Breast cancer hypoxia in relation to prognosis and benefit from radiotherapy after breast-conserving surgery in a large, randomised trial with long-term follow-up
Open accessAbstract
Background: Breast-conserving surgery followed by radiotherapy is part of standard treatment for early-stage breast cancer. Hypoxia is common in cancer and may affect the benefit of radiotherapy. Cells adapt to hypoxic stress largely via the transcriptional activity of hypoxia-inducible factor (HIF)-1α. Here, we aim to determine whether tumour HIF-1α-positivity and hypoxic gene-expression signatures associated with the benefit of radiotherapy, and outcome. Methods: Tumour HIF-1α-status and expression of hypoxic gene signatures were retrospectively analysed in a clinical trial where 1178 women with primary T1-2N0M0 breast cancer were randomised to receive postoperative radiotherapy or not and followed 15 years for recurrence and 20 years for breast cancer death. Results: The benefit from radiotherapy was similar in patients with HIF-1α-positive and -negative primary tumours. Both ipsilateral and any breast cancer recurrence were more frequent in women with HIF-1α-positive primary tumours (hazard ratio, HR 0–5 yrs 1.9 [1.3–2.9], p = 0.003 and HR 0–5 yrs = 2.0 [1.5–2.8], p < 0.0001). Tumour HIF-1α-positivity is also associated with increased breast cancer death (HR 0–10 years 1.9 [1.2–2.9], p = 0.004). Ten of the 11 investigated hypoxic gene signatures correlated positively to HIF-1α-positivity, and 5 to increased rate/risk of recurrence. Conclusions: The benefit of postoperative radiotherapy persisted in patients with hypoxic primary tumours. Patients with hypoxic primary breast tumours had an increased risk of recurrence and breast cancer death.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In breast cancer, hypoxia is more evident in TNBC than in other breast cancer subtypes.
“In breast cancer, hypoxia is more evident in TNBC than in other breast cancer subtypes11,12.”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212 · see citing works
Elston, C. W., & Ellis, I. O. (1991) · Histopathology · doi:10.1111/j.1365-2559.1991.tb00229.x · Cited by 6,181 · see citing works
The GeneCards suite: from gene data mining to disease genome sequence analyses
Stelzer, G., Rosen, N., Plaschkes, I., Zimmerman, S., Twik, M., Fishilevich, S., Stein, T. I., Nudel, R., Lieder, I., Mazor, Y., et al. (2016) · Current Protocols in Bioinformatics · doi:10.1002/cpbi.5 · Cited by 5,550 · see citing works
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535 · see citing works
Hypoxia — a key regulatory factor in tumour growth
Harris, A. L. (2002) · Nature Reviews Cancer · doi:10.1038/nrc704 · Cited by 5,177 · see citing works
Darby, S. C., McGale, P., Correa, C. R., Taylor, C., Arriagada, R., Clarke, M. J., Cutter, D. J., Davies, C., Ewertz, M., Godwin, J., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)61629-2 · Cited by 3,942 · see citing works
Goldhirsch, A., Winer, E. P., Coates, A. S., Gelber, R. D., Piccart, M. J., Thurlimann, B. J. K., Senn, H.-J., Albain, K. S., André, F., Bergh, J. C. S., et al. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt303 · Cited by 3,767 · see citing works
Self-citationPartial residuals for the proportional hazards regression model
SCHOENFELD, D. (1982) · Biometrika · doi:10.1093/biomet/69.1.239 · Cited by 3,111 · see citing works
Hypoxia in cancer: significance and impact on clinical outcome
Vaupel, P., & Mayer, A. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9055-1 · Cited by 2,240 · see citing works
Gray, L. H., Conger, A. D., Ebert, M., Hornsey, S., & Scott, O. C. A. (1953) · The British Journal of Radiology · doi:10.1259/0007-1285-26-312-638 · Cited by 2,158 · see citing works
Harvey, J. M., Clark, G. M., Osborne, C. K., & Allred, D. C. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.5.1474 · Cited by 2,054 · see citing works
