Amuc_1100 pretreatment alleviates acute pancreatitis in a mouse model through regulating gut microbiota and inhibiting inflammatory infiltration
Open accessAbstract
Amuc_1100 is a membrane protein from Akkermansia muciniphila, which has been found to play a role in host immunological homeostasis in the gastrointestinal tract by activating TLR2 and TLR4. In this study we investigated the effects and underlying mechanisms of Amuc_1100 on acute pancreatitis (AP) induced in mice by intraperitoneal injection of caerulein and lipopolysaccharide (LPS). The mice were treated with the protein Amuc_1100 (3 μg, i.g.) for 20 days before caerulein injection. Cecal contents of the mice were collected for 16S rRNA sequencing. We found that pretreatment with Amuc_1100 significantly alleviated AP-associated pancreatic injury, reduced serum amylase and lipase. Amuc_1100 pretreatment significantly inhibited the expression of proinflammatory cytokines (TNF-α, IL-1β, IFN-γ and IL-6) in spleen and pancreas through inhibiting NF-κB signaling pathway. Moreover, Amuc_1100 pretreatment significantly decreased the inflammatory infiltration, accompanied by the reduction of Ly6C+ macrophages and neutrophils in the spleen of AP mice. Gut microbiome analysis showed that the abundance of Bacteroidetes, Proteobacteria, Desulfobacterota and Campilobacterota was decreased, while the proportion of Firmicutes and Actinobacteriota was increased in AP mice pretreated with Amuc_1100. We further demonstrated that Amuc_1100 pretreatment restored the enrichment of tryptophan metabolism, which was mediated by intestinal flora. These results provide new evidence that Amuc_1100 lessens the severity of AP through its anti-inflammatory properties with a reduction of macrophages and neutrophil infiltration, as well as its regulation of the composition of intestinal flora and tryptophan metabolism.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Management of intestinal microbiota disruption centers on probiotic therapy.
“Management of intestinal microbiota disruption centers on probiotic therapy (Li et al. 2022; Wang et al. 2024).”
From Odoribacter laneus protects intestinal barrier by bile acid-FXR axis in acute pancreatitis (2026) · cites this paper as Wang et al. 2024
The Discussion (page unavailable) says probiotics have been used alongside prebiotics and synbiotics to maintain gut microbiota balance in acute pancreatitis. The Introduction (page unavailable) describes restoring intestinal flora as a valuable treatment strategy, but the paper does not say management of microbiota disruption centers on probiotics, particularly beyond acute pancreatitis. (LLM, conf=0.86)
Experimental — accuracy not yet measuredUnder the right conditions, some specific bacterial strains can alleviate AP, mitigate the risk of microbial interactions, and provide a specific mechanism.
“Under the right conditions, some specific bacteria strains can alleviate AP, mitigate the risk of microbial interactions and provide a specific mechanism (Li et al. 2022; Wang et al. 2024).”
