The DOI matches its Crossref record; 218 of the 218 references it cites were found in a registry or an index.
Helper T cell differentiation
Open accessAbstract
CD4+ T helper cells are key regulators of host health and disease. In the original model, specialized subsets of T helper cells are generated following activation through lineage-specifying cytokines and transcriptional programs, but recent studies have revealed increasing complexities for CD4+ T-cell differentiation. Here, we first discuss CD4+ T-cell differentiation from a historical perspective by highlighting the major studies that defined the distinct subsets of T helper cells. We next describe the mechanisms underlying CD4+ T-cell differentiation, including cytokine-induced signaling and transcriptional networks. We then review current and emerging topics of differentiation, including the plasticity and heterogeneity of T cells, the tissue-specific effects, and the influence of cellular metabolism on cell fate decisions. Importantly, recent advances in cutting-edge approaches, especially systems biology tools, have contributed to new concepts and mechanisms underlying T-cell differentiation and will likely continue to advance this important research area of adaptive immunity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, the current view is that CD4 Th cell subsets are not separate lineages but have plasticity and form a continuum of mixed functional capacities [177, 178].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [178]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Items 201–218 of 218
Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling
Yang, K., Blanco, D. B., Neale, G. A. M., Vogel, P., Ávila-Pacheco, J., Clish, C. B., Wu, C., Shrestha, S., Rankin, S. L., Long, L., et al. (2017) · Nature · doi:10.1038/nature23665 · Cited by 203
Self-citationRunx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells
Rudra, D., Egawa, T., Chong, M. M. W., Treuting, P. M., Littman, D. R., & Rudensky, A. Y. (2009) · Nature Immunology · doi:10.1038/ni.1795 · Cited by 202
Henriksson, J., Chen, X. X., Gomes, T., Ullah, U., Meyer, K. B., Miragaia, R. J., Duddy, G., Pramanik, J., Yusa, K., Lahesmaa, R., et al. (2019) · Cell · doi:10.1016/j.cell.2018.11.044 · Cited by 198
Chapman, N. M., Zeng, H., Nguyen, T.-L. M., Wang, Y., Vogel, P., Dhungana, Y., Liu, X., Neale, G. A. M., Locasale, J. W., & Chi, H. (2018) · Nature Communications · doi:10.1038/s41467-018-04392-5 · Cited by 194
Self-citationMolecular diversification of regulatory T cells in nonlymphoid tissues
DiSpirito, J. R., Zemmour, D., Ramanan, D., Cho, J., Žilionis, R., Klein, A. M., Benoist, C. O., & Mathis, D. J. (2018) · Science Immunology · doi:10.1126/sciimmunol.aat5861 · Cited by 165
Kano, S., Sato, K., Morishita, Y., Vollstedt, S., Kim, S.-H., Bishop, K., Honda, K., Kubo, M., & Taniguchi, T. (2007) · Nature Immunology · doi:10.1038/ni1538 · Cited by 164
Wang, S., Charbonnier, L.-M., Noval Rivas, M., Georgiev, P., Li, N., Gerber, G., Bry, L., & Chatila, T. A. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.014 · Cited by 161
Gabryšová, L., Alvarez-Martinez, M., Luisier, R., Cox, L. S., Sodenkamp, J., Hosking, C., Pérez‐Mazliah, D., Whicher, C., Kannan, Y., Potempa, K., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0083-5 · Cited by 150
Löhning, M., Hegazy, A. N., Pinschewer, D. D., Busse, D., Lang, K. S., Höfer, T., Radbruch, A., Zinkernagel, R. M., & Hengartner, H. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071855 · Cited by 142
Campbell, C., Dikiy, S., Bhattarai, S. K., Chinen, T., Matheis, F., Calafiore, M., Hoyos, B. E., Hanash, A. M., Mucida, D., Bucci, V., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.013 · Cited by 121
Chisolm, D. A., Savic, D., Moore, A. J., Ballesteros‐Tato, A., León, B., Crossman, D. K., Murre, C., Myers, R., & Weinmann, A. S. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.015 · Cited by 105
Hallmarks of T-cell Exit from Quiescence
Chapman, N. M., & Chi, H. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0605 · Cited by 95
Self-citationRoss, S. H., Rollings, C., Anderson, K. E., Hawkins, P. T., Stephens, L. R., & Cantrell, D. A. (2016) · Immunity · doi:10.1016/j.immuni.2016.07.022 · Cited by 89
Rapid In Vivo Conversion of Effector T Cells into Th2 Cells during Helminth Infection
Panzer, M., Sitte, S., Wirth, S., Drexler, I., Sparwasser, T. D., & Voehringer, D. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101164 · Cited by 83
Davis, M. M., & Brodin, P. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053206 · Cited by 76
Cutting Edge: c-Maf Is Required for Regulatory T Cells To Adopt RORγt+ and Follicular Phenotypes
Wheaton, J. D., Yeh, C., & Ciofani, M. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1701134 · Cited by 70
調節性T細胞移動はグルコキナーゼ仲介される解糖に依存している【Powered by NICT】
Madhav, K., Kenneth, C. P. C., Hongmei, F., et al. (2017) · Immunity · Cited by 62
Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation
Shin, B., Kress, R. L., Kramer, P. A., Darley-Usmar, V. M., Bellis, S. L., & Harrington, L. E. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20172335 · Cited by 39
Cited by
Sorted by citations
Sun, L., Su, Y., Jiao, A., Wang, X., & Zhang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01471-y · Cited by 1,153
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531
Drug repurposing for cancer therapy
Xia, Y., Sun, M., Huang, H., & Jin, W.-L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01808-1 · Cited by 443
RNA modifications: importance in immune cell biology and related diseases
Cui, L., Ma, R., Cai, J., Guo, C., Chen, Z., Yao, L., Wang, Y., Fan, R., Wang, X., & Shi, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01175-9 · Cited by 432
Differentiation and Regulation of TH Cells: A Balancing Act for Cancer Immunotherapy
Basu, A. B., Ramamoorthi, G., Albert, G. K., Gallen, C., Beyer, A., Snyder, C., Koski, G. K., Disis, M. L., Czerniecki, B. J., & Kodumudi, K. N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.669474 · Cited by 329
Metadata
- Authors
- Saravia, J., Chapman, N. M., & Chi, H.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Chi, Hongbo
- Venue
- Cellular & Molecular Immunology
- Published
- 2019-03-12
- Volume
- 16
- Issue
- 7
- Pages
- 634-643
- ISSN
- 1672-7681 (ISSN-L)
- 2042-0226
- PMC
- PMC6804569
- OpenAlex
- W2921191661
- Cited by
- 489
- References
- 218
- Citations by year
- 2026: 33 · 2025: 85 · 2024: 114 · 2023: 94 · 2022: 80 · 2021: 44 · 2020: 34 · 2019: 5
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Foundation for the National Institutes of Health
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- CD4+ T helper cells, T helper cell differentiation, T helper cell subsets, transcriptional regulatory networks, T cell plasticity, T cell heterogeneity, cellular metabolism, cell fate determination, systems biology
- MeSH terms
- Animals, Cell Differentiation, T-Lymphocytes, Helper-Inducer, Humans, Cytokines, Cell Lineage, Gene Regulatory Networks, Adaptive Immunity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
