The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.
The untapped potential of ascites in ovarian cancer research and treatment
Open accessAbstract
The build-up of fluid in the peritoneal cavity-ascites-is a hallmark of ovarian cancer, the most lethal of all gynaecological malignancies. This remarkable fluid, which contains a variety of cellular and acellular components, is known to contribute to patient morbidity and mortality by facilitating metastasis and contributing to chemoresistance, but remains largely under-researched. In this review, we will critically analyse the evidence associating ascites with metastasis and chemoresistance in ovarian cancer and provide an update on research in the field. We will argue the case for ascites as a unique and accessible substrate for tracking tumour progression and for translational research that will enhance our understanding of this cancer and lead to improvements in patient outcomes.
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“They disseminate by forming aggregates of multicellular spheroids that float in malignant ascitic fluid alongside fibroblasts, adipocytes, mesothelial, endothelial and inflammatory cells, as well as cell-free DNA, before “seeding” onto new microenvironments and establishing metastatic deposits (Ford et al., 2020).”
From Three-dimensional modelling of ovarian cancer: from cell lines to organoids for discovery and personalized medicine (2022) · cites this paper as Ford et al., 2020
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Kumari, A., Shonibare, Z., Monavarian, M., Arend, R. C., Lee, N. Y., Inman, G. J., & Mythreye, K. (2021) · Clinical & Experimental Metastasis · doi:10.1007/s10585-021-10077-z · Cited by 78
Metadata
- Authors
- Ford, C. E., Werner, B., Hacker, N. F., & Warton, K.
- Affiliations
- UNSW Sydney (AU)
- Corresponding author
- Ford, Caroline Elizabeth
- Venue
- British Journal of Cancer
- Published
- 2020-05-08
- Volume
- 123
- Issue
- 1
- Pages
- 9-16
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC7341795
- OpenAlex
- W3022087601
- Cited by
- 261
- References
- 110
- Citations by year
- 2026: 44 · 2025: 51 · 2024: 60 · 2023: 46 · 2022: 42 · 2021: 18
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- British Journal of Cancer (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Translational Cancer Research Network
- Topics
- Health Sciences › Medicine › Oncology › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Surgery › Intraperitoneal and Appendiceal Malignancies
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- ascites, ovarian cancer, peritoneal carcinomatosis, chemoresistance, translational research
- MeSH terms
- Ascites, Female, Humans, Ovarian Neoplasms, Ovary, Biomarkers, Tumor, Proteomics
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