V., Chaudhuri, A. D., Flynn, C. T., & Fox, H. S. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-52 · Cited by 40 · see citing works
Self-citationTang, Y., Ling, Z., Fu, R., Li, Y., Cheng, X., Song, F.-H., Luo, H., & Zhou, L. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-92 · Cited by 38 · see citing works
Expression profiling of MicroRNAs in hippocampus of rats following traumatic brain injury
Sun, T., Chen, X., Liu, Z.-L., Zhao, L., Jiang, Y., Qu, G., Wang, R., Huang, S., & Liu, L. (2014) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-014-1313-1 · Cited by 35 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Microglia: Agents of the CNS Pro-Inflammatory Response
Rodríguez-Gómez, J. A., Kavanagh, E., Engskog-Vlachos, P., Engskog, M. K. R., Herrera, A. J., Espinosa-Oliva, A. M., Joseph, B., Hajji, N., Venero, J. L., & Burguillos, M. A. (2020) · Cells · doi:10.3390/cells9071717 · Cited by 365 · see citing works
Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury
Kumar, A., Stoica, B. A., Loane, D. J., Yang, M., Abulwerdi, G. A., Khan, N., Kumar, A., Thom, S. R., & Faden, A. I. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0819-4 · Cited by 318 · see citing works
Slota, J. A., & Booth, S. A. (2019) · Non-Coding RNA · doi:10.3390/ncrna5020035 · Cited by 233 · see citing works
Traumatic Brain Injury: Mechanisms of Glial Response
Mira, R. G., Lira, M., & Cerpa, W. F. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.740939 · Cited by 215 · see citing works
Traumatic brain injury: classification, models, and markers
Najem, D., Rennie, K., Ribecco‐Lutkiewicz, M., Ly, D., Haukenfrers, J., Liu, Q., Nzau, M., Fraser, D. D., & Bani‐Yaghoub, M. (2018) · Biochemistry and Cell Biology · doi:10.1139/bcb-2016-0160 · Cited by 206 · see citing works
Exosomes and Their MicroRNA Cargo: New Players in Peripheral Nerve Regeneration
Qing, L., Chen, H. A., Tang, J., & Jia, X. (2018) · Neurorehabilitation and neural repair · doi:10.1177/1545968318798955 · Cited by 180 · see citing works
miR-212-5p attenuates ferroptotic neuronal death after traumatic brain injury by targeting Ptgs2
Xiao, X., Jiang, Y., Liang, W., Wang, Y., Cao, S., He, Y., Gao, L., & Zhang, L. (2019) · Molecular Brain · doi:10.1186/s13041-019-0501-0 · Cited by 173 · see citing works
MicroRNAs as regulators of brain function and targets for treatment of epilepsy
Brennan, G. P., & Henshall, D. C. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0369-8 · Cited by 168 · see citing works
Yin, Z., Han, Z., Hu, T., Zhang, S., Ge, X., Huang, S., Wang, L., Yu, J., Li, W., Wang, Y., et al. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.11.004 · Cited by 171 · see citing works
Zhai, K., Duan, H. Q., Wang, W., Zhao, S., Khan, G. J., Wang, M., Zhang, Y., Thakur, K., Fang, X., Wu, C., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.032 · Cited by 153 · see citing works
Extracellular Vesicles: Packages Sent With Complement
Karasu, E., Eisenhardt, S. U., Harant, J., & Huber-Lang, M. S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00721 · Cited by 145 · see citing works
Exosomes, an Unmasked Culprit in Neurodegenerative Diseases
Soria, F. N., Pampliega, O., Bourdenx, M., Meissner, W. G., Bézard, E., & Dehay, B. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00026 · Cited by 144 · see citing works
Molecular Communication of a Dying Neuron in Stroke
Puig, B., Brenna, S., & Magnus, T. U. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092834 · Cited by 138 · see citing works
Nooshabadi, V. T., Mardpour, S., Yousefi‐Ahmadipour, A., Allahverdi, A., Izadpanah, M., Daneshimehr, F., Ai, J., Banafshe, H. R., & Ebrahimi‐Barough, S. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26726 · Cited by 133 · see citing works
A Review of MicroRNA Biomarkers in Traumatic Brain Injury
Atif, H., & Hicks, S. D. (2019) · Journal of Experimental Neuroscience · doi:10.1177/1179069519832286 · Cited by 132 · see citing works
Extracellular vesicles in the diagnosis and treatment of central nervous system diseases
Rizvanov, A. A., Shaimardanova, A. A., Solovyeva, V. V., Chulpanova, D. S., James, V. H., & Kitaeva, K. V. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.266908 · Cited by 103 · see citing works
Exosomes in Acquired Neurological Disorders: New Insights into Pathophysiology and Treatment
Osier, N. D., Motamedi, V., Edwards, K. A., Puccio, A. M., Diaz-Arrastia, R. R., Kenney, K., & Gill, J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1054-4 · Cited by 101 · see citing works
Fernandes, A., Ribeiro, A. R., Monteiro, M., Garcia, G., Vaz, A. R., & Brites, D. (2018) · Biochimie · doi:10.1016/j.biochi.2018.05.015 · Cited by 93 · see citing works
Busatto, S., Morad, G., Guo, P., & Moses, M. A. (2021) · FASEB BioAdvances · doi:10.1096/fba.2021-00045 · Cited by 90 · see citing works
MicroRNA Signature of Traumatic Brain Injury: From the Biomarker Discovery to the Point-of-Care
Pietro, V. D., Yakoub, K. M., Scarpa, U., Pietro, C. D., & Belli, A. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00429 · Cited by 86 · see citing works
Exosomes: A new horizon in modern medicine.
