CoChat
Sign Up
Cited by 118Deep Brain Stimulation and Movement DisordersTreatment of Major DepressionObsessive-Compulsive Spectrum Disorders

The DOI matches its Crossref record; 53 of the 54 references it cites were found in a registry or an index.

A longitudinal study on deep brain stimulation of the medial forebrain bundle for treatment-resistant depression

Open access
Fenoy, Albert J., Schulz, Paul E., Selvaraj, Sudhakar, Burrows, Christina L., Zunta-Soares, Giovanna, Durkin, Kathryn, Zanotti-Fregonara, Paolo, Quevedo, Joao, Soares, Jair C.·2018·Translational Psychiatry
DOI 10.1038/s41398-018-0160-4PMC PMC5986795
Open this paper in CoChat — free accountOpen PDF

Abstract

Abstract Deep brain stimulation (DBS) to the superolateral branch of the medial forebrain bundle (MFB) has been reported to lead to rapid antidepressant effects. In this longitudinal study, we expand upon the initial results we reported at 26 weeks (Fenoy et al., 2016), showing sustained antidepressant effects of MFB DBS on six patients with treatment-resistant depression (TRD) over 1 year. The Montgomery-Åsberg Depression Rating Scale (MADRS) was used as the primary assessment tool. Deterministic fiber tracking was used to individually map the target area; analysis was performed to compare modulated fiber tracts between patients. Intraoperatively, upon stimulation at target, responders reported immediate increases in energy and motivation. An insertional effect was seen during the 4-week sham stimulation phase from baseline (28% mean MADRS reduction,p = 0.02). However, after 1 week of initiating stimulation, three of six patients had a > 50% decrease in MADRS scores relative to baseline (43% mean MADRS reduction,p = 0.005). One patient withdrew from study participation. At 52 weeks, four of remaining five patients have > 70% decrease in MADRS scores relative to baseline (73% mean MADRS reduction,p = 0.007). Evaluation of modulated fiber tracts reveals significant common orbitofrontal connectivity to the target region in all responders. Neuropsychological testing and18F-fluoro-deoxyglucose-positron emission tomography cerebral metabolism evaluations performed at baseline and at 52 weeks showed minimal changes and verified safety. This longitudinal evaluation of MFB DBS demonstrated rapid antidepressant effects, as initially reported by Schlaepfer et al. (2013), and supports the use of DBS for TRD.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/s41398-018-0160-4

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Figures

Fig. 1 Study protocol. DBS, deep brain stimulation; SE, side effects; PET, positron emission tomography; Hz, Hertz; us, microseconds; V, volts; MADRS, Montgomery-Åsburg Depression Rating Scale, HAM-A, Hamilton Anxiety Scale; YMRS, Young Mania Rating Scale; CGI, Clinical Global Impressions
Fig. 1 Study protocol. DBS, deep brain stimulation; SE, side effects; PET, positron emission tomography; Hz, Hertz; us, microseconds; V, volts; MADRS, Montgomery-Åsburg Depression Rating Scale, HAM-A, Hamilton Anxiety Scale; YMRS, Young Mania Rating Scale; CGI, Clinical Global ImpressionsCC BY · PubMed Central
Fig. 2 MADRS scores recorded over time. Initiation = bilateral DBS ON at t = 4w OFF following MADRS assessment. End-sham = 4w OFF. DBS initiation begun after End-Sham assessment. Mean % change MADRS baseline–12 w ON = 64%; mean % change MADRS baseline–52 w = 73%. MADRS, Montgomery-Åsburg Depression Rating Scale. Insert: Chronology of > 50% treatment response by month ( ±) for each patient for 12 months
Fig. 2 MADRS scores recorded over time. Initiation = bilateral DBS ON at t = 4w OFF following MADRS assessment. End-sham = 4w OFF. DBS initiation begun after End-Sham assessment. Mean % change MADRS baseline–12 w ON = 64%; mean % change MADRS baseline–52 w = 73%. MADRS, Montgomery-Åsburg Depression Rating Scale. Insert: Chronology of > 50% treatment response by month ( ±) for each patient for 12 monthsCC BY · PubMed Central
Fig. 3 Representation of active cathodal contacts in two planes for each of the six patients presented in this series, superimposed upon the deterministic tractography-defined target of the medial forebrain bundle for Patient 1; this is presented on adaptations of stereotactic atlas slices from Schaltenbrand and Wahren50. a H.v. 4.5, axial view b F.p. 3.0, Coronal view. STN = subthalamic nucleus; RN = red nucleus; SNr = substantia nigra; Mmt = mammillothalamic tract; Fx = fornix; V3 = 3rd ventricle
Fig. 3 Representation of active cathodal contacts in two planes for each of the six patients presented in this series, superimposed upon the deterministic tractography-defined target of the medial forebrain bundle for Patient 1; this is presented on adaptations of stereotactic atlas slices from Schaltenbrand and Wahren50. a H.v. 4.5, axial view b F.p. 3.0, Coronal view. STN = subthalamic nucleus; RN = red nucleus; SNr = substantia nigra; Mmt = mammillothalamic tract; Fx = fornix; V3 = 3rd ventricleCC BY · PubMed Central
Fig. 4 Depiction of modulated fiber tracts (assuming an isotropic model) from active cathodal contacts in patients #1–#6. Chronological order of implantation. Significant orbitofrontal connectivity to the MFB target region seen in all responder patients but minimally seen in the non-responder Patient no. 3
Fig. 4 Depiction of modulated fiber tracts (assuming an isotropic model) from active cathodal contacts in patients #1–#6. Chronological order of implantation. Significant orbitofrontal connectivity to the MFB target region seen in all responder patients but minimally seen in the non-responder Patient no. 3CC BY · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 54 references

Research works printed but not linked: 1

  1. Russo, S. J. & Nestler, E. J. The brain reward circuitry in mood disorders. Nat. Rev. Neurosci. 14, 609–625 (2013). · DOI · Paper page

Cited by

Sorted by citations

See all 118

Related

Metadata

Authors
Fenoy, A. J., Schulz, P. E., Selvaraj, S., Burrows, C. L., Zunta-Soares, G., Durkin, K., Zanotti-Fregonara, P., Quevedo, J., & Soares, J. C.
Affiliations
The University of Texas Health Science Center at Houston (US)
Corresponding author
Fenoy, Albert J.
ORCID
Venue
Translational Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2018-06-04
Volume
8
Issue
1
Pages
111-111
ISSN
2158-3188 (ISSN-L)
DOI
10.1038/s41398-018-0160-4
PMC
PMC5986795
OpenAlex
W2805696691
Cited by
118
References
54
Citations by year
2026: 6 · 2025: 11 · 2024: 19 · 2023: 15 · 2022: 17 · 2021: 24 · 2020: 16 · 2019: 9 · 2018: 1
FWCI
8.49
Type
journal article
Language
en
Open access
Licence
Locations
  • Translational Psychiatry (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Medtronic
  • John S. Dunn Foundation
  • National Institutes of Health (UL1TR000371)
  • National Center for Advancing Translational Sciences
Topics
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Keywords
deep brain stimulation, medial forebrain bundle, treatment-resistant depression, deterministic fiber tracking, sham stimulation, brain glucose metabolism
MeSH terms
Adult, Female, Humans, Longitudinal Studies, Male, Medial Forebrain Bundle, Middle Aged, Motivation, Neuropsychological Tests, Psychiatric Status Rating Scales, Texas, Treatment Outcome, Deep Brain Stimulation, Positron-Emission Tomography, Young Adult, Depressive Disorder, Treatment-Resistant

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review