The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Ductal carcinoma in situ: to treat or not to treat, that is the question
Open accessAbstract
Ductal carcinoma in situ (DCIS) now represents 20-25% of all 'breast cancers' consequent upon detection by population-based breast cancer screening programmes. Currently, all DCIS lesions are treated, and treatment comprises either mastectomy or breast-conserving surgery supplemented with radiotherapy. However, most DCIS lesions remain indolent. Difficulty in discerning harmless lesions from potentially invasive ones can lead to overtreatment of this condition in many patients. To counter overtreatment and to transform clinical practice, a global, comprehensive and multidisciplinary collaboration is required. Here we review the incidence of DCIS, the perception of risk for developing invasive breast cancer, the current treatment options and the known molecular aspects of progression. Further research is needed to gain new insights for improved diagnosis and management of DCIS, and this is integrated in the PRECISION (PREvent ductal Carcinoma In Situ Invasive Overtreatment Now) initiative. This international effort will seek to determine which DCISs require treatment and prevent the consequences of overtreatment on the lives of many women affected by DCIS.
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Siegel, R. L., Miller, K. D., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21442 · Cited by 16,579
Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes
Parker, J. S., Mullins, M., Cheang, M. C. U., Leung, S., Voduc, D., Vickery, T., Davies, S., Fauron, C., He, X., Hu, Z., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.1370 · Cited by 4,721
The benefits and harms of breast cancer screening: an independent review
(2012) · The Lancet · doi:10.1016/s0140-6736(12)61611-0 · Cited by 1,492
Evolution and impact of subclonal mutations in chronic lymphocytic leukemia
Landau, D. A., Carter, S. L., Stojanov, P., McKenna, A., Stevenson, K., Lawrence, M. S., Sougnez, C., Stewart, C., Sivachenko, A., Wang, L., et al. (2013) · Cell · doi:10.1016/j.cell.2013.01.019 · Cited by 1,379
Effect of Three Decades of Screening Mammography on Breast-Cancer Incidence
Bleyer, A., & Welch, H. G. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1206809 · Cited by 1,367
Clinical relevance of host immunity in breast cancer: from TILs to the clinic
Savas, P., Salgado, R., Denkert, C., Sotiriou, C., Darcy, P. K., Smyth, M. J., & Loi, S. (2016) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2015.215 · Cited by 890
Subclonal diversification of primary breast cancer revealed by multiregion sequencing
Yates, L. R., Gerstung, M., Knappskog, S., Desmedt, C., Gundem, G., Van Loo, P., Aas, T., Alexandrov, L. B., Larsimont, D., Davies, H., et al. (2015) · Nature Medicine · doi:10.1038/nm.3886 · Cited by 816
Self-citationWapnir, I. L., Dignam, J. J., Fisher, B., Mamounas, E. P., Anderson, S. J., Julian, T. B., Land, S. R., Margolese, R. G., Swain, S. M., Costantino, J. P., et al. (2011) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djr027 · Cited by 785
Overview of the Randomized Trials of Radiotherapy in Ductal Carcinoma In Situ of the Breast
Early Breast Cancer Trialists' Collaborative Group (EBCTCG) (2010) · JNCI Monographs · doi:10.1093/jncimonographs/lgq039 · Cited by 672
Breast Cancer Mortality After a Diagnosis of Ductal Carcinoma In Situ
Narod, S. A., Iqbal, J., Giannakeas, V., Sopik, V., & Sun, P. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.2510 · Cited by 613
Cited by
Hernström, V., Josefsson, V., Sartor, H., Schmidt, D., Larsson, A.-M., Hofvind, S., Andersson, I., Rosso, A., Hagberg, O., & Lång, K. (2025) · The Lancet Digital Health · doi:10.1016/s2589-7500(24)00267-x · Cited by 174
Optimizing risk-based breast cancer screening policies with reinforcement learning
Yala, A., Mikhael, P. G., Lehman, C., Lin, G., Strand, F., Wan, Y.-L., Hughes, K., Satuluru, S., Kim, T., Banerjee, I., et al. (2022) · Nature Medicine · doi:10.1038/s41591-021-01599-w · Cited by 103
Mohile, S., Dumontier, C., Mian, H., Loh, K. P., Williams, G. R., Wildes, T. M., Boyd, K., Ramsdale, E., Pyne, S., Magnuson, A., et al. (2020) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2020.04.010 · Cited by 40
Metadata
- Authors
- on behalf of the PRECISION team, van Seijen, M., Lips, E. H., Thompson, A. M., Nik-Zainal, S., Futreal, A., Hwang, E. S., Verschuur, E., Lane, J., Jonkers, J., Rea, D. W., & Wesseling, J.
- Venue
- British Journal of Cancer
- Published
- 2019-07-09
- Volume
- 121
- Issue
- 4
- Pages
- 285-292
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2957751887
- Cited by
- 320
- References
- 66
- FWCI
- 20.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- on behalf of the PRECISION team, van Seijen, M., Lips, E. H., Thompson, A. M., Nik-Zainal, S., Futreal, A., Hwang, E. S., Verschuur, E., Lane, J., Jonkers, J., Rea, D. W., & Wesseling, J. (2019). Ductal carcinoma in situ: to treat or not to treat, that is the question. British Journal of Cancer. https://doi.org/10.1038/s41416-019-0478-6
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