The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.
The multifaceted role of ferroptosis in liver disease
Open accessAbstract
Ferroptosis is an iron-dependent form of non-apoptotic cell death characterized by excessive lipid peroxidation and associated with a plethora of pathological conditions in the liver. Emerging evidence supports the notion that dysregulated metabolic pathways and impaired iron homeostasis play a role in the progression of liver disease via ferroptosis. Although the molecular mechanisms by which ferroptosis causes disease are poorly understood, several ferroptosis-associated genes and pathways have been implicated in liver disease. Here, we review the physiological role of the liver in processing nutrients, our current understanding of iron metabolism, the characteristics of ferroptosis, and the mechanisms that regulate ferroptosis. In addition, we summarize the role of ferroptosis in the pathogenesis of liver disease, including liver injury, non-alcoholic steatohepatitis, liver fibrosis, liver cirrhosis, and hepatocellular carcinoma. Finally, we discuss the therapeutic potential of targeting ferroptosis for managing liver disease.
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Citations
Cites
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
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Cited by
Targeting ferroptosis opens new avenues for the development of novel therapeutics
Sun, S., Shen, J., Jiang, J., Wang, F., & Min, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01606-1 · Cited by 608
Self-citationGPX4, ferroptosis, and diseases
Zhang, W., Liu, Y., Liao, Y., Zhu, C., & Zou, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116512 · Cited by 426
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Endoplasmic reticulum stress-mediated cell death in liver injury
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Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype
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Metadata
- Authors
- Chen, J., Li, X., Ge, C., Min, J., & Wang, F.
- Venue
- Cell Death & Differentiation
- Published
- 2022-01-24
- Volume
- 29
- Issue
- 3
- Pages
- 467-480
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- OpenAlex
- W4206972726
- Cited by
- 665
- References
- 141
- FWCI
- 79.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
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