Single-cell transcriptomics reveals intestinal cell heterogeneity and identifies Ep300 as a potential therapeutic target in mice with acute liver failure

Yin, Jie; Zhao, Ziming; Huang, Jianzheng; Xiao, Yang; Rehmutulla, Mewlude; Zhang, Biqiong; Zhang, Zijun; Xiang, Ming; Tong, Qingyi; Zhang, Yonghui

doi:10.1038/s41421-023-00578-4

Single-cell transcriptomics reveals intestinal cell heterogeneity and identifies Ep300 as a potential therapeutic target in mice with acute liver failure

Acute liver failure (ALF) is a severe life-threatening disease associated with the disorder of the gut-liver axis. However, the cellular characteristics of ALF in the gut and related therapeutic targets remain unexplored. Here, we utilized the D-GALN/LPS (D/L)-induced ALF model to characterize 33…