Deb, A., Gupta, S., & Mazumder, P. (2020) · Life Science · doi:10.1016/j.lfs.2020.118623 · Cited by 78 · see citing works
Extracellular Vesicle Proteins and MicroRNAs as Biomarkers for Traumatic Brain Injury
Guedes, V. A., Devoto, C., Leete, J., Sass, D., Acott, J. D., Mithani, S., & Gill, J. M. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00663 · Cited by 85 · see citing works
Sun, L., Zhao, M., Wang, Y., Liu, A., Lv, M., Li, Y., Yang, X., & Wu, Z. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.12.001 · Cited by 85 · see citing works
The link between neuroinflammation and the neurovascular unit in synucleinopathies
Wang, Q., Zheng, J., Pettersson, S., Reynolds, R., & Tan, E.-K. (2023) · Science Advances · doi:10.1126/sciadv.abq1141 · Cited by 81 · see citing works
Shetgaonkar, G. G., Marques, S. M., DCruz, C. E. M., Vibhavari, R. J. A., Kumar, L., & Shirodkar, R. K. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01026-0 · Cited by 83 · see citing works
Effects of Protocatechuic Acid (PCA) on Global Cerebral Ischemia-Induced Hippocampal Neuronal Death
Kho, A. R., Choi, B. Y., Lee, S. H., Hong, D. K., Lee, S. H., Jeong, J. H., Park, K., Song, H. K., Choi, H., & Suh, S. W. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051420 · Cited by 82 · see citing works
Yang, L., Patel, K. D., Rathnam, C., Thangam, R., Hou, Y., Kang, H., & Lee, K. (2022) · Small · doi:10.1002/smll.202104783 · Cited by 81 · see citing works
miRNA in Circulating Microvesicles as Biomarkers for Age-Related Cognitive Decline
Rani, A., O’Shea, A. M., Ianov, L., Cohen, R. A., Woods, A. J., & Foster, T. C. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00323 · Cited by 77 · see citing works
Epigenetic mechanisms of neurodegenerative diseases and acute brain injury
Bertogliat, M. J., Morris-Blanco, K. C., & Vemuganti, R. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104642 · Cited by 77 · see citing works
Wang, Y.-D., Yang, X., Wen, L., Shen, D., Zheng, P., Tu, M., You, W., Zhu, Y.-R., Wang, H., & Feng, J. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.339489 · Cited by 76 · see citing works
Exosomes in the Diseased Brain: First Insights from In vivo Studies
Levy, E. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00142 · Cited by 75 · see citing works
Exacerbation of Acute Traumatic Brain Injury by Circulating Extracellular Vesicles
Hazelton, I., Yates, A. G., Dale, A., Roodselaar, J., Akbar, N., Ruitenberg, M. J., Anthony, D. C., & Couch, Y. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2017.5049 · Cited by 75 · see citing works
Li, L., Zhou, X., Zhang, J., Liu, A., Zhang, C., Han, J.-C., Zhang, X., Wu, S., Zhang, X., & Lv, F.-Q. (2021) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-020-02160-0 · Cited by 72 · see citing works
Bai, X., & Bian, Z. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.842288 · Cited by 66 · see citing works
Li, Q., Fu, X., Kou, Y., & Han, N. (2023) · Theranostics · doi:10.7150/thno.84971 · Cited by 63 · see citing works
HIV-1 Tat-Induced Astrocytic Extracellular Vesicle miR-7 Impairs Synaptic Architecture
Hu, G., Niu, F., Liao, K., Periyasamy, P., Sil, S., Liu, J., Dravid, S. M., & Buch, S. J. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09869-8 · Cited by 63 · see citing works
Zhao, C., Deng, Y., He, Y., Huang, X., Wang, C., & Li, W. (2021) · Neurotherapeutics · doi:10.1007/s13311-020-00999-z · Cited by 61 · see citing works
Janoušková, O., Herma, R., Semerádtová, A., Poustka, D., Liegertová, M., Malinská, H. A., & Malý, J. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.846650 · Cited by 64 · see citing works
microRNAs Sculpt Neuronal Communication in a Tight Balance That Is Lost in Neurological Disease
