Amino acid metabolism, redox balance and epigenetic regulation in cancer

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Glutaminolysis: A Hallmark of Cancer Metabolism

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Amino acids in cancer

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Branched Chain Amino Acids

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Methionine metabolism in health and cancer: a nexus of diet and precision medicine

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Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer

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Protein arginine methylation: from enigmatic functions to therapeutic targeting

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Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan–Kynurenine–Aryl Hydrocarbon Axis

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Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

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Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth

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BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

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xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling

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Targeting <scp>ASCT2</scp>‐mediated glutamine uptake blocks prostate cancer growth and tumour development

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The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer

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Asparagine synthetase: Function, structure, and role in disease

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Branched-chain amino acids in disease

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Tryptophan in health and disease

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Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression

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Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers

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Protein arginine methyltransferases: promising targets for cancer therapy

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Cysteine metabolic circuitries: druggable targets in cancer

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Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth

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The Critical Role of the Branched Chain Amino Acids (BCAAs) Catabolism-Regulating Enzymes, Branched-Chain Aminotransferase (BCAT) and Branched-Chain α-Keto Acid Dehydrogenase (BCKD), in Human Pathophysiology

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GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

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DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase

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System Xc−: a key regulatory target of ferroptosis in cancer

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MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancerPreprint

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Targeting Epigenetics in Cancer

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BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma

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Cystathionine-β-synthase: Molecular Regulation and Pharmacological Inhibition

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Multifaceted role of branched-chain amino acid metabolism in cancer

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Amino acid metabolism in hematologic malignancies and the era of targeted therapy

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ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

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Amino Acid Metabolism

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Methionine deficiency facilitates antitumour immunity by altering m 6 A methylation of immune checkpoint transcripts

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PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

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mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT

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Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours

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Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses

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Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth

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Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

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mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

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Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling

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Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation

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Asparagine Synthetase in Cancer: Beyond Acute Lymphoblastic Leukemia

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Proline Metabolism in Tumor Growth and Metastatic Progression

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α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development

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Tryptophan metabolites modulate inflammatory bowel disease and colorectal cancer by affecting immune system

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Cysteine Dioxygenase 1 Is a Tumor Suppressor Gene Silenced by Promoter Methylation in Multiple Human Cancers

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Proline metabolism and redox; maintaining a balance in health and disease

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5-Fluorouracil Enhances the Antitumor Activity of the Glutaminase Inhibitor CB-839 against PIK3CA -Mutant Colorectal Cancers

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Targeting Tryptophan Catabolism in Cancer Immunotherapy Era: Challenges and Perspectives

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Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth

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Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death

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Amino Acid Transporters as Targets for Cancer Therapy: Why, Where, When, and How

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STK11 /LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition

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Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells

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Amino Acid Metabolism in Cancer Drug Resistance

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Asparagine: A Metabolite to Be Targeted in Cancers

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Amino acids and its pharmaceutical applications: A mini review

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Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

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Amino acid deprivation using enzymes as a targeted therapy for cancer and viral infections

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Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers

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Cystine uptake inhibition potentiates front-line therapies in acute myeloid leukemia

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The Role of D-3-Phosphoglycerate Dehydrogenase in Cancer

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Tryptophan: A Rheostat of Cancer Immune Escape Mediated by Immunosuppressive Enzymes IDO1 and TDO

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Frequent Inactivation of Cysteine Dioxygenase Type 1 Contributes to Survival of Breast Cancer Cells and Resistance to Anthracyclines

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Targeting extracellular nutrient dependencies of cancer cells

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Recent advances in clinical trials targeting the kynurenine pathway

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ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase

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Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions

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