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Cited by 262Ovarian cancer diagnosis and treatmentIntraperitoneal and Appendiceal MalignanciesCancer Cells and Metastasis

The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.

The untapped potential of ascites in ovarian cancer research and treatment

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Ford, Caroline Elizabeth, Werner, Bonnita, Hacker, Neville Frederick, Warton, Kristina·2020·British Journal of Cancer
DOI 10.1038/s41416-020-0875-xPMC PMC7341795
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Abstract

The build-up of fluid in the peritoneal cavity-ascites-is a hallmark of ovarian cancer, the most lethal of all gynaecological malignancies. This remarkable fluid, which contains a variety of cellular and acellular components, is known to contribute to patient morbidity and mortality by facilitating metastasis and contributing to chemoresistance, but remains largely under-researched. In this review, we will critically analyse the evidence associating ascites with metastasis and chemoresistance in ovarian cancer and provide an update on research in the field. We will argue the case for ascites as a unique and accessible substrate for tracking tumour progression and for translational research that will enhance our understanding of this cancer and lead to improvements in patient outcomes.

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Crossref · 10.1038/s41416-020-0875-x

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Figures

Fig. 1 Abdominal accumulation of ascites fluid in ovarian cancer patients. The fluid contains tumour cells, non-tumour cells, circulating free DNA (cfDNA) and signalling molecules. CD-95L CD-95 ligand, OPG osteoprotegerin.
Fig. 1 Abdominal accumulation of ascites fluid in ovarian cancer patients. The fluid contains tumour cells, non-tumour cells, circulating free DNA (cfDNA) and signalling molecules. CD-95L CD-95 ligand, OPG osteoprotegerin.CC BY · PubMed Central
Fig. 2 Mechanism of ascites build-up in ovarian cancer. Increased vascular permeability and impaired drainage drive the accumulation of ascites fluid.
Fig. 2 Mechanism of ascites build-up in ovarian cancer. Increased vascular permeability and impaired drainage drive the accumulation of ascites fluid.CC BY · PubMed Central
Fig. 3 Three different sized spheroids isolated from a patient with low-grade serous ovarian cancer (LGSOC). a) large spheroid b) medium spheroid c) small spheroid. Spheroids stained with Trypan Blue. Black bar = 100 µM. Unpublished data (B.W.).
Fig. 3 Three different sized spheroids isolated from a patient with low-grade serous ovarian cancer (LGSOC). a) large spheroid b) medium spheroid c) small spheroid. Spheroids stained with Trypan Blue. Black bar = 100 µM. Unpublished data (B.W.).CC BY · PubMed Central

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Metadata

Authors
Ford, C. E., Werner, B., Hacker, N. F., & Warton, K.
Affiliations
UNSW Sydney (AU)
Corresponding author
Ford, Caroline Elizabeth
ORCID
Venue
British Journal of Cancer
Publisher
Springer Science and Business Media LLC
Published
2020-05-08
Volume
123
Issue
1
Pages
9-16
ISSN
  • 0007-0920 (ISSN-L)
  • 1532-1827
DOI
10.1038/s41416-020-0875-x
PMC
PMC7341795
OpenAlex
W3022087601
Cited by
261
References
110
Citations by year
2026: 44 · 2025: 51 · 2024: 60 · 2023: 46 · 2022: 42 · 2021: 18
FWCI
3.95
Type
journal article
Language
en
Open access
Licence
Locations
  • British Journal of Cancer (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Translational Cancer Research Network
Topics
  • Health Sciences › Medicine › Oncology › Ovarian cancer diagnosis and treatment
  • Health Sciences › Medicine › Surgery › Intraperitoneal and Appendiceal Malignancies
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
ascites, ovarian cancer, peritoneal carcinomatosis, chemoresistance, translational research
MeSH terms
Ascites, Female, Humans, Ovarian Neoplasms, Ovary, Biomarkers, Tumor, Proteomics

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