Thomas, K. T., Groß, C., & Bassell, G. J. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00455 · Cited by 61 · see citing works
Kumar, A., Henry, R. J., Stoica, B. A., Loane, D. J., Abulwerdi, G. A., Bhat, S. A., & Faden, A. I. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.253955 · Cited by 63 · see citing works
Human Lung Cell Pyroptosis Following Traumatic Brain Injury
Kerr, N. A., Vaccari, J. P. D. R., Umland, O., Bullock, M. R., Conner, G. E., Dietrich, W. D., & Keane, R. W. (2019) · Cells · doi:10.3390/cells8010069 · Cited by 61 · see citing works
Impact of aging immune system on neurodegeneration and potential immunotherapies
Liang, Z., Zhao, Y., Ruan, L., Zhu, L., Jin, K., Zhuge, Q., Su, D., & Zhao, Y. L. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.07.006 · Cited by 61 · see citing works
T he roles of extracellular vesicle micro RNA s in the central nervous system
Blandford, S. N., Galloway, D. A., & Moore, C. S. (2018) · Glia · doi:10.1002/glia.23445 · Cited by 60 · see citing works
Liao, K., Niu, F., Hu, G., Yang, L., Dallon, B. W., Villarreal, D. J., & Buch, S. J. (2020) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12027 · Cited by 57 · see citing works
The protective effect of microRNA-21 in neurons after spinal cord injury
Zhang, T., Ni, S., Luo, Z., Lang, Y., Hu, J., & Lu, H. (2019) · Spinal Cord · doi:10.1038/s41393-018-0180-1 · Cited by 51 · see citing works
Neural-respiratory inflammasome axis in traumatic brain injury
Kerr, N. A., Vaccari, J. P. D. R., Dietrich, W. D., & Keane, R. W. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113080 · Cited by 57 · see citing works
Extracellular Vesicles miRNA Cargo for Microglia Polarization in Traumatic Brain Injury
Panaro, M. A., Benameur, T., & Porro, C. (2020) · Biomolecules · doi:10.3390/biom10060901 · Cited by 54 · see citing works
Altered Extracellular Vesicle miRNA Profile in Prodromal Alzheimer’s Disease
Visconte, C., Fenoglio, C., Serpente, M., Muti, P. C., Sacconi, A., Rigoni, M., Arighi, A., Borracci, V., Arcaro, M., Arosio, B., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914749 · Cited by 54 · see citing works
Prospects and challenges of tissue-derived extracellular vesicles
Lee, C. J., Ray, R. M., & Scott, T. A. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.06.025 · Cited by 54 · see citing works
Extracellular vesicles: pathogenetic, diagnostic and therapeutic value in traumatic brain injury
Mondello, S., Thelin, E. P., Shaw, G., Salzet, M., Visalli, C., Cizkova, D., Kobeissy, F., & Buki, A. (2018) · Expert Review of Proteomics · doi:10.1080/14789450.2018.1464914 · Cited by 53 · see citing works
Khan, N. A., Asim, M., El-Menyar, A. A., Biswas, K. H., Rizoli, S. B., & Al-Thani, H. A. S. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.933434 · Cited by 52 · see citing works
Cellular microparticles and pathophysiology of traumatic brain injury
Zhao, Z., Zhou, Y., Tian, Y., Li, M., Dong, J., & Zhang, J. (2017) · Protein & Cell · doi:10.1007/s13238-017-0414-6 · Cited by 52 · see citing works
The role of exosomal microRNAs in central nervous system diseases
Yu, Y., Hou, K., Ji, T., Wang, X., Liu, Y., Zheng, Y., Xu, J., Hou, Y., & Chi, G. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04053-0 · Cited by 53 · see citing works
Neuroinflammation of traumatic brain injury: Roles of extracellular vesicles
Liu, X.-L., Zhang, L., Cao, Y.-Y., Jia, H.-R., Li, X.-T., Li, F., Zhang, S., & Zhang, J.-N. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1088827 · Cited by 56 · see citing works
Shahjin, F., Guda, R. S., Schaal, V. L., Odegaard, K. E., Clark, A. R., Gowen, A. M., Xiao, P., Lisco, S. J., Pendyala, G., & Yelamanchili, S. V. (2019) · Cells · doi:10.3390/cells9010021 · Cited by 50 · see citing works
