Cited by 141Cervical Cancer and HPV ResearchWomen's cancer prevention and managementGlobal Cancer Incidence and Screening

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Offering HPV self-sampling kits: an updated meta-analysis of the effectiveness of strategies to increase participation in cervical cancer screening

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Costa, Stefanie, Verberckmoes, Bo, Castle, Philip E., Arbyn, Marc·2023·British Journal of Cancer

DOI 10.1038/s41416-022-02094-wPMC PMC9977737

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Abstract

Background Human papillomavirus (HPV) testing on self-samples represents a great opportunity to increase cervical cancer screening uptake among under-screened women. Methods A systematic review and meta-analysis on randomised controlled trials (RCTs) were performed to update the evidence on the efficacy of strategies for offering self-sampling kits for HPV testing compared to conventional invitations and to compare different self-sampling invitation scenarios. Four experimental invitational scenarios were considered. Women in the control group were invited for screening according to existing practice: collection of a cervical specimen by a healthcare professional. Random-effects models were used to pool proportions, relative participation rates and absolute participation differences. Results Thirty-three trials were included. In the intention-to-treat analysis, all self-sampling invitation scenarios were more effective in reaching under-screened women compared to controls. Pooled participation difference (PD) and 95% confidence interval (CI) for experimental vs. control was 13.2% (95% CI = 11.0-15.3%) for mail-to-all, 4.4% (95% CI = 1.2-7.6%) for opt-in, 39.1% (95% CI = 8.4-69.9%) for community mobilisation & outreach and 28.1% (23.5-32.7%) for offer at healthcare service. PD for the comparison opt-in vs. mail-to-all, assessed in nine trials, was -8.2% (95% CI = -10.8 to -5.7%). Discussion Overall, screening participation was higher among women invited for self-sampling compared to control, regardless of the invitation strategy used. Opt-in strategies were less effective than send-to-all strategies.

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Authors: Costa, S., Verberckmoes, B., Castle, P. E., & Arbyn, M.
Affiliations: Sciensano (Belgium) (BE)
Ghent University Hospital (BE)
National Cancer Institute (US)
Ghent University (BE)
Corresponding author: Arbyn, Marc
ORCID: Costa, Stefanie
Verberckmoes, Bo
Castle, Philip E.
Arbyn, Marc
Venue: British Journal of Cancer
Publisher: Springer Science and Business Media LLC
Published: 2022-12-14
Volume: 128
Issue: 5
Pages: 805-813
ISSN: 0007-0920 (ISSN-L)
1532-1827
DOI: 10.1038/s41416-022-02094-w
PMC: PMC9977737
OpenAlex: W4311399768
Cited by: 139
References: 63
Citations by year: 2026: 44 · 2025: 45 · 2024: 38 · 2023: 12
FWCI: 3.77
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: British Journal of Cancer (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders: EC | Horizon 2020 Framework Programme (825747, 847845)
U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (ZIACP101237-01)
VALHUDES researcher-induced frameworks for comparison and validation of HPV tests used on clinician-collected and self-collected samples
Topics: Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
Keywords: HPV self-sampling, cervical cancer screening, screening uptake, community mobilization, underscreened women, HPV testing
MeSH terms: Uterine Cervical Neoplasms, Female, Humans, Mass Screening, Self Care, Specimen Handling, Vaginal Smears, Papillomaviridae, Papillomavirus Infections, Early Detection of Cancer

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Offering HPV self-sampling kits: an updated meta-analysis of the effectiveness of strategies to increase participation in cervical cancer screening

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