From Odoribacter laneus protects intestinal barrier by bile acid-FXR axis in acute pancreatitis (2026) · cites this paper as Wang et al. 2024
The Discussion reports that Amuc_1100 attenuated pancreatic injury in AP mice, while the microbiota results and Discussion describe changes in gut flora and tryptophan metabolism as possible mechanisms. But Amuc_1100 is a protein derived from a bacterium, not a bacterial strain administered in the study, and these passages do not establish that it mitigates the risk of microbial interactions. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Banks, P. A., Bollen, T. L., Dervenis, C., Gooszen, H. G., Johnson, C. D., Sarr, M. G., Tsiotos, G. G., & Vege, S. S. (2013) · Gut · doi:10.1136/gutjnl-2012-302779 · Cited by 7,187 · see citing works
A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase
Sanger, F., & Coulson, A. R. (1975) · Journal of Molecular Biology · doi:10.1016/0022-2836(75)90213-2 · Cited by 2,709 · see citing works
Plovier, H., Everard, A., Druart, C., Depommier, C., Van Hul, M., Geurts, L., Chilloux, J., Ottman, N., Duparc, T., Lichtenstein, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4236 · Cited by 2,204 · see citing works
Lankisch, P. G., Apte, M. V., & Banks, P. A. (2015) · The Lancet · doi:10.1016/s0140-6736(14)60649-8 · Cited by 1,216 · see citing works
Boxhoorn, L., Voermans, R. P., Bouwense, S. A. W., Bruno, M. J., Verdonk, R. C., Boermeester, M. A., van Santvoort, H. C., & Besselink, M. G. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31310-6 · Cited by 1,111 · see citing works
Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila
Cani, P. D., & de Vos, W. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01765 · Cited by 1,058 · see citing works
Mederos, M. A., Reber, H. A., & Girgis, M. D. (2021) · JAMA · doi:10.1001/jama.2020.20317 · Cited by 1,056 · see citing works
Forsmark, C. E., Vege, S. S., & Wilcox, C. M. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1505202 · Cited by 869 · see citing works
Wang, L., Tang, L., Feng, Y., Zhao, S., Han, M., Zhang, C., Yuan, G., Zhu, J., Cao, S., Wu, Q., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-320105 · Cited by 630 · see citing works
Self-citationSalminen, A., Huuskonen, J., Ojala, J., Kauppinen, A., Kaarniranta, K., & Suuronen, T. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.09.002 · Cited by 581 · see citing works
Ottman, N., Reunanen, J., Meijerink, M., Pietilä, T. E., Kainulainen, V., Klievink, J., Huuskonen, L., Aalvink, S., Skurnik, M., Boeren, S. A., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173004 · Cited by 522 · see citing works
Malla, M. A., Dubey, A., Kumar, A., Yadav, S., Hashem, A., & Allah, E. F. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02868 · Cited by 350 · see citing works
Vege, S. S., Dimagno, M. J., Forsmark, C. E., Martel, M., & Barkun, A. N. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.01.031 · Cited by 284 · see citing works
The Changing Epidemiology of Acute Pancreatitis Hospitalizations
Krishna, S. G., Kamboj, A. K., Hart, P. A., Hinton, A. M., & Conwell, D. L. (2017) · Pancreas · doi:10.1097/mpa.0000000000000783 · Cited by 263 · see citing works
Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice
Zhu, Y., He, C., Li, X., Cai, Y., Hu, J., Liao, Y., Zhao, J., Xia, L., He, W., Liu, L., et al. (2019) · Journal of Gastroenterology · doi:10.1007/s00535-018-1529-0 · Cited by 250 · see citing works
Tan, C., Ling, Z., Huang, Y., Cao, Y.-D., Liu, Q., Cai, T., Yuan, H., Liu, C., Li, Y., & Ke-qian, X. (2015) · Pancreas · doi:10.1097/mpa.0000000000000355 · Cited by 184 · see citing works
Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice
Kusske, A. M., Rongione, A. J., Ashley, S. W., McFadden, D. W., & Reber, H. A. (1996) · Surgery · doi:10.1016/s0039-6060(96)80299-6 · Cited by 177 · see citing works
Intestinal Hypoperfusion Contributes to Gut Barrier Failure in Severe Acute Pancreatitis
Rahman, S. H., Ammori, B. J., Holmfield, J. H. M., Larvin, M., & McMahon, M. J. (2003) · Journal of Gastrointestinal Surgery · doi:10.1016/s1091-255x(02)00090-2 · Cited by 158 · see citing works
Wang, J., Xu, W., Wang, R., Cheng, R., Tang, Z., & Zhang, M. (2021) · Food & Function · doi:10.1039/d1fo00115a · Cited by 127 · see citing works
Self-citationLi, X., Zhang, Z., Zabed, H. M., Yun, J., Zhang, G., & Qi, X. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000461 · Cited by 124 · see citing works
Gardner, T. B. (2021) · Annals of Internal Medicine · doi:10.7326/aitc202102160 · Cited by 122 · see citing works
Elucidation of Akkermansia muciniphila Probiotic Traits Driven by Mucin Depletion
Shin, J., Noh, J., Chang, D., Kim, Y., Kim, M. H., Lee, E. S., Cho, S., Ku, B. J., Rhee, M.-S., Kim, B., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01137 · Cited by 118 · see citing works
Li, Q., Wang, C., Tang, C. X., Zhao, X., He, Q., & Li, J. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00005 · Cited by 96 · see citing works
Self-citationA newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion
Cani, P. D., & Knauf, C. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.05.004 · Cited by 92 · see citing works
Gut microbiome in acute pancreatitis: A review based on current literature
Patel, B. K., Patel, K. H., Bhatia, M., Iyer, S. G., Madhavan, K. K., & Moochhala, S. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i30.5019 · Cited by 69 · see citing works
Shi, R., Wang, J., Zhang, Z., Leng, Y., & Chen, A. F. (2023) · Life Sciences · doi:10.1016/j.lfs.2022.121339 · Cited by 57 · see citing works
Self-citationSchmitt, F. C. F., Brenner, T., Uhle, F., Loesch, S., Hackert, T., Ulrich, A. B., Hofer, S., Dalpke, A. H., Weigand, M. A., & Boutin, S. (2019) · BMC Microbiology · doi:10.1186/s12866-019-1399-5 · Cited by 56 · see citing works
Mulhall, H., DiChiara, J. M., Deragon, M. A., Iyer, R., Huck, O., & Amar, S. (2020) · Infection and Immunity · doi:10.1128/iai.00500-20 · Cited by 54 · see citing works
Piao, X., Liu, B., Sui, X., Li, S., Niu, W., Zhang, Q., Shi, X., Cai, S., & Fan, Y. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3589497 · Cited by 53 · see citing works
Gassen, N. V., Overmeire, E. V., Leuckx, G., Heremans, Y., Groef, S. D., Cai, Y., Elkrim, Y., Gysemans, C. A., Stijlemans, B., de Casteele, M. V., et al. (2015) · European Journal of Immunology · doi:10.1002/eji.201445013 · Cited by 50 · see citing works
Rychter, J. W., van Minnen, L. P., Verheem, A., Timmerman, H. M., Rijkers, G. T., Schipper, M. E. I., Gooszen, H. G., Akkermans, L. M. A., & Kroese, A. B. A. (2009) · Surgery · doi:10.1016/j.surg.2008.09.011 · Cited by 50 · see citing works
Mulhall, H., DiChiara, J. M., Huck, O., & Amar, S. (2022) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13629 · Cited by 45 · see citing works
The variable oligomeric state of Amuc_1100 from Akkermansia muciniphila
Wang, J., Xiang, R., Wang, R., Zhang, B., Gong, W., Zhang, J., Zhang, M., & Wang, M. (2020) · Journal of Structural Biology · doi:10.1016/j.jsb.2020.107593 · Cited by 38 · see citing works
Self-citationIncreased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis
Skouras, C., Zheng, X., Binnie, M., Homer, N. Z. M., Murray, T. B. J., Robertson, D. C., Briody, L., Paterson, F., Spence, H., Derr, L. M., et al. (2016) · Scientific Reports · doi:10.1038/srep33951 · Cited by 34 · see citing works
Implication of Gut Microbiota in Human Health
Khan, I., Yasir, M., Azhar, E. I., Kumosani, T. A., Barbour, E. K., Bibi, F., & Kamal, M. A. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141023153506 · Cited by 33 · see citing works
Oh, S. J., Pimentel, M. L., Leite, G. G. S., Celly, S., Villanueva-Millán, M. J., Lacsina, I., Chuang, B., Parodi, G., Morales, W., Weitsman, S. R., et al. (2020) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2020-000412 · Cited by 28 · see citing works
Xu, X., Qiao, Y., Peng, Q., Día, V. P., & Shi, B. (2023) · Food & Function · doi:10.1039/d2fo03761k · Cited by 23 · see citing works
Zhang, D., Zhu, C., Fang, Z., Zhang, H., Yang, J., Tao, K., Hu, D., Han, J., & Yang, X. (2020) · Burns · doi:10.1016/j.burns.2020.01.007 · Cited by 22 · see citing works
Liu, K., Yang, L., Wang, X., Huang, Q. Z., Tuerhong, K., Yang, M., Zhang, R., Li, Y., & Yang, S. (2022) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13748 · Cited by 20 · see citing works
Self-citationGuo, J., Li, X., Wang, D., Guo, Y., & Cao, T. (2019) · RSC Advances · doi:10.1039/c9ra02186h · Cited by 18 · see citing works
Liu, J., Luo, M. B., Qin, S., Li, B., Huang, L., & Xia, X. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.808991 · Cited by 16 · see citing works
Zhang, K., Li, X., Wang, X., Zheng, H., Tang, S., Lü, L., & Ma, X. (2020) · Current Protein and Peptide Science · doi:10.2174/1389203721666200615171928 · Cited by 15 · see citing works
Dong, X., Liu, M., Liu, X., Liu, M., Zhang, X., & Wang, G. (2020) · PubMed · doi:10.19813/j.cnki.weishengyanjiu.2020.05.016 · Cited by 5 · see citing works
β-hydroxybutyrate enhances bovine neutrophil adhesion by inhibiting autophagy
He, J., Wang, K., Liu, M., Zeng, W., Li, D., Zolzaya, M., Batbaatar, T., Li, Y., Liu, S., Du, X., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1096813 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dietary inulin ameliorates obesity-induced severe acute pancreatitis via gut-pancreas axis
Li, X., Zheng, P., Zou, Y., Guan, L., Li, N., Liu, J., Lü, N., Zhu, Y., & He, C. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2436949 · Cited by 49 · see citing works
Wang, Y., Jia, X., & Cong, B. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1396031 · Cited by 37 · see citing works
Wu, Q., Li, P., Li, X., Ma, L., Chen, K., & Man, S. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c05365 · Cited by 29 · see citing works
Advancements in gene editing technologies for probiotic-enabled disease therapy
Wang, L., Hu, J., Li, K., Zhao, Y., & Zhu, M. (2024) · iScience · doi:10.1016/j.isci.2024.110791 · Cited by 28 · see citing works
Self-citationWu, X., Yu, D., Ma, Y., Fang, X., & Sun, P. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.142442 · Cited by 24 · see citing works
Ye, W.-Y., & Cai, Y. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07149-z · Cited by 25 · see citing works
Xie, J., Du, L., Lu, Y., Guo, X., Zhou, X., Tong, Y., Shen, B., Yu, X., Guo, F., & Yu, H. (2025) · Advanced Science · doi:10.1002/advs.202504214 · Cited by 22 · see citing works
The Role of Akkermansia muciniphila in Disease Regulation
Ding, Y., Hou, Y., & Lao, X. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10642-y · Cited by 21 · see citing works
Yang, L., Yang, J., Kong, X., Tang, Q., Song, R., Zhou, K., Quan, X., Zhang, Q., Zhang, Y., Zhang, C., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2587405 · Cited by 15 · see citing works
Xu, X., Yang, H., Cheng, Z., Zhang, H., Chu, Y., Wang, Z., & An, X. (2024) · Environment International · doi:10.1016/j.envint.2024.109130 · Cited by 14 · see citing works
Akkermansia muciniphila: A Potential Target for the Prevention of Diabetes
He, K., An, F., Zhang, H., Yan, D., Li, T., Wu, J., & Wu, R. (2024) · Foods · doi:10.3390/foods14010023 · Cited by 15 · see citing works
Li, H., Wen, H., Liu, J., Luo, X., Pei, B., Ge, P., Sun, Z., Liu, J., Wang, J., & Chen, H. (2025) · Human Cell · doi:10.1007/s13577-025-01227-6 · Cited by 12 · see citing works
Self-citationZhang, J.-B., Zhou, Y.-N., Mei, X., Yan, S., Mao, J., Li, Y., Bian, Z.-H., Li, L., Ji, D., Lu, T.-L., et al. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03763-w · Cited by 12 · see citing works
Zhao, M., Cui, M.-Y., Fan, M.-Y., Huang, C., Wang, J., Zeng, Y., Wang, X., & Lu, Y. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177314 · Cited by 12 · see citing works
Self-citationThe microbial revolution: Akkermansia muciniphila's role in overcoming immunotherapy challenges
Shi, Y., Fu, Y., & Tang, D. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115374 · Cited by 11 · see citing works
Peipert, D., Montgomery, T. L., Toppen, L. C., Lee, M. F. J., Scarborough, M., & Krementsov, D. N. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1655428 · Cited by 11 · see citing works
Chen, Y., Ma, S., Cui, J., Huang, A., Chen, Z., Pi, D., Yi, Z., Ye, H., Ma, M., & Ouyang, M. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145232 · Cited by 11 · see citing works
Big lessons from the little Akkermansia muciniphila in hepatocellular carcinoma
Yang, Y., & Shi, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1524563 · Cited by 9 · see citing works
Zhang, K., Dong, Y., Ding, Y., Wang, X., Liu, T., Zhong, W., & Cao, H. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128240 · Cited by 8 · see citing works
Wang, H., Chen, Y., Han, Y., Mu, S., Wei, W., Lan, L., Li, X., Xiang, H., Tong, C., & Du, S. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.107030 · Cited by 8 · see citing works
Zhang, N., Zhang, X., Li, J., Li, B., Wang, S., Liu, X., Meng, H., & Zhu, M. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202405159 · Cited by 5 · see citing works
Self-citationFu, Z., Zhou, H., Liu, H., Li, X., Cao, L., & Zheng, W. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120153 · Cited by 5 · see citing works
Dinkov, B. (2026) · Biomedicines · doi:10.3390/biomedicines14061235 · Cited by 4 · see citing works
Shen, Q., Wang, S., Wu, K., Wang, L., Gong, W., Lu, G., Chen, W., Yuan, C., Tu, B., Li, W., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1575880 · Cited by 4 · see citing works
Self-citationJia, Y. J., Shi, Y., Wang, J., Liu, H., Wang, H., Huang, Y., Liu, Y., Chen, P., & Peng, J. (2025) · Bioresources and Bioprocessing · doi:10.1186/s40643-025-00977-3 · Cited by 4 · see citing works
Self-citationZou, Y., Yu, B.-J., He, C., Ding, L., Xu, X., Wan, J., Lei, Y., Huang, X., Xiong, H., He, W., et al. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.01299-25 · Cited by 3 · see citing works
Zhang, H., Liu, C., Huang, Y., Ma, X., & Ren, D. (2025) · Foods · doi:10.3390/foods14234063 · Cited by 3 · see citing works
Yang, G., Yin, M., Guo, S., Yang, B., Gu, J., Zhang, Y., Zhang, Y., 张新党, Chang, X., Feng, S., et al. (2025) · Aquaculture · doi:10.1016/j.aquaculture.2025.743232 · Cited by 3 · see citing works
Wang, L., Zhang, R., Zhao, L., Xiao, L., Zhang, X., Liu, L., Wang, J., Chen, K., Li, J., Zhang, M., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-71140-5 · Cited by 4 · see citing works