Self-citationInduction of miR-155 after Brain Injury Promotes Type 1 Interferon and has a Neuroprotective Effect
Harrison, E. B., Emanuel, K., Lamberty, B. G., Morsey, B. M., Li, M., Kelso, M. L., Yelamanchili, S. V., & Fox, H. S. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00228 · Cited by 48 · see citing works
Self-citationCircular RNA Expression Profiles Alter Significantly after Traumatic Brain Injury in Rats
Xie, B., Wang, Y., Lin, Y., Zhao, C.-C., Mao, Q., Feng, J., Cao, J., Gao, G., & Jiang, J. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5468 · Cited by 47 · see citing works
Overexpression of miR-124 in Motor Neurons Plays a Key Role in ALS Pathological Processes
Vaz, A. R., Vizinha, D., Morais, H. M. M., Colaço, A. R. A., Loch-Neckel, G., Barbosa, M., & Brites, D. M. T. O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116128 · Cited by 45 · see citing works
Extracellular miRNAs as Biomarkers of Head and Neck Cancer Progression and Metastasis
Nowicka, Z., Stawiski, K., Tomasik, B., & Fendler, W. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194799 · Cited by 46 · see citing works
Zhiguo, F., Ji, W., Chen, S., Guoyou, Z., Chen, K., Hui, Q., Xu, W., & Zhai, X. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02051-6 · Cited by 45 · see citing works
Devoto, C., Lai, C., Qu, B., Guedes, V. A., Leete, J. J., Wilde, E. A., Walker, W. C., Diaz-Arrastia, R. R., Kenney, K., & Gill, J. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2019.6933 · Cited by 45 · see citing works
Plasma Exosome-derived MicroRNAs as Novel Biomarkers of Traumatic Brain Injury in Rats
Wang, P., Ma, H., Zhang, Y., Zeng, R., Yu, J., Liu, R., Jin, X., & Zhao, Y. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.39667 · Cited by 44 · see citing works
Sancandi, M., Uysal-Onganer, P., Kraev, I., Mercer, A., & Lange, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082743 · Cited by 41 · see citing works
Wang, J., Wang, J., Li, X., & Shu, K. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11113223 · Cited by 41 · see citing works
Extracellular vesicles as mediators and markers of acute organ injury: current concepts
Weber, B., Franz, N., Marzi, İ., Henrich, D. M., & Leppik, L. P. (2021) · European Journal of Trauma and Emergency Surgery · doi:10.1007/s00068-021-01607-1 · Cited by 41 · see citing works
Giuliani, A., Gaetani, S., Sorgentoni, G., Agarbati, S., Laggetta, M., Matacchione, G., Gobbi, M., Rossi, T., Galeazzi, R., Piccinini, G., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.647015 · Cited by 41 · see citing works
Chand, S., Gowen, A. M., Savine, M., Moore, D. Y., Clark, A. R., Huynh, W., Wu, N., Odegaard, K. E., Weyrich, L., Bevins, R. A., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12177 · Cited by 41 · see citing works
Self-citationEpigenetic Mechanisms of Traumatic Brain Injuries
Balasubramanian, N., Sagarkar, S., & Sakharkar, A. J. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.12.013 · Cited by 40 · see citing works
Laliberté, A. M., Karadimas, S. K., Vidal, P. M., Satkunendrarajah, K., & Fehlings, M. G. (2021) · Brain Communications · doi:10.1093/braincomms/fcaa234 · Cited by 37 · see citing works
Qiu, M., Zong, J., He, Q., Liu, Y., Wan, Y., Li, M., Zhou, Y., Wu, J., & Hu, B. (2022) · Aging and Disease · doi:10.14336/ad.2022.0212 · Cited by 38 · see citing works
Unraveling the Emerging Niche Role of Extracellular Vesicles (EVs) in Traumatic Brain Injury (TBI)
Ashique, S., Pal, R., Sharma, H., Mishra, N., & Garg, A. (2024) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273288155240201065041 · Cited by 36 · see citing works