Rankin, E. B., & Giaccia, A. J. (2016) · Science · doi:10.1126/science.aaf4405 · Cited by 1,340 · see citing works
(1996) · PubMed · Cited by 1,188 · see citing works
Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1
Jiang, B.-H., Rue, E., Wang, G. L., Roe, R., & Semenza, G. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17771 · Cited by 1,106 · see citing works
Nordsmark, M., Bentzen, S. M., Rudat, V., Brizel, D., Lartigau, E., Stadler, P., Becker, A., Adam, M., Molls, M., Dunst, J., et al. (2005) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2005.06.038 · Cited by 953 · see citing works
Taylor, C. W., Correa, C. R., Duane, F. K., Aznar, M. C., Anderson, S., Bergh, J. C. S., Dodwell, D. J., Ewertz, M., Gray, R. G., Jagsi, R., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.72.0722 · Cited by 787 · see citing works
Identification of molecular apocrine breast tumours by microarray analysis
Farmer, P. J., Bonnefoi, H. R., Becette, V., Tubiana-Hulin, M., Fumoleau, P., Larsimont, D., MacGrogan, G. M., Bergh, J. C. S., Cameron, D., Goldstein, D., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208561 · Cited by 783 · see citing works
Tian, H., Hammer, R. E., Matsumoto, A. M., Russell, D. W., & McKnight, S. L. (1998) · Genes & Development · doi:10.1101/gad.12.21.3320 · Cited by 647 · see citing works
Buffa, F. M., Harris, A. L., West, C., & Miller, C. J. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605450 · Cited by 558 · see citing works
Single sample scoring of molecular phenotypes
Foroutan, M., Bhuva, D. D., Horan, K., Lyu, R., Cursons, J., & Davis, M. J. (2018) · BMC Bioinformatics · doi:10.1186/s12859-018-2435-4 · Cited by 548 · see citing works
Bos, R., van der Groep, P., Greijer, A. E., Shvarts, A., Meijer, S., Pinedo, H. M., Semenza, G. L., van Diest, P. J., & van der Wall, E. (2003) · Cancer · doi:10.1002/cncr.11246 · Cited by 500 · see citing works
Loncaster, J. A., Harris, A. L., Davidson, S. E., Logue, J. P., Hunter, R. D., Wycoff, C. C., Pastorek, J., Ratcliffe, P. J., Stratford, I. J., & West, C. (2001) · PubMed · Cited by 482 · see citing works
Elvidge, G. P., Glenny, L., Appelhoff, R. J., Ratcliffe, P. J., Ragoussis, J., & Gleadle, J. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511408200 · Cited by 464 · see citing works
Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers
Winter, S. C., Buffa, F. M., Silva, P., Miller, C., Valentine, H. R., Turley, H., Shah, K. A., Cox, G. J., Corbridge, R. J., Homer, J. J., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3322 · Cited by 410 · see citing works
Identification of molecular apocrine breast tumours by microarray analysis
Farmer, P. J., Bonnefoi, H. R., Becette, V., Tubiana-Hulin, M., Fumoleau, P., Larsimont, D., MacGrogan, G. M., Bergh, J. C. S., Cameron, D., Goldstein, D. R., et al. (2005) · Breast Cancer Research · doi:10.1186/bcr1122 · Cited by 307 · see citing works
104 candidate genes for the hypoxic tumor phenotype
Koong, A. C., Denko, N. C., Schindler, C., Le, Q., Terris, D. T., Ibrahim, H. Z., Goffinet, D. R., & Giaccia, A. J. (1999) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(99)90122-0 · Cited by 290 · see citing works
Overgaard, J., Eriksen, J. G., Nordsmark, M., Alsner, J., & Horsman, M. R. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)70292-8 · Cited by 274 · see citing works
Generali, D., Berruti, A., Brizzi, M. P., Campo, L., Bonardi, S., Wigfield, S., Bersiga, A., Allevi, G., Milani, M., Aguggini, S., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2690 · Cited by 250 · see citing works
A single-sample microarray normalization method to facilitate personalized-medicine workflows
Piccolo, S., Sun, Y., Campbell, J. D., Lenburg, M. E., Bild, A. H., & Johnson, W. E. (2012) · Genomics · doi:10.1016/j.ygeno.2012.08.003 · Cited by 244 · see citing works
Hypoxia promotes a dedifferentiated phenotype in ductal breast carcinoma in situ.
