The DOI matches its Crossref record; 229 of the 229 references it cites were found in a registry or an index.
Cysteine metabolic circuitries: druggable targets in cancer
Open accessAbstract
To enable survival in adverse conditions, cancer cells undergo global metabolic adaptations. The amino acid cysteine actively contributes to cancer metabolic remodelling on three different levels: first, in its free form, in redox control, as a component of the antioxidant glutathione or its involvement in protein s-cysteinylation, a reversible post-translational modification; second, as a substrate for the production of hydrogen sulphide (H 2 S), which feeds the mitochondrial electron transfer chain and mediates per-sulphidation of ATPase and glycolytic enzymes, thereby stimulating cellular bioenergetics; and, finally, as a carbon source for epigenetic regulation, biomass production and energy production. This review will provide a systematic portrayal of the role of cysteine in cancer biology as a source of carbon and sulphur atoms, the pivotal role of cysteine in different metabolic pathways and the importance of H 2 S as an energetic substrate and signalling molecule. The different pools of cysteine in the cell and within the body, and their putative use as prognostic cancer markers will be also addressed. Finally, we will discuss the pharmacological means and potential of targeting cysteine metabolism for the treatment of cancer.
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Cited by
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
Cirino, G., Szabo, C., & Papapetropoulos, A. (2023) · Physiological Reviews · doi:10.1152/physrev.00028.2021 · Cited by 553
SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells
Yan, Y., Teng, H., Hang, Q., Kondiparthi, L., Lei, G., Horbath, A., Liu, X., Mao, C., Wu, S., Zhuang, L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39401-9 · Cited by 341
Amino acid metabolism, redox balance and epigenetic regulation in cancer
Li, X., & Zhang, H. (2024) · The FEBS Journal · doi:10.1111/febs.16803 · Cited by 90
Metadata
- Authors
- Bonifácio, V. D. B., Pereira, S. A., Serpa, J., & Vicente, J. B.
- Venue
- British Journal of Cancer
- Published
- 2020-11-23
- Volume
- 124
- Issue
- 5
- Pages
- 862-879
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W3108143284
- Cited by
- 264
- References
- 229
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
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