Combined bioscaffold with stem cells and exosomes can improve traumatic brain injury
Yuan, J., Botchway, B. O. A., Zhang, Y., Wang, X., & Liu, X. (2019) · Stem Cell Reviews and Reports · doi:10.1007/s12015-019-09927-x · Cited by 36 · see citing works
Batool, A., Hill, T. D. M., Nguyen, T. N., Langa, E., Diviney, M., Mooney, C., Brennan, G. P., Connolly, N. M. C., Sanz‐Rodriguez, A., Cavanagh, B., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01404 · Cited by 35 · see citing works
Extracellular vesicles as distinct biomarker reservoirs for mild traumatic brain injury diagnosis
Beard, K., Yang, Z., Haber, M., Flamholz, M., Diaz-Arrastia, R. R., Sandsmark, D. K., Meaney, D. F., & Issadore, D. (2021) · Brain Communications · doi:10.1093/braincomms/fcab151 · Cited by 35 · see citing works
Pang, Q., Zheng, L., Ren, Z., Xu, H., Guo, H., Shan, W., Liu, R., Gu, Z., & Wang, T. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1274550 · Cited by 34 · see citing works
Extracellular Vesicles as Diagnostics and Therapeutics for Structural Epilepsies
Karttunen, J., Heiskanen, M., Lipponen, A., Poulsen, D. J., & Pitkänen, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061259 · Cited by 33 · see citing works
Kuharić, J., Grabušić, K., Tokmadžić, V. S., Štifter, S., Tulić, K., Shevchuk, O., Lučin, P., & Šustić, A. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5515 · Cited by 32 · see citing works
Potential of different cells-derived exosomal microRNA cargos for treating spinal cord injury
Pan, D., Liu, W., Zhu, S., Fan, B., Yu, N., Ning, G., & Feng, S. (2021) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2021.09.008 · Cited by 30 · see citing works
Moore, D. Y., Meays, B. M., Madduri, L. S. V., Shahjin, F., Chand, S., Niu, M., Albahrani, A., Guda, C., Pendyala, G., Fox, H. S., et al. (2019) · Stem Cells International · doi:10.1155/2019/8710180 · Cited by 30 · see citing works
Self-citationLiu, L., & Deng, Q. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.335825 · Cited by 29 · see citing works
MicroRNA-21 in the Pathogenesis of Traumatic Brain Injury
Ji, W., Jiao, J., Cheng, C., & Shao, J. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2602-z · Cited by 28 · see citing works
Pait, M. C., Kaye, S. D., Su, Y., Kumar, A., Singh, S., Gironda, S. C., Vincent, S., Anwar, M., Carroll, C. M., Snipes, J. A., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12398 · Cited by 27 · see citing works
Dong, M., Tang, Z., Hicks, S. D., & Guan, W. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c04781 · Cited by 27 · see citing works
Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions
Choi, H. K., Chen, M., Goldston, L. L., & Lee, K.-B. (2024) · Nano Convergence · doi:10.1186/s40580-024-00426-5 · Cited by 26 · see citing works
Developing Biomarkers of Mild Traumatic Brain Injury: Promise and Progress of CNS-Derived Exosomes
Vaughn, M. N., Winston, C. N., Levin, N., Rissman, R. A., & Risbrough, V. B. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.698206 · Cited by 26 · see citing works
Dong, X., Dong, J., & Zhang, J. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01165-6 · Cited by 24 · see citing works
miR-146a Mimics Ameliorates Traumatic Brain Injury Involving JNK and NF-κB Signaling Pathway
Zhang, L., Zhao, L., Zhu, W., Ding, Y., Chen, H., & Chi, N. (2020) · NeuroMolecular Medicine · doi:10.1007/s12017-020-08599-y · Cited by 25 · see citing works
Role of regulatory non-coding RNAs in traumatic brain injury
Li, S., Qiu, N., Ni, A., Hamblin, M. H., & Yin, K. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105643 · Cited by 26 · see citing works
Circulating Exosomes of Neuronal Origin as Potential Early Biomarkers for Development of Stroke