Helczynska, K., Kronblad, Å., Jögi, A., Nilsson, E., Beckman, S., Landberg, G., & Påhlman, S. (2003) · PubMed · Cited by 202 · see citing works
Self-citationA compact VEGF signature associated with distant metastases and poor outcomes
Hu, Z., Fan, C., Livasy, C., He, X., Oh, D. S., Ewend, M. G., Carey, L., Subramanian, S., West, R. B., Ikpatt, F., et al. (2009) · BMC Medicine · doi:10.1186/1741-7015-7-9 · Cited by 185 · see citing works
Malmström, P., Holmberg, L., Anderson, H., Mattsson, J., Jönsson, P.-E., Tennvall-Nittby, L., BALLDIN, G., Lovén, L., Svensson, J.-H., Ingvar, C., et al. (2003) · European Journal of Cancer · doi:10.1016/s0959-8049(03)00324-1 · Cited by 174 · see citing works
Self-citationLeung, S. C. Y., Nielsen, T. O., Zabaglo, L. A., Arun, I., Badve, S., Bane, A. L., Bartlett, J. M. S., Borgquist, S., Chang, M. C., Dodson, A. R., et al. (2016) · npj Breast Cancer · doi:10.1038/npjbcancer.2016.14 · Cited by 153 · see citing works
Yang, L., Roberts, D. L., Takhar, M. M., Erho, N., Bibby, B. A. S., Thiruthaneeswaran, N., Bhandari, V., Cheng, W., Haider, S. A., McCorry, A. M. B., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.04.019 · Cited by 147 · see citing works
Candidate genes for the hypoxic tumor phenotype.
Koong, A. C., Denko, N. C., Hudson, K. M., Schindler, C., Swiersz, L. M., Koch, C., Evans, S. M., Ibrahim, H., Le, Q., Terris, D. J., et al. (2000) · PubMed · Cited by 130 · see citing works
Mense, S. M., Sengupta, A., Zhou, M., Lan, C., Bentsman, G., Volsky, D. J., & Li, Z. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00315.2005 · Cited by 120 · see citing works
Gene Expression Signatures as Biomarkers of Tumour Hypoxia
Harris, B. H. L., Barberis, A., West, C., & Buffa, F. M. (2015) · Clinical Oncology · doi:10.1016/j.clon.2015.07.004 · Cited by 117 · see citing works
Sjöström, M., Lundstedt, D., Hartman, L. W., Holmberg, E. C., Killander, F., Kovács, A., Malmström, P., Niméus, E., Rönnerman, E. W., Fernö, M., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.72.7263 · Cited by 116 · see citing works
Self-citationMolecular Portrait of Hypoxia in Breast Cancer: A Prognostic Signature and Novel HIF-Regulated Genes
Ye, I. C., Fertig, E. J., DiGiacomo, J. W., Considine, M., Godet, I., & Gilkes, D. M. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-18-0345 · Cited by 95 · see citing works
Identifying pH independent hypoxia induced genes in human squamous cell carcinomas in vitro
Sørensen, B. S., Toustrup, K., Horsman, M. R., Overgaard, J., & Alsner, J. (2010) · Acta Oncologica · doi:10.3109/02841861003614343 · Cited by 82 · see citing works
Jögi, A., Ehinger, A., Hartman, L. W., & Alkner, S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226150 · Cited by 70 · see citing works
Self-citationKillander, F., Karlsson, P., Anderson, H., Mattsson, J., Holmberg, E. C., Lundstedt, D., Holmberg, L., & Malmström, P. (2016) · European Journal of Cancer · doi:10.1016/j.ejca.2016.08.001 · Cited by 66 · see citing works
Self-citationPrognostic Potential Of The Pretherapeutic Tumor Oxygenation Status
Vaupel, P. W. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-85998-9_36 · Cited by 63 · see citing works
Risk Factors of Developing Long-Lasting Breast Pain After Breast Cancer Radiotherapy
