Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

Cani, Patrice D.; de Vos, Willem M.

doi:10.3389/fmicb.2017.01765

Cited by 1,058Gut microbiota and healthProbiotics and Fermented FoodsMicrobial Metabolites in Food Biotechnology

Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

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Cani, Patrice D., de Vos, Willem M.·2017·Frontiers in Microbiology

DOI 10.3389/fmicb.2017.01765PMC PMC5614963

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Abstract

Metabolic disorders associated with obesity and cardiometabolic disorders are worldwide epidemic. Among the different environmental factors, the gut microbiota is now considered as a key player interfering with energy metabolism and host susceptibility to several non-communicable diseases. Among the next- generation beneficial microbes that have been identified, Akkermansia muciniphila is a promising candidate. Indeed, A. muciniphila is inversely associated with obesity, diabetes, cardiometabolic diseases and low-grade inflammation. Besides the numerous correlations observed, a large body of evidence has demonstrated the causal beneficial impact of this bacterium in a variety of preclinical models. Translating these exciting observations to human would be the next logic step and it now appears that several obstacles that would prevent the use of A.muciniphila administration in humans have been overcome. Moreover, several lines of evidence indicate that pasteurization of A. muciniphila not only increases its stability but more importantly increases its efficacy. This strongly positions A. muciniphila in the forefront of next- generation candidates for developing novel food or pharma supplements with beneficial effects. Finally, a specific protein present on the outer membrane of A. muciniphila, termed Amuc_1100, could be strong candidate for future drug development. In conclusion, as plants and its related knowledge, known as pharmacognosy, have been the source for designing drugs over the last century, we propose that microbes and microbiomegnosy, or knowledge of our gut microbiome, can become a novel source of future therapies.

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Studies in the past decade have demonstrated that gut microbiome composition changes with age, that exceptionally long-lived individuals have a different microbiome composition from average older adults, and that certain microorganisms and the metabolites they produce are beneficial to human health.
“Studies in the past decade have demonstrated that gut microbiome composition changes with age, that exceptionally long-lived individuals have a different microbiome composition from average older adults131–133, and that certain microorganisms131,134,135 and the metabolites they produce132,134,136 are beneficial to human health.”
From Measuring biological age using omics data (2022) · cites this paper as [135]

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Authors: Cani, P. D., & de Vos, W. M.
Affiliations: Walloon Excellence in Lifesciences and Biotechnology (BE)
Corresponding author: Cani, Patrice D.
ORCID: Cani, Patrice D.
Venue: Frontiers in Microbiology
Publisher: Frontiers Media SA
Published: 2017-09-22
Volume: 8
Pages: 1765-1765
ISSN: 1664-302X (ISSN-L)
DOI: 10.3389/fmicb.2017.01765
PMC: PMC5614963
OpenAlex: W2758183934
Cited by: 1,058
References: 74
Citations by year: 2026: 79 · 2025: 104 · 2024: 111 · 2023: 101 · 2022: 181 · 2021: 161 · 2020: 169 · 2019: 108 · 2018: 44
FWCI: 8.26
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Microbiology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion, cc-by)
DIAL (Catholic University of Leuven) (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Työväentutkimus Vuosikirja (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
Funders: European Research Council (336452-ENIGMO, Microbes4U_713547, 250172)
Fonds De La Recherche Scientifique - FNRS (T.0138.14)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: Akkermansia muciniphila, gut microbiota, obesity, cardiometabolic disease, diabetes mellitus, low-grade inflammation, energy metabolism, probiotics, pasteurization, Amuc_1100, prebiotics, functional food supplement

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Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

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