Yousif, G., Qadri, S. M., Haik, M. Y., Haik, Y., Parray, A., & Shuaib, A. M. (2021) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-020-00508-0 · Cited by 25 · see citing works
Tang, B. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.10.008 · Cited by 26 · see citing works
Immune regulation in neurovascular units after traumatic brain injury
Wang, Z., & Chen, G. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106060 · Cited by 24 · see citing works
The role of circTmeff-1 in incubation of context-induced morphine craving
Yu, H., Xie, B., Zhang, J., Luo, Y., Galaj, E., Zhang, X., Shen, Q., Liu, Y., Cong, B., Wen, D., et al. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105722 · Cited by 23 · see citing works
Zhang, C., Yang, X., Jiang, T., Yan, C., Xu, X., & Chen, Z. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121624 · Cited by 23 · see citing works
Koul, S., Schaal, V. L., Chand, S., Pittenger, S. T., Vellichirammal, N. N., Kumar, V., Guda, C., Bevins, R. A., Yelamanchili, S. V., & Pendyala, G. (2020) · Cells · doi:10.3390/cells9081883 · Cited by 23 · see citing works
Self-citationRole of exosomal ncRNAs in traumatic brain injury
Beylerli, O., Тамразов, Р. И., Фанилевич, Г. И., Ilyasova, T., Shumadalova, A. V., Bai, Y., & Yang, B. (2023) · Non-coding RNA Research · doi:10.1016/j.ncrna.2023.10.004 · Cited by 21 · see citing works
Baratta, A. M., Mangieri, R. A., Aziz, H. C., Lopez, M. F., Farris, S. P., & Homanics, G. E. (2022) · Alcohol · doi:10.1016/j.alcohol.2022.08.006 · Cited by 20 · see citing works
Infection-induced extracellular vesicles evoke neuronal transcriptional and epigenetic changes
Tedford, E., Badya, N. B., Laing, C., Asaoka, N., Kaneko, S., Filippi, B., & McConkey, G. A. (2023) · Scientific Reports · doi:10.1038/s41598-023-34074-2 · Cited by 20 · see citing works
Chand, S., Jo, A., Vellichirammal, N. N., Gowen, A. M., Guda, C., Schaal, V. L., Odegaard, K. E., Lee, H., Pendyala, G., & Yelamanchili, S. V. (2020) · ACS Applied Nano Materials · doi:10.1021/acsanm.0c01654 · Cited by 20 · see citing works
Self-citationChiang, C.-S., Fu, S.-J., Hsu, C., Jeng, C., Tang, C., Huang, Y., & Tang, S. (2021) · NeuroMolecular Medicine · doi:10.1007/s12017-020-08641-z · Cited by 20 · see citing works
Herrold, A. A., Kletzel, S., Foecking, E. M., Saban, K. L., Przybycien–Szymanska, M. M., Zilliox, M. J., Bhaumik, D. K., Lange, D., Radke, J. R., Salinas, I. G., et al. (2020) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000632 · Cited by 18 · see citing works
- Authors
- Harrison, E. B., Hochfelder, C. G., Lamberty, B. G., Meays, B. M., Morsey, B. M., Kelso, M. L., Fox, H. S., & Yelamanchili, S. V.
- Affiliations
- University of Nebraska Medical Center (US)
- Corresponding author
- Yelamanchili, Sowmya V.
- Venue
- FEBS Open Bio
- Publisher
- Wiley
- Published
- 2016-06-14
- Volume
- 6
- Issue
- 8
- Pages
- 835-846
- ISSN
- 2211-5463 (ISSN-L)
- PMC
- PMC4971839
- OpenAlex
- W2397416734
- Cited by
- 151
- References
- 61
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 11 · 2023: 20 · 2022: 18 · 2021: 21 · 2020: 17 · 2019: 17 · 2018: 21 · 2017: 10 · 2016: 1
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- FEBS Open Bio (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DigitalCommons@UNMC (submittedVersion, cc-by)
- Funders
- Nebraska Research Initiative Grant
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Keywords
- traumatic brain injury, extracellular vesicles, microRNA, miR-21, neuroinflammation, intercellular communication, microglial activation, neuronal injury, miR-212, miR-146, miR-7, vesicle cargo, brain injury biomarkers
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