Lundstedt, D., Gustafsson, M., Steineck, G., Malmström, P., Alsadius, D., Sundberg, A., Wilderäng, U., Holmberg, E. C., Johansson, K.-A., & Karlsson, P. (2011) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2011.05.065 · Cited by 54 · see citing works
Self-citationSymptoms 10–17 years after breast cancer radiotherapy data from the randomised SWEBCG91-RT trial
Lundstedt, D., Gustafsson, M., Malmström, P., Johansson, K.-A., Alsadius, D., Sundberg, A., Wilderäng, U., Holmberg, E. C., Anderson, H., Steineck, G., et al. (2010) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2010.09.018 · Cited by 37 · see citing works
Self-citationRadioresistant tumours: From identification to targeting
Moyal, E. C., Vendrely, V., Motte, L., Balosso, J., & Thariat, J. (2020) · Cancer/Radiothérapie · doi:10.1016/j.canrad.2020.05.005 · Cited by 23 · see citing works
Sjöström, M., Chang, S. L., Fishbane, N., Davicioni, E., Hartman, L. W., Holmberg, E. C., Feng, F. Y.-C., Speers, C. W., Pierce, L. J., Malmström, P., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-1038 · Cited by 20 · see citing works
Self-citationJögi, A. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1824-5_4 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
1 of the 50 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Ma, S., Zhao, Y., Lee, W. C., Ong, L.-T., Lee, P. L., Jiang, Z., Oguz, G., Niu, Z., Liu, M., Goh, J. Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31764-9 · Cited by 200 · see citing works
Targeting hypoxia-inducible factor-1alpha: A new strategy for triple-negative breast cancer therapy
Liu, Q., Guan, C., Liu, C., Li, H., Wu, J., & Sun, C. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113861 · Cited by 84 · see citing works
Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity
Ortmann, B. M. (2024) · BMJ Oncology · doi:10.1136/bmjonc-2023-000154 · Cited by 67 · see citing works
Colak, B., & Ertas, Y. N. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c17024 · Cited by 50 · see citing works
Recent progress in immune evasion mechanisms of triple-negative breast cancer
Yang, Y., & Wang, W. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07370-w · Cited by 50 · see citing works
Liu, Q., Palmgren, V. A. C., Danen, E. H. J., & Dévédec, S. E. L. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07802-6 · Cited by 41 · see citing works
Gupta, A., Nishchaya, K., Saha, M., Naik, G. A. R. R., Yadav, S., Srivastava, S., Roy, A. A., Moorkoth, S., Mutalik, S., & Dhas, N. L. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105401 · Cited by 35 · see citing works
Li, W., Li, R., Ye, Q., Zou, Y., Lü, X., Zhang, W., Chen, J.-X., & Zhao, Y. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202202280 · Cited by 32 · see citing works
Defining hypoxia in cancer: A landmark evaluation of hypoxia gene expression signatures
Giovannantonio, M. D., Hartley, F., Elshenawy, B., Barberis, A., Hudson, D., Shafique, H. S., Allott, V. E. S., Harris, D. A., Lord, S., Haider, S. A., et al. (2025) · Cell Genomics · doi:10.1016/j.xgen.2025.100764 · Cited by 25 · see citing works
Tian, S., Liao, X., Cao, W., Wu, X., Chen, Z., Lu, J., Wang, Q., Zhang, J., Chen, L., & Zhang, W. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.08.017 · Cited by 24 · see citing works
Liu, L., Bai, J., Hu, L., & Jiang, D. (2023) · Medicine · doi:10.1097/md.0000000000035493 · Cited by 20 · see citing works
Decoding the adaptive survival mechanisms of breast cancer dormancy
Barnieh, F. M., MORTON, J. K., Olanrewaju, O., & El‐Khamisy, S. F. (2025) · Oncogene · doi:10.1038/s41388-025-03529-3 · Cited by 17 · see citing works
The role of metabolic reprogramming in immune escape of triple-negative breast cancer
Bao, R., Qu, H., Li, B., Cheng, K., Miao, Y., & Wang, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1424237 · Cited by 20 · see citing works
A translational review of hyperthermia biology
Dewhirst, M. W. (2025) · International Journal of Hyperthermia · doi:10.1080/02656736.2024.2447952 · Cited by 14 · see citing works
Patwardhan, R. S., Rai, A., Sharma, D., Sandur, S. K., & Patwardhan, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27011 · Cited by 13 · see citing works
Han, Y. J., Liu, S., Hardeman, A., Rajagopal, P. S., Mueller, J. S., Khramtsova, G. F., Sanni, A., Ajani, M., Clayton, W., Hurley, I. W., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-1526 · Cited by 12 · see citing works
Identification of a hypoxia-suppressed lncRNA RAMP2-AS1 in breast cancer
Lou, W., Xiao, S., & Lin, K. (2024) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.02.007 · Cited by 11 · see citing works
Interpreting Cancer Incidence Rates and Trends: A Review of Control Factors and Worldwide Statistics
Bahrami, H. (2024) · Journal of Cancer Research and Practice · doi:10.4103/ejcrp.ejcrp-d-23-00046 · Cited by 11 · see citing works
A Pyroptosis Radiosensitizer Facilitates Hypoxic Tumor Necrosis
Gu, C., Wang, D., Zhu, S., Wang, X., Tian, X., Liao, Y., & Gu, Z. (2025) · Small · doi:10.1002/smll.202409594 · Cited by 10 · see citing works
Qin, W., Chen, B., Li, X., Zhao, W., Wang, L., Zhang, N., Wang, X., Luo, D., Liang, Y., Li, Y., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07580-6 · Cited by 10 · see citing works
Endogenous double-stranded RNA: Bridging immune activation and cancer therapeutics
Liu, X., Che, L., & Weng, H. (2025) · Cell investigation. · doi:10.1016/j.clnves.2025.100018 · Cited by 8 · see citing works
Canha-Borges, A., Nunes, B., Quintas, S. T., Paredes, J., Meziani, L., Mondini, M., Oliveira, M. J., Deutsch, É., & Castro, F. (2025) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2025.103026 · Cited by 8 · see citing works
Analyses of hypoxia-related risk factors and clinical relevance in breast cancer
Li, Y., Yu, H., Han, X., & Pan, Y. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1350426 · Cited by 9 · see citing works
Time-Resolved stereoscopic PIV measurements of cyclic variations in an internal combustion engine
Karhoff, D.-C., Bücker, I., Klaas, M., & Schröder, W. (2013) · Research Repository (Delft University of Technology) · Cited by 8 · see citing works
Harris, A. R., Panigrahi, G., Liu, H., Kopardé, V. N., Bailey‐Whyte, M., Dorsey, T. H., Yates, C. C., & Ambs, S. (2023) · Cancer Research Communications · doi:10.1158/2767-9764.crc-23-0236 · Cited by 7 · see citing works
Attia, Y. M., Hakeem, A. N., Samir, R., Mohammed, A., Elsayed, A., Khallaf, A., Essam, E., Amin, H., Abdullah, S., Hikmat, S., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1362675 · Cited by 7 · see citing works
Lundgren, C., Tutzauer, J., Church, S., Stål, O., Ekholm, M., Forsare, C., Nordenskjöld, B. A., Fernö, M., Bendahl, P., & Rydén, L. (2023) · Breast Cancer Research · doi:10.1186/s13058-023-01719-z · Cited by 7 · see citing works
Self-citationNoguchi, S., Yagi, K., Okamoto, N., Wada, Y., & Tanaka, T. T. (2022) · Veterinary Sciences · doi:10.3390/vetsci10010004 · Cited by 6 · see citing works
Fang, Z., Zhou, X., Zou, P., Chen, J., Chen, X., Huang, N., Gong, C., Quan, L., Tang, J., Mi, Y., et al. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-01178-z · Cited by 5 · see citing works
Affinity of PET-MRI Tracers for Hypoxic Cells in Breast Cancer: A Systematic Review
Costin, I.-C., & Marcu, L. G. (2024) · Cells · doi:10.3390/cells13121048 · Cited by 5 · see citing works
Elhamamsy, A. R., Metge, B. J., Swain, C. A., Elbahoty, M. H., Hinshaw, D. C., Kammerud, S. C., Chen, D., Samant, R. S., & Shevde, L. A. (2025) · Nature Communications · doi:10.1038/s41467-025-63315-3 · Cited by 4 · see citing works
Computational Pathology Detection of Hypoxia-Induced Morphologic Changes in Breast Cancer
Manescu, P., Geradts, J., & Fernández-Reyes, D. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.10.023 · Cited by 3 · see citing works
Ba, L., Zhao, Z., Zhang, C., Chu, Y., & Wu, C. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113810 · Cited by 3 · see citing works
Vu, M. N., Le, D. H., Vu, T. T., Nguyen, T. N., Chu, H. H., & Bui, V. N. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46110702 · Cited by 2 · see citing works
Novin, A., Wali, K. H., Pant, A., Liu, S., Du, W., Liu, Y., Wang, L., Xu, M., Wang, B., Suhail, Y., et al. (2024) · Cancers · doi:10.3390/cancers16050969 · Cited by 2 · see citing works
Correlation analysis of DLG5 and PD-L1 expression in triple-negative breast cancer
Che, J., Chen, B., Wang, X., Liu, B., Xu, C., Wang, H., Sun, J., Feng, Q., Zhao, X., & Song, Z. (2025) · BMC Cancer · doi:10.1186/s12885-025-13428-1 · Cited by 2 · see citing works
Belisario, D. C., Sapino, A., Roato, I., Bosìa, A., Doublier, S., & Marchiò, S. (2025) · Cancers · doi:10.3390/cancers17142382 · Cited by 2 · see citing works
Luo, J., Peng, H., Luo, H., Zeng, X., Jin, F., & Xie, Y. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-6026 · Cited by 1 · see citing works
Blood transfusion mediated tumor microenvironment remodeling in breast cancer
Yin, Q., Zhang, S., Ouchari, M., Wang, P., Zhao, A., Zeng, L., Wang, J., Yao, K., Tang, S., Ma, H., et al. (2025) · Acta Histochemica · doi:10.1016/j.acthis.2025.152289 · Cited by 1 · see citing works
Putra, W. E., Hidayatullah, A., Widiastuti, D., Heikal, M. F., & Sustiprijatno (2025) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-025-00854-y · Cited by 1 · see citing works
Pershikova, E., Kontareva, E., Ilyina, I., Alexandrova, A., Pustovalova, M. V., Leonov, S., & Merkher, Y. (2026) · International Electronic Conference on Applied Sciences (ASEC) · doi:10.3390/engproc2026124073 · Cited by 1 · see citing works
Zhou, C., Crusher, J. T., Friesen, K., Twigger, S. A., Petrosyan, E., Booker, G., Samuel, P., Parkes, E. E., & Hammond, E. M. (2026) · npj Breast Cancer · doi:10.1038/s41523-026-00927-y · Cited by 1 · see citing works
Lu, W., Wang, W., Chen, B., Huang, Z., & Jiang, R. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.154365 · Cited by 1 · see citing works
Malcolm, J. R., Stenning, J., Pope, J., Lukaszonek, J., Rose, S. F., Smith, T. E., Gilbert, L., James, S. R., Bridge, K. S., Brackenbury, W. J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.03.680339 · Cited by 1 · see citing works
