Implantable, 3D-Printed Alginate Scaffolds with Bismuth Sulfide Nanoparticles for the Treatment of Local Breast Cancer via Enhanced Radiotherapy
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High Resolution Image Download MS PowerPoint Slide Surgical removal of tumor tissue remains the primary clinical approach for addressing breast cancer; however, complete tumor excision is challenging, and the remaining tumor cells can lead to tumor recurrence and metastasis over time, which substantially deteriorates the life quality of the patients. With the aim to improve local cancer radiotherapy, this work reports the fabrication of alginate (Alg) scaffolds containing bovine serum albumin (BSA)-coated bismuth sulfide (Bi 2 S 3 @BSA) nanoradiosensitizers using three-dimensional (3D) printing. Under single-dose X-ray irradiation in vitro, Alg-Bi 2 S 3 @BSA scaffolds significantly increase the formation of reactive oxygen species, enhance the inhibition of breast cancer cells, and suppress their colony formation capacity. In addition, scaffolds implanted under tumor tissue in murine model show high therapeutic efficacy by reducing the tumor volume growth rate under single-dose X-ray irradiation, while histological observation of main organs reveals no cytotoxicity or side effects. 3D-printed Alg-Bi 2 S 3 @BSA scaffolds produced with biocompatible and biodegradable materials may potentially lower the recurrence and metastasis rates in breast cancer patients by inhibiting residual tumor cells following postsurgery as well as exhibit anticancer properties in other solid tumors.
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Safety assessments were reported in a proportion of studies, with limited systemic toxicity observed based on body weight, organ histology, and hematological parameters.
“Safety assessments were reported in a proportion of studies, with limited systemic toxicity observed based on body weight, organ histology, and hematological parameters [34,40,48,83].”
From Nanoparticle-Mediated Radiosensitization in Breast Cancer: A Systematic Review of Preclinical Evidence and Translational Challenges (2026) · cites this paper as [83]
The Results and Discussion (In Vivo Anticancer Studies; page unavailable) report that scaffold-treated mice gained weight and that major organs showed no visible tissue damage. The paper therefore supports limited toxicity based on body weight and organ histology, but our copy does not report hematological parameters; it also cannot establish what proportion of the citing review’s studies performed safety assessments. (LLM, conf=0.88)
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- Authors
- Colak, B., & Ertas, Y. N.
- Affiliations
- Erciyes University (TR)
- ERNAM─Nanotechnology Research and Application Center, Erciyes University, Kayseri 38039, Türkiye
- ORCID
- Ertas, Yavuz Nuri
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2024-03-20
- Volume
- 16
- Issue
- 13
- Pages
- 15718-15729
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- PMC
- PMC10995896
- OpenAlex
- W4392974264
- Cited by
- 50
- References
- 50
- Citations by year
- 2026: 16 · 2025: 23 · 2024: 11
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- ACS Applied Materials & Interfaces (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Bilkent University Institutional Repository (Bilkent University) (submittedVersion, cc-by)
- Funders
- Bilimsel Arastirma Projeleri, Erciyes ?niversitesi (FYL-2022-11807)
- T?rkiye Bilimsel ve Teknolojik Arastirma Kurumu (118C346)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Physical Sciences › Physics and Astronomy › Radiation › Advanced Radiotherapy Techniques
- Keywords
- breast cancer, radiotherapy, alginate scaffolds, bismuth sulfide nanoparticles, bovine serum albumin coating, 3D-printed scaffolds, reactive oxygen species, tumor recurrence, metastasis, implantable scaffolds, mouse tumor model
- MeSH terms
- Alginates, Animals, Bismuth, Breast Neoplasms, Female, Humans, Sulfides, Tissue Engineering, Mice, Nanoparticles, Tissue Scaffolds, Printing, Three-Dimensional
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