Self-citationThe role of probiotic foods in acute pancreatitis: current status and future directions
Qin, W., Wang, G., Xia, Y., Song, X., Xiong, Z., Huang, C., Chen, G., Zeng, Y., & Ai, L. (2024) · Current Opinion in Food Science · doi:10.1016/j.cofs.2024.101231 · Cited by 3 · see citing works
Jia, X., Dun, Y., Xiang, G., Wang, S., Zhang, H., Zhou, W., Li, Y., & Liang, Y. (2025) · Animals · doi:10.3390/ani15121737 · Cited by 3 · see citing works
Advances in Immunoassays for detection of pancreatitis biomarkers
Srinivasamurthy, S. K., Mittal, P., Saleem, S., Kumar, K., Goyal, K., Rana, M., Ali, H., Singh, S. K., Negi, P., Prasher, P., et al. (2025) · Clinica Chimica Acta · doi:10.1016/j.cca.2025.120492 · Cited by 2 · see citing works
Tryptophan’s Journey Through Pregnancy: The Role of Serotonin
Gendrot, B., Vaillancourt, C., & Fouquet, G. (2026) · International Journal of Tryptophan Research · doi:10.1177/11786469261449491 · Cited by 2 · see citing works
Tang, Y., Ma, J., Wu, J., Zhou, J., Wu, S., Chen, R., Wang, H., Wei, 兀. W., Sun, D., & Lou, H. (2026) · Journal of Functional Foods · doi:10.1016/j.jff.2026.107365 · Cited by 2 · see citing works
Du, Y., An, Y., Cao, Z., Xu, G., Chu, M., & Lu, Y. (2026) · Food & Function · doi:10.1039/d5fo03902a · Cited by 2 · see citing works
Alterations in microbiome associated with acute pancreatitis
Yazıcı, C., Priyadarshini, M., Boulay, B. R., Dai, Y. D., & Layden, B. T. (2024) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000001046 · Cited by 2 · see citing works
Odoribacter laneus protects intestinal barrier by bile acid-FXR axis in acute pancreatitis
Gu, R., Li, J., Qi, J., Sun, R., Wu, H., & Jin, B. (2026) · AMB Express · doi:10.1186/s13568-026-02071-z · Cited by 2 · see citing works
“Pro-biotics as therapeutic agents for AP are the hot topics in clinical and laboratory research, which can prevent leaky gut and translocation of pathogens (Li et al. 2022; Wang et al. 2024).”
Self-citationLuo, Q., Zhang, H., Pu, Y., Wei, Y., Yu, J., Wang, X., Cai, Q., Hu, Y., & Yuan, W. (2025) · The Journal of Microbiology · doi:10.71150/jm.2502007 · Cited by 1 · see citing works
Zhou, B., Lv, Z., Zu, R., Liu, J., Yang, Y., Zhou, Z., & Li, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1556600 · Cited by 1 · see citing works
Ahmed, A. Y., Rajai, A., Fullwood, C., Rivett, D. W., McLaughlin, J. T., Gast, C., & Marsh, R. (2025) · BMC Gastroenterology · doi:10.1186/s12876-025-04327-7 · Cited by 1 · see citing works
Li, Y., Li, J., Zhang, F., Liang, Z., Lan, M., Kang, W., & Zhang, Y. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.149679 · Cited by 1 · see citing works
Self-citationFunctional Proteins of Akkermansia Muciniphila: Impacts on Host Health and Metabolism
Safari, F., Golafshan, F., Malekpour, E., Mirzaei, S. A., Rouzbahani, H., Hajarzadeh, M. O., Harandi, S. N., Nasirharandi, S., & Noursina, A. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10871-1 · Cited by 1 · see citing works
Chen, N., Pang, D., & Shang, H. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128436 · Cited by 3 · see citing works
MiR-324-5p mitigates experimental acute pancreatitis by suppressing Rock2 expression
Chen, Q., Shen, Z., Wang, Q., Jiao, R., Liu, Y., Meng, T., Fei, Y., & Liu, C. (2026) · Mammalian Genome · doi:10.1007/s00335-025-10190-4 · Cited by 1 · see citing works
Long, Z., Li, J.-X., Zhu, F.-N., Liu, X.-J., Zhoua, J., Li, J., & Xu, W. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.151199 · Cited by 1 · see citing works
Self-citationLu, H., Shen, H., Cui, J., & Yang, J. (2026) · Chinese Medical Journal · doi:10.1097/cm9.0000000000004085 · Cited by 1 · see citing works
Han, Y., Lu, J., Bu, X., Hu, L., Niu, C., Qiao, J., Wu, H., & Caiyin, Q. (2026) · Microorganisms · doi:10.3390/microorganisms14040820 · Cited by 1 · see citing works
Li, Y., Song, W., Liu, X., Du, J., Li, L., Wang, F., & Zhang, K. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1908600 · Cited by 1 · see citing works
Sitsskiy, A. A., Kakotkin, V. V., & Агапов, М. А. (2024) · Annaly khirurgicheskoy gepatologii = Annals of HPB surgery · doi:10.16931/1995-5464.2024-4-135-143
Ahmed, A. Y., Rajai, A., Fullwood, C., Rivett, D. W., McLaughlin, J. T., Gast, C., & Marsh, R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.04.647187
Associations between gut microbiota and immune status in untreated B-cell lymphoma patients
Zhou, J., Yao, J., Hu, N., & Su, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1663066
Shi, Y., He, S., Li, C., Chan, H., Liu, Z., Yang, B., & Li, Q. (2026) · Advanced Science · doi:10.1002/advs.202518588
Shen, X., Yao, J., Wang, Z., Chen, R., Li, L., Xu, X., & Huang, Y. (2026) · PLoS ONE · doi:10.1371/journal.pone.0344110
Stein, R. A., Ganesh, A., Rianom, N. A., & Paratore, A. W. (2026) · Physiological Genomics · doi:10.1152/physiolgenomics.00230.2025
Dysregulation of the Gut-Immune Axis in Acute Pancreatitis and Advances in Its Regulatory Mechanisms
黄, 家. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.1662341
Gut microbiota as a modifier of acute pancreatitis course: therapeutic perspectives
Chooklin, S., & Chuklin, S. S. (2026) · EMERGENCY MEDICINE · doi:10.22141/2224-0586.22.4.2026.2031
Lee, D. W., Lee, C. E., Lim, J. S., Lim, S., Hong, S. A., Lee, H. J., Chung, J.-W., & Myung, S. C. (2026) · Archives of Microbiology · doi:10.1007/s00203-026-05115-x
Yao, J., Ma, A., Chen, Y., Zhang, Y., Tang, X., Shi, S., Han, X., & Zhang, T. (2026) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2026.108023
Tian, J., Chen, K., Wang, L., & Wang, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1932634
Self-citationJiang, Y.-T., Li, G., Zhou, Y., Jiang, Z.-D., Zhao, Y., Zhang, Y., Yin, X.-M., Li, S., Tong, H., Feng, L.-S., et al. (2026) · Cell Host & Microbe · doi:10.1016/j.chom.2026.09.014
- Authors
- Wang, L.-J., Jin, Y.-L., Pei, W.-L., Li, J.-C., Zhang, R.-L., Wang, J.-J., & Lin, W.
- Affiliations
- Nanjing University of Chinese Medicine (CN)
- Corresponding author
- Lin, Wei
- Venue
- Acta Pharmacologica Sinica
- Published
- 2023-11-27
- Volume
- 45
- Issue
- 3
- Pages
- 570-580
- ISSN
- 0253-9756 (ISSN-L)
- 1671-4083
- 1745-7254
- PMC
- PMC10834448
- OpenAlex
- W4389051433
- Cited by
- 60
- References
- 44
- Citations by year
- 2026: 21 · 2025: 29 · 2024: 10
- FWCI
- 16.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Acta Pharmacologica Sinica (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chinese Academy of Sciences
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province (BK20230064)
- Nanjing University of Chinese Medicine (2020YLXK008)
- Nanjing University
- Fok Ying Tung Education Foundation (171033)
- State Key Laboratory of Bioreactor Engineering
- State Key Laboratory of Drug Research (SIMM2205KF, SIMM2205KF-15)
- Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Amuc_1100, Akkermansia muciniphila, acute pancreatitis, gut microbiota, NF-κB signaling, tryptophan metabolism, macrophage infiltration, neutrophil infiltration, inflammatory cytokines, cerulein-induced pancreatitis, lipopolysaccharide, anti-inflammatory peptides, Firmicutes, Bacteroidetes
- MeSH terms
- Gastrointestinal Microbiome, Acute Disease, Animals, Ceruletide, Pancreatitis, RNA, Ribosomal, 16S, Tryptophan, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