West, C. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01707-8
Yiğittürk, G., Ergözen, S., Elbe, H., YÜCEL, A., Çavuşoğlu, T., Baygar, T., & Uyanıkgil, Y. (2023) · Ege Tıp Dergisi · doi:10.19161/etd.1235892
Lundgren, C., Tutzauer, J., Church, S., Stål, O., Ekholm, M., Forsare, C., Nordenskjöld, B. A., Fernö, M., Bendahl, P.-O., & Rydén, L. (2024) · Figshare · doi:10.6084/m9.figshare.26620855
Self-citationLundgren, C., Tutzauer, J., Church, S., Stål, O., Ekholm, M., Forsare, C., Nordenskjöld, B. A., Fernö, M., Bendahl, P.-O., & Rydén, L. (2024) · Figshare · doi:10.6084/m9.figshare.26620858
Self-citationLundgren, C., Tutzauer, J., Church, S., Stål, O., Ekholm, M., Forsare, C., Nordenskjöld, B. A., Fernö, M., Bendahl, P.-O., & Rydén, L. (2024) · Figshare · doi:10.6084/m9.figshare.24223867
Self-citationLundgren, C., Tutzauer, J., Church, S., Stål, O., Ekholm, M., Forsare, C., Nordenskjöld, B. A., Fernö, M., Bendahl, P.-O., & Rydén, L. (2023) · Figshare · doi:10.6084/m9.figshare.24223816
Self-citationLundgren, C., Tutzauer, J., Church, S., Stål, O., Ekholm, M., Forsare, C., Nordenskjöld, B. A., Fernö, M., Bendahl, P.-O., & Rydén, L. (2024) · Figshare · doi:10.6084/m9.figshare.26620852
Self-citationLundgren, C., Tutzauer, J., Church, S., Stål, O., Ekholm, M., Forsare, C., Nordenskjöld, B. A., Fernö, M., Bendahl, P.-O., & Rydén, L. (2024) · Figshare · doi:10.6084/m9.figshare.26620861
Self-citationPIEZO Channels in Breast Cancer: Emerging Roles and Therapeutic Potential
Adams, E., Reddock, M., Gillen, B., Wang, X., Wang, Q., Opyrchal, M., & Yu, T. (2026) · Receptors · doi:10.3390/receptors5020019
A non-canonical function of RNF8 opposes TRAF6-mediated stabilization of HIF1α
Ringelstetter, L., Mersdorf-Weber, E., Schorpp, K., & Hadian, K. (2026) · RSC Chemical Biology · doi:10.1039/d5cb00209e
- Authors
- Tutzauer, J., Sjöström, M., Holmberg, E., Karlsson, P., Killander, F., Leeb-Lundberg, L. M. F., Malmström, P., Niméus, E., Fernö, M., & Jögi, A.
- Affiliations
- Lund University (SE)
- University of Gothenburg (SE)
- Corresponding author
- Jögi, Annika
- ORCID
- Venue
- British Journal of Cancer
- Published
- 2022-02-09
- Volume
- 126
- Issue
- 8
- Pages
- 1145-1156
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC9023448
- OpenAlex
- W4210934033
- Cited by
- 53
- References
- 50
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 20 · 2023: 6 · 2022: 6 · 2013: 1
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- British Journal of Cancer (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Falk Foundation
- Swedish Cancer Foundation
- Percy Falk Foundation
- Cancerfonden
- Allmänna Sjukhusets i Malmö Stiftelse för Bekämpande av Cancer
- Marcus och Amalia Wallenbergs minnesfond
- University of California, San Francisco
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Keywords
- breast cancer, tumor hypoxia, hypoxia-inducible factor-1α, HIF-1α expression, breast-conserving surgery, postoperative radiotherapy, breast cancer recurrence, breast cancer mortality, early breast cancer, prognostic factors
- MeSH terms
- Hypoxia, Breast Neoplasms, Female, Follow-Up Studies, Humans, Neoplasm Recurrence, Local, Prognosis, Retrospective Studies, Mastectomy, Segmental, Hypoxia-Inducible Factor 1, alpha